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The map label for this gene is strD [H]

Identifier: 156937083

GI number: 156937083

Start: 245698

End: 246765

Strand: Direct

Name: strD [H]

Synonym: Igni_0289

Alternate gene names: 156937083

Gene position: 245698-246765 (Clockwise)

Preceding gene: 156937082

Following gene: 156937084

Centisome position: 18.94

GC content: 61.52

Gene sequence:

>1068_bases
TTGGAAGGGATAATACTGGCCGCTGGGAAGGGGAGCAGGCTGAGGCCCTTAACGCTCACCGTGCCCAAGCCGTTGATCCC
CGTGGCCGGGAAGCCCTTGGTTCAGTACGGCATAGAGCAGCTGAGGGGGGTGGGCGTTGAGAGGGCCGTGGTGGTGGTCG
GCTGGCTGGGCGAGCTCTTCAAGGAGGTCTTGGGGGACGGGAGCGCCCTGGGGATGAGGTTCGAGTACGTGCTCCAACCC
AAGAGGCTCGGGGTGGCACACGCGATACACACGGCGATAGTTAACGCGAACGTGAGGTCCCCCTTCCTAGTCTACTTCGG
GGACAACGTGTTTGACGACGAGTGGGTAAAGAAGTTCAACTCGGTTGACGAGGAGTTCGACGCGTTCGTGGTGCTCGCCA
AGGTAGAGGACCCGAGGCGCTTCGGGGTGCCAGTAATCGAGTCCGGGAGGATAGTTAAGTTCGTGGAGAAGCCCGAGAGG
CCCCCCTCCAACTACGCCCTGACCGGCCTCTACGCCTTCAGAGATCCGGAGCAGTACGAGAGCTGCTTCTCGGAGCTCAA
GCCCTCGTGGCGGGGCGAGTACGAGATAACCGACTTGTTGAACTGTTACATAAGGAGGGGTTACGACGTCAAGTACGCCG
TGGTGGAGGGCTGGTGGAAGGACACCGGGGTCCCGGAGGACCTTATCGAAGCTATGAAGTTTATCTTGGAGAAGAAGTTG
ATCCACAAAGTGGAGGGGTCGGTGGAGGGCGAGGTGGTGGGGAAGGTTTACGTGGCGAGGGGGGCGACCGTGGAGGGGAG
GCTCGTGGGCCCGGCCTACGTGGGCCCCGGCGCGGAGGTGAGGGGCTCCGCGGGCCCGTTCGTGGACGTGGAGGAGGGCT
CGGTTGCAGAGGGCTCTTTCGTAGAATCCTTAATCCTCAAGGGATCTAAAGTTTTGATGAGGGGAGGCGCGACCTTGAAG
AGGAGCGTGGTGGGGGACTACTCCAACATAGAGGTGGACGCCCCAGTGAGCTTAGAGGACGCGCTGTTCGCCTCTGAGAG
CGCCCTTAAGGTGGGGCGCCTTGACTAG

Upstream 100 bases:

>100_bases
GCGACCTTACCACGGGCGTAGAAATGGCGAGGGTAGCTAGGGCCCTCTCTGGCGAATAATTTACCTAAAGCCCGCCCCCG
ACTCGTGGGGAAATAACTCC

Downstream 100 bases:

>100_bases
CTTCACCTTGCCCCCCTCCAGCCTCACCACCCCGTCCTCCGCGAGCTCCTTAACCGCTCCCTCTATGCAGCTCAAGAGCC
CCTCCTCCGTGACCTCCGGC

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MEGIILAAGKGSRLRPLTLTVPKPLIPVAGKPLVQYGIEQLRGVGVERAVVVVGWLGELFKEVLGDGSALGMRFEYVLQP
KRLGVAHAIHTAIVNANVRSPFLVYFGDNVFDDEWVKKFNSVDEEFDAFVVLAKVEDPRRFGVPVIESGRIVKFVEKPER
PPSNYALTGLYAFRDPEQYESCFSELKPSWRGEYEITDLLNCYIRRGYDVKYAVVEGWWKDTGVPEDLIEAMKFILEKKL
IHKVEGSVEGEVVGKVYVARGATVEGRLVGPAYVGPGAEVRGSAGPFVDVEEGSVAEGSFVESLILKGSKVLMRGGATLK
RSVVGDYSNIEVDAPVSLEDALFASESALKVGRLD

Sequences:

>Translated_355_residues
MEGIILAAGKGSRLRPLTLTVPKPLIPVAGKPLVQYGIEQLRGVGVERAVVVVGWLGELFKEVLGDGSALGMRFEYVLQP
KRLGVAHAIHTAIVNANVRSPFLVYFGDNVFDDEWVKKFNSVDEEFDAFVVLAKVEDPRRFGVPVIESGRIVKFVEKPER
PPSNYALTGLYAFRDPEQYESCFSELKPSWRGEYEITDLLNCYIRRGYDVKYAVVEGWWKDTGVPEDLIEAMKFILEKKL
IHKVEGSVEGEVVGKVYVARGATVEGRLVGPAYVGPGAEVRGSAGPFVDVEEGSVAEGSFVESLILKGSKVLMRGGATLK
RSVVGDYSNIEVDAPVSLEDALFASESALKVGRLD
>Mature_355_residues
MEGIILAAGKGSRLRPLTLTVPKPLIPVAGKPLVQYGIEQLRGVGVERAVVVVGWLGELFKEVLGDGSALGMRFEYVLQP
KRLGVAHAIHTAIVNANVRSPFLVYFGDNVFDDEWVKKFNSVDEEFDAFVVLAKVEDPRRFGVPVIESGRIVKFVEKPER
PPSNYALTGLYAFRDPEQYESCFSELKPSWRGEYEITDLLNCYIRRGYDVKYAVVEGWWKDTGVPEDLIEAMKFILEKKL
IHKVEGSVEGEVVGKVYVARGATVEGRLVGPAYVGPGAEVRGSAGPFVDVEEGSVAEGSFVESLILKGSKVLMRGGATLK
RSVVGDYSNIEVDAPVSLEDALFASESALKVGRLD

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=339, Percent_Identity=28.3185840707965, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI11761619, Length=339, Percent_Identity=28.3185840707965, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI1788351, Length=242, Percent_Identity=37.1900826446281, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790224, Length=242, Percent_Identity=36.3636363636364, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790168, Length=354, Percent_Identity=23.4463276836158, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=302, Percent_Identity=30.4635761589404, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17509979, Length=350, Percent_Identity=24, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17509981, Length=340, Percent_Identity=23.8235294117647, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=348, Percent_Identity=27.2988505747126, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355443, Length=334, Percent_Identity=28.4431137724551, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24644084, Length=334, Percent_Identity=28.4431137724551, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653912, Length=387, Percent_Identity=26.0981912144703, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 38913; Mature: 38913

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGIILAAGKGSRLRPLTLTVPKPLIPVAGKPLVQYGIEQLRGVGVERAVVVVGWLGELF
CCCEEEECCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KEVLGDGSALGMRFEYVLQPKRLGVAHAIHTAIVNANVRSPFLVYFGDNVFDDEWVKKFN
HHHHCCCCEECEEEEEEECHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCHHHHHHHH
SVDEEFDAFVVLAKVEDPRRFGVPVIESGRIVKFVEKPERPPSNYALTGLYAFRDPEQYE
CCCCCCCEEEEEEEECCCHHHCCCEECCCCEEEEECCCCCCCCCEEEEEEEECCCHHHHH
SCFSELKPSWRGEYEITDLLNCYIRRGYDVKYAVVEGWWKDTGVPEDLIEAMKFILEKKL
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
IHKVEGSVEGEVVGKVYVARGATVEGRLVGPAYVGPGAEVRGSAGPFVDVEEGSVAEGSF
HHHHCCCCCCEEEEEEEEECCCEECCEEECCEEECCCCCCCCCCCCEEECCCCCCCCHHH
VESLILKGSKVLMRGGATLKRSVVGDYSNIEVDAPVSLEDALFASESALKVGRLD
HHHHHHCCCEEEEECCCHHHHHHCCCCCCEEECCCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MEGIILAAGKGSRLRPLTLTVPKPLIPVAGKPLVQYGIEQLRGVGVERAVVVVGWLGELF
CCCEEEECCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KEVLGDGSALGMRFEYVLQPKRLGVAHAIHTAIVNANVRSPFLVYFGDNVFDDEWVKKFN
HHHHCCCCEECEEEEEEECHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCHHHHHHHH
SVDEEFDAFVVLAKVEDPRRFGVPVIESGRIVKFVEKPERPPSNYALTGLYAFRDPEQYE
CCCCCCCEEEEEEEECCCHHHCCCEECCCCEEEEECCCCCCCCCEEEEEEEECCCHHHHH
SCFSELKPSWRGEYEITDLLNCYIRRGYDVKYAVVEGWWKDTGVPEDLIEAMKFILEKKL
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
IHKVEGSVEGEVVGKVYVARGATVEGRLVGPAYVGPGAEVRGSAGPFVDVEEGSVAEGSF
HHHHCCCCCCEEEEEEEEECCCEECCEEECCEEECCCCCCCCCCCCEEECCCCCCCCHHH
VESLILKGSKVLMRGGATLKRSVVGDYSNIEVDAPVSLEDALFASESALKVGRLD
HHHHHHCCCEEEEECCCHHHHHHCCCCCCEEECCCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]