Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15679216

GI number: 15679216

Start: 1108185

End: 1109210

Strand: Direct

Name: Not Available

Synonym: MTH1205

Alternate gene names: 15679216

Gene position: 1108185-1109210 (Clockwise)

Preceding gene: 15679215

Following gene: 15679217

Centisome position: 63.28

GC content: 52.44

Gene sequence:

>1026_bases
ATGAGGATAAGCCCTGAAGAGGAAGTTAAAATCATAAAGGAAATACTCACCGCCATGAATGTTCCGGAGGAGAGCTCAGA
TATAGTTGCAGACGTCACACTGGACGCTGACCTGAAGGGATTCAGCTCACATGGAATCGGCAGGTTCCCCCAGTACGTTG
ATGGGTTGAGGCATGGAACAATAAGGGCAGATGGTGACATAACCATTGAGCGGGAAACCGAGTCAACGGCCCTCATAAAT
GGTAACCACATATTCGGACACGTTGTTGCCTACAGGGCCATGGAGCTTGCCATTGAGAAGGCCAGGAATACGGGTGTTGG
CCTTGTCGGTGTCCATGACTCCAACCATTTCGGGGTCGCCGGCTACTACTCTGATATGGCCGTCATGAATGACATGATAG
GTGTTGTTATAGCAAACACCGAGCCGGCCGTCGCACCCATCGGGGGCAGGAAACCCATCCTTGGAACAAACCCGGTGGCC
ATTGGCATCCCATCAAACAGGTACTACGTCTCCGTGGACATGGCAACCTCTGCATCGGCCAGGGGAAAACTCCTGGAGGC
CGCCAGGAAAGGCGAGAGCATACCTGAAAATGTGGCCCTGGATGCAGAGGGTAAACCCACCACCGACCCTGAAATGGCCC
TTAAGGGCTCCATCCTCCCCTTCGGTGGACACAAGGGATACGCCCTCTCATTCATGATAGAGATACTTGCAGGGCCCCTC
GTTGGTGCTGCCTTCGGAACCGCTGTCACGGGAACAGCGAACCCTGAGGAGATGTGCACCAAGGGAGACCTCATGATGGC
CATCGACCCATCAAAGATGGTTGACCCCGATGAGTTCAGGGCCCAGGTTGATGAATTCATTGAGGAGGTTAAATCAAGCG
GTGACGTCCTCATACCCGGGGACATTGAGAGCATGAACATAAAGAGAAGGCGTGCTGAGGGTATCGAACTGGATGAAAAG
CTCCTTGAGAGGATTCTTGGAATAGCCAGAGAACTTGATATAAATCTCGAAATTAAGGAGTTATGA

Upstream 100 bases:

>100_bases
GGAGACAGGGCCCACCCCATCGGGGAGGTTACAGATAGGGGATCAGAGGTTGAACTCGAAGCCTGCACCGGTGAAACCAT
AAAACTTTAGGAGGACTTTT

Downstream 100 bases:

>100_bases
AAGTGGATAGCAGCGAAGCTGTTTACGCGGGTATGAAGGATGCAGGGATAGACTTCGCCGTCAGCGTCCCCTGTGTGAAT
CTCAGGACGGTCCTTGAAAT

Product: malate dehydrogenase

Products: NA

Alternate protein names: (R)-sulfolactate dehydrogenase

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MRISPEEEVKIIKEILTAMNVPEESSDIVADVTLDADLKGFSSHGIGRFPQYVDGLRHGTIRADGDITIERETESTALIN
GNHIFGHVVAYRAMELAIEKARNTGVGLVGVHDSNHFGVAGYYSDMAVMNDMIGVVIANTEPAVAPIGGRKPILGTNPVA
IGIPSNRYYVSVDMATSASARGKLLEAARKGESIPENVALDAEGKPTTDPEMALKGSILPFGGHKGYALSFMIEILAGPL
VGAAFGTAVTGTANPEEMCTKGDLMMAIDPSKMVDPDEFRAQVDEFIEEVKSSGDVLIPGDIESMNIKRRRAEGIELDEK
LLERILGIARELDINLEIKEL

Sequences:

>Translated_341_residues
MRISPEEEVKIIKEILTAMNVPEESSDIVADVTLDADLKGFSSHGIGRFPQYVDGLRHGTIRADGDITIERETESTALIN
GNHIFGHVVAYRAMELAIEKARNTGVGLVGVHDSNHFGVAGYYSDMAVMNDMIGVVIANTEPAVAPIGGRKPILGTNPVA
IGIPSNRYYVSVDMATSASARGKLLEAARKGESIPENVALDAEGKPTTDPEMALKGSILPFGGHKGYALSFMIEILAGPL
VGAAFGTAVTGTANPEEMCTKGDLMMAIDPSKMVDPDEFRAQVDEFIEEVKSSGDVLIPGDIESMNIKRRRAEGIELDEK
LLERILGIARELDINLEIKEL
>Mature_341_residues
MRISPEEEVKIIKEILTAMNVPEESSDIVADVTLDADLKGFSSHGIGRFPQYVDGLRHGTIRADGDITIERETESTALIN
GNHIFGHVVAYRAMELAIEKARNTGVGLVGVHDSNHFGVAGYYSDMAVMNDMIGVVIANTEPAVAPIGGRKPILGTNPVA
IGIPSNRYYVSVDMATSASARGKLLEAARKGESIPENVALDAEGKPTTDPEMALKGSILPFGGHKGYALSFMIEILAGPL
VGAAFGTAVTGTANPEEMCTKGDLMMAIDPSKMVDPDEFRAQVDEFIEEVKSSGDVLIPGDIESMNIKRRRAEGIELDEK
LLERILGIARELDINLEIKEL

Specific function: Catalyzes the reduction of sulfopyruvate to (R)- sulfolactate. Involved in the biosynthesis of both coenzyme M (with (R)-sulfolactate) and methanopterin (with alpha- ketoglutarate)

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family

Homologues:

Organism=Escherichia coli, GI1787020, Length=347, Percent_Identity=31.9884726224784, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1786727, Length=336, Percent_Identity=31.25, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1790000, Length=333, Percent_Identity=26.7267267267267, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17507179, Length=355, Percent_Identity=31.830985915493, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17536633, Length=341, Percent_Identity=33.1378299120235, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24667908, Length=349, Percent_Identity=31.5186246418338, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24667904, Length=349, Percent_Identity=31.8051575931232, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45553211, Length=349, Percent_Identity=31.5186246418338, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24667912, Length=349, Percent_Identity=31.5186246418338, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24648360, Length=340, Percent_Identity=31.1764705882353, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24658010, Length=311, Percent_Identity=29.903536977492, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COMC_METTH (O27273)

Other databases:

- EMBL:   AE000666
- PIR:   H69027
- RefSeq:   NP_276333.1
- ProteinModelPortal:   O27273
- SMR:   O27273
- STRING:   O27273
- GeneID:   1471613
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1205
- NMPDR:   fig|187420.1.peg.1188
- eggNOG:   arNOG04825
- HOGENOM:   HBG553037
- OMA:   ATSESAM
- PhylomeDB:   O27273
- ProtClustDB:   CLSK876570
- BioCyc:   MTHE187420:MTH1205-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003767
- PANTHER:   PTHR11091

Pfam domain/function: PF02615 Ldh_2; SSF89733 MDH_LDH

EC number: 1.1.1.- [C]

Molecular weight: Translated: 36631; Mature: 36631

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISPEEEVKIIKEILTAMNVPEESSDIVADVTLDADLKGFSSHGIGRFPQYVDGLRHGT
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCC
IRADGDITIERETESTALINGNHIFGHVVAYRAMELAIEKARNTGVGLVGVHDSNHFGVA
EEECCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
GYYSDMAVMNDMIGVVIANTEPAVAPIGGRKPILGTNPVAIGIPSNRYYVSVDMATSASA
HHHHHHHHHHHCEEEEEECCCCCEECCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCH
RGKLLEAARKGESIPENVALDAEGKPTTDPEMALKGSILPFGGHKGYALSFMIEILAGPL
HHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHCHH
VGAAFGTAVTGTANPEEMCTKGDLMMAIDPSKMVDPDEFRAQVDEFIEEVKSSGDVLIPG
HHHHHCCEECCCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECC
DIESMNIKRRRAEGIELDEKLLERILGIARELDINLEIKEL
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MRISPEEEVKIIKEILTAMNVPEESSDIVADVTLDADLKGFSSHGIGRFPQYVDGLRHGT
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCC
IRADGDITIERETESTALINGNHIFGHVVAYRAMELAIEKARNTGVGLVGVHDSNHFGVA
EEECCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
GYYSDMAVMNDMIGVVIANTEPAVAPIGGRKPILGTNPVAIGIPSNRYYVSVDMATSASA
HHHHHHHHHHHCEEEEEECCCCCEECCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCH
RGKLLEAARKGESIPENVALDAEGKPTTDPEMALKGSILPFGGHKGYALSFMIEILAGPL
HHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHCHH
VGAAFGTAVTGTANPEEMCTKGDLMMAIDPSKMVDPDEFRAQVDEFIEEVKSSGDVLIPG
HHHHHCCEECCCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECC
DIESMNIKRRRAEGIELDEKLLERILGIARELDINLEIKEL
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463