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The map label for this gene is argH

Identifier: 15672107

GI number: 15672107

Start: 127981

End: 129360

Strand: Direct

Name: argH

Synonym: L0114

Alternate gene names: 15672107

Gene position: 127981-129360 (Clockwise)

Preceding gene: 30023975

Following gene: 15672109

Centisome position: 5.41

GC content: 34.71

Gene sequence:

>1380_bases
ATGGTAGAAAAACTTTGGGGAGGACGTTTTGAGGCGTCACTAGATAAACAAACGGAAGAATTTGGAGCATCAATTAAATT
TGAGCAACGACTTGCTCCTTTTGATTTAAAAGGCTCATTAGCTCATGTAAAGATGTTGGGTGAAACAGGAATTATTACTA
CCGAGGAATCCAAAAAAATTGCCGAAGGTCTGAAAAAAGTAGAAGAAAAGCTTCTTAATGGCCAAATTGAATTCAAGATG
GAAAATGAAGATATCCATATGAATATGGAATCTTATCTTCATCAAGAAATTGGTCCACTAGCTGGTAAATTGCATACGGC
TCGCTCTAGAAATGATCAAGTGGTAACAGATATGCATCTATACCTCAAAAGTATCTTAGAAGCCGTTTTAGAAGCTTTAA
AAGTGTTAAGAGAAACAATTGTAAAGCTCGCTGTAAACCAAATTGACACTATTATGCCTGGTTATACTCATTTGCAACAT
GCACAACCAATTTCCTTTGGTCAACATCTAATGGCTTACTATCAAATGCTGACACGTGATTTTGAACGTTTTGAATTTAA
TGTTAAGCATACAGATATGAATCCTTTAGGAGCGGCAGCTCTAGCTGGGACGACGTTTCCGATTGATAGAATGTTGACGA
CGAAACTACTTGGTTTTGAGAAGGCTTATGATAATTCAATGGATGCGGTCAGTGACCGTGACTTTATTTTAGAATTTCTC
TCAAATGCAAGTTTGTTAATGATGCACTTATCAAGATTTTGTGAGGAGCTTTTACTATGGTCTAGTCATGAATTCAAATT
TGTCAGTCTGTCTGATACATATTCTACGGGTTCTTCTATTATGCCACAGAAGAAGAATCCAGATATGGCAGAATTAATCA
GAGGAAAAACAGGCCGCGTTTATGGAAATCTTACAGCTTTATTGACTGTGATGAAAGGTTTACCTTTAGCTTATAACAAA
GATTTTCAAGAAGATAAAGAAGGAATGTTTGATAGTGCTGATACTATAATAACTTCTTTAACAGTTATGAATGGGATGTT
GTCAACTTTAACTGTAAACCGTGTAAACATGGAAAAATCAACTGAACAAGATTTTTCTAATGCAACAGAGTTGGCTGATT
ACCTTGCAACAAAGGGTCTTCCTTTTAGAAAAGCTCATGAATTAGTGGGTCTCTTAGTGTTAGATTGTATAAAAAAAGGA
ATTTACCTCCAAGATGTAAATTTACAAGATTATCAAATGCTATCTCCATTAATCAATGAAGATGTTTATGAAGTTTTAAA
ATCAAGAACGGCAGTTTCAAGAAGAAATTCTCTAGGTGGTACAGGATTTGAATCGGTTAAAAAACAAATAGAAGAAGCTA
AAAAAGAACTTCAAATTTGA

Upstream 100 bases:

>100_bases
AGCGGCAGTTGGATTTATTAAATTGTGGGGTCTACCTACTCAAGTCAATGCTCAAGTAAATCTCAAATAATAGCTATAGG
AAAATTTGGAAAGTAAGAGA

Downstream 100 bases:

>100_bases
AGTTCTTTTTTATAATTAGTTTTTTACAGCAAGTGATTTAGTATGTGTAAAGTAGTTTATTAAATTAAAGACAACCAGAA
TTGCTGAACCCACAAAGACA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITTEESKKIAEGLKKVEEKLLNGQIEFKM
ENEDIHMNMESYLHQEIGPLAGKLHTARSRNDQVVTDMHLYLKSILEAVLEALKVLRETIVKLAVNQIDTIMPGYTHLQH
AQPISFGQHLMAYYQMLTRDFERFEFNVKHTDMNPLGAAALAGTTFPIDRMLTTKLLGFEKAYDNSMDAVSDRDFILEFL
SNASLLMMHLSRFCEELLLWSSHEFKFVSLSDTYSTGSSIMPQKKNPDMAELIRGKTGRVYGNLTALLTVMKGLPLAYNK
DFQEDKEGMFDSADTIITSLTVMNGMLSTLTVNRVNMEKSTEQDFSNATELADYLATKGLPFRKAHELVGLLVLDCIKKG
IYLQDVNLQDYQMLSPLINEDVYEVLKSRTAVSRRNSLGGTGFESVKKQIEEAKKELQI

Sequences:

>Translated_459_residues
MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITTEESKKIAEGLKKVEEKLLNGQIEFKM
ENEDIHMNMESYLHQEIGPLAGKLHTARSRNDQVVTDMHLYLKSILEAVLEALKVLRETIVKLAVNQIDTIMPGYTHLQH
AQPISFGQHLMAYYQMLTRDFERFEFNVKHTDMNPLGAAALAGTTFPIDRMLTTKLLGFEKAYDNSMDAVSDRDFILEFL
SNASLLMMHLSRFCEELLLWSSHEFKFVSLSDTYSTGSSIMPQKKNPDMAELIRGKTGRVYGNLTALLTVMKGLPLAYNK
DFQEDKEGMFDSADTIITSLTVMNGMLSTLTVNRVNMEKSTEQDFSNATELADYLATKGLPFRKAHELVGLLVLDCIKKG
IYLQDVNLQDYQMLSPLINEDVYEVLKSRTAVSRRNSLGGTGFESVKKQIEEAKKELQI
>Mature_459_residues
MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITTEESKKIAEGLKKVEEKLLNGQIEFKM
ENEDIHMNMESYLHQEIGPLAGKLHTARSRNDQVVTDMHLYLKSILEAVLEALKVLRETIVKLAVNQIDTIMPGYTHLQH
AQPISFGQHLMAYYQMLTRDFERFEFNVKHTDMNPLGAAALAGTTFPIDRMLTTKLLGFEKAYDNSMDAVSDRDFILEFL
SNASLLMMHLSRFCEELLLWSSHEFKFVSLSDTYSTGSSIMPQKKNPDMAELIRGKTGRVYGNLTALLTVMKGLPLAYNK
DFQEDKEGMFDSADTIITSLTVMNGMLSTLTVNRVNMEKSTEQDFSNATELADYLATKGLPFRKAHELVGLLVLDCIKKG
IYLQDVNLQDYQMLSPLINEDVYEVLKSRTAVSRRNSLGGTGFESVKKQIEEAKKELQI

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=455, Percent_Identity=45.7142857142857, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI68303542, Length=455, Percent_Identity=45.7142857142857, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI68303549, Length=455, Percent_Identity=43.5164835164835, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI68303547, Length=455, Percent_Identity=43.2967032967033, Blast_Score=354, Evalue=9e-98,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=45.5947136563877, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1787896, Length=345, Percent_Identity=24.6376811594203, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=42.2657952069717, Blast_Score=369, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=38.716814159292, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=38.716814159292, Blast_Score=333, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_LACLA (Q9CJ76)

Other databases:

- EMBL:   AE005176
- PIR:   E86640
- RefSeq:   NP_266281.1
- ProteinModelPortal:   Q9CJ76
- SMR:   Q9CJ76
- GeneID:   1113731
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0114
- NMPDR:   fig|272623.1.peg.132
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- BioCyc:   LLAC272623:L0114-MONOMER
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51901; Mature: 51901

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITTEESKKI
CCCCCCCCCCCCHHHHHHHHHCCCCEEHHCCCCCCCCCCHHHHEEECCCCCEECCHHHHH
AEGLKKVEEKLLNGQIEFKMENEDIHMNMESYLHQEIGPLAGKLHTARSRNDQVVTDMHL
HHHHHHHHHHHHCCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YLKSILEAVLEALKVLRETIVKLAVNQIDTIMPGYTHLQHAQPISFGQHLMAYYQMLTRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
FERFEFNVKHTDMNPLGAAALAGTTFPIDRMLTTKLLGFEKAYDNSMDAVSDRDFILEFL
HHHHEEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
SNASLLMMHLSRFCEELLLWSSHEFKFVSLSDTYSTGSSIMPQKKNPDMAELIRGKTGRV
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCH
YGNLTALLTVMKGLPLAYNKDFQEDKEGMFDSADTIITSLTVMNGMLSTLTVNRVNMEKS
HHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
TEQDFSNATELADYLATKGLPFRKAHELVGLLVLDCIKKGIYLQDVNLQDYQMLSPLINE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHH
DVYEVLKSRTAVSRRNSLGGTGFESVKKQIEEAKKELQI
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITTEESKKI
CCCCCCCCCCCCHHHHHHHHHCCCCEEHHCCCCCCCCCCHHHHEEECCCCCEECCHHHHH
AEGLKKVEEKLLNGQIEFKMENEDIHMNMESYLHQEIGPLAGKLHTARSRNDQVVTDMHL
HHHHHHHHHHHHCCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YLKSILEAVLEALKVLRETIVKLAVNQIDTIMPGYTHLQHAQPISFGQHLMAYYQMLTRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
FERFEFNVKHTDMNPLGAAALAGTTFPIDRMLTTKLLGFEKAYDNSMDAVSDRDFILEFL
HHHHEEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
SNASLLMMHLSRFCEELLLWSSHEFKFVSLSDTYSTGSSIMPQKKNPDMAELIRGKTGRV
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCH
YGNLTALLTVMKGLPLAYNKDFQEDKEGMFDSADTIITSLTVMNGMLSTLTVNRVNMEKS
HHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
TEQDFSNATELADYLATKGLPFRKAHELVGLLVLDCIKKGIYLQDVNLQDYQMLSPLINE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHH
DVYEVLKSRTAVSRRNSLGGTGFESVKKQIEEAKKELQI
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471