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Identifier: 15678079

GI number: 15678079

Start: 28630

End: 29607

Strand: Direct

Name: Not Available

Synonym: MTH50

Alternate gene names: 15678079

Gene position: 28630-29607 (Clockwise)

Preceding gene: 15678078

Following gene: 15678080

Centisome position: 1.63

GC content: 53.48

Gene sequence:

>978_bases
ATGATGGAAGTAATGGATATTCTAAGGAAGTACTCTGAAATGGCTGATGAGAGGATAAGGGAGTCCATCAGTGACATAAC
ACCCGAGACGTTACTCAGAGCATCAGAACACCTCATCACAGCAGGCGGTAAGAAGATAAGACCATCACTGGCCCTCTTAA
GCTCTGAGGCTGTTGGCGGAGACCCCGGGGATGCTGCGGGTGTTGCAGCGGCAATAGAACTGATCCACACATTCTCACTC
ATCCACGATGATATAATGGATGACGATGAGATCAGGAGAGGCGAACCTGCCGTCCATGTCCTCTGGGGGGAACCCATGGC
CATACTCGCCGGTGATGTTCTCTTCTCAAAGGCCTTCGAGGCGGTTATCAGGAACGGTGACTCTGAAATGGTGAAGGAAG
CTCTTGCAGTTGTCGTTGACTCCTGCGTCAAGATATGTGAGGGCCAGGCCCTTGACATGGGATTCGAGGAGAGGCTGGAC
GTCACAGAGGAGGAATACATGGAGATGATCTACAAGAAGACAGCAGCCCTCATCGCAGCAGCAACAAAGGCCGGGGCGAT
AATGGGTGGTGGTTCACCCCAGGAGATCGCCGCCCTCGAGGACTATGGCAGATGCATTGGTCTCGCATTCCAGATACACG
ACGACTACCTCGACGTGGTCAGTGACGAGGAATCCCTTGGCAAACCAGTGGGCAGTGACATAGCAGAGGGAAAGATGACC
CTCATGGTTGTGAAGGCACTTGAGAGGGCATCAGAGAAGGACAGGGAGAGGCTGATATCCATCCTGGGCTCCGGGGACGA
GAAACTTGTGGCAGAGGCCATAGAGATATTTGAACGATACGGGGCAACAGAATATGCCCATGCTGTGGCCCTGGACCATG
TGAGGATGGCAAAGGAACGCCTCGAGGTACTTGAGGAATCGGATGCAAGGGAAGCCCTCGCCATGATAGCCGACTTCGTC
CTTGAAAGGGAACACTAG

Upstream 100 bases:

>100_bases
CGGCCTACGCAGAGATAGCAGAGGAGGAGGGCTACAAGCTGGGTAACGATATACATATCCTAAGGAATGGACAGGCACAG
GTCTTTAATGGAGGTATCCG

Downstream 100 bases:

>100_bases
GTGGTGCCAGTGGAGGACCTTGTCTACAGGTACGCACTCCTGAACGCTGTGAAACACAGGGGAAGGGCAAACCCGGGGGC
CGTCATGGGGGCCGTCATGA

Product: bifunctional short chain isoprenyl diphosphate synthase

Products: NA

Alternate protein names: (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl pyrophosphate synthase; FPP synthase; Geranyltranstransferase

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MMEVMDILRKYSEMADERIRESISDITPETLLRASEHLITAGGKKIRPSLALLSSEAVGGDPGDAAGVAAAIELIHTFSL
IHDDIMDDDEIRRGEPAVHVLWGEPMAILAGDVLFSKAFEAVIRNGDSEMVKEALAVVVDSCVKICEGQALDMGFEERLD
VTEEEYMEMIYKKTAALIAAATKAGAIMGGGSPQEIAALEDYGRCIGLAFQIHDDYLDVVSDEESLGKPVGSDIAEGKMT
LMVVKALERASEKDRERLISILGSGDEKLVAEAIEIFERYGATEYAHAVALDHVRMAKERLEVLEESDAREALAMIADFV
LEREH

Sequences:

>Translated_325_residues
MMEVMDILRKYSEMADERIRESISDITPETLLRASEHLITAGGKKIRPSLALLSSEAVGGDPGDAAGVAAAIELIHTFSL
IHDDIMDDDEIRRGEPAVHVLWGEPMAILAGDVLFSKAFEAVIRNGDSEMVKEALAVVVDSCVKICEGQALDMGFEERLD
VTEEEYMEMIYKKTAALIAAATKAGAIMGGGSPQEIAALEDYGRCIGLAFQIHDDYLDVVSDEESLGKPVGSDIAEGKMT
LMVVKALERASEKDRERLISILGSGDEKLVAEAIEIFERYGATEYAHAVALDHVRMAKERLEVLEESDAREALAMIADFV
LEREH
>Mature_325_residues
MMEVMDILRKYSEMADERIRESISDITPETLLRASEHLITAGGKKIRPSLALLSSEAVGGDPGDAAGVAAAIELIHTFSL
IHDDIMDDDEIRRGEPAVHVLWGEPMAILAGDVLFSKAFEAVIRNGDSEMVKEALAVVVDSCVKICEGQALDMGFEERLD
VTEEEYMEMIYKKTAALIAAATKAGAIMGGGSPQEIAALEDYGRCIGLAFQIHDDYLDVVSDEESLGKPVGSDIAEGKMT
LMVVKALERASEKDRERLISILGSGDEKLVAEAIEIFERYGATEYAHAVALDHVRMAKERLEVLEESDAREALAMIADFV
LEREH

Specific function: Supplies Octaprenyl Diphosphate, The Precursor For The Side Chain Of The Isoprenoid Quinones Ubiquinone And Menaquinone. [C]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family

Homologues:

Organism=Homo sapiens, GI50659086, Length=314, Percent_Identity=31.8471337579618, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI4758430, Length=271, Percent_Identity=25.830258302583, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI83700220, Length=271, Percent_Identity=25.830258302583, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI209571582, Length=252, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI4503685, Length=252, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI209571584, Length=252, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789578, Length=289, Percent_Identity=34.6020761245675, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1786623, Length=226, Percent_Identity=38.0530973451327, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17505681, Length=280, Percent_Identity=28.9285714285714, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17508563, Length=257, Percent_Identity=28.4046692607004, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319475, Length=307, Percent_Identity=28.6644951140065, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6325188, Length=258, Percent_Identity=26.7441860465116, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322294, Length=263, Percent_Identity=26.2357414448669, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24651612, Length=291, Percent_Identity=31.2714776632302, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281365769, Length=268, Percent_Identity=26.4925373134328, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24660002, Length=268, Percent_Identity=26.4925373134328, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IDSA_METTH (O26156)

Other databases:

- EMBL:   AE000666
- PIR:   G69165
- RefSeq:   NP_275193.1
- ProteinModelPortal:   O26156
- SMR:   O26156
- STRING:   O26156
- GeneID:   1470012
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH50
- NMPDR:   fig|187420.1.peg.48
- eggNOG:   arNOG04398
- HOGENOM:   HBG732667
- OMA:   TFQIQDD
- PhylomeDB:   O26156
- ProtClustDB:   CLSK797822
- BioCyc:   MTHE187420:MTH50-MONOMER
- BRENDA:   2.5.1.1
- BRENDA:   2.5.1.10
- GO:   GO:0005737
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949
- Gene3D:   G3DSA:1.10.600.10
- PANTHER:   PTHR12001

Pfam domain/function: PF00348 polyprenyl_synt; SSF48576 Terpenoid_synth

EC number: =2.5.1.1; =2.5.1.10

Molecular weight: Translated: 35486; Mature: 35486

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00723 POLYPRENYL_SYNTHASE_1; PS00444 POLYPRENYL_SYNTHASE_2

Important sites: BINDING 44-44 BINDING 47-47 BINDING 76-76 BINDING 92-92 BINDING 93-93 BINDING 173-173 BINDING 174-174 BINDING 211-211 BINDING 228-228 BINDING 238-238

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEVMDILRKYSEMADERIRESISDITPETLLRASEHLITAGGKKIRPSLALLSSEAVGG
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHCHHHHHHHHHCCCC
DPGDAAGVAAAIELIHTFSLIHDDIMDDDEIRRGEPAVHVLWGEPMAILAGDVLFSKAFE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHH
AVIRNGDSEMVKEALAVVVDSCVKICEGQALDMGFEERLDVTEEEYMEMIYKKTAALIAA
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
ATKAGAIMGGGSPQEIAALEDYGRCIGLAFQIHDDYLDVVSDEESLGKPVGSDIAEGKMT
HHHHCEEECCCCHHHHHHHHHHHHHHHHHEEECHHHHHHHCCHHHHCCCCCCHHHHHHHH
LMVVKALERASEKDRERLISILGSGDEKLVAEAIEIFERYGATEYAHAVALDHVRMAKER
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LEVLEESDAREALAMIADFVLEREH
HHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMEVMDILRKYSEMADERIRESISDITPETLLRASEHLITAGGKKIRPSLALLSSEAVGG
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHCHHHHHHHHHCCCC
DPGDAAGVAAAIELIHTFSLIHDDIMDDDEIRRGEPAVHVLWGEPMAILAGDVLFSKAFE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHH
AVIRNGDSEMVKEALAVVVDSCVKICEGQALDMGFEERLDVTEEEYMEMIYKKTAALIAA
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
ATKAGAIMGGGSPQEIAALEDYGRCIGLAFQIHDDYLDVVSDEESLGKPVGSDIAEGKMT
HHHHCEEECCCCHHHHHHHHHHHHHHHHHEEECHHHHHHHCCHHHHCCCCCCHHHHHHHH
LMVVKALERASEKDRERLISILGSGDEKLVAEAIEIFERYGATEYAHAVALDHVRMAKER
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LEVLEESDAREALAMIADFVLEREH
HHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463