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Identifier: 15678474

GI number: 15678474

Start: 383563

End: 385314

Strand: Direct

Name: Not Available

Synonym: MTH446

Alternate gene names: 15678474

Gene position: 383563-385314 (Clockwise)

Preceding gene: 15678473

Following gene: 15678475

Centisome position: 21.9

GC content: 51.54

Gene sequence:

>1752_bases
ATGTCAGAGAAATTGAAGGTACTGATACTTGAGGACGTCCCGCTTGACGCTGAACTTGTCATAAGGGAACTGCAGAGGGA
TGGTATAGAATTCGAGCACCTCACAGTTGACAGCGAGGACTCATTCAGGAGGGCCCTTGAGGAATTCAGCCCGGATATAA
TACTTGCAGACCACGCACTCCCCAGCTTCGACGGAGTATCTGCCCTGAGGATTGTGAGGGAGAACTATGACATCCCCTTC
ATATTTGTCAGTGGAAAGATCGGGGAGGAATTCGCTGTTGACATGCTCAAGGCAGGGGCCACCGATTACGTACTTAAGAA
TAACCTGTCAAAACTTCCACTTGCCTTCAGGAGGGCGCTGCAGGAGGCTGAAGAAGAGAGAAAGATTAAAAAGGCCAGGA
AAGCCCTTGAAGAGAGTGAAAGGAAATACAGGGCACTCTTTGAGAAATCAGGAAACCCGATATTCATCTGTTCAACCGAT
GGCATCATACTGGACGTTAACCCTGCAGCCGCAGGCTTCCTCAAGTCCTTCAGGGAGGATATAATCGGGAGAAACATAAG
GGAGTGGATCCATGAGGAGGACGCTGACAGGATATTCAGGGATGGAGAGGGCGGCCATCTGAAGTTCAGGGTGGGCCTCC
GGGGACGCACCCTGGACACATCGGTAACAGCAGTTGAACTGGACCATGAGAAGCTCATATATATCATGGGTAAGGATGTG
ACCGCCCAGAAACGTATTGAGAAGGAACTCAAATCCAGCAAGGAGGAGTACAGGGTAATCTTCGAAAACACAGGCACACT
CACTGTAATCTGCGGCAGCGACATGGTGATTGAACTTGCGAACTCAGCCTTTGAGGAGTTCTCAGGTTACAGTAAGGGCG
AGATCCAGGGCTACATGAAGTTCACAGACTTTGTTGACGCCTCTGACGCAGCTCGCATCGAGGCATACTACCGCCTTAAA
GGTATCAACCCGGATGCCATCCCCCACAACTTCGAGGTGGTCCTCAGGAACCGGCAGGGTGAGGAGAGAAACTTCTTCGC
AACCTCCGTTGTGATCCCGGGGAGTGAGAGGTGCCTCATATCCCTCATGGACATAACCCACAGGAAATCCGTTGAGAAAC
GCCTCAGGCGGTCCCTCAGGGAGAAGGAACTCCTCTTAAGGGAGGTGCACCATCGGGTCAAGAACAACCTCCAGATAATA
TCAACACTCCTCATGCTCCAGGCATCCACCACCGGCGACAAGAGACTGAGGGACCTCTACAGGGACAGCCAGCACAGGAT
AGATGCCATATCCCTCATACACGAGAAGCTCTACGAGTCGAGGGACCTCTCAAGGGTTAACCTCAGGGACTACATCAAGA
CACTCCTCAGCGACCTCCTGGATTCCTATGGAGCAGACAGTAACGGCATCGATGTGAGGGTGAAGGTGGATGATGTGAGG
CTCAACATTGAAACAGCCATCCCCTGCGGCCTCATAATCAATGAACTGGTATCAAATTCCCTCAAGTATGCATTCCCTGA
TGGTAAGGGTGAAATCACCGTTGAAGTCCACAGTACCGGCGAGGGATACGAAATGACGGTTTCAGATAATGGGGTCGGCC
TCCCGGAGGACCTTGACCTTGAGGGATCAGGCACACTGGGCCTCAGGATCGTCAGGAACCTCGTGGAGCAGATAGACGGG
GAACTTGAAATAGAAAGGCCTGCAAGGTTCACAATAAAATTCACTGAGGTTGAGTACAGGAGGAGGTTCTAG

Upstream 100 bases:

>100_bases
TAGGCATGTCTTGAAGACCAGACACCAGTGAAGAGCCCACAATAAAATTTCCAGGCTTAAGGTGTCTTGAGCTCATTAAC
CGTAATGAAGAGGAACCGGA

Downstream 100 bases:

>100_bases
TCTGGTCACGGCGTCACATTAAACCTTATTCTGCAGTGACATCAAAGTATCAGGGGCAATGTCCAGACATTAGTCCTCAG
TGATAGCGGTTCCATAAAGG

Product: sensory transduction regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 583; Mature: 582

Protein sequence:

>583_residues
MSEKLKVLILEDVPLDAELVIRELQRDGIEFEHLTVDSEDSFRRALEEFSPDIILADHALPSFDGVSALRIVRENYDIPF
IFVSGKIGEEFAVDMLKAGATDYVLKNNLSKLPLAFRRALQEAEEERKIKKARKALEESERKYRALFEKSGNPIFICSTD
GIILDVNPAAAGFLKSFREDIIGRNIREWIHEEDADRIFRDGEGGHLKFRVGLRGRTLDTSVTAVELDHEKLIYIMGKDV
TAQKRIEKELKSSKEEYRVIFENTGTLTVICGSDMVIELANSAFEEFSGYSKGEIQGYMKFTDFVDASDAARIEAYYRLK
GINPDAIPHNFEVVLRNRQGEERNFFATSVVIPGSERCLISLMDITHRKSVEKRLRRSLREKELLLREVHHRVKNNLQII
STLLMLQASTTGDKRLRDLYRDSQHRIDAISLIHEKLYESRDLSRVNLRDYIKTLLSDLLDSYGADSNGIDVRVKVDDVR
LNIETAIPCGLIINELVSNSLKYAFPDGKGEITVEVHSTGEGYEMTVSDNGVGLPEDLDLEGSGTLGLRIVRNLVEQIDG
ELEIERPARFTIKFTEVEYRRRF

Sequences:

>Translated_583_residues
MSEKLKVLILEDVPLDAELVIRELQRDGIEFEHLTVDSEDSFRRALEEFSPDIILADHALPSFDGVSALRIVRENYDIPF
IFVSGKIGEEFAVDMLKAGATDYVLKNNLSKLPLAFRRALQEAEEERKIKKARKALEESERKYRALFEKSGNPIFICSTD
GIILDVNPAAAGFLKSFREDIIGRNIREWIHEEDADRIFRDGEGGHLKFRVGLRGRTLDTSVTAVELDHEKLIYIMGKDV
TAQKRIEKELKSSKEEYRVIFENTGTLTVICGSDMVIELANSAFEEFSGYSKGEIQGYMKFTDFVDASDAARIEAYYRLK
GINPDAIPHNFEVVLRNRQGEERNFFATSVVIPGSERCLISLMDITHRKSVEKRLRRSLREKELLLREVHHRVKNNLQII
STLLMLQASTTGDKRLRDLYRDSQHRIDAISLIHEKLYESRDLSRVNLRDYIKTLLSDLLDSYGADSNGIDVRVKVDDVR
LNIETAIPCGLIINELVSNSLKYAFPDGKGEITVEVHSTGEGYEMTVSDNGVGLPEDLDLEGSGTLGLRIVRNLVEQIDG
ELEIERPARFTIKFTEVEYRRRF
>Mature_582_residues
SEKLKVLILEDVPLDAELVIRELQRDGIEFEHLTVDSEDSFRRALEEFSPDIILADHALPSFDGVSALRIVRENYDIPFI
FVSGKIGEEFAVDMLKAGATDYVLKNNLSKLPLAFRRALQEAEEERKIKKARKALEESERKYRALFEKSGNPIFICSTDG
IILDVNPAAAGFLKSFREDIIGRNIREWIHEEDADRIFRDGEGGHLKFRVGLRGRTLDTSVTAVELDHEKLIYIMGKDVT
AQKRIEKELKSSKEEYRVIFENTGTLTVICGSDMVIELANSAFEEFSGYSKGEIQGYMKFTDFVDASDAARIEAYYRLKG
INPDAIPHNFEVVLRNRQGEERNFFATSVVIPGSERCLISLMDITHRKSVEKRLRRSLREKELLLREVHHRVKNNLQIIS
TLLMLQASTTGDKRLRDLYRDSQHRIDAISLIHEKLYESRDLSRVNLRDYIKTLLSDLLDSYGADSNGIDVRVKVDDVRL
NIETAIPCGLIINELVSNSLKYAFPDGKGEITVEVHSTGEGYEMTVSDNGVGLPEDLDLEGSGTLGLRIVRNLVEQIDGE
LEIERPARFTIKFTEVEYRRRF

Specific function: Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to pdtaR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR022066
- InterPro:   IPR011495
- InterPro:   IPR005467 [H]

Pfam domain/function: PF12282 H_kinase_N; PF02518 HATPase_c; PF07568 HisKA_2 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66486; Mature: 66354

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKLKVLILEDVPLDAELVIRELQRDGIEFEHLTVDSEDSFRRALEEFSPDIILADHAL
CCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCEEEECCCC
PSFDGVSALRIVRENYDIPFIFVSGKIGEEFAVDMLKAGATDYVLKNNLSKLPLAFRRAL
CCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHH
QEAEEERKIKKARKALEESERKYRALFEKSGNPIFICSTDGIILDVNPAAAGFLKSFRED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHHHHHHHHHHH
IIGRNIREWIHEEDADRIFRDGEGGHLKFRVGLRGRTLDTSVTAVELDHEKLIYIMGKDV
HHCCHHHHHHCCCCHHHHHCCCCCCEEEEEEECCCCEECCCEEEEEECCCEEEEEECCCC
TAQKRIEKELKSSKEEYRVIFENTGTLTVICGSDMVIELANSAFEEFSGYSKGEIQGYMK
HHHHHHHHHHHCCHHHEEEEEECCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEE
FTDFVDASDAARIEAYYRLKGINPDAIPHNFEVVLRNRQGEERNFFATSVVIPGSERCLI
EHHCCCCCCCHHEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCHHE
SLMDITHRKSVEKRLRRSLREKELLLREVHHRVKNNLQIISTLLMLQASTTGDKRLRDLY
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHH
RDSQHRIDAISLIHEKLYESRDLSRVNLRDYIKTLLSDLLDSYGADSNGIDVRVKVDDVR
HCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEE
LNIETAIPCGLIINELVSNSLKYAFPDGKGEITVEVHSTGEGYEMTVSDNGVGLPEDLDL
EEEECCCCHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCC
EGSGTLGLRIVRNLVEQIDGELEIERPARFTIKFTEVEYRRRF
CCCCCHHHHHHHHHHHHCCCCEEEECCCEEEEEEEEEHHHHCC
>Mature Secondary Structure 
SEKLKVLILEDVPLDAELVIRELQRDGIEFEHLTVDSEDSFRRALEEFSPDIILADHAL
CCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCEEEECCCC
PSFDGVSALRIVRENYDIPFIFVSGKIGEEFAVDMLKAGATDYVLKNNLSKLPLAFRRAL
CCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHH
QEAEEERKIKKARKALEESERKYRALFEKSGNPIFICSTDGIILDVNPAAAGFLKSFRED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHHHHHHHHHHH
IIGRNIREWIHEEDADRIFRDGEGGHLKFRVGLRGRTLDTSVTAVELDHEKLIYIMGKDV
HHCCHHHHHHCCCCHHHHHCCCCCCEEEEEEECCCCEECCCEEEEEECCCEEEEEECCCC
TAQKRIEKELKSSKEEYRVIFENTGTLTVICGSDMVIELANSAFEEFSGYSKGEIQGYMK
HHHHHHHHHHHCCHHHEEEEEECCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEE
FTDFVDASDAARIEAYYRLKGINPDAIPHNFEVVLRNRQGEERNFFATSVVIPGSERCLI
EHHCCCCCCCHHEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCHHE
SLMDITHRKSVEKRLRRSLREKELLLREVHHRVKNNLQIISTLLMLQASTTGDKRLRDLY
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHH
RDSQHRIDAISLIHEKLYESRDLSRVNLRDYIKTLLSDLLDSYGADSNGIDVRVKVDDVR
HCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEE
LNIETAIPCGLIINELVSNSLKYAFPDGKGEITVEVHSTGEGYEMTVSDNGVGLPEDLDL
EEEECCCCHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCC
EGSGTLGLRIVRNLVEQIDGELEIERPARFTIKFTEVEYRRRF
CCCCCHHHHHHHHHHHHCCCCEEEECCCEEEEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]