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The map label for this gene is mer

Identifier: 15669729

GI number: 15669729

Start: 1511806

End: 1512801

Strand: Direct

Name: mer

Synonym: MJ1534

Alternate gene names: 15669729

Gene position: 1511806-1512801 (Clockwise)

Preceding gene: 15669727

Following gene: 15669730

Centisome position: 90.8

GC content: 39.46

Gene sequence:

>996_bases
GTGAAATTTGGTATCGAATTTGTTCCAAACGAGCCAATACAAAAGCTCTGTTACTATGTTAAGTTAGCTGAAGACAACGG
ATTTGAATACTGTTGGATTACAGACCACTACAACAACAGAAATGTCTATATGGCTTTAACAGCTATCGCAATGAACACAA
ACAAAATTAAGTTAGGACCAGGAGTTACAAACCCATACGTTAGAAGCCCAGCAATAACAGCTTCAGCTATTGCAACATTG
GACGAGTTATCAGGAGGAAGAGCTGTTTTAGGTATCGGTCCAGGAGATAAGGCTACTTTTGATGCATTAGGAATTGAGTG
GGTTAAGCCAGTTACAACATTAAAAGAATCAATTGAAGTTATAAGAAAGTTGTTAGCTGGAGAGAGAGTTTCTTATGAAG
GAAAGGTTGTCAAGATTGCAGGAGCTGCTTTAGCAGTTAAACCAATCCAAAAGGCAGTTCCTGTTTATATGGGAGCTCAA
GGACCAAAGATGTTAGAAACAGCTGGTATGATTGCTGATGGAGTTTTAATTAATGCATCAAACCCAAAAGACTTCGAAGC
AGCAATCCCATTAATTAAGAAAGGTGCCGAAGCTGCTGGAAGAAGCATGGACGAGATTGATGTCGCTGCCTACGCATGTA
TGTCAGTTGATAAGAATGCAGATAAAGCTAAGCAGGCAGCAGTTCCAGTTGTTGCATTCATCGCAGCAGGTTCTCCACCA
GTTGTCTTAGAGAGACATGGAATTGACATGGAGAAAGTTGAGGCAATAAGAAACGCTTTAAAATCAGGAAACTTCCCAGA
AGCATTCAAGAATGTTGATGACACAATGTTAGAGGCATTCTCAATCTACGGAACACCAGAAGATGTTGTTGAGAAGTGTA
AAAAATTAGCTGAGATGGGAGTTACTCAAATCGTTGCTGGTTCCCCAATTGGACCAAACAAAGAAACAGCAATTAAATTA
ATTGGTAAGAAGGTTATTCCAGCATTAAAAGAGTAA

Upstream 100 bases:

>100_bases
TATAAATATTTTTCGATTTGCGGTAAATAGAAAACTTAATTACTACCATAAATTGATAATATAATAATTGTTGTTAAATA
ACAAAATTGAGGGTGAGATT

Downstream 100 bases:

>100_bases
ATTAACTTAACTTTTCTTTTTTTATTTTAATTTTTTATATTTTTTGTTTTATTTGGTGATAGTATGAAAAGGCTGTTCTT
TATTTTTGTTATGCTTATTG

Product: methylenetetrahydromethanopterin reductase

Products: NA

Alternate protein names: Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase; Methylene-H(4)MPT reductase

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKFGIEFVPNEPIQKLCYYVKLAEDNGFEYCWITDHYNNRNVYMALTAIAMNTNKIKLGPGVTNPYVRSPAITASAIATL
DELSGGRAVLGIGPGDKATFDALGIEWVKPVTTLKESIEVIRKLLAGERVSYEGKVVKIAGAALAVKPIQKAVPVYMGAQ
GPKMLETAGMIADGVLINASNPKDFEAAIPLIKKGAEAAGRSMDEIDVAAYACMSVDKNADKAKQAAVPVVAFIAAGSPP
VVLERHGIDMEKVEAIRNALKSGNFPEAFKNVDDTMLEAFSIYGTPEDVVEKCKKLAEMGVTQIVAGSPIGPNKETAIKL
IGKKVIPALKE

Sequences:

>Translated_331_residues
MKFGIEFVPNEPIQKLCYYVKLAEDNGFEYCWITDHYNNRNVYMALTAIAMNTNKIKLGPGVTNPYVRSPAITASAIATL
DELSGGRAVLGIGPGDKATFDALGIEWVKPVTTLKESIEVIRKLLAGERVSYEGKVVKIAGAALAVKPIQKAVPVYMGAQ
GPKMLETAGMIADGVLINASNPKDFEAAIPLIKKGAEAAGRSMDEIDVAAYACMSVDKNADKAKQAAVPVVAFIAAGSPP
VVLERHGIDMEKVEAIRNALKSGNFPEAFKNVDDTMLEAFSIYGTPEDVVEKCKKLAEMGVTQIVAGSPIGPNKETAIKL
IGKKVIPALKE
>Mature_331_residues
MKFGIEFVPNEPIQKLCYYVKLAEDNGFEYCWITDHYNNRNVYMALTAIAMNTNKIKLGPGVTNPYVRSPAITASAIATL
DELSGGRAVLGIGPGDKATFDALGIEWVKPVTTLKESIEVIRKLLAGERVSYEGKVVKIAGAALAVKPIQKAVPVYMGAQ
GPKMLETAGMIADGVLINASNPKDFEAAIPLIKKGAEAAGRSMDEIDVAAYACMSVDKNADKAKQAAVPVVAFIAAGSPP
VVLERHGIDMEKVEAIRNALKSGNFPEAFKNVDDTMLEAFSIYGTPEDVVEKCKKLAEMGVTQIVAGSPIGPNKETAIKL
IGKKVIPALKE

Specific function: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mer family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MER_METJA (Q58929)

Other databases:

- EMBL:   L77117
- RefSeq:   NP_248542.1
- ProteinModelPortal:   Q58929
- SMR:   Q58929
- GeneID:   1452442
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1534
- NMPDR:   fig|243232.1.peg.1579
- TIGR:   MJ1534
- HOGENOM:   HBG497169
- OMA:   MGVTQIV
- ProtClustDB:   PRK02271
- BioCyc:   MJAN243232:MJ_1534-MONOMER
- BRENDA:   1.5.99.11
- GO:   GO:0005737
- GO:   GO:0015948
- HAMAP:   MF_01091
- InterPro:   IPR011251
- InterPro:   IPR016048
- InterPro:   IPR019946
- Gene3D:   G3DSA:3.20.20.30
- TIGRFAMs:   TIGR03555

Pfam domain/function: PF00296 Bac_luciferase; SSF51679 Luciferase_like

EC number: =1.5.99.11

Molecular weight: Translated: 35354; Mature: 35354

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGIEFVPNEPIQKLCYYVKLAEDNGFEYCWITDHYNNRNVYMALTAIAMNTNKIKLGP
CCCCCCCCCCCHHHHHHEEEEEECCCCEEEEEEECCCCCCEEEEEEEEEEECCCEEEECC
GVTNPYVRSPAITASAIATLDELSGGRAVLGIGPGDKATFDALGIEWVKPVTTLKESIEV
CCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHH
IRKLLAGERVSYEGKVVKIAGAALAVKPIQKAVPVYMGAQGPKMLETAGMIADGVLINAS
HHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCEEEECC
NPKDFEAAIPLIKKGAEAAGRSMDEIDVAAYACMSVDKNADKAKQAAVPVVAFIAAGSPP
CCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCC
VVLERHGIDMEKVEAIRNALKSGNFPEAFKNVDDTMLEAFSIYGTPEDVVEKCKKLAEMG
EEEEECCCCHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
VTQIVAGSPIGPNKETAIKLIGKKVIPALKE
HHHEEECCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFGIEFVPNEPIQKLCYYVKLAEDNGFEYCWITDHYNNRNVYMALTAIAMNTNKIKLGP
CCCCCCCCCCCHHHHHHEEEEEECCCCEEEEEEECCCCCCEEEEEEEEEEECCCEEEECC
GVTNPYVRSPAITASAIATLDELSGGRAVLGIGPGDKATFDALGIEWVKPVTTLKESIEV
CCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHH
IRKLLAGERVSYEGKVVKIAGAALAVKPIQKAVPVYMGAQGPKMLETAGMIADGVLINAS
HHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCEEEECC
NPKDFEAAIPLIKKGAEAAGRSMDEIDVAAYACMSVDKNADKAKQAAVPVVAFIAAGSPP
CCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCC
VVLERHGIDMEKVEAIRNALKSGNFPEAFKNVDDTMLEAFSIYGTPEDVVEKCKKLAEMG
EEEEECCCCHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
VTQIVAGSPIGPNKETAIKLIGKKVIPALKE
HHHEEECCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087