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The map label for this gene is thrB [H]

Identifier: 156937995

GI number: 156937995

Start: 1077105

End: 1078010

Strand: Direct

Name: thrB [H]

Synonym: Igni_1208

Alternate gene names: 156937995

Gene position: 1077105-1078010 (Clockwise)

Preceding gene: 156937993

Following gene: 156937999

Centisome position: 83.01

GC content: 65.67

Gene sequence:

>906_bases
TTGTGGGTTTGCGCGAGAGCCCCCTCGAGCTCCGCTAACTTAGGCCCCGGCTACGACGTGCTCGCCTTGGCGCACGACGC
TTACTTCGACGTGGTCTGCGTAAGGCCCTCGGAAGAAACTAGGGTAGTAAAGGTGACCGGCGAGTGGAAGGTGCCGCTAG
AGAGGAACAGCGCCTTGGCGGCTGCCGAGGAAGCCCTCAAGAGGCTCGGGGGGAAGGGGGTTGAGATATGGGTACACAAG
GGCGTCCCCCCGGGAAGGGGGCTAGGCTCCTCCGGCGCCAGCGCGGCCGCCGCCGTCAAGGCTGTAGAGCTCCTCTTGGG
TAAGTCGTTGAGTCCCGAGGAAGCTGTTATGAGTGCGGCTGAGGGCGAGAGGCTGGTCTCCGGGGCCGCCCACGCGGACA
ACGTGGCGGCCTCCTACCTAGGGGGATTGGTAGCCGTAACCTACGACCCGTTCAAGGTGCTCAAGTTCGAGGTGGCCGAG
GTAGAGCTCTACGTGGTGACCCCGTGGCACGAGGTCCCGGAGGGGAAGACCGGCGCCGCCAGGTCGGTCCTCCCGGAGGA
GGTGAAGCTGAGGGACGCCGTCAAGATGGTCGGCGGCGCTGCGGCAGTGATCAAGGCTTTGACCTCCGGCGACGAGGACC
TCTTAGCAAAGGCCATAGAAATGGACCCCGTGGTGACGCCGGCCCGCTCGAAGCTGATACCGTGCTTCGAGGAAGTGGTG
AAGGCGGCGAAGGGAGGAGGGGCGAAGGGCGTCACCATCTCCGGCGCGGGGCCCAGCTTGCTCCTCGTCGGAGGGGGAGC
GGAAGAGGCCAAGGCCGCTTGGGAGAGGTGCGGGGTCAAGGCGACTTACAAGAAGGTCAAGCCCGCTCGCGGCTCCTCCG
CCGTTCCTCCTCCCTCTCTTGGATGA

Upstream 100 bases:

>100_bases
GTCTATTATGAGCAAGGCCTTCATTTCGGCGCCCCGTGGTGCTTCAGTAAGCCTTAGCAAGTTATATGCAAGGGCTTTAC
CCAACGGGCGGTGCGGGCCT

Downstream 100 bases:

>100_bases
GCCTCTCCATCATCGCCAAGCTTCCCGAAACTCCTAAGACGGCCAGCGCCGCGTACATTATCGTTTGTAACACGTCCCCG
TTCAAGAGCCTCTCCAGCGC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MWVCARAPSSSANLGPGYDVLALAHDAYFDVVCVRPSEETRVVKVTGEWKVPLERNSALAAAEEALKRLGGKGVEIWVHK
GVPPGRGLGSSGASAAAAVKAVELLLGKSLSPEEAVMSAAEGERLVSGAAHADNVAASYLGGLVAVTYDPFKVLKFEVAE
VELYVVTPWHEVPEGKTGAARSVLPEEVKLRDAVKMVGGAAAVIKALTSGDEDLLAKAIEMDPVVTPARSKLIPCFEEVV
KAAKGGGAKGVTISGAGPSLLLVGGGAEEAKAAWERCGVKATYKKVKPARGSSAVPPPSLG

Sequences:

>Translated_301_residues
MWVCARAPSSSANLGPGYDVLALAHDAYFDVVCVRPSEETRVVKVTGEWKVPLERNSALAAAEEALKRLGGKGVEIWVHK
GVPPGRGLGSSGASAAAAVKAVELLLGKSLSPEEAVMSAAEGERLVSGAAHADNVAASYLGGLVAVTYDPFKVLKFEVAE
VELYVVTPWHEVPEGKTGAARSVLPEEVKLRDAVKMVGGAAAVIKALTSGDEDLLAKAIEMDPVVTPARSKLIPCFEEVV
KAAKGGGAKGVTISGAGPSLLLVGGGAEEAKAAWERCGVKATYKKVKPARGSSAVPPPSLG
>Mature_301_residues
MWVCARAPSSSANLGPGYDVLALAHDAYFDVVCVRPSEETRVVKVTGEWKVPLERNSALAAAEEALKRLGGKGVEIWVHK
GVPPGRGLGSSGASAAAAVKAVELLLGKSLSPEEAVMSAAEGERLVSGAAHADNVAASYLGGLVAVTYDPFKVLKFEVAE
VELYVVTPWHEVPEGKTGAARSVLPEEVKLRDAVKMVGGAAAVIKALTSGDEDLLAKAIEMDPVVTPARSKLIPCFEEVV
KAAKGGGAKGVTISGAGPSLLLVGGGAEEAKAAWERCGVKATYKKVKPARGSSAVPPPSLG

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=280, Percent_Identity=31.0714285714286, Blast_Score=92, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 30926; Mature: 30926

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWVCARAPSSSANLGPGYDVLALAHDAYFDVVCVRPSEETRVVKVTGEWKVPLERNSALA
CEEECCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCEEEEEECCEECCCCCCCHHH
AAEEALKRLGGKGVEIWVHKGVPPGRGLGSSGASAAAAVKAVELLLGKSLSPEEAVMSAA
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
EGERLVSGAAHADNVAASYLGGLVAVTYDPFKVLKFEVAEVELYVVTPWHEVPEGKTGAA
CCHHHHHCCCCHHHHHHHHHCCEEEEEECCHHHEEEEEEEEEEEEECCHHHCCCCCCCCH
RSVLPEEVKLRDAVKMVGGAAAVIKALTSGDEDLLAKAIEMDPVVTPARSKLIPCFEEVV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCHHHHHHH
KAAKGGGAKGVTISGAGPSLLLVGGGAEEAKAAWERCGVKATYKKVKPARGSSAVPPPSL
HHHCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCC
G
C
>Mature Secondary Structure
MWVCARAPSSSANLGPGYDVLALAHDAYFDVVCVRPSEETRVVKVTGEWKVPLERNSALA
CEEECCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCEEEEEECCEECCCCCCCHHH
AAEEALKRLGGKGVEIWVHKGVPPGRGLGSSGASAAAAVKAVELLLGKSLSPEEAVMSAA
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
EGERLVSGAAHADNVAASYLGGLVAVTYDPFKVLKFEVAEVELYVVTPWHEVPEGKTGAA
CCHHHHHCCCCHHHHHHHHHCCEEEEEECCHHHEEEEEEEEEEEEECCHHHCCCCCCCCH
RSVLPEEVKLRDAVKMVGGAAAVIKALTSGDEDLLAKAIEMDPVVTPARSKLIPCFEEVV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCHHHHHHH
KAAKGGGAKGVTISGAGPSLLLVGGGAEEAKAAWERCGVKATYKKVKPARGSSAVPPPSL
HHHCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]