Click here to switch to the map view.

The map label for this gene is hemD

Identifier: 15669184

GI number: 15669184

Start: 922913

End: 923635

Strand: Reverse

Name: hemD

Synonym: MJ0994

Alternate gene names: 15669184

Gene position: 923635-922913 (Counterclockwise)

Preceding gene: 15669185

Following gene: 15669183

Centisome position: 55.47

GC content: 29.32

Gene sequence:

>723_bases
ATGAAAGTTGTGATAACGAGACCTAAGGAAAGGGCTGATGTTTTTGCCAGTTTATTAAAAAAAGAAGGGTTTGAACCAAT
AATATTTCCAACATTGGAGATTGTATATAATAAAGATTTAGATGTTAATTTAGACAGCTATGATTGGATAGCTTTTACCT
CACCAAGTGGTGTTATTGGACTATACAATATACTAACTGAAAATGAAAGAGAAAATGTAAAAAATAAAAAAATTGCAGTT
ATTGGAGAAAAAACAGCAAAAACTTTTAAAAAATATTTTGGTAGGGACCCAGATATAATGCCTAATGAATACACTGCAGA
GTCCCTCCTAAGAGAGATTAAAAAAGTTTCTAAAGAGGAGGAAAAATTTTTAATCCCAACAACACCATCAACAAGAGACG
TTTTAAAGAATAACTTAAATGCTGATTTGTTATTTGTGTATAAATCAGCAGAGCCAGAAAACTTAAAAGAGGATATTAAA
AAACTAAAAGAGTTAATAGCAAAAGATAAATTTATTCTAACATTTACAAGTGGATTAACAGCTAAGAATTTTTTTAAGTA
TGTGGATGATGAGTTTGCTGAAATTATAAAAGATAACTACATAGTCGCCATTGGTCCTATAACTGCCAAAGTTATTGAAA
AATTTGGTTTTAAACCATTAATTCCTAAAGTATATACGATTGAAGGGATGTTAGAAGTTATTAGAACATTAAAGGAGAGG
TAG

Upstream 100 bases:

>100_bases
CAAATGCAGTTGATTGTAATGTAGTTGATATGGGGGACAAAGTTTATGTTTATTTGGAGTTTAATGGGATAGATTTAAAT
TTAATAAATAACGGGATAAC

Downstream 100 bases:

>100_bases
GAAAATGATTAATATCAATGATAGAGCCTTAATAAAAAAAGCCATAGATAAGATAAACAAACTTGCTGAGAAGATAGATA
AATTAAAGATTATGCACGTC

Product: uroporphyrinogen III synthase HemD

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MKVVITRPKERADVFASLLKKEGFEPIIFPTLEIVYNKDLDVNLDSYDWIAFTSPSGVIGLYNILTENERENVKNKKIAV
IGEKTAKTFKKYFGRDPDIMPNEYTAESLLREIKKVSKEEEKFLIPTTPSTRDVLKNNLNADLLFVYKSAEPENLKEDIK
KLKELIAKDKFILTFTSGLTAKNFFKYVDDEFAEIIKDNYIVAIGPITAKVIEKFGFKPLIPKVYTIEGMLEVIRTLKER

Sequences:

>Translated_240_residues
MKVVITRPKERADVFASLLKKEGFEPIIFPTLEIVYNKDLDVNLDSYDWIAFTSPSGVIGLYNILTENERENVKNKKIAV
IGEKTAKTFKKYFGRDPDIMPNEYTAESLLREIKKVSKEEEKFLIPTTPSTRDVLKNNLNADLLFVYKSAEPENLKEDIK
KLKELIAKDKFILTFTSGLTAKNFFKYVDDEFAEIIKDNYIVAIGPITAKVIEKFGFKPLIPKVYTIEGMLEVIRTLKER
>Mature_240_residues
MKVVITRPKERADVFASLLKKEGFEPIIFPTLEIVYNKDLDVNLDSYDWIAFTSPSGVIGLYNILTENERENVKNKKIAV
IGEKTAKTFKKYFGRDPDIMPNEYTAESLLREIKKVSKEEEKFLIPTTPSTRDVLKNNLNADLLFVYKSAEPENLKEDIK
KLKELIAKDKFILTFTSGLTAKNFFKYVDDEFAEIIKDNYIVAIGPITAKVIEKFGFKPLIPKVYTIEGMLEVIRTLKER

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM4_METJA (Q58401)

Other databases:

- EMBL:   L77117
- PIR:   B64424
- RefSeq:   NP_247989.1
- ProteinModelPortal:   Q58401
- SMR:   Q58401
- GeneID:   1451892
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0994
- NMPDR:   fig|243232.1.peg.1026
- TIGR:   MJ0994
- HOGENOM:   HBG541220
- OMA:   SITTEAI
- ProtClustDB:   CLSK876416
- BioCyc:   MJAN243232:MJ_0994-MONOMER
- BRENDA:   4.2.1.75
- InterPro:   IPR003754

Pfam domain/function: PF02602 HEM4; SSF69618 HEM4_synth

EC number: =4.2.1.75

Molecular weight: Translated: 27614; Mature: 27614

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVITRPKERADVFASLLKKEGFEPIIFPTLEIVYNKDLDVNLDSYDWIAFTSPSGVIG
CEEEEECCHHHHHHHHHHHHHCCCCCEEHHHEEEEECCCCCCCCCCCCEEEEECCCCCHH
LYNILTENERENVKNKKIAVIGEKTAKTFKKYFGRDPDIMPNEYTAESLLREIKKVSKEE
HHHHHCCCCHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
EKFLIPTTPSTRDVLKNNLNADLLFVYKSAEPENLKEDIKKLKELIAKDKFILTFTSGLT
CCEEECCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
AKNFFKYVDDEFAEIIKDNYIVAIGPITAKVIEKFGFKPLIPKVYTIEGMLEVIRTLKER
HHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVVITRPKERADVFASLLKKEGFEPIIFPTLEIVYNKDLDVNLDSYDWIAFTSPSGVIG
CEEEEECCHHHHHHHHHHHHHCCCCCEEHHHEEEEECCCCCCCCCCCCEEEEECCCCCHH
LYNILTENERENVKNKKIAVIGEKTAKTFKKYFGRDPDIMPNEYTAESLLREIKKVSKEE
HHHHHCCCCHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
EKFLIPTTPSTRDVLKNNLNADLLFVYKSAEPENLKEDIKKLKELIAKDKFILTFTSGLT
CCEEECCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
AKNFFKYVDDEFAEIIKDNYIVAIGPITAKVIEKFGFKPLIPKVYTIEGMLEVIRTLKER
HHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087