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The map label for this gene is ilvC [H]

Identifier: 15669738

GI number: 15669738

Start: 1521358

End: 1522404

Strand: Direct

Name: ilvC [H]

Synonym: MJ1543

Alternate gene names: 15669738

Gene position: 1521358-1522404 (Clockwise)

Preceding gene: 15669735

Following gene: 15669740

Centisome position: 91.37

GC content: 36.2

Gene sequence:

>1047_bases
ATGGCTAATAAAGGTAGCGAGTATTTAATAAAAAGAGTCTTTATGGTGATAGAAATGGTTAAAATATTCTACGATAAGGA
TGTAACCTTTGACGCAGTTAAAGACAAAACAATAGCAGTTATTGGTTATGGAAGTCAAGGAAGAGCTCAAGCTTTAAATA
TGAAGGATAGTGGTTTAAATGTTATAGTTGGTTTGAGACCAAATGGAGCATCATGGAACAAGGCAATTAAAGATGGACAC
AAAGTTATGACAATTGAGGAAGCAGCAGAGAAAGCAGATATCATCCACATATTAATCCCAGATGAAGTCCAGCCAGCAGT
TTATAAAAAGCAGATTGAGCCTTACTTAACAGAAGGAAAAACAATAAGCTTCTCACATGGATACAACATCCACTATGGAT
TTATAAGACCTCCAGAGAATGTTAATATAACAATGGTAGCTCCAAAATCACCAGGGGCAATGGTTAGAAAAACATATGAA
GAAGGATTTGGAGTTCCAGGATTGGTTGCTGTTGAGAGAGATTATACAGGAGATGCTTTACAAATTGCTTTGGGAATGGC
TAAAGGTATTGGATTAACAAAAGTTGGAGTAATACAAACAACTTTTAGAGAAGAAACAGAAACAGATTTATTTGGAGAGC
AAGTAGTTTTGTGTGGAGGAGTTACCGAGTTAATTAAAGCTGCGTTTGAAACATTAGTTGAAGCTGGTTACGCTCCAGAG
ATGGCATACTTTGAAACATGCCATGAGTTAAAGCTAATAGTTGATTTAATCTATCAAAAGGGATTACAGGGAATGTGGGA
GAACGTCTCAAACACTGCTGAATATGGAGGTTTAACAAGAAGGGCAAGAGTTATAAATGAGGAGTCAAGAAAGGCAATGA
AAGAGATTTTAAAAGAGATACAAGATGGAAGATTTGCAAAAGAATGGAGCTTAGAAAGAGAAGCTGGCTTCCCACACTTG
AATGCTTTAAGAAGATTAGAGAAAGAGCATTTAATTGAGAAGGTTGGAAAAGAGTTAAGAAAGATGTGTGGCTTGGAGAA
GGAATAA

Upstream 100 bases:

>100_bases
TTGTGTTCTAATGGTATTTAAATTCTATGTTATTATTATATGGTTTTTATAGTATCGATTTCTGAATATCAAATTAAACC
GAAAACCTTAAAATAGTATT

Downstream 100 bases:

>100_bases
TTTTTAATCTCTTTTTTATTTTATTAATTTAAAAATGTCTTTTACATTATTAAAATATCAATAGGTTAAACTCCACTTCC
AGAATGGAACAATCTCTATC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MANKGSEYLIKRVFMVIEMVKIFYDKDVTFDAVKDKTIAVIGYGSQGRAQALNMKDSGLNVIVGLRPNGASWNKAIKDGH
KVMTIEEAAEKADIIHILIPDEVQPAVYKKQIEPYLTEGKTISFSHGYNIHYGFIRPPENVNITMVAPKSPGAMVRKTYE
EGFGVPGLVAVERDYTGDALQIALGMAKGIGLTKVGVIQTTFREETETDLFGEQVVLCGGVTELIKAAFETLVEAGYAPE
MAYFETCHELKLIVDLIYQKGLQGMWENVSNTAEYGGLTRRARVINEESRKAMKEILKEIQDGRFAKEWSLEREAGFPHL
NALRRLEKEHLIEKVGKELRKMCGLEKE

Sequences:

>Translated_348_residues
MANKGSEYLIKRVFMVIEMVKIFYDKDVTFDAVKDKTIAVIGYGSQGRAQALNMKDSGLNVIVGLRPNGASWNKAIKDGH
KVMTIEEAAEKADIIHILIPDEVQPAVYKKQIEPYLTEGKTISFSHGYNIHYGFIRPPENVNITMVAPKSPGAMVRKTYE
EGFGVPGLVAVERDYTGDALQIALGMAKGIGLTKVGVIQTTFREETETDLFGEQVVLCGGVTELIKAAFETLVEAGYAPE
MAYFETCHELKLIVDLIYQKGLQGMWENVSNTAEYGGLTRRARVINEESRKAMKEILKEIQDGRFAKEWSLEREAGFPHL
NALRRLEKEHLIEKVGKELRKMCGLEKE
>Mature_347_residues
ANKGSEYLIKRVFMVIEMVKIFYDKDVTFDAVKDKTIAVIGYGSQGRAQALNMKDSGLNVIVGLRPNGASWNKAIKDGHK
VMTIEEAAEKADIIHILIPDEVQPAVYKKQIEPYLTEGKTISFSHGYNIHYGFIRPPENVNITMVAPKSPGAMVRKTYEE
GFGVPGLVAVERDYTGDALQIALGMAKGIGLTKVGVIQTTFREETETDLFGEQVVLCGGVTELIKAAFETLVEAGYAPEM
AYFETCHELKLIVDLIYQKGLQGMWENVSNTAEYGGLTRRARVINEESRKAMKEILKEIQDGRFAKEWSLEREAGFPHLN
ALRRLEKEHLIEKVGKELRKMCGLEKE

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=287, Percent_Identity=34.4947735191638, Blast_Score=155, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=334, Percent_Identity=35.3293413173653, Blast_Score=166, Evalue=6e-42,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 38939; Mature: 38807

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKGSEYLIKRVFMVIEMVKIFYDKDVTFDAVKDKTIAVIGYGSQGRAQALNMKDSGLN
CCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEECCCCCCEEECCCCCCCE
VIVGLRPNGASWNKAIKDGHKVMTIEEAAEKADIIHILIPDEVQPAVYKKQIEPYLTEGK
EEEEECCCCCCHHHHHHCCCEEEEHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHCCCC
TISFSHGYNIHYGFIRPPENVNITMVAPKSPGAMVRKTYEEGFGVPGLVAVERDYTGDAL
EEEEECCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHH
QIALGMAKGIGLTKVGVIQTTFREETETDLFGEQVVLCGGVTELIKAAFETLVEAGYAPE
HHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCC
MAYFETCHELKLIVDLIYQKGLQGMWENVSNTAEYGGLTRRARVINEESRKAMKEILKEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
QDGRFAKEWSLEREAGFPHLNALRRLEKEHLIEKVGKELRKMCGLEKE
HCCCCCHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ANKGSEYLIKRVFMVIEMVKIFYDKDVTFDAVKDKTIAVIGYGSQGRAQALNMKDSGLN
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEECCCCCCEEECCCCCCCE
VIVGLRPNGASWNKAIKDGHKVMTIEEAAEKADIIHILIPDEVQPAVYKKQIEPYLTEGK
EEEEECCCCCCHHHHHHCCCEEEEHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHCCCC
TISFSHGYNIHYGFIRPPENVNITMVAPKSPGAMVRKTYEEGFGVPGLVAVERDYTGDAL
EEEEECCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHH
QIALGMAKGIGLTKVGVIQTTFREETETDLFGEQVVLCGGVTELIKAAFETLVEAGYAPE
HHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCC
MAYFETCHELKLIVDLIYQKGLQGMWENVSNTAEYGGLTRRARVINEESRKAMKEILKEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
QDGRFAKEWSLEREAGFPHLNALRRLEKEHLIEKVGKELRKMCGLEKE
HCCCCCHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]