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Identifier: 15678403

GI number: 15678403

Start: 320326

End: 321324

Strand: Direct

Name: Not Available

Synonym: MTH375

Alternate gene names: 15678403

Gene position: 320326-321324 (Clockwise)

Preceding gene: 15678402

Following gene: 15678404

Centisome position: 18.29

GC content: 52.95

Gene sequence:

>999_bases
TTGATTATGGATGAATTCAGGGCTTATGATGGTAAATGTGTTCTTGTAACAGGTGGAGCTGGATGCGTTGGAAGCAATCT
CACAGGGAACCTTGCAAAGGCAGGGGCCAATGTGATCATACTGGATAATCTCTCATCAAGCTATGAGTGGAACATCCCGG
AATATGAGAACATAGAATTCGTTAAGGGCGACATACTCGACGATGAGGTCCTTAAACGGGTATTCAAGGAGAGGCCGGAC
TACGTCTTCCACCTCGCAGCCCACTTTGCAAACCAGAACAGTGTTGACAACCCGGAGAAGGACCTCCTGGTCAACGGGCT
GGGCATACTGAAGGTCCTTGAGTATGCACAGCTTGTGGGTGTTGAGCGCTTCGTTTACTCATCATCAGGGTGCGGTGTCT
ACGGCCTGGACTCAAAGATACCCTTTGAGGAACACGACATCTCAATATCACTGCACACCCCCTACCAGGTCACCAAGCTC
CTCGGTGAACTGTACACCAACTACTTCCACAACCTCTACGAGATGCCCATAGTCAATGCAAGGTTCTTCAACGTCTTCGG
CCCGGGTGAGGTCCCAGGGAAGTACCGTAACGTCATCCCCAACTTCTTCTACTGGGCCATGAACCAGCAACCATTACCCA
TAACCGGGGACGGCTCAGAGACCAGGGACTGGACCTTCGTGGAGGACATAGTCAGGGGCCTCATGGCCATGGGTGTCAGA
AGGGAGGCCATAGGCGAGGCCATCAACCTTGGCTCAGGGACCGAGCACCAGGTCATAGAGATGGCGGGTATCATAAACGA
GCTCACAGAAAACCCTGCAGGCGTGGTCTACAGGCCGAGGAGGGACTGGGACGCCAAGACAAGGCTCCTGTCATCAATCG
ATAAGGCCAGAAGACTCCTGGACTACGAGCCACAGGTATCCTTCAGGGAGGGACTTGAGAGGACCCACAGGTGGTTCACA
GAGAACTGGGAGCTCATAAGGAAGAGCGCAGAGTTCTAA

Upstream 100 bases:

>100_bases
TCGGGACCTTCTTCATATTCACAGGCATCATCCTCGACTCCATGAGGAGGATGATCATCCACTATGGAAGGTGACTGCAG
AATCTACTGATGGAAGGTGA

Downstream 100 bases:

>100_bases
TCAAAAACCTTCTTTTTCTGATCGCATATGAGGATACTGGTTGTACAGGAATCGGACTGGATAGAAAGGAACCCCCACCA
GCAGCACCACCTCTTTGACA

Product: UDP-glucose 4-epimerase related protein

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MIMDEFRAYDGKCVLVTGGAGCVGSNLTGNLAKAGANVIILDNLSSSYEWNIPEYENIEFVKGDILDDEVLKRVFKERPD
YVFHLAAHFANQNSVDNPEKDLLVNGLGILKVLEYAQLVGVERFVYSSSGCGVYGLDSKIPFEEHDISISLHTPYQVTKL
LGELYTNYFHNLYEMPIVNARFFNVFGPGEVPGKYRNVIPNFFYWAMNQQPLPITGDGSETRDWTFVEDIVRGLMAMGVR
REAIGEAINLGSGTEHQVIEMAGIINELTENPAGVVYRPRRDWDAKTRLLSSIDKARRLLDYEPQVSFREGLERTHRWFT
ENWELIRKSAEF

Sequences:

>Translated_332_residues
MIMDEFRAYDGKCVLVTGGAGCVGSNLTGNLAKAGANVIILDNLSSSYEWNIPEYENIEFVKGDILDDEVLKRVFKERPD
YVFHLAAHFANQNSVDNPEKDLLVNGLGILKVLEYAQLVGVERFVYSSSGCGVYGLDSKIPFEEHDISISLHTPYQVTKL
LGELYTNYFHNLYEMPIVNARFFNVFGPGEVPGKYRNVIPNFFYWAMNQQPLPITGDGSETRDWTFVEDIVRGLMAMGVR
REAIGEAINLGSGTEHQVIEMAGIINELTENPAGVVYRPRRDWDAKTRLLSSIDKARRLLDYEPQVSFREGLERTHRWFT
ENWELIRKSAEF
>Mature_332_residues
MIMDEFRAYDGKCVLVTGGAGCVGSNLTGNLAKAGANVIILDNLSSSYEWNIPEYENIEFVKGDILDDEVLKRVFKERPD
YVFHLAAHFANQNSVDNPEKDLLVNGLGILKVLEYAQLVGVERFVYSSSGCGVYGLDSKIPFEEHDISISLHTPYQVTKL
LGELYTNYFHNLYEMPIVNARFFNVFGPGEVPGKYRNVIPNFFYWAMNQQPLPITGDGSETRDWTFVEDIVRGLMAMGVR
REAIGEAINLGSGTEHQVIEMAGIINELTENPAGVVYRPRRDWDAKTRLLSSIDKARRLLDYEPQVSFREGLERTHRWFT
ENWELIRKSAEF

Specific function: INVOLVED IN THE SYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN (ECA) AND REQUIRED FOR SYNTHESIS OF LIPOPOLYSACCHARIDE O-SIDE CHAINS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=322, Percent_Identity=30.7453416149068, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI7657641, Length=336, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI56237023, Length=341, Percent_Identity=28.1524926686217, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI56118217, Length=341, Percent_Identity=28.1524926686217, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI189083684, Length=341, Percent_Identity=28.1524926686217, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI48994969, Length=342, Percent_Identity=29.2397660818713, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786974, Length=328, Percent_Identity=29.8780487804878, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1788353, Length=340, Percent_Identity=26.1764705882353, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788366, Length=346, Percent_Identity=26.878612716763, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI115532424, Length=329, Percent_Identity=30.0911854103343, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17539532, Length=315, Percent_Identity=28.5714285714286, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17568069, Length=329, Percent_Identity=27.0516717325228, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71982035, Length=341, Percent_Identity=26.6862170087977, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71982038, Length=344, Percent_Identity=26.453488372093, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=345, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21356223, Length=315, Percent_Identity=30.4761904761905, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI19923002, Length=340, Percent_Identity=29.1176470588235, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37722; Mature: 37722

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMDEFRAYDGKCVLVTGGAGCVGSNLTGNLAKAGANVIILDNLSSSYEWNIPEYENIEF
CCCCHHHCCCCEEEEEECCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCCCCCCEE
VKGDILDDEVLKRVFKERPDYVFHLAAHFANQNSVDNPEKDLLVNGLGILKVLEYAQLVG
EECCCCCHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHH
VERFVYSSSGCGVYGLDSKIPFEEHDISISLHTPYQVTKLLGELYTNYFHNLYEMPIVNA
HHHHEECCCCCCEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCE
RFFNVFGPGEVPGKYRNVIPNFFYWAMNQQPLPITGDGSETRDWTFVEDIVRGLMAMGVR
EEEEEECCCCCCCHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHH
REAIGEAINLGSGTEHQVIEMAGIINELTENPAGVVYRPRRDWDAKTRLLSSIDKARRLL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
DYEPQVSFREGLERTHRWFTENWELIRKSAEF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIMDEFRAYDGKCVLVTGGAGCVGSNLTGNLAKAGANVIILDNLSSSYEWNIPEYENIEF
CCCCHHHCCCCEEEEEECCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCCCCCCEE
VKGDILDDEVLKRVFKERPDYVFHLAAHFANQNSVDNPEKDLLVNGLGILKVLEYAQLVG
EECCCCCHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHH
VERFVYSSSGCGVYGLDSKIPFEEHDISISLHTPYQVTKLLGELYTNYFHNLYEMPIVNA
HHHHEECCCCCCEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCE
RFFNVFGPGEVPGKYRNVIPNFFYWAMNQQPLPITGDGSETRDWTFVEDIVRGLMAMGVR
EEEEEECCCCCCCHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHH
REAIGEAINLGSGTEHQVIEMAGIINELTENPAGVVYRPRRDWDAKTRLLSSIDKARRLL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
DYEPQVSFREGLERTHRWFTENWELIRKSAEF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]