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The map label for this gene is argD

Identifier: 15668902

GI number: 15668902

Start: 655122

End: 656318

Strand: Direct

Name: argD

Synonym: MJ0721

Alternate gene names: 15668902

Gene position: 655122-656318 (Clockwise)

Preceding gene: 15668897

Following gene: 15668904

Centisome position: 39.35

GC content: 35.92

Gene sequence:

>1197_bases
ATGAGCCAAGAGAATTGGATAGATTTAGAGAAAAAATACCATCTCCAAATCTACGGAAGATTACCAGTTGTTTTAGTTGA
AGGTAAAGGAATGGAAGTTTATGATATTGATGGAAAGAAATATCTTGATTTCTTAGCTGGAATTGGAGTTAATAATGTAG
GGCATTGTCATCCAAAGGTTGTTGAAGCAATAAAAAAACAGGCTGAAACTTTAATCCATACCTCCAACATATATTACACA
ATCCCTCAAATAAAATTAGCTAAAAAGTTAGTTGAGCTAAGTGGTTTGGATAGAGCATTTTTCTGCAACAGTGGAGCTGA
AGCTAACGAAGGAGCTATAAAGTTTGCAAGGAAGTATGTATCAAAAGTATTAGGAAGAGAAGGAGGAGAAATAATCAGCA
TGTATAACGCATTTCATGGTAGAACTTTAACAACACTGGCAGCAACACCAAAACCAAAGTATCAGGATGGGTTTTATCCT
CTACCTCCTGGATTTAAGTATGTTCCATTCAACGATATAGAGGCGTTAAAGGAGGCTATAACAGACAAAACCGCTGCTAT
AATGATTGAGCCTGTTCAGGGAGAAGGAGGAATTCATGTAGCTGATAAAGATTATTTAAAGGCCGTTAGGGATTTATGTG
ATGATAAAAATATCGTCTTAATCTTTGATGAAGTGCAGTGTGGAATGGGGAGAACTGGAAGGATGTTTGCCTTTGAGCAT
TATGGTGTTGAGCCAGATATTTTAACATTGGCAAAAGCCCTTGGAGGGGGGGTCCCAATAGGAGCTGTTGTTTTAAAGGA
AGAGATTGCAAAGGCATTGAGTTATGGAGACCATGGAACAACGTTTGGAGGAAATCCATTGGCTTGCTCTGCCGCTTTGG
CGTCAGTTGAAGTTATAGAGGAATTGATTAAAGATGATAAAGTTATAGAGAAAGGTAAATATTTCATTCGAAAACTCGAA
AACCTTATAGAGAAATACAACTTCATAAAAGAGGTTAGGGGATTAGGATTAATGATTGGAGCAGAGCTTGAATTTAATGG
AGCTGATATTGTTAAGAAAATGCTTGAGAAAGGATTTTTAATCAACTGTACTTCTGACACAGTTTTAAGATTTTTACCTC
CATTAATTGTAGAGAAAGAGCATATAGATGCTTTAATTAATGCATTGGATGAAGTATTTACTGAGATAAAAAAATAA

Upstream 100 bases:

>100_bases
TAAAATACTCAACAAAAAACAACACAAAATATAAATACTTATAATGCATTACTTCCCTTAAAAGTTTTATTTTTAATTTT
AAAATCATTTTGGTGATTAA

Downstream 100 bases:

>100_bases
TTACTTTTTATTTTTATTTTCATCTTTCTTTTTTGGTTTAACCACTTTAATTAATATTGCATTTGTAGGGCATCTACCAG
CACAAAACTTACAGTTGTGG

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSQENWIDLEKKYHLQIYGRLPVVLVEGKGMEVYDIDGKKYLDFLAGIGVNNVGHCHPKVVEAIKKQAETLIHTSNIYYT
IPQIKLAKKLVELSGLDRAFFCNSGAEANEGAIKFARKYVSKVLGREGGEIISMYNAFHGRTLTTLAATPKPKYQDGFYP
LPPGFKYVPFNDIEALKEAITDKTAAIMIEPVQGEGGIHVADKDYLKAVRDLCDDKNIVLIFDEVQCGMGRTGRMFAFEH
YGVEPDILTLAKALGGGVPIGAVVLKEEIAKALSYGDHGTTFGGNPLACSAALASVEVIEELIKDDKVIEKGKYFIRKLE
NLIEKYNFIKEVRGLGLMIGAELEFNGADIVKKMLEKGFLINCTSDTVLRFLPPLIVEKEHIDALINALDEVFTEIKK

Sequences:

>Translated_398_residues
MSQENWIDLEKKYHLQIYGRLPVVLVEGKGMEVYDIDGKKYLDFLAGIGVNNVGHCHPKVVEAIKKQAETLIHTSNIYYT
IPQIKLAKKLVELSGLDRAFFCNSGAEANEGAIKFARKYVSKVLGREGGEIISMYNAFHGRTLTTLAATPKPKYQDGFYP
LPPGFKYVPFNDIEALKEAITDKTAAIMIEPVQGEGGIHVADKDYLKAVRDLCDDKNIVLIFDEVQCGMGRTGRMFAFEH
YGVEPDILTLAKALGGGVPIGAVVLKEEIAKALSYGDHGTTFGGNPLACSAALASVEVIEELIKDDKVIEKGKYFIRKLE
NLIEKYNFIKEVRGLGLMIGAELEFNGADIVKKMLEKGFLINCTSDTVLRFLPPLIVEKEHIDALINALDEVFTEIKK
>Mature_397_residues
SQENWIDLEKKYHLQIYGRLPVVLVEGKGMEVYDIDGKKYLDFLAGIGVNNVGHCHPKVVEAIKKQAETLIHTSNIYYTI
PQIKLAKKLVELSGLDRAFFCNSGAEANEGAIKFARKYVSKVLGREGGEIISMYNAFHGRTLTTLAATPKPKYQDGFYPL
PPGFKYVPFNDIEALKEAITDKTAAIMIEPVQGEGGIHVADKDYLKAVRDLCDDKNIVLIFDEVQCGMGRTGRMFAFEHY
GVEPDILTLAKALGGGVPIGAVVLKEEIAKALSYGDHGTTFGGNPLACSAALASVEVIEELIKDDKVIEKGKYFIRKLEN
LIEKYNFIKEVRGLGLMIGAELEFNGADIVKKMLEKGFLINCTSDTVLRFLPPLIVEKEHIDALINALDEVFTEIKK

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=401, Percent_Identity=35.6608478802993, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI284507298, Length=301, Percent_Identity=36.2126245847176, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI13994255, Length=368, Percent_Identity=34.5108695652174, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI37574042, Length=415, Percent_Identity=30.1204819277108, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI226442709, Length=384, Percent_Identity=30.46875, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI226442705, Length=415, Percent_Identity=29.6385542168675, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=27.2076372315036, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI188536080, Length=434, Percent_Identity=26.2672811059908, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI38679950, Length=434, Percent_Identity=26.2672811059908, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI38679946, Length=434, Percent_Identity=26.2672811059908, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1789759, Length=373, Percent_Identity=45.0402144772118, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1788044, Length=386, Percent_Identity=42.4870466321244, Blast_Score=338, Evalue=5e-94,
Organism=Escherichia coli, GI145693181, Length=382, Percent_Identity=40.0523560209424, Blast_Score=262, Evalue=2e-71,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=37, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1789016, Length=409, Percent_Identity=35.9413202933985, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786991, Length=407, Percent_Identity=30.2211302211302, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786349, Length=301, Percent_Identity=29.9003322259136, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=406, Percent_Identity=37.192118226601, Blast_Score=284, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI25144274, Length=404, Percent_Identity=32.4257425742574, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=33.7837837837838, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71992977, Length=438, Percent_Identity=31.7351598173516, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71981843, Length=187, Percent_Identity=34.7593582887701, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=447, Percent_Identity=26.1744966442953, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71992985, Length=105, Percent_Identity=40.9523809523809, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324432, Length=404, Percent_Identity=37.8712871287129, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6323470, Length=405, Percent_Identity=36.7901234567901, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324386, Length=470, Percent_Identity=26.3829787234043, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=429, Percent_Identity=26.8065268065268, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357415, Length=384, Percent_Identity=36.9791666666667, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI161085790, Length=430, Percent_Identity=33.7209302325581, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI28574759, Length=436, Percent_Identity=33.7155963302752, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI21356575, Length=430, Percent_Identity=30.2325581395349, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281366494, Length=423, Percent_Identity=23.8770685579196, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24667139, Length=423, Percent_Identity=23.8770685579196, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24667143, Length=423, Percent_Identity=23.8770685579196, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ARGD_METJA (Q58131)

Other databases:

- EMBL:   L77117
- PIR:   A64390
- RefSeq:   NP_247706.1
- ProteinModelPortal:   Q58131
- SMR:   Q58131
- GeneID:   1451598
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0721
- NMPDR:   fig|243232.1.peg.743
- TIGR:   MJ0721
- HOGENOM:   HBG725944
- OMA:   INCTSDT
- ProtClustDB:   PRK02627
- BioCyc:   MJAN243232:MJ_0721-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 44066; Mature: 43935

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 138-138 BINDING 141-141 BINDING 280-280 BINDING 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQENWIDLEKKYHLQIYGRLPVVLVEGKGMEVYDIDGKKYLDFLAGIGVNNVGHCHPKV
CCCCCCCCCCCEEEEEEEECCCEEEEECCCCEEEECCCHHHHHHHHCCCCCCCCCCCHHH
VEAIKKQAETLIHTSNIYYTIPQIKLAKKLVELSGLDRAFFCNSGAEANEGAIKFARKYV
HHHHHHHHHHHEEECCEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHH
SKVLGREGGEIISMYNAFHGRTLTTLAATPKPKYQDGFYPLPPGFKYVPFNDIEALKEAI
HHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHH
TDKTAAIMIEPVQGEGGIHVADKDYLKAVRDLCDDKNIVLIFDEVQCGMGRTGRMFAFEH
CCCCEEEEEEEECCCCCEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEC
YGVEPDILTLAKALGGGVPIGAVVLKEEIAKALSYGDHGTTFGGNPLACSAALASVEVIE
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
ELIKDDKVIEKGKYFIRKLENLIEKYNFIKEVRGLGLMIGAELEFNGADIVKKMLEKGFL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECEEECCCHHHHHHHHHCCEE
INCTSDTVLRFLPPLIVEKEHIDALINALDEVFTEIKK
EEECHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQENWIDLEKKYHLQIYGRLPVVLVEGKGMEVYDIDGKKYLDFLAGIGVNNVGHCHPKV
CCCCCCCCCCEEEEEEEECCCEEEEECCCCEEEECCCHHHHHHHHCCCCCCCCCCCHHH
VEAIKKQAETLIHTSNIYYTIPQIKLAKKLVELSGLDRAFFCNSGAEANEGAIKFARKYV
HHHHHHHHHHHEEECCEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHH
SKVLGREGGEIISMYNAFHGRTLTTLAATPKPKYQDGFYPLPPGFKYVPFNDIEALKEAI
HHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHH
TDKTAAIMIEPVQGEGGIHVADKDYLKAVRDLCDDKNIVLIFDEVQCGMGRTGRMFAFEH
CCCCEEEEEEEECCCCCEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEC
YGVEPDILTLAKALGGGVPIGAVVLKEEIAKALSYGDHGTTFGGNPLACSAALASVEVIE
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
ELIKDDKVIEKGKYFIRKLENLIEKYNFIKEVRGLGLMIGAELEFNGADIVKKMLEKGFL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECEEECCCHHHHHHHHHCCEE
INCTSDTVLRFLPPLIVEKEHIDALINALDEVFTEIKK
EEECHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087