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Identifier: 15678402

GI number: 15678402

Start: 319424

End: 320299

Strand: Direct

Name: Not Available

Synonym: MTH374

Alternate gene names: 15678402

Gene position: 319424-320299 (Clockwise)

Preceding gene: 15678401

Following gene: 15678403

Centisome position: 18.24

GC content: 55.48

Gene sequence:

>876_bases
ATGAGGATAGTCGCGGTCATCCCTGCCTTCAACGAGGAGGTTGCCATAGGTTCAGTTGTGCTCCTCACAGGGGAACACGT
TGATGAGGTTATCGTTGTTGATGATGGGTCGGCTGACAGGACAGCCCACGTGGCTGAGATGGCAGGCGCAAGGGTTATAA
GGCACCACAGGAACCTGGGAAAGGGTGCAGCCCTCAAAACAGGGTTTGAGGCTGCAGATGCAGATGTAATAGTCACCCTT
GACGCTGATGCACAGCACAACCCTGCAGAGATACCTAAACTCGTGGAGCCCATACTGAGGGGGGAGGCCGACGTTGTGAA
CGGGAGCCGCTACCTCCATGGGAGGGACGAGAACACCCCCCGCTACCGCAGGGTGGGCCAGAAGATACTTGACAGGGCCA
CCAACATATCAACGGGCCTGGACATAACCGATACCCAGAGCGGCTTCAGGGCCTTCTCATCAGCCAGCATACCCCATTTC
AGGTTCAGGGACCCGGGCTTCGTGGTTGAAAGCGAGATGCTTGCAGACGCCGCCGAGGCCGGCCTCAGGATAGTGGAGGT
GGAGGTCGGAGTGAGGTATGATGTGGATGGGTCCACCAGGAACCCCATAAGCCACGGTGTATCGGTGCTCCTTAGGATCA
TAGGGGACCTTGAACTCAAGCGCCCCCTCTACTACTTCACACTCCCGGGCCTCATAATAGGGATTACAGGGGCAATCCTA
AGTTTAATGTTCATAAGGGACTACATAACGGGTTTAAGTGTGAACATGGGTCCCACCATCGTGGCGGTGATGCTCACACT
CTTCGGGACCTTCTTCATATTCACAGGCATCATCCTCGACTCCATGAGGAGGATGATCATCCACTATGGAAGGTGA

Upstream 100 bases:

>100_bases
CCATAAGGGACCTCAAACATGACCCACAGGTACCCCCCGAGGAGGGTATCAGGCGTACAGTCGAGTGGATGAAGTGGTAC
TACAGGATAGAGGACTGAAA

Downstream 100 bases:

>100_bases
CTGCAGAATCTACTGATGGAAGGTGATTGATTATGGATGAATTCAGGGCTTATGATGGTAAATGTGTTCTTGTAACAGGT
GGAGCTGGATGCGTTGGAAG

Product: dolichyl-phosphate mannose synthase related protein

Products: GDP; dolichyl D-mannosyl phosphate

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MRIVAVIPAFNEEVAIGSVVLLTGEHVDEVIVVDDGSADRTAHVAEMAGARVIRHHRNLGKGAALKTGFEAADADVIVTL
DADAQHNPAEIPKLVEPILRGEADVVNGSRYLHGRDENTPRYRRVGQKILDRATNISTGLDITDTQSGFRAFSSASIPHF
RFRDPGFVVESEMLADAAEAGLRIVEVEVGVRYDVDGSTRNPISHGVSVLLRIIGDLELKRPLYYFTLPGLIIGITGAIL
SLMFIRDYITGLSVNMGPTIVAVMLTLFGTFFIFTGIILDSMRRMIIHYGR

Sequences:

>Translated_291_residues
MRIVAVIPAFNEEVAIGSVVLLTGEHVDEVIVVDDGSADRTAHVAEMAGARVIRHHRNLGKGAALKTGFEAADADVIVTL
DADAQHNPAEIPKLVEPILRGEADVVNGSRYLHGRDENTPRYRRVGQKILDRATNISTGLDITDTQSGFRAFSSASIPHF
RFRDPGFVVESEMLADAAEAGLRIVEVEVGVRYDVDGSTRNPISHGVSVLLRIIGDLELKRPLYYFTLPGLIIGITGAIL
SLMFIRDYITGLSVNMGPTIVAVMLTLFGTFFIFTGIILDSMRRMIIHYGR
>Mature_291_residues
MRIVAVIPAFNEEVAIGSVVLLTGEHVDEVIVVDDGSADRTAHVAEMAGARVIRHHRNLGKGAALKTGFEAADADVIVTL
DADAQHNPAEIPKLVEPILRGEADVVNGSRYLHGRDENTPRYRRVGQKILDRATNISTGLDITDTQSGFRAFSSASIPHF
RFRDPGFVVESEMLADAAEAGLRIVEVEVGVRYDVDGSTRNPISHGVSVLLRIIGDLELKRPLYYFTLPGLIIGITGAIL
SLMFIRDYITGLSVNMGPTIVAVMLTLFGTFFIFTGIILDSMRRMIIHYGR

Specific function: Unknown

COG id: COG0463

COG function: function code M; Glycosyltransferases involved in cell wall biogenesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4503363, Length=219, Percent_Identity=26.4840182648402, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788588, Length=291, Percent_Identity=25.7731958762887, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24585265, Length=203, Percent_Identity=27.5862068965517, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: 2.4.1.83

Molecular weight: Translated: 31766; Mature: 31766

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVAVIPAFNEEVAIGSVVLLTGEHVDEVIVVDDGSADRTAHVAEMAGARVIRHHRNLG
CEEEEEECCCCCCEEECEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC
KGAALKTGFEAADADVIVTLDADAQHNPAEIPKLVEPILRGEADVVNGSRYLHGRDENTP
CCCHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEECCCEEECCCCCCCH
RYRRVGQKILDRATNISTGLDITDTQSGFRAFSSASIPHFRFRDPGFVVESEMLADAAEA
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCCEEHHHHHHHHHHC
GLRIVEVEVGVRYDVDGSTRNPISHGVSVLLRIIGDLELKRPLYYFTLPGLIIGITGAIL
CCEEEEEEECEEEECCCCCCCHHHHHHHHHHHHHHCHHHCCCEEEEEHHHHHHHHHHHHH
SLMFIRDYITGLSVNMGPTIVAVMLTLFGTFFIFTGIILDSMRRMIIHYGR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIVAVIPAFNEEVAIGSVVLLTGEHVDEVIVVDDGSADRTAHVAEMAGARVIRHHRNLG
CEEEEEECCCCCCEEECEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC
KGAALKTGFEAADADVIVTLDADAQHNPAEIPKLVEPILRGEADVVNGSRYLHGRDENTP
CCCHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEECCCEEECCCCCCCH
RYRRVGQKILDRATNISTGLDITDTQSGFRAFSSASIPHFRFRDPGFVVESEMLADAAEA
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCCEEHHHHHHHHHHC
GLRIVEVEVGVRYDVDGSTRNPISHGVSVLLRIIGDLELKRPLYYFTLPGLIIGITGAIL
CCEEEEEEECEEEECCCCCCCHHHHHHHHHHHHHHCHHHCCCEEEEEHHHHHHHHHHHHH
SLMFIRDYITGLSVNMGPTIVAVMLTLFGTFFIFTGIILDSMRRMIIHYGR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDPmannose; dolichyl phosphate

Specific reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]