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The map label for this gene is kinE

Identifier: 15672986

GI number: 15672986

Start: 1031646

End: 1032971

Strand: Direct

Name: kinE

Synonym: L0128

Alternate gene names: 15672986

Gene position: 1031646-1032971 (Clockwise)

Preceding gene: 15672985

Following gene: 15672987

Centisome position: 43.61

GC content: 32.73

Gene sequence:

>1326_bases
ATGAAAGAAATAGAATCAAAAACAAGTGCCAAAATTATTACCGATACTTTTGTCCGTATTTTCTTAATTTTTAGTCTGTT
GATTACAATCATTGTTTCCGGAATTGTTGCATTTACAAGTTTACAAATCCGTAAGAGTGAGGGAGCGGCACTTTTAAATT
CCGTTCAAACGGCAGCAACTAATGGGCAAGTGAATTGGGATGAATTTAAACTTGATAGTGAAAAAGACGAAAAAGCTACA
TTTGTTCGACTGACAAGTCCTTCAGGTCAAAGAGAAGAGAGTCAAGGAACAACAAATTTTTTAAAATCACGAAAATCTTG
GGGAAATTTTAGTCTATTAAGAGATGATATCTTTTTATATAGTTCAAAAACTTCTAAAAATGGAACCAAAGCCGAATTAT
GGTTGAATATAAATGTTGTAGTTAAATCGATGATTAGAGCTATATTAGTTATTATTGCTGTCATGATTTTCCTCTTTTTC
CTTGCTTTGATTTTAATTCAAAAAGCAGCCAGAACGATTAGTCAGCCTTTGACAGATATTGTGGTGGCAACTGATGGAAA
GGATGTTAAACAAGTTCCTGTCAGTAAAAATCCTCTTGAAGTTCATCAGTTAAGTCAAAGTTTCAATCGTTTGCTCAATC
GACTGAATCAAAAAATTGAAAATGAGCAACAATTTGTCTCGGATGCTTCACATGAGCTAAGAACGCCAGTTGCTGCAATT
CGCGGACATGTGAATTTACTCAAAAGACGTTGGCATGAACATCCGGAAATTGTTGATGAGTCACTTTCTTATATTGATGA
AGAATCAATGAGAATGAAAGTTTTAATCGAAAATTTACTGACCATTTCTAGAGGAAATCATTTAGAAATAAAAAAAGAAA
GAATTAACTTAAGTAAATTTACTGACAAAGTGGTCAGTGAAATTCAACTCGCGCTAAGACAAAAAATAAACTTTGATATC
CAAACAGATTTATTTGTCAGCATGGATAAAATGGCGCTATACAAAATTATTATTATCTTTCTTGAAAATGCTGGAAAATA
TTCACCTTCCAACTCAGAAATTACAATAAATATTACTTTGGAAAATCATCAAGTTGATTTTCAGGTTGCTGACGAAGGTA
TTGGCGTTCCAGAAGAAGAAAAAGATAATATTTTTGAACGATTTTATCGAATTGATAAATCTCGTTCAAGTGAAATTCCT
GGAACAGGACTTGGTTTAGCAATTGCGAAGGAATATGCACAATTGAATGATGCCAAAGTCTTTGTTTCAAATAATTCTCC
GAAAGGGTCAACTTTTCATCTCCTAATGGAGTCTATAGAAAACTAA

Upstream 100 bases:

>100_bases
GATGATTATTTTAACCTTATTAGAATACCGTAAGTTAAAAGCACATATTTCAAAAGAGGGCTCATACTCTTCCTTAAAAA
ATAGTAAAGTAAATTAGCGA

Downstream 100 bases:

>100_bases
TTAATTATGAATAAAAAAATCTATTATATTTCGGGTGCTATTACCACCCTTGCCTTTTTAATTTTAGCGCTCTTTGTTAA
AATTGATTTTACTCATGGTC

Product: sensor protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKEIESKTSAKIITDTFVRIFLIFSLLITIIVSGIVAFTSLQIRKSEGAALLNSVQTAATNGQVNWDEFKLDSEKDEKAT
FVRLTSPSGQREESQGTTNFLKSRKSWGNFSLLRDDIFLYSSKTSKNGTKAELWLNINVVVKSMIRAILVIIAVMIFLFF
LALILIQKAARTISQPLTDIVVATDGKDVKQVPVSKNPLEVHQLSQSFNRLLNRLNQKIENEQQFVSDASHELRTPVAAI
RGHVNLLKRRWHEHPEIVDESLSYIDEESMRMKVLIENLLTISRGNHLEIKKERINLSKFTDKVVSEIQLALRQKINFDI
QTDLFVSMDKMALYKIIIIFLENAGKYSPSNSEITINITLENHQVDFQVADEGIGVPEEEKDNIFERFYRIDKSRSSEIP
GTGLGLAIAKEYAQLNDAKVFVSNNSPKGSTFHLLMESIEN

Sequences:

>Translated_441_residues
MKEIESKTSAKIITDTFVRIFLIFSLLITIIVSGIVAFTSLQIRKSEGAALLNSVQTAATNGQVNWDEFKLDSEKDEKAT
FVRLTSPSGQREESQGTTNFLKSRKSWGNFSLLRDDIFLYSSKTSKNGTKAELWLNINVVVKSMIRAILVIIAVMIFLFF
LALILIQKAARTISQPLTDIVVATDGKDVKQVPVSKNPLEVHQLSQSFNRLLNRLNQKIENEQQFVSDASHELRTPVAAI
RGHVNLLKRRWHEHPEIVDESLSYIDEESMRMKVLIENLLTISRGNHLEIKKERINLSKFTDKVVSEIQLALRQKINFDI
QTDLFVSMDKMALYKIIIIFLENAGKYSPSNSEITINITLENHQVDFQVADEGIGVPEEEKDNIFERFYRIDKSRSSEIP
GTGLGLAIAKEYAQLNDAKVFVSNNSPKGSTFHLLMESIEN
>Mature_441_residues
MKEIESKTSAKIITDTFVRIFLIFSLLITIIVSGIVAFTSLQIRKSEGAALLNSVQTAATNGQVNWDEFKLDSEKDEKAT
FVRLTSPSGQREESQGTTNFLKSRKSWGNFSLLRDDIFLYSSKTSKNGTKAELWLNINVVVKSMIRAILVIIAVMIFLFF
LALILIQKAARTISQPLTDIVVATDGKDVKQVPVSKNPLEVHQLSQSFNRLLNRLNQKIENEQQFVSDASHELRTPVAAI
RGHVNLLKRRWHEHPEIVDESLSYIDEESMRMKVLIENLLTISRGNHLEIKKERINLSKFTDKVVSEIQLALRQKINFDI
QTDLFVSMDKMALYKIIIIFLENAGKYSPSNSEITINITLENHQVDFQVADEGIGVPEEEKDNIFERFYRIDKSRSSEIP
GTGLGLAIAKEYAQLNDAKVFVSNNSPKGSTFHLLMESIEN

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=269, Percent_Identity=26.7657992565056, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790551, Length=296, Percent_Identity=26.3513513513513, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788279, Length=306, Percent_Identity=28.7581699346405, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786783, Length=300, Percent_Identity=26.6666666666667, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790861, Length=242, Percent_Identity=30.1652892561983, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=244, Percent_Identity=27.0491803278689, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790346, Length=250, Percent_Identity=29.2, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082128, Length=299, Percent_Identity=25.4180602006689, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786912, Length=210, Percent_Identity=27.1428571428571, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=25.4166666666667, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789403, Length=297, Percent_Identity=26.5993265993266, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789808, Length=290, Percent_Identity=25.8620689655172, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1787894, Length=242, Percent_Identity=25.6198347107438, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=24.896265560166, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=251, Percent_Identity=24.3027888446215, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=221, Percent_Identity=27.6018099547511, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=24.3119266055046, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49979; Mature: 49979

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIESKTSAKIITDTFVRIFLIFSLLITIIVSGIVAFTSLQIRKSEGAALLNSVQTAAT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHC
NGQVNWDEFKLDSEKDEKATFVRLTSPSGQREESQGTTNFLKSRKSWGNFSLLRDDIFLY
CCCCCHHHEECCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHEEEE
SSKTSKNGTKAELWLNINVVVKSMIRAILVIIAVMIFLFFLALILIQKAARTISQPLTDI
ECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHE
VVATDGKDVKQVPVSKNPLEVHQLSQSFNRLLNRLNQKIENEQQFVSDASHELRTPVAAI
EEECCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
RGHVNLLKRRWHEHPEIVDESLSYIDEESMRMKVLIENLLTISRGNHLEIKKERINLSKF
HHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEHHHCCHHHH
TDKVVSEIQLALRQKINFDIQTDLFVSMDKMALYKIIIIFLENAGKYSPSNSEITINITL
HHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEE
ENHQVDFQVADEGIGVPEEEKDNIFERFYRIDKSRSSEIPGTGLGLAIAKEYAQLNDAKV
ECCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
FVSNNSPKGSTFHLLMESIEN
EEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKEIESKTSAKIITDTFVRIFLIFSLLITIIVSGIVAFTSLQIRKSEGAALLNSVQTAAT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHC
NGQVNWDEFKLDSEKDEKATFVRLTSPSGQREESQGTTNFLKSRKSWGNFSLLRDDIFLY
CCCCCHHHEECCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHEEEE
SSKTSKNGTKAELWLNINVVVKSMIRAILVIIAVMIFLFFLALILIQKAARTISQPLTDI
ECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHE
VVATDGKDVKQVPVSKNPLEVHQLSQSFNRLLNRLNQKIENEQQFVSDASHELRTPVAAI
EEECCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
RGHVNLLKRRWHEHPEIVDESLSYIDEESMRMKVLIENLLTISRGNHLEIKKERINLSKF
HHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEHHHCCHHHH
TDKVVSEIQLALRQKINFDIQTDLFVSMDKMALYKIIIIFLENAGKYSPSNSEITINITL
HHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEE
ENHQVDFQVADEGIGVPEEEKDNIFERFYRIDKSRSSEIPGTGLGLAIAKEYAQLNDAKV
ECCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
FVSNNSPKGSTFHLLMESIEN
EEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA