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Identifier: 15679322

GI number: 15679322

Start: 1192622

End: 1193842

Strand: Direct

Name: Not Available

Synonym: MTH1322

Alternate gene names: NA

Gene position: 1192622-1193842 (Clockwise)

Preceding gene: 15679321

Following gene: 15679323

Centisome position: 68.1

GC content: 54.55

Gene sequence:

>1221_bases
ATGGATGTTCAGCAGAGACTGGGAGGACTGCTTGAAATCACAGAGTCCAGAATATGTCTGCACTGCCTTGGCAGGCACTT
TGTTGATTTGGTTGAAGGGCCAGGGAACCGTCTGAGGGGTGAGAAGCTCCAGAAGAAATTCTCGCTGAAACTATCCGGGC
CATGCATGATATGCGGTGACGTCTTTGACAGGATTGATGAGGCCGCAGGGATGGTTAAGGAGAAGGTGGATGAACTTGGC
CTTGAATACTCTTCGGTACTTGTGGGTACAAGGTTGCCCCCCAAAATGGTGGAACTTGATGATGAGATCAGAAAGCGCCT
CGGAATCCAGACTGAGGGGCTTAAAAGGGATCTCAACCGTGAACTTGGTAAGAGGGTTGTCAAACTGCTGGGCTGCAGCG
CAGAATTTGAGGACCCCGACCTCGTGGTGATGGTGGACTTCAGGGGGGACATCAGGGTCTGGATCCAGATAAACCCCCTC
TTCCTTGAGGGGAGGTACCGCAAGCTGGTTAGGGGAATACCCCAGACCCGCTGGCCCTGCAGGAAGTGCAGGGGGAGGGG
CTGTGAGAGGTGCAATTACACCGGTAAGATGTATCCCACGTCTGTGGAGGAGCTCATAGCCGGGCCCATCCTGGAGGCCA
GCCAGGGACGTGATGCAAGGTTCCATGGCTCAGGCAGGGAGGATGTGGACGTCCGGATGCTCGGGACAGGGAGACCCTTT
GTCCTGGAGATAAGGGAACCCCGGGTGAGGAACCTGGACCCTGAATCCCTTGAGGAGGAGGTGAACCGCAGGGCCCAGGG
CATGGTTGAGGTTGAGGGCCTCAGATTCTCCACAAGGAAGAGGAAGGTTGAACTGAAGGACTCATCCCAGAGCAGGTACA
AGGTTTACCGGGCCCTGGTTGAACTGGATGGAGACGTTACTGATGAGGACCTTGAGAGACTCGGGTCACTTGACATCATA
AAACAGCGGACCCCTGTGAGAGTTTCCCACCGCAGGGCTGACAGGGTCAGAGAGAGGAGAGTCCTGGAAATATCATGGAA
CTTGCTGGATGGTTGCCTTGAGTTGATAATAAAGGGTGAGGGCGGCCTCTACATAAAGGAGCTTATTTCAGGGGATTCGG
GACGTACAGAACCAAGTGTGAGCAGTGTTCTGGGGGTCCCTGCAAGGTGCGTGGCCCTTGATGTCCTTGAGGTCGGTGAT
GAACCATCAGAAAAAGATTAA

Upstream 100 bases:

>100_bases
ATGAAGGGGCTTGGAAGGAGAAAAATGGGCGGACCCATGGGCCAGCTCATGAGGCAGTTCATGAGATAGCATCCTGAAGG
GCAGAGATCAGGGGATAACC

Downstream 100 bases:

>100_bases
GCAGATGATCGAAAAAATAAAACACTGCGTCCCATGCAGAATAGCCATGATAAGGAAAAATATATATTAATGGAGATATT
AAATAGAGAACTTATAAGTT

Product: putative pseudouridylate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MDVQQRLGGLLEITESRICLHCLGRHFVDLVEGPGNRLRGEKLQKKFSLKLSGPCMICGDVFDRIDEAAGMVKEKVDELG
LEYSSVLVGTRLPPKMVELDDEIRKRLGIQTEGLKRDLNRELGKRVVKLLGCSAEFEDPDLVVMVDFRGDIRVWIQINPL
FLEGRYRKLVRGIPQTRWPCRKCRGRGCERCNYTGKMYPTSVEELIAGPILEASQGRDARFHGSGREDVDVRMLGTGRPF
VLEIREPRVRNLDPESLEEEVNRRAQGMVEVEGLRFSTRKRKVELKDSSQSRYKVYRALVELDGDVTDEDLERLGSLDII
KQRTPVRVSHRRADRVRERRVLEISWNLLDGCLELIIKGEGGLYIKELISGDSGRTEPSVSSVLGVPARCVALDVLEVGD
EPSEKD

Sequences:

>Translated_406_residues
MDVQQRLGGLLEITESRICLHCLGRHFVDLVEGPGNRLRGEKLQKKFSLKLSGPCMICGDVFDRIDEAAGMVKEKVDELG
LEYSSVLVGTRLPPKMVELDDEIRKRLGIQTEGLKRDLNRELGKRVVKLLGCSAEFEDPDLVVMVDFRGDIRVWIQINPL
FLEGRYRKLVRGIPQTRWPCRKCRGRGCERCNYTGKMYPTSVEELIAGPILEASQGRDARFHGSGREDVDVRMLGTGRPF
VLEIREPRVRNLDPESLEEEVNRRAQGMVEVEGLRFSTRKRKVELKDSSQSRYKVYRALVELDGDVTDEDLERLGSLDII
KQRTPVRVSHRRADRVRERRVLEISWNLLDGCLELIIKGEGGLYIKELISGDSGRTEPSVSSVLGVPARCVALDVLEVGD
EPSEKD
>Mature_406_residues
MDVQQRLGGLLEITESRICLHCLGRHFVDLVEGPGNRLRGEKLQKKFSLKLSGPCMICGDVFDRIDEAAGMVKEKVDELG
LEYSSVLVGTRLPPKMVELDDEIRKRLGIQTEGLKRDLNRELGKRVVKLLGCSAEFEDPDLVVMVDFRGDIRVWIQINPL
FLEGRYRKLVRGIPQTRWPCRKCRGRGCERCNYTGKMYPTSVEELIAGPILEASQGRDARFHGSGREDVDVRMLGTGRPF
VLEIREPRVRNLDPESLEEEVNRRAQGMVEVEGLRFSTRKRKVELKDSSQSRYKVYRALVELDGDVTDEDLERLGSLDII
KQRTPVRVSHRRADRVRERRVLEISWNLLDGCLELIIKGEGGLYIKELISGDSGRTEPSVSSVLGVPARCVALDVLEVGD
EPSEKD

Specific function: Unknown

COG id: COG1258

COG function: function code J; Predicted pseudouridylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 THUMP domain [H]

Homologues:

Organism=Homo sapiens, GI207113130, Length=245, Percent_Identity=35.1020408163265, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17537241, Length=240, Percent_Identity=34.5833333333333, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19920442, Length=254, Percent_Identity=37.7952755905512, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005912
- InterPro:   IPR020103
- InterPro:   IPR004114 [H]

Pfam domain/function: PF02926 THUMP [H]

EC number: NA

Molecular weight: Translated: 46040; Mature: 46040

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS51165 THUMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVQQRLGGLLEITESRICLHCLGRHFVDLVEGPGNRLRGEKLQKKFSLKLSGPCMICGD
CCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCEEECCCEEEHHH
VFDRIDEAAGMVKEKVDELGLEYSSVLVGTRLPPKMVELDDEIRKRLGIQTEGLKRDLNR
HHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCHHHHCCHHHHHHHCCCCHHHHHHHHH
ELGKRVVKLLGCSAEFEDPDLVVMVDFRGDIRVWIQINPLFLEGRYRKLVRGIPQTRWPC
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEEEEEEECCHHHHHHHCCCCCCCCH
RKCRGRGCERCNYTGKMYPTSVEELIAGPILEASQGRDARFHGSGREDVDVRMLGTGRPF
HHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCE
VLEIREPRVRNLDPESLEEEVNRRAQGMVEVEGLRFSTRKRKVELKDSSQSRYKVYRALV
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCEEECCCCEEEECCCCHHHHHHHHHHH
ELDGDVTDEDLERLGSLDIIKQRTPVRVSHRRADRVRERRVLEISWNLLDGCLELIIKGE
HCCCCCCHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHCEEEEEHHHHHHHHHHHEEECC
GGLYIKELISGDSGRTEPSVSSVLGVPARCVALDVLEVGDEPSEKD
CCEEHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDVQQRLGGLLEITESRICLHCLGRHFVDLVEGPGNRLRGEKLQKKFSLKLSGPCMICGD
CCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCEEECCCEEEHHH
VFDRIDEAAGMVKEKVDELGLEYSSVLVGTRLPPKMVELDDEIRKRLGIQTEGLKRDLNR
HHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCHHHHCCHHHHHHHCCCCHHHHHHHHH
ELGKRVVKLLGCSAEFEDPDLVVMVDFRGDIRVWIQINPLFLEGRYRKLVRGIPQTRWPC
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEEEEEEECCHHHHHHHCCCCCCCCH
RKCRGRGCERCNYTGKMYPTSVEELIAGPILEASQGRDARFHGSGREDVDVRMLGTGRPF
HHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCE
VLEIREPRVRNLDPESLEEEVNRRAQGMVEVEGLRFSTRKRKVELKDSSQSRYKVYRALV
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCEEECCCCEEEECCCCHHHHHHHHHHH
ELDGDVTDEDLERLGSLDIIKQRTPVRVSHRRADRVRERRVLEISWNLLDGCLELIIKGE
HCCCCCCHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHCEEEEEHHHHHHHHHHHEEECC
GGLYIKELISGDSGRTEPSVSSVLGVPARCVALDVLEVGDEPSEKD
CCEEHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]