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The map label for this gene is eif6 [H]

Identifier: 156937082

GI number: 156937082

Start: 244985

End: 245656

Strand: Direct

Name: eif6 [H]

Synonym: Igni_0288

Alternate gene names: 156937082

Gene position: 244985-245656 (Clockwise)

Preceding gene: 156937081

Following gene: 156937083

Centisome position: 18.88

GC content: 55.51

Gene sequence:

>672_bases
ATGAACTTCGACGTAGTCCCCATATCCATTTTTGGGAACCCGAATATTGGCGTGTACATGTTCGCCAACGACGACTTCGC
CCTAATTCCGCCCGGGGTGAAGGAGGACGTCGTTAAGAAGGTAGAGAGCGCGCTCAAAGTGACTGTCGTCGAGGCGAAGG
TAGCCGACAGCACCCTCCTAGGCCTCTTCGTTAACGGAAACAACCACGCCTTGGTGGTCCCTTCAATAATAAAGGAGTAT
GAATTAGAGAACTTAAAAAGAGAGTTGGACTTGCCCATAAAGGTCGTATACAGCAAACTCACCGCAATGGGTAACGTGAT
ACTCTGCAACGACAAGTTCGCCCTCTTCCATCCCGAAATGAGCAACTGGGTTAAGGACGTAACCGAGGTCCTCGGGGTCC
CGGGCGAGACCGGGACCATAGCGGGGGTCCCCACCGTGGGCTCGGTGGCGGTGATAAACGACAAGGGAGGTTTGGTCCAC
CCGGACGCCAGCGACGAGGAGCTGAACGAGCTGGAGAAGAAGTTCCAAGTGGTGTTGGACATAGGAACGGTGAACTACGG
CGTGCCCTACGTTAAGACGGGCCTCGTGGCCAACAACAAAGGGGCGGTCGTGGGCGACCTTACCACGGGCGTAGAAATGG
CGAGGGTAGCTAGGGCCCTCTCTGGCGAATAA

Upstream 100 bases:

>100_bases
AGTGTACGTCACCGTCAAGACCGAGTCCGGCGAGGAAGGCGAGAGGAAGGTAGCCTACGTCACCCTCGCTAACGTAAAGG
ACGTGGAGGACTGAAGCGAC

Downstream 100 bases:

>100_bases
TTTACCTAAAGCCCGCCCCCGACTCGTGGGGAAATAACTCCTTGGAAGGGATAATACTGGCCGCTGGGAAGGGGAGCAGG
CTGAGGCCCTTAACGCTCAC

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6 [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MNFDVVPISIFGNPNIGVYMFANDDFALIPPGVKEDVVKKVESALKVTVVEAKVADSTLLGLFVNGNNHALVVPSIIKEY
ELENLKRELDLPIKVVYSKLTAMGNVILCNDKFALFHPEMSNWVKDVTEVLGVPGETGTIAGVPTVGSVAVINDKGGLVH
PDASDEELNELEKKFQVVLDIGTVNYGVPYVKTGLVANNKGAVVGDLTTGVEMARVARALSGE

Sequences:

>Translated_223_residues
MNFDVVPISIFGNPNIGVYMFANDDFALIPPGVKEDVVKKVESALKVTVVEAKVADSTLLGLFVNGNNHALVVPSIIKEY
ELENLKRELDLPIKVVYSKLTAMGNVILCNDKFALFHPEMSNWVKDVTEVLGVPGETGTIAGVPTVGSVAVINDKGGLVH
PDASDEELNELEKKFQVVLDIGTVNYGVPYVKTGLVANNKGAVVGDLTTGVEMARVARALSGE
>Mature_223_residues
MNFDVVPISIFGNPNIGVYMFANDDFALIPPGVKEDVVKKVESALKVTVVEAKVADSTLLGLFVNGNNHALVVPSIIKEY
ELENLKRELDLPIKVVYSKLTAMGNVILCNDKFALFHPEMSNWVKDVTEVLGVPGETGTIAGVPTVGSVAVINDKGGLVH
PDASDEELNELEKKFQVVLDIGTVNYGVPYVKTGLVANNKGAVVGDLTTGVEMARVARALSGE

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex [H]

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family [H]

Homologues:

Organism=Homo sapiens, GI4504771, Length=214, Percent_Identity=34.5794392523364, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI31563378, Length=214, Percent_Identity=34.5794392523364, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17506075, Length=208, Percent_Identity=29.3269230769231, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6325273, Length=210, Percent_Identity=35.7142857142857, Blast_Score=118, Evalue=8e-28,
Organism=Drosophila melanogaster, GI21492634, Length=207, Percent_Identity=35.2657004830918, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002769 [H]

Pfam domain/function: PF01912 eIF-6 [H]

EC number: NA

Molecular weight: Translated: 23836; Mature: 23836

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDVVPISIFGNPNIGVYMFANDDFALIPPGVKEDVVKKVESALKVTVVEAKVADSTLL
CCCEEEEEEEECCCCEEEEEEECCCEEEECCCCHHHHHHHHHHHHEEEEEEEEECCCEEE
GLFVNGNNHALVVPSIIKEYELENLKRELDLPIKVVYSKLTAMGNVILCNDKFALFHPEM
EEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCEEEECCCH
SNWVKDVTEVLGVPGETGTIAGVPTVGSVAVINDKGGLVHPDASDEELNELEKKFQVVLD
HHHHHHHHHHHCCCCCCCCEECCCCCCEEEEEECCCCEECCCCCHHHHHHHHHHHEEEEE
IGTVNYGVPYVKTGLVANNKGAVVGDLTTGVEMARVARALSGE
ECCCCCCCCEEEECEEECCCCCEEECHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFDVVPISIFGNPNIGVYMFANDDFALIPPGVKEDVVKKVESALKVTVVEAKVADSTLL
CCCEEEEEEEECCCCEEEEEEECCCEEEECCCCHHHHHHHHHHHHEEEEEEEEECCCEEE
GLFVNGNNHALVVPSIIKEYELENLKRELDLPIKVVYSKLTAMGNVILCNDKFALFHPEM
EEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCEEEECCCH
SNWVKDVTEVLGVPGETGTIAGVPTVGSVAVINDKGGLVHPDASDEELNELEKKFQVVLD
HHHHHHHHHHHCCCCCCCCEECCCCCCEEEEEECCCCEECCCCCHHHHHHHHHHHEEEEE
IGTVNYGVPYVKTGLVANNKGAVVGDLTTGVEMARVARALSGE
ECCCCCCCCEEEECEEECCCCCEEECHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA