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Identifier: 15678401

GI number: 15678401

Start: 318417

End: 319421

Strand: Direct

Name: Not Available

Synonym: MTH373

Alternate gene names: 15678401

Gene position: 318417-319421 (Clockwise)

Preceding gene: 15678400

Following gene: 15678402

Centisome position: 18.18

GC content: 51.04

Gene sequence:

>1005_bases
ATGTTACCAGGAAAACCCTTATTCTTACAAGGGAAATCATCCAAAATAGGGAGTGATGCTAATATGGAAACTCAGAGAAT
ACTCGTGACCGGTGGCGCCGGATTCATAGGTACAAACCTTGTCAATGAACTGAGGAACAGGGGCCATGAGGTCCTTGCGG
TTGACCTCATGCACACAGAACGCGAGGACTACATGAGGGCCGATGTCAGGGAGTACAGGCAGGTTGAGAGGATCTTTGAG
GAAGATAAATTCGACTACGTATACCACCTGGCCGCAGAGTACGGGAGATGGAACGGTGAGGACTACTATGAGAACCTCTG
GAAGACCAACGTCATAGGTACAAAGCACATGCTGAGGATGCAGGAGAAGCTTGGCTTCAGGATGATATTCTTCTCCTCAG
CAGAGGTCTACGGGGACTACAGTGGTTTGATGAGTGAGGATGTGATGGTCAAAAACCCCATAAGCGACACCTACCAGATG
AATGACTACGCCATAACCAAGTGGGCCGGTGAACTCATGTGCATGAACTCTGCAGAGATGTTCGGCACAGAGACTGTCCG
TGTGAGGCCGGTGAACTGTTACGGCCCCCATGAGAAGTACTCACCCTACAAGGGCTTCATACCCATATTCATCTACCATG
CACTACACAGGAAGCCCTACACCGTCTATAAGGGCCATAAGAGGATAATCGACTACGTGGAGGACTCCGTGAGGACCTTC
GCCAATATCGTGGATAACTTCATCCCCGGGGAGGTCTACAATGTCGGCGGGCGAACCGAGTGGGAGCATGACATCAAGGA
GTACTCAGACATGGTCCTTGAGGCTGTGGGGATAGATGACTCCATAGTCACCTACAGGGAGTCAGAGCCCTTCACCACAA
AGGTGAAGACCATGGACTTCTCAAAGGCCATAAGGGACCTCAAACATGACCCACAGGTACCCCCCGAGGAGGGTATCAGG
CGTACAGTCGAGTGGATGAAGTGGTACTACAGGATAGAGGACTGA

Upstream 100 bases:

>100_bases
ATTTATATGGCGAGTTCAATAACTAGTTTGAGTTAAACTAGGATATACTCTGAATCGTATATTGTGGGAAGGAAATCTTT
ATTCATTCATATCATGAATA

Downstream 100 bases:

>100_bases
AAATGAGGATAGTCGCGGTCATCCCTGCCTTCAACGAGGAGGTTGCCATAGGTTCAGTTGTGCTCCTCACAGGGGAACAC
GTTGATGAGGTTATCGTTGT

Product: dTDP-glucose 4,6-dehydratase related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MLPGKPLFLQGKSSKIGSDANMETQRILVTGGAGFIGTNLVNELRNRGHEVLAVDLMHTEREDYMRADVREYRQVERIFE
EDKFDYVYHLAAEYGRWNGEDYYENLWKTNVIGTKHMLRMQEKLGFRMIFFSSAEVYGDYSGLMSEDVMVKNPISDTYQM
NDYAITKWAGELMCMNSAEMFGTETVRVRPVNCYGPHEKYSPYKGFIPIFIYHALHRKPYTVYKGHKRIIDYVEDSVRTF
ANIVDNFIPGEVYNVGGRTEWEHDIKEYSDMVLEAVGIDDSIVTYRESEPFTTKVKTMDFSKAIRDLKHDPQVPPEEGIR
RTVEWMKWYYRIED

Sequences:

>Translated_334_residues
MLPGKPLFLQGKSSKIGSDANMETQRILVTGGAGFIGTNLVNELRNRGHEVLAVDLMHTEREDYMRADVREYRQVERIFE
EDKFDYVYHLAAEYGRWNGEDYYENLWKTNVIGTKHMLRMQEKLGFRMIFFSSAEVYGDYSGLMSEDVMVKNPISDTYQM
NDYAITKWAGELMCMNSAEMFGTETVRVRPVNCYGPHEKYSPYKGFIPIFIYHALHRKPYTVYKGHKRIIDYVEDSVRTF
ANIVDNFIPGEVYNVGGRTEWEHDIKEYSDMVLEAVGIDDSIVTYRESEPFTTKVKTMDFSKAIRDLKHDPQVPPEEGIR
RTVEWMKWYYRIED
>Mature_334_residues
MLPGKPLFLQGKSSKIGSDANMETQRILVTGGAGFIGTNLVNELRNRGHEVLAVDLMHTEREDYMRADVREYRQVERIFE
EDKFDYVYHLAAEYGRWNGEDYYENLWKTNVIGTKHMLRMQEKLGFRMIFFSSAEVYGDYSGLMSEDVMVKNPISDTYQM
NDYAITKWAGELMCMNSAEMFGTETVRVRPVNCYGPHEKYSPYKGFIPIFIYHALHRKPYTVYKGHKRIIDYVEDSVRTF
ANIVDNFIPGEVYNVGGRTEWEHDIKEYSDMVLEAVGIDDSIVTYRESEPFTTKVKTMDFSKAIRDLKHDPQVPPEEGIR
RTVEWMKWYYRIED

Specific function: INVOLVED IN THE SYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN (ECA) AND REQUIRED FOR SYNTHESIS OF LIPOPOLYSACCHARIDE O-SIDE CHAINS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=314, Percent_Identity=31.2101910828025, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI7657641, Length=334, Percent_Identity=26.9461077844311, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI48994969, Length=356, Percent_Identity=28.0898876404494, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788353, Length=340, Percent_Identity=29.4117647058824, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788365, Length=331, Percent_Identity=23.5649546827795, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539532, Length=329, Percent_Identity=26.1398176291793, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17568069, Length=336, Percent_Identity=25.8928571428571, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115532424, Length=325, Percent_Identity=24.6153846153846, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356223, Length=321, Percent_Identity=27.1028037383178, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 39157; Mature: 39157

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPGKPLFLQGKSSKIGSDANMETQRILVTGGAGFIGTNLVNELRNRGHEVLAVDLMHTE
CCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEHHCC
REDYMRADVREYRQVERIFEEDKFDYVYHLAAEYGRWNGEDYYENLWKTNVIGTKHMLRM
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHH
QEKLGFRMIFFSSAEVYGDYSGLMSEDVMVKNPISDTYQMNDYAITKWAGELMCMNSAEM
HHHCCEEEEEEECHHHHCCHHHHCCCCCEEECCCCCCEECCCEEEEECCCCEEEECCHHH
FGTETVRVRPVNCYGPHEKYSPYKGFIPIFIYHALHRKPYTVYKGHKRIIDYVEDSVRTF
CCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
ANIVDNFIPGEVYNVGGRTEWEHDIKEYSDMVLEAVGIDDSIVTYRESEPFTTKVKTMDF
HHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCH
SKAIRDLKHDPQVPPEEGIRRTVEWMKWYYRIED
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MLPGKPLFLQGKSSKIGSDANMETQRILVTGGAGFIGTNLVNELRNRGHEVLAVDLMHTE
CCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEHHCC
REDYMRADVREYRQVERIFEEDKFDYVYHLAAEYGRWNGEDYYENLWKTNVIGTKHMLRM
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHH
QEKLGFRMIFFSSAEVYGDYSGLMSEDVMVKNPISDTYQMNDYAITKWAGELMCMNSAEM
HHHCCEEEEEEECHHHHCCHHHHCCCCCEEECCCCCCEECCCEEEEECCCCEEEECCHHH
FGTETVRVRPVNCYGPHEKYSPYKGFIPIFIYHALHRKPYTVYKGHKRIIDYVEDSVRTF
CCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
ANIVDNFIPGEVYNVGGRTEWEHDIKEYSDMVLEAVGIDDSIVTYRESEPFTTKVKTMDF
HHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCH
SKAIRDLKHDPQVPPEEGIRRTVEWMKWYYRIED
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]