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The map label for this gene is purM [H]

Identifier: 156937105

GI number: 156937105

Start: 265071

End: 266030

Strand: Direct

Name: purM [H]

Synonym: Igni_0311

Alternate gene names: 156937105

Gene position: 265071-266030 (Clockwise)

Preceding gene: 156937103

Following gene: 156937110

Centisome position: 20.43

GC content: 64.48

Gene sequence:

>960_bases
GTGTGCCGCGTGGGGTGGACCTACTCGAAGGCGGGCGTTGACGTCTCCGCCCAAAAGGCAATGGAAGAGCAATTCATTAA
GAAGAGCAAGAAGCTTGCGAACGGGATCGGGGGCTACGCCTCCTCCTTCAACGTCTGCGGGGAGGTAACCCTCCACGTGG
ACGGGGTGGGCACCAAGACCGAGCTCCTCCGAAAGTATTCCCGAAACTGGGTGGCCGGGTGGGACTGCTTGATGGTCAAC
GCCAACGACGTCGCTTGTGAGGGCTTTAGGGTCTTCGCCTACGTAGATTACTTGGCCGTGGAGAGGGGAGACCCAGTGTT
GGCAAGGGAGGTTGCCGAGGGGATGAGCAAGGCGGCCGAGGCCTTGGGGGCCGTGCTGGCCGGCGGGGAGACCGCCATAA
TGCCGGACGTGGTCAAGGGGTACGACGTCTCTTGCACGGTCTTGGGCGTTAGAGAGGCGAGGCCCCAGCCCCCGAGGCCC
GGCGACGCCGTCATAGCGGTCGCCTCCAACGGGCCCCACGCCAACGGCTACACCCTCATACGGAGGCTCATCCAAGCCGG
CTTGCTCGACCCCGAGCCGTTGCTGGACTTCCTCCTCGCCCCCGTGGCGAACTACCACAACCCCCTCTTGAGGGCAATGA
AGGAGGGTAAGGCCAAGTGGGGGGCCCACGTGACCGGAGGGGCCTTCTACAAGGTGCACTCCAGGCTCCCCAAGGGGCTA
GGGGTGAGGCTCGAGGCTTGGGAGGTCCCGGAGGGGTTCGTGAAGATAGTTGAGGCGGCTGGGATGAGCGCGGAGGAGGC
GTACAAGACCTTCAACATGGGCGTCGGGATGCTTGTGGTGGGCTCCGAGGAGGCAGTGGAGGCGTTCGAGAGGGAGGGGC
TGAAGGCTTGGAAGGCGGGGGAAGTGGTGGAGGGGCCGACGGAGATAGAAACCCCGTGGGGCAAGGTGGTCATCCGCTGA

Upstream 100 bases:

>100_bases
CACTAGTTTCAGTGACCCCTCACCTTTTTTCTGAGAAAGACAAAGGTGCTTACCCAAAGTATACGCTTACTTTTCTAAGG
TAGCCGTCGTGGAGGGCCCG

Downstream 100 bases:

>100_bases
CGAACTTCTTCACCAGCTTCTCGGCGTCCCCCTTAGGGACCCCCACCACGTTGACCACTTCCCCGGTCCTAAGCTTCACG
GTGACGTTCGAGTAGCCCAA

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MCRVGWTYSKAGVDVSAQKAMEEQFIKKSKKLANGIGGYASSFNVCGEVTLHVDGVGTKTELLRKYSRNWVAGWDCLMVN
ANDVACEGFRVFAYVDYLAVERGDPVLAREVAEGMSKAAEALGAVLAGGETAIMPDVVKGYDVSCTVLGVREARPQPPRP
GDAVIAVASNGPHANGYTLIRRLIQAGLLDPEPLLDFLLAPVANYHNPLLRAMKEGKAKWGAHVTGGAFYKVHSRLPKGL
GVRLEAWEVPEGFVKIVEAAGMSAEEAYKTFNMGVGMLVVGSEEAVEAFEREGLKAWKAGEVVEGPTEIETPWGKVVIR

Sequences:

>Translated_319_residues
MCRVGWTYSKAGVDVSAQKAMEEQFIKKSKKLANGIGGYASSFNVCGEVTLHVDGVGTKTELLRKYSRNWVAGWDCLMVN
ANDVACEGFRVFAYVDYLAVERGDPVLAREVAEGMSKAAEALGAVLAGGETAIMPDVVKGYDVSCTVLGVREARPQPPRP
GDAVIAVASNGPHANGYTLIRRLIQAGLLDPEPLLDFLLAPVANYHNPLLRAMKEGKAKWGAHVTGGAFYKVHSRLPKGL
GVRLEAWEVPEGFVKIVEAAGMSAEEAYKTFNMGVGMLVVGSEEAVEAFEREGLKAWKAGEVVEGPTEIETPWGKVVIR
>Mature_319_residues
MCRVGWTYSKAGVDVSAQKAMEEQFIKKSKKLANGIGGYASSFNVCGEVTLHVDGVGTKTELLRKYSRNWVAGWDCLMVN
ANDVACEGFRVFAYVDYLAVERGDPVLAREVAEGMSKAAEALGAVLAGGETAIMPDVVKGYDVSCTVLGVREARPQPPRP
GDAVIAVASNGPHANGYTLIRRLIQAGLLDPEPLLDFLLAPVANYHNPLLRAMKEGKAKWGAHVTGGAFYKVHSRLPKGL
GVRLEAWEVPEGFVKIVEAAGMSAEEAYKTFNMGVGMLVVGSEEAVEAFEREGLKAWKAGEVVEGPTEIETPWGKVVIR

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=336, Percent_Identity=31.547619047619, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI209869995, Length=336, Percent_Identity=31.547619047619, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI209869993, Length=336, Percent_Identity=31.547619047619, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1788845, Length=336, Percent_Identity=30.3571428571429, Blast_Score=138, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17567511, Length=319, Percent_Identity=26.6457680250784, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321203, Length=344, Percent_Identity=27.906976744186, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24582400, Length=278, Percent_Identity=30.9352517985612, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 34312; Mature: 34312

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCRVGWTYSKAGVDVSAQKAMEEQFIKKSKKLANGIGGYASSFNVCGEVTLHVDGVGTKT
CCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCHH
ELLRKYSRNWVAGWDCLMVNANDVACEGFRVFAYVDYLAVERGDPVLAREVAEGMSKAAE
HHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ALGAVLAGGETAIMPDVVKGYDVSCTVLGVREARPQPPRPGDAVIAVASNGPHANGYTLI
HHHHHHCCCCCEECCHHHCCCCCEEEEEEEHHCCCCCCCCCCEEEEEECCCCCCCHHHHH
RRLIQAGLLDPEPLLDFLLAPVANYHNPLLRAMKEGKAKWGAHVTGGAFYKVHSRLPKGL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCEECCCHHHHHHHHCCCCC
GVRLEAWEVPEGFVKIVEAAGMSAEEAYKTFNMGVGMLVVGSEEAVEAFEREGLKAWKAG
CCEEEEECCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCCCCCC
EVVEGPTEIETPWGKVVIR
CCCCCCCCCCCCCCCEEEC
>Mature Secondary Structure
MCRVGWTYSKAGVDVSAQKAMEEQFIKKSKKLANGIGGYASSFNVCGEVTLHVDGVGTKT
CCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCHH
ELLRKYSRNWVAGWDCLMVNANDVACEGFRVFAYVDYLAVERGDPVLAREVAEGMSKAAE
HHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ALGAVLAGGETAIMPDVVKGYDVSCTVLGVREARPQPPRPGDAVIAVASNGPHANGYTLI
HHHHHHCCCCCEECCHHHCCCCCEEEEEEEHHCCCCCCCCCCEEEEEECCCCCCCHHHHH
RRLIQAGLLDPEPLLDFLLAPVANYHNPLLRAMKEGKAKWGAHVTGGAFYKVHSRLPKGL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCEECCCHHHHHHHHCCCCC
GVRLEAWEVPEGFVKIVEAAGMSAEEAYKTFNMGVGMLVVGSEEAVEAFEREGLKAWKAG
CCEEEEECCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCCCCCC
EVVEGPTEIETPWGKVVIR
CCCCCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]