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Identifier: 15679321

GI number: 15679321

Start: 1191262

End: 1192590

Strand: Direct

Name: Not Available

Synonym: MTH1321

Alternate gene names: 15679321

Gene position: 1191262-1192590 (Clockwise)

Preceding gene: 15679304

Following gene: 15679322

Centisome position: 68.02

GC content: 51.77

Gene sequence:

>1329_bases
ATGCTTGGGAATCTGGGCAGAAGTCTCAGTAAAACTATGAAAAAGCTGGCAGGGATGACAATTGTTGATGAGGAGGTCGT
CAGGGAGGTCATAAAGGATATACAGAGGGCCCTGATCCAGTCCGATGTCAACATAAAACTTGTATTCAACCTGTCAAAGT
CAATTGAGGAACGGGCACTCAACGAGGAACCCCCTAAGGGGATAACGCCAAAGGAGCACATCATAAGCATAGTGTACGAT
GAGATGGTCAAACTCCTGGGTGAGAAGAGCCATGAACTTGTCATAGATGATAAACCGTACCGCATACTCTTCCTTGGACT
CCAGGGTAGCGGTAAAACAACAACCATAGGTAAACTTGCAAGGTACCTCCGCAAGAAGGGTTTCACTGTTGGGGTGGTCT
GTACAGACACCTGGCGCCCTGCGGCCCTTGAGCAGCTGAAACAGTATACCGAGGGACAGGACGTGAGCATATACGGCGAC
CCCCAGAACAGGGACGCCCTGGACCTTGCAGAGAAGGGACTTGCCCGGTTCCAGAAGAAGGACGTTATCATATTCGATAC
GGCCGGAAGACACAAGGAGGAGAAGGACCTCCTCAGGGAGATGGAGGAACTTTCAGCCATTGTGGAGCCCCATGAGGCCA
TACTTGTAATCGACGGAACCATAGGCCAGCAGGCAAGGGAACAGGCCCTCGCATTCAGAAAAGCCACAGATATAGGTTCA
ATAATTGTGACCAAGCTCGATGGTTCAGCCAAGGGTGGTGGGGCCCTCTCGGCCGTTGCAGAGATAGGTGCTCCCATAAA
GTTCATAGGTACCGGTGAGAGGATAGATGACCTGGAGGTCTTCGATCCCGAAAGGTTCATATCACGTCTCCTGGGTATGG
GGGACCTCAGAAGTCTCCTCGAGAAGGTTGAAGAGGTTTCAGAGGAGGAGATTGCAGAGGAATCCCTCGACGCAATACTC
TCAGGTAAGTTCACCCTCAGGGATATGAGGGTGCAGTTTGAGATGATGGGTAAGATGGGGCCCCTCCAGCAGGTTATGAG
TATGCTGCCCGGTGCCGGGAAACTCCCAAAGGACGCCAGCAGGATGACCGAGGAGACCATACGGAAGTACCTCATAATAA
TGGACTCCATGACAGAGGAGGAACTGGAAAAACCAGACATCATAAAGCACTCAAGAATACGCAGGATAGCCCGGGGTTCA
GGGACACGCAATGAGGACGTTAAGGAGCTCCTGAAGTACTACAGGGTCACCAAAAAGGCCATGAAGGGGCTTGGAAGGAG
AAAAATGGGCGGACCCATGGGCCAGCTCATGAGGCAGTTCATGAGATAG

Upstream 100 bases:

>100_bases
CACCCTGTGACCTTTATATGGCACAGCCCATCCACCACTCTTAATTATATAAGGTGATCCCAACAATAGTTAATGATTAT
CCATCACTGCAGGTGAAACC

Downstream 100 bases:

>100_bases
CATCCTGAAGGGCAGAGATCAGGGGATAACCATGGATGTTCAGCAGAGACTGGGAGGACTGCTTGAAATCACAGAGTCCA
GAATATGTCTGCACTGCCTT

Product: signal recognition particle protein Srp54

Products: NA

Alternate protein names: SRP54

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MLGNLGRSLSKTMKKLAGMTIVDEEVVREVIKDIQRALIQSDVNIKLVFNLSKSIEERALNEEPPKGITPKEHIISIVYD
EMVKLLGEKSHELVIDDKPYRILFLGLQGSGKTTTIGKLARYLRKKGFTVGVVCTDTWRPAALEQLKQYTEGQDVSIYGD
PQNRDALDLAEKGLARFQKKDVIIFDTAGRHKEEKDLLREMEELSAIVEPHEAILVIDGTIGQQAREQALAFRKATDIGS
IIVTKLDGSAKGGGALSAVAEIGAPIKFIGTGERIDDLEVFDPERFISRLLGMGDLRSLLEKVEEVSEEEIAEESLDAIL
SGKFTLRDMRVQFEMMGKMGPLQQVMSMLPGAGKLPKDASRMTEETIRKYLIIMDSMTEEELEKPDIIKHSRIRRIARGS
GTRNEDVKELLKYYRVTKKAMKGLGRRKMGGPMGQLMRQFMR

Sequences:

>Translated_442_residues
MLGNLGRSLSKTMKKLAGMTIVDEEVVREVIKDIQRALIQSDVNIKLVFNLSKSIEERALNEEPPKGITPKEHIISIVYD
EMVKLLGEKSHELVIDDKPYRILFLGLQGSGKTTTIGKLARYLRKKGFTVGVVCTDTWRPAALEQLKQYTEGQDVSIYGD
PQNRDALDLAEKGLARFQKKDVIIFDTAGRHKEEKDLLREMEELSAIVEPHEAILVIDGTIGQQAREQALAFRKATDIGS
IIVTKLDGSAKGGGALSAVAEIGAPIKFIGTGERIDDLEVFDPERFISRLLGMGDLRSLLEKVEEVSEEEIAEESLDAIL
SGKFTLRDMRVQFEMMGKMGPLQQVMSMLPGAGKLPKDASRMTEETIRKYLIIMDSMTEEELEKPDIIKHSRIRRIARGS
GTRNEDVKELLKYYRVTKKAMKGLGRRKMGGPMGQLMRQFMR
>Mature_442_residues
MLGNLGRSLSKTMKKLAGMTIVDEEVVREVIKDIQRALIQSDVNIKLVFNLSKSIEERALNEEPPKGITPKEHIISIVYD
EMVKLLGEKSHELVIDDKPYRILFLGLQGSGKTTTIGKLARYLRKKGFTVGVVCTDTWRPAALEQLKQYTEGQDVSIYGD
PQNRDALDLAEKGLARFQKKDVIIFDTAGRHKEEKDLLREMEELSAIVEPHEAILVIDGTIGQQAREQALAFRKATDIGS
IIVTKLDGSAKGGGALSAVAEIGAPIKFIGTGERIDDLEVFDPERFISRLLGMGDLRSLLEKVEEVSEEEIAEESLDAIL
SGKFTLRDMRVQFEMMGKMGPLQQVMSMLPGAGKLPKDASRMTEETIRKYLIIMDSMTEEELEKPDIIKHSRIRRIARGS
GTRNEDVKELLKYYRVTKKAMKGLGRRKMGGPMGQLMRQFMR

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=445, Percent_Identity=41.3483146067416, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI226371618, Length=384, Percent_Identity=41.9270833333333, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI89061728, Length=144, Percent_Identity=50, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI23308697, Length=302, Percent_Identity=26.158940397351, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI295424842, Length=302, Percent_Identity=26.158940397351, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1788963, Length=420, Percent_Identity=36.1904761904762, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1789874, Length=311, Percent_Identity=31.8327974276527, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=37.8923766816144, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI193206261, Length=275, Percent_Identity=28, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325345, Length=447, Percent_Identity=40.2684563758389, Blast_Score=316, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6320498, Length=224, Percent_Identity=27.6785714285714, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647949, Length=445, Percent_Identity=40.4494382022472, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=29.0909090909091, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_METTH (O27376)

Other databases:

- EMBL:   AE000666
- PIR:   F69042
- RefSeq:   NP_276438.1
- ProteinModelPortal:   O27376
- SMR:   O27376
- STRING:   O27376
- GeneID:   1471038
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1321
- NMPDR:   fig|187420.1.peg.1293
- eggNOG:   arNOG04631
- HOGENOM:   HBG562580
- OMA:   SKKEHII
- PhylomeDB:   O27376
- ProtClustDB:   PRK00771
- BioCyc:   MTHE187420:MTH1321-MONOMER
- HAMAP:   MF_00306
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 49581; Mature: 49581

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGNLGRSLSKTMKKLAGMTIVDEEVVREVIKDIQRALIQSDVNIKLVFNLSKSIEERAL
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHC
NEEPPKGITPKEHIISIVYDEMVKLLGEKSHELVIDDKPYRILFLGLQGSGKTTTIGKLA
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCHHHHHHH
RYLRKKGFTVGVVCTDTWRPAALEQLKQYTEGQDVSIYGDPQNRDALDLAEKGLARFQKK
HHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHC
DVIIFDTAGRHKEEKDLLREMEELSAIVEPHEAILVIDGTIGQQAREQALAFRKATDIGS
CEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
IIVTKLDGSAKGGGALSAVAEIGAPIKFIGTGERIDDLEVFDPERFISRLLGMGDLRSLL
EEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
EKVEEVSEEEIAEESLDAILSGKFTLRDMRVQFEMMGKMGPLQQVMSMLPGAGKLPKDAS
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHH
RMTEETIRKYLIIMDSMTEEELEKPDIIKHSRIRRIARGSGTRNEDVKELLKYYRVTKKA
HHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
MKGLGRRKMGGPMGQLMRQFMR
HHCCCCCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MLGNLGRSLSKTMKKLAGMTIVDEEVVREVIKDIQRALIQSDVNIKLVFNLSKSIEERAL
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHC
NEEPPKGITPKEHIISIVYDEMVKLLGEKSHELVIDDKPYRILFLGLQGSGKTTTIGKLA
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCHHHHHHH
RYLRKKGFTVGVVCTDTWRPAALEQLKQYTEGQDVSIYGDPQNRDALDLAEKGLARFQKK
HHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHC
DVIIFDTAGRHKEEKDLLREMEELSAIVEPHEAILVIDGTIGQQAREQALAFRKATDIGS
CEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
IIVTKLDGSAKGGGALSAVAEIGAPIKFIGTGERIDDLEVFDPERFISRLLGMGDLRSLL
EEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
EKVEEVSEEEIAEESLDAILSGKFTLRDMRVQFEMMGKMGPLQQVMSMLPGAGKLPKDAS
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHH
RMTEETIRKYLIIMDSMTEEELEKPDIIKHSRIRRIARGSGTRNEDVKELLKYYRVTKKA
HHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
MKGLGRRKMGGPMGQLMRQFMR
HHCCCCCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463