Click here to switch to the map view.

The map label for this gene is dnaH

Identifier: 15674176

GI number: 15674176

Start: 2278073

End: 2279731

Strand: Reverse

Name: dnaH

Synonym: L0279

Alternate gene names: 15674176

Gene position: 2279731-2278073 (Counterclockwise)

Preceding gene: 15674177

Following gene: 15674174

Centisome position: 96.37

GC content: 36.95

Gene sequence:

>1659_bases
ATGGCATATCAAGCATTATATAGAAAATATCGAAGTCAAAGATTTGATGAAATGGTGGGGCAAGAAGTTGTAGCAACAAC
ATTAAAAAATGCGATTGTCAATCATCAAATTTCACATGCTTATCTTTTTTCTGGTCCAAGAGGGACAGGGAAAACCTCAG
CAGCTAAAATTTTTGCTAAGGCAATAAATTGTCCTAATCAAGTGGATGGAGAGCCCTGCAATAATTGCTTTATTTGTGAC
TCAATCACCAAAGGAAGCTTAGATGATGTCATTGAACTTGATGCGGCATCAAATAATGGGGTTGACGAAATTCGAGAAAT
TCGAGATAAATCAACTTACGCAGCTAGTCAAGCCACTTACAAGGTTTATATTATTGATGAAGTGCATATGCTTTCAACAG
GGGCTTTTAATGCACTTTTGAAAACACTAGAAGAACCTACAGAAAATGTTGTTTTCGTCCTGGCTACTACTGAATTACAA
AAAATTCCAGCAACCATTATCTCGCGTGTTCAACGTTTTGCTTTTAAATCAATCACAACAGGAGATATTCGGACTTATTT
AGCAAAAATAATGGCTGATGAAGGACTTGAATTCGACGGTAAAGCACTCGATGTTATTGCTAAAGCAGCTGAAGGTGGAA
TGCGTGATGCCCTCTCTTTATTAGACCAAGCCTTATCGTTTTCATCAGGAAAATTAGAAGAAAATGATGCACTACTTGTC
ACAGGGTCGATTGCTGCAGATGCTTTAGTAACATATGTTGCAGCACTTTTTGAGCATGATGAAGCAAAAGCGATGACGGA
ACTTGATAAGATTTTTGCTGAAGGAAAAAATATGCTTCGATTTACGGAAGATTTATTAGCATACCTTCGGGATTTACTCT
TGGATAAAAATTCTCAGTATGACCGGGGTCAAATTTTTTCATGGATTGATGTTGCAATTGAAAGTTTGAAAACGATAAAG
GAAACGACTCAAACAAAAATTGCGGCAGACGTCATGACCATGCGTTTGGCTGAAATTGGACAAAATAATTTACTGACAGC
TTCGCAAGGAGAAATCCCTAATCAGCTGACAGCCGAAATTGCTACTTTAAAAACCGAAATTAATCAATTGAAAGCTCAAA
TTTCAGCTGGTCAAATTCAGGTAAATTCAGATTCACAAAATAATTTACTGACAGAAAATGTTAAAGCCAGTCCGAAACCA
ATAGCATCTAAAAAACGCCAAATTAACAAAGATTTAATTTATAAAGCTTTGGCTGAGGCGACAAATGAAGCTAGAAAAGC
TGCTCTAAGTGCGTGGCCAGAACTTGTTGCTTCGGTAACTAAACCGGCAGACCGAGCTTTACTTAATAATACAGCGCCTG
TCGCTGCGTCAGAAAATTTCCTTGTGGTGACTTTTCCTCATGAGAATCTTGCTAAAAGAGTCAGTGAAAATGAAGAATTG
CAACTTTTTTGTGGGAATCTCTTGAGTTCAATTGTTGGATTTGCGCCAGAAATTATCTCTCTTGCTGAACAAGACTGGCA
AGAAGTTCGAGCAGAATATGTTTCTAATTTAAAATCTGAAAATGTTCAAGAAGATGAAGAAGATGAAAAAGAGCCGGATG
AAACGGTAAACTTAGCTAAAGAACTCTTTGGTGAAAAAGTAGTTGAAATTAATGATTAA

Upstream 100 bases:

>100_bases
AACTGAAATTTTAAAAGACTTAAACTATAGTCTTGGGCGAGATTTCTATTGAAACAAGCGGATATGAAAAGAATACTAAG
TAAAAAATTGGAAGAGAAAA

Downstream 100 bases:

>100_bases
ACTAATAAAAAAGCCGCTCATTGAGCGACTTTTTTTAATCTTTATGACGACTTAAATCAACCTCTTTAAGGGGGATAAGT
TTCGTTTTGTTTTTAAATTT

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MAYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSGPRGTGKTSAAKIFAKAINCPNQVDGEPCNNCFICD
SITKGSLDDVIELDAASNNGVDEIREIRDKSTYAASQATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQ
KIPATIISRVQRFAFKSITTGDIRTYLAKIMADEGLEFDGKALDVIAKAAEGGMRDALSLLDQALSFSSGKLEENDALLV
TGSIAADALVTYVAALFEHDEAKAMTELDKIFAEGKNMLRFTEDLLAYLRDLLLDKNSQYDRGQIFSWIDVAIESLKTIK
ETTQTKIAADVMTMRLAEIGQNNLLTASQGEIPNQLTAEIATLKTEINQLKAQISAGQIQVNSDSQNNLLTENVKASPKP
IASKKRQINKDLIYKALAEATNEARKAALSAWPELVASVTKPADRALLNNTAPVAASENFLVVTFPHENLAKRVSENEEL
QLFCGNLLSSIVGFAPEIISLAEQDWQEVRAEYVSNLKSENVQEDEEDEKEPDETVNLAKELFGEKVVEIND

Sequences:

>Translated_552_residues
MAYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSGPRGTGKTSAAKIFAKAINCPNQVDGEPCNNCFICD
SITKGSLDDVIELDAASNNGVDEIREIRDKSTYAASQATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQ
KIPATIISRVQRFAFKSITTGDIRTYLAKIMADEGLEFDGKALDVIAKAAEGGMRDALSLLDQALSFSSGKLEENDALLV
TGSIAADALVTYVAALFEHDEAKAMTELDKIFAEGKNMLRFTEDLLAYLRDLLLDKNSQYDRGQIFSWIDVAIESLKTIK
ETTQTKIAADVMTMRLAEIGQNNLLTASQGEIPNQLTAEIATLKTEINQLKAQISAGQIQVNSDSQNNLLTENVKASPKP
IASKKRQINKDLIYKALAEATNEARKAALSAWPELVASVTKPADRALLNNTAPVAASENFLVVTFPHENLAKRVSENEEL
QLFCGNLLSSIVGFAPEIISLAEQDWQEVRAEYVSNLKSENVQEDEEDEKEPDETVNLAKELFGEKVVEIND
>Mature_551_residues
AYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSGPRGTGKTSAAKIFAKAINCPNQVDGEPCNNCFICDS
ITKGSLDDVIELDAASNNGVDEIREIRDKSTYAASQATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQK
IPATIISRVQRFAFKSITTGDIRTYLAKIMADEGLEFDGKALDVIAKAAEGGMRDALSLLDQALSFSSGKLEENDALLVT
GSIAADALVTYVAALFEHDEAKAMTELDKIFAEGKNMLRFTEDLLAYLRDLLLDKNSQYDRGQIFSWIDVAIESLKTIKE
TTQTKIAADVMTMRLAEIGQNNLLTASQGEIPNQLTAEIATLKTEINQLKAQISAGQIQVNSDSQNNLLTENVKASPKPI
ASKKRQINKDLIYKALAEATNEARKAALSAWPELVASVTKPADRALLNNTAPVAASENFLVVTFPHENLAKRVSENEELQ
LFCGNLLSSIVGFAPEIISLAEQDWQEVRAEYVSNLKSENVQEDEEDEKEPDETVNLAKELFGEKVVEIND

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=236, Percent_Identity=28.3898305084746, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI194306571, Length=236, Percent_Identity=28.3898305084746, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI194306567, Length=236, Percent_Identity=28.3898305084746, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4506491, Length=257, Percent_Identity=24.9027237354086, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI31881687, Length=257, Percent_Identity=24.9027237354086, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI31563534, Length=221, Percent_Identity=26.2443438914027, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194306569, Length=155, Percent_Identity=30.3225806451613, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1786676, Length=323, Percent_Identity=40.5572755417957, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1787119, Length=232, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=298, Percent_Identity=26.510067114094, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17554730, Length=221, Percent_Identity=27.6018099547511, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17541988, Length=217, Percent_Identity=27.6497695852535, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=290, Percent_Identity=26.551724137931, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322528, Length=236, Percent_Identity=25.4237288135593, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324478, Length=214, Percent_Identity=24.2990654205607, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921076, Length=239, Percent_Identity=29.7071129707113, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI18859927, Length=222, Percent_Identity=27.4774774774775, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17647857, Length=214, Percent_Identity=25.2336448598131, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 60766; Mature: 60635

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSGPRGTGKTSAAKIFAK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHH
AINCPNQVDGEPCNNCFICDSITKGSLDDVIELDAASNNGVDEIREIRDKSTYAASQATY
HHCCCCCCCCCCCCCEEEECCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCEE
KVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQKIPATIISRVQRFAFKSITT
EEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCC
GDIRTYLAKIMADEGLEFDGKALDVIAKAAEGGMRDALSLLDQALSFSSGKLEENDALLV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEE
TGSIAADALVTYVAALFEHDEAKAMTELDKIFAEGKNMLRFTEDLLAYLRDLLLDKNSQY
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCC
DRGQIFSWIDVAIESLKTIKETTQTKIAADVMTMRLAEIGQNNLLTASQGEIPNQLTAEI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHH
ATLKTEINQLKAQISAGQIQVNSDSQNNLLTENVKASPKPIASKKRQINKDLIYKALAEA
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TNEARKAALSAWPELVASVTKPADRALLNNTAPVAASENFLVVTFPHENLAKRVSENEEL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHCCCCCHH
QLFCGNLLSSIVGFAPEIISLAEQDWQEVRAEYVSNLKSENVQEDEEDEKEPDETVNLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHH
ELFGEKVVEIND
HHHCCCCEEECC
>Mature Secondary Structure 
AYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSGPRGTGKTSAAKIFAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHH
AINCPNQVDGEPCNNCFICDSITKGSLDDVIELDAASNNGVDEIREIRDKSTYAASQATY
HHCCCCCCCCCCCCCEEEECCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCEE
KVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQKIPATIISRVQRFAFKSITT
EEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCC
GDIRTYLAKIMADEGLEFDGKALDVIAKAAEGGMRDALSLLDQALSFSSGKLEENDALLV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEE
TGSIAADALVTYVAALFEHDEAKAMTELDKIFAEGKNMLRFTEDLLAYLRDLLLDKNSQY
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCC
DRGQIFSWIDVAIESLKTIKETTQTKIAADVMTMRLAEIGQNNLLTASQGEIPNQLTAEI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHH
ATLKTEINQLKAQISAGQIQVNSDSQNNLLTENVKASPKPIASKKRQINKDLIYKALAEA
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TNEARKAALSAWPELVASVTKPADRALLNNTAPVAASENFLVVTFPHENLAKRVSENEEL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHCCCCCHH
QLFCGNLLSSIVGFAPEIISLAEQDWQEVRAEYVSNLKSENVQEDEEDEKEPDETVNLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHH
ELFGEKVVEIND
HHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]