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The map label for this gene is fwdA

Identifier: 15669358

GI number: 15669358

Start: 1108536

End: 1110239

Strand: Direct

Name: fwdA

Synonym: MJ1169

Alternate gene names: 15669358

Gene position: 1108536-1110239 (Clockwise)

Preceding gene: 15669357

Following gene: 15669359

Centisome position: 66.58

GC content: 38.5

Gene sequence:

>1704_bases
ATGGAATATATCATAAAAAATGGAATTGTTTATGACCCATTAAATGGGATTAATGGAGAAAAAATGGATATATGTGTTAA
AGATGGAAAGATAGTTGAGAGCGTCTCTGATAATGCAAAAGTTATTGATGCATCTGGATGCGTAGTAATGCCTGGTGGAA
TCGATTCACACAGCCACGTTGCAGGGGCAAAGGTTAACGTCGGAAGAATATTCAGACCAGAAGATAGTAAAAGAGAAATC
TATGCTAAAAAAGGATTAAGAACTGGAACAGGATTTTCAGTTCCATCAACCTATAAAACAGGTTATCAATATTCAGAAAT
GGGTTATACAACTGTCATTGAGGCAGCAATGCCCCCATTGATTGCAAGACACACACATGAGGAATTTATGGAGACTCCAC
AAATAGACAAGGCAGCAATGCCATTGTTTGGAAACAACTGGATGGTCTTAGAGTATTTAAAAGAAGGAGACATTAAGGCA
TGTGCTGCTTTTGTTGCATGGCTGTTAAAGGCTGTTAAAGGATTTGCTATAAAGATAGTTAATCCAGGAGGAACAGAAGC
TTGGGGTTGGGGTAAAAACGTTCATAGCTTAGATGACCCAGTTCCATACTTTGATATAACACCAAGAGAGATTGTTAGAG
GTTTAGCAGAGGTTAATGAGTTACTTGGTTTGCCTCACTCAATCCACGTCCATCCAAACAACTTAGGACATCCAGGAAAC
TGGGAGACAACATTAGAGACAATGAAGTGTGTTGAAGGCGTTGAGGCAAAACCAAGAGTTGGAGAGAGGGAAACATCATA
CTACAACACACATTGCCAATTTCACTCCTATGGAGGGACTTCATGGAAGGACTTTGAAAGTAAGGCAATAGAGATAGCTG
AATATGTAAATAAATCAAAACACGTTGTTATTGATGTTGGACAAGTTACCTTAGATGAAACAACAACAATGACTGCAGAT
GGACCAATGGAGTATGATTTACACATGACTAATGGATTGAAGTGGGCAAACTGTGATGTTGAGCTTGAGACAGGTTCTGG
AGTAGTTCCTTTCATTTACAGCCCAAAAGGTCCAGTTTATGCTGTCCAATGGGCAATTGGTTTAGAACTCTTCCTAAATA
CAAACACAGATAAGGTATTATTAACAACCGACCATCCAAACGCAGGGCCTTTCACAAGATATCCAAGAGTTATTGCATGG
TTAATGAGTAAGAAGTATAGGGATGAATGGTTATACAACAAAGTTCATAAGTGGGCACAGCAAAGAAGCCATGTAGCGGA
TGCTGATAAAGAATACGACTTATATGAAATAGCAAAAATAACAAGAGCTAACCAAGCTAAGGTTTTAGGATTGAGTGAGA
CAAAAGGACACTTAGGAGTTGGAGCTGAGGCTGACATAGCAATATATGCAATAGACCCAGAAGAGAAAGATGGTAAGAAG
ATTGAAAAGGCATTTAGATATGCTAAGTATGTATTGAAGGGAGGAGAAGTAGTTGTTAAGGATGGAAACGTTGTTAAAGA
AGTCTTTGGAGACACAATCTATGTAGATGTGCAGGTGGGAGAGGACTTAATGAATGAAGTCCTTAAAGATGTTGGGGAGA
AGTTTAGAAGATACTACTCAGTTAACTTAGAGAACTACCCAGTTTCAGATGAATATGCAAACAGCTGGAGAGTTATAAAG
ATAGATGCAACTGATATAAACTAA

Upstream 100 bases:

>100_bases
TTGAGAAGACAGACGAAGAATTTTTAGATATGAGGTCTTTAATGAGAAAAAAATACATTGAAGCTGTTGAATAAACCAAA
TATTAATAAATGGTGATAAG

Downstream 100 bases:

>100_bases
ATATCCTTTTCTTTCTAAAATTTAATTTTTAAGTGATTTTGATGATAACTTCCACAACTGACAACTTAGAAGGTTTTAAA
ATTGTAAAATATTTGGGTGT

Product: formylmethanofuran dehydrogenase subunit FwdA

Products: CO2; methanofuran; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MEYIIKNGIVYDPLNGINGEKMDICVKDGKIVESVSDNAKVIDASGCVVMPGGIDSHSHVAGAKVNVGRIFRPEDSKREI
YAKKGLRTGTGFSVPSTYKTGYQYSEMGYTTVIEAAMPPLIARHTHEEFMETPQIDKAAMPLFGNNWMVLEYLKEGDIKA
CAAFVAWLLKAVKGFAIKIVNPGGTEAWGWGKNVHSLDDPVPYFDITPREIVRGLAEVNELLGLPHSIHVHPNNLGHPGN
WETTLETMKCVEGVEAKPRVGERETSYYNTHCQFHSYGGTSWKDFESKAIEIAEYVNKSKHVVIDVGQVTLDETTTMTAD
GPMEYDLHMTNGLKWANCDVELETGSGVVPFIYSPKGPVYAVQWAIGLELFLNTNTDKVLLTTDHPNAGPFTRYPRVIAW
LMSKKYRDEWLYNKVHKWAQQRSHVADADKEYDLYEIAKITRANQAKVLGLSETKGHLGVGAEADIAIYAIDPEEKDGKK
IEKAFRYAKYVLKGGEVVVKDGNVVKEVFGDTIYVDVQVGEDLMNEVLKDVGEKFRRYYSVNLENYPVSDEYANSWRVIK
IDATDIN

Sequences:

>Translated_567_residues
MEYIIKNGIVYDPLNGINGEKMDICVKDGKIVESVSDNAKVIDASGCVVMPGGIDSHSHVAGAKVNVGRIFRPEDSKREI
YAKKGLRTGTGFSVPSTYKTGYQYSEMGYTTVIEAAMPPLIARHTHEEFMETPQIDKAAMPLFGNNWMVLEYLKEGDIKA
CAAFVAWLLKAVKGFAIKIVNPGGTEAWGWGKNVHSLDDPVPYFDITPREIVRGLAEVNELLGLPHSIHVHPNNLGHPGN
WETTLETMKCVEGVEAKPRVGERETSYYNTHCQFHSYGGTSWKDFESKAIEIAEYVNKSKHVVIDVGQVTLDETTTMTAD
GPMEYDLHMTNGLKWANCDVELETGSGVVPFIYSPKGPVYAVQWAIGLELFLNTNTDKVLLTTDHPNAGPFTRYPRVIAW
LMSKKYRDEWLYNKVHKWAQQRSHVADADKEYDLYEIAKITRANQAKVLGLSETKGHLGVGAEADIAIYAIDPEEKDGKK
IEKAFRYAKYVLKGGEVVVKDGNVVKEVFGDTIYVDVQVGEDLMNEVLKDVGEKFRRYYSVNLENYPVSDEYANSWRVIK
IDATDIN
>Mature_567_residues
MEYIIKNGIVYDPLNGINGEKMDICVKDGKIVESVSDNAKVIDASGCVVMPGGIDSHSHVAGAKVNVGRIFRPEDSKREI
YAKKGLRTGTGFSVPSTYKTGYQYSEMGYTTVIEAAMPPLIARHTHEEFMETPQIDKAAMPLFGNNWMVLEYLKEGDIKA
CAAFVAWLLKAVKGFAIKIVNPGGTEAWGWGKNVHSLDDPVPYFDITPREIVRGLAEVNELLGLPHSIHVHPNNLGHPGN
WETTLETMKCVEGVEAKPRVGERETSYYNTHCQFHSYGGTSWKDFESKAIEIAEYVNKSKHVVIDVGQVTLDETTTMTAD
GPMEYDLHMTNGLKWANCDVELETGSGVVPFIYSPKGPVYAVQWAIGLELFLNTNTDKVLLTTDHPNAGPFTRYPRVIAW
LMSKKYRDEWLYNKVHKWAQQRSHVADADKEYDLYEIAKITRANQAKVLGLSETKGHLGVGAEADIAIYAIDPEEKDGKK
IEKAFRYAKYVLKGGEVVVKDGNVVKEVFGDTIYVDVQVGEDLMNEVLKDVGEKFRRYYSVNLENYPVSDEYANSWRVIK
IDATDIN

Specific function: Unknown

COG id: COG1229

COG function: function code C; Formylmethanofuran dehydrogenase subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FWDA_METJA (Q58569)

Other databases:

- EMBL:   L77117
- PIR:   H64445
- RefSeq:   NP_248163.1
- ProteinModelPortal:   Q58569
- GeneID:   1452067
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1169
- NMPDR:   fig|243232.1.peg.1200
- TIGR:   MJ1169
- HOGENOM:   HBG373023
- OMA:   VVPFIYS
- ProtClustDB:   CLSK862747
- BioCyc:   MJAN243232:MJ_1169-MONOMER
- InterPro:   IPR013108
- InterPro:   IPR012027
- InterPro:   IPR011059
- PIRSF:   PIRSF006453
- TIGRFAMs:   TIGR03121

Pfam domain/function: PF07969 Amidohydro_3; SSF51338 Metalo_hydrolase

EC number: 1.2.99.5

Molecular weight: Translated: 63412; Mature: 63412

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYIIKNGIVYDPLNGINGEKMDICVKDGKIVESVSDNAKVIDASGCVVMPGGIDSHSHV
CCEEECCCEEECCCCCCCCCEEEEEEECCCEEECCCCCCEEEECCCCEEECCCCCCCCCC
AGAKVNVGRIFRPEDSKREIYAKKGLRTGTGFSVPSTYKTGYQYSEMGYTTVIEAAMPPL
CCCEEECCEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHCCHHHHHHHHCCCH
IARHTHEEFMETPQIDKAAMPLFGNNWMVLEYLKEGDIKACAAFVAWLLKAVKGFAIKIV
HHHCCHHHHHCCCCCCCCCCCEECCCEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEE
NPGGTEAWGWGKNVHSLDDPVPYFDITPREIVRGLAEVNELLGLPHSIHVHPNNLGHPGN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
WETTLETMKCVEGVEAKPRVGERETSYYNTHCQFHSYGGTSWKDFESKAIEIAEYVNKSK
CHHHHHHHHHHHCCCCCCCCCCCCCCEEECEEEEECCCCCCCHHHHHHHHHHHHHHCCCC
HVVIDVGQVTLDETTTMTADGPMEYDLHMTNGLKWANCDVELETGSGVVPFIYSPKGPVY
EEEEEECEEEECCCEEEECCCCEEEEEEECCCCEEECCEEEEECCCCEEEEEECCCCCEE
AVQWAIGLELFLNTNTDKVLLTTDHPNAGPFTRYPRVIAWLMSKKYRDEWLYNKVHKWAQ
EEEEEEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRSHVADADKEYDLYEIAKITRANQAKVLGLSETKGHLGVGAEADIAIYAIDPEEKDGKK
HHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHH
IEKAFRYAKYVLKGGEVVVKDGNVVKEVFGDTIYVDVQVGEDLMNEVLKDVGEKFRRYYS
HHHHHHHHHHHHCCCEEEEECCCCHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHEEE
VNLENYPVSDEYANSWRVIKIDATDIN
ECCCCCCCCCHHCCCEEEEEEECCCCC
>Mature Secondary Structure
MEYIIKNGIVYDPLNGINGEKMDICVKDGKIVESVSDNAKVIDASGCVVMPGGIDSHSHV
CCEEECCCEEECCCCCCCCCEEEEEEECCCEEECCCCCCEEEECCCCEEECCCCCCCCCC
AGAKVNVGRIFRPEDSKREIYAKKGLRTGTGFSVPSTYKTGYQYSEMGYTTVIEAAMPPL
CCCEEECCEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHCCHHHHHHHHCCCH
IARHTHEEFMETPQIDKAAMPLFGNNWMVLEYLKEGDIKACAAFVAWLLKAVKGFAIKIV
HHHCCHHHHHCCCCCCCCCCCEECCCEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEE
NPGGTEAWGWGKNVHSLDDPVPYFDITPREIVRGLAEVNELLGLPHSIHVHPNNLGHPGN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
WETTLETMKCVEGVEAKPRVGERETSYYNTHCQFHSYGGTSWKDFESKAIEIAEYVNKSK
CHHHHHHHHHHHCCCCCCCCCCCCCCEEECEEEEECCCCCCCHHHHHHHHHHHHHHCCCC
HVVIDVGQVTLDETTTMTADGPMEYDLHMTNGLKWANCDVELETGSGVVPFIYSPKGPVY
EEEEEECEEEECCCEEEECCCCEEEEEEECCCCEEECCEEEEECCCCEEEEEECCCCCEE
AVQWAIGLELFLNTNTDKVLLTTDHPNAGPFTRYPRVIAWLMSKKYRDEWLYNKVHKWAQ
EEEEEEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRSHVADADKEYDLYEIAKITRANQAKVLGLSETKGHLGVGAEADIAIYAIDPEEKDGKK
HHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHH
IEKAFRYAKYVLKGGEVVVKDGNVVKEVFGDTIYVDVQVGEDLMNEVLKDVGEKFRRYYS
HHHHHHHHHHHHCCCEEEEECCCCHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHEEE
VNLENYPVSDEYANSWRVIKIDATDIN
ECCCCCCCCCHHCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formylmethanofuran; H2O; acceptor

Specific reaction: formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087