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Identifier: 15645892

GI number: 15645892

Start: 1353148

End: 1354329

Strand: Reverse

Name: Not Available

Synonym: HP1278

Alternate gene names: 15645892

Gene position: 1354329-1353148 (Counterclockwise)

Preceding gene: 15645893

Following gene: 15645891

Centisome position: 81.2

GC content: 43.99

Gene sequence:

>1182_bases
ATGAATAAAAAAGCGTATTTTGGGGAGTTTGGAGGGAGTTTTGTTTCGGAGTTGTTAGTGCCTGCATTAAGAGAATTAGA
ACAGGCGTTTGATGCGTGTTTGAAAGATGAAAAATTCCAAAAAGAATATTTTCGTCTTTTAAAGGATTTTGTGGGCCGTC
CTAGCCCTTTAACCTTGTGTCAAAATATCGTTTCTAACCCTAAAGTCAAGCTTTATTTAAAACGAGAGGATTTAATCCAT
GGCGGGGCGCATAAGACTAATCAAGCCTTAGGGCAAGCCCTTTTAGCGAAAAAAATGGGTAAAACAAGGATCATCGCTGA
AACAGGCGCCGGTCAGCATGGCGTGGCGACGGCTATCGCTTGCGCATTATTGAACTTAAAATGCGTGGTTTTTATGGGAT
CTAAAGACATCAAGCGCCAGGAAATGAATGTTTTTAGAATGCACTTATTAGGCGCTGAAGTGAGAGAGGTTAATTCAGGG
AGCGCGACGCTTAAAGACGCTGTGAATGAAGCCTTAAGAGATTGGGCGAGCAGTTACAAGGACACGCATTATTTGCTAGG
CACAGCCGCCGGGCCACACCCTTACCCCACAATGGTTAAAACCTTTCAAAAAATGATAGGCGATGAGGTTAAAAGCCAGA
TTTTAGAAAAAGAAAACCGCTTGCCTGATTATGTGATCGCATGCGTTGGAGGGGGGTCTAACGCTATAGGGATATTCAGC
GCATTTTTAAACGACAAAGAAGTTAAACTCATAGGCGTAGAGCCGGCGGGTTTAGGGCTAGAAACCAATAAGCATGGGGC
GACTTTGAATAAGGGGCGTGTGGGGATTTTGCATGGGAATAAAACCTATCTTTTACAAGATGATGAAGGCCAGATTGCAG
AAAGCCATAGCATTAGCGCCGGGCTTGATTATCCAGGAGTGGGGCCAGAACACAGCTATTTAAAAGAAAGTGGGCGTGCG
GTTTATGAAAGCGCAAGCGATGCTGAAGCGCTAGAAGCCTTCAAGTTGTTGTGCCAAAAAGAAGGCATTATCCCAGCGCT
AGAAAGCTCACACGCCTTAGCGTATGCCTTAAAGCTCGCTCAAAAATGCGAAGAAGAAAGCATCATCGTAGTGAATTTAA
GCGGCAGAGGGGATAAGGATTTAAGCACCGTTTATAACGCTTTAAAAGGAGGTTTAAAATGA

Upstream 100 bases:

>100_bases
GCGTTGGGTTTGGATTTCAATTCCGGTTTAGAAATAAGCCCTGGGATTAAAAATAAGGATAAAATCAAGCGATTAGCCCG
AATTTTAAGAGAGTATTAAG

Downstream 100 bases:

>100_bases
GGTATCAAAACATGTTTGAAACCTTAAAAAAACACGAAAAAATGGCGTTTATCCCGTTTGTAACCTTGGGCGATCCTAAT
TATGAATTGAGTTTTGAAAT

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNKKAYFGEFGGSFVSELLVPALRELEQAFDACLKDEKFQKEYFRLLKDFVGRPSPLTLCQNIVSNPKVKLYLKREDLIH
GGAHKTNQALGQALLAKKMGKTRIIAETGAGQHGVATAIACALLNLKCVVFMGSKDIKRQEMNVFRMHLLGAEVREVNSG
SATLKDAVNEALRDWASSYKDTHYLLGTAAGPHPYPTMVKTFQKMIGDEVKSQILEKENRLPDYVIACVGGGSNAIGIFS
AFLNDKEVKLIGVEPAGLGLETNKHGATLNKGRVGILHGNKTYLLQDDEGQIAESHSISAGLDYPGVGPEHSYLKESGRA
VYESASDAEALEAFKLLCQKEGIIPALESSHALAYALKLAQKCEEESIIVVNLSGRGDKDLSTVYNALKGGLK

Sequences:

>Translated_393_residues
MNKKAYFGEFGGSFVSELLVPALRELEQAFDACLKDEKFQKEYFRLLKDFVGRPSPLTLCQNIVSNPKVKLYLKREDLIH
GGAHKTNQALGQALLAKKMGKTRIIAETGAGQHGVATAIACALLNLKCVVFMGSKDIKRQEMNVFRMHLLGAEVREVNSG
SATLKDAVNEALRDWASSYKDTHYLLGTAAGPHPYPTMVKTFQKMIGDEVKSQILEKENRLPDYVIACVGGGSNAIGIFS
AFLNDKEVKLIGVEPAGLGLETNKHGATLNKGRVGILHGNKTYLLQDDEGQIAESHSISAGLDYPGVGPEHSYLKESGRA
VYESASDAEALEAFKLLCQKEGIIPALESSHALAYALKLAQKCEEESIIVVNLSGRGDKDLSTVYNALKGGLK
>Mature_393_residues
MNKKAYFGEFGGSFVSELLVPALRELEQAFDACLKDEKFQKEYFRLLKDFVGRPSPLTLCQNIVSNPKVKLYLKREDLIH
GGAHKTNQALGQALLAKKMGKTRIIAETGAGQHGVATAIACALLNLKCVVFMGSKDIKRQEMNVFRMHLLGAEVREVNSG
SATLKDAVNEALRDWASSYKDTHYLLGTAAGPHPYPTMVKTFQKMIGDEVKSQILEKENRLPDYVIACVGGGSNAIGIFS
AFLNDKEVKLIGVEPAGLGLETNKHGATLNKGRVGILHGNKTYLLQDDEGQIAESHSISAGLDYPGVGPEHSYLKESGRA
VYESASDAEALEAFKLLCQKEGIIPALESSHALAYALKLAQKCEEESIIVVNLSGRGDKDLSTVYNALKGGLK

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine [H]

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family [H]

Homologues:

Organism=Escherichia coli, GI1787515, Length=385, Percent_Identity=66.2337662337662, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6321412, Length=384, Percent_Identity=54.4270833333333, Blast_Score=433, Evalue=1e-122,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 42685; Mature: 42685

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKAYFGEFGGSFVSELLVPALRELEQAFDACLKDEKFQKEYFRLLKDFVGRPSPLTLC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHH
QNIVSNPKVKLYLKREDLIHGGAHKTNQALGQALLAKKMGKTRIIAETGAGQHGVATAIA
HHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
CALLNLKCVVFMGSKDIKRQEMNVFRMHLLGAEVREVNSGSATLKDAVNEALRDWASSYK
HHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
DTHYLLGTAAGPHPYPTMVKTFQKMIGDEVKSQILEKENRLPDYVIACVGGGSNAIGIFS
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHH
AFLNDKEVKLIGVEPAGLGLETNKHGATLNKGRVGILHGNKTYLLQDDEGQIAESHSISA
HHHCCCCEEEEEECCCCCCCCCCCCCCEECCCEEEEEECCEEEEEECCCCCCHHCCCCCC
GLDYPGVGPEHSYLKESGRAVYESASDAEALEAFKLLCQKEGIIPALESSHALAYALKLA
CCCCCCCCCCHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
QKCEEESIIVVNLSGRGDKDLSTVYNALKGGLK
HHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKKAYFGEFGGSFVSELLVPALRELEQAFDACLKDEKFQKEYFRLLKDFVGRPSPLTLC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHH
QNIVSNPKVKLYLKREDLIHGGAHKTNQALGQALLAKKMGKTRIIAETGAGQHGVATAIA
HHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
CALLNLKCVVFMGSKDIKRQEMNVFRMHLLGAEVREVNSGSATLKDAVNEALRDWASSYK
HHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
DTHYLLGTAAGPHPYPTMVKTFQKMIGDEVKSQILEKENRLPDYVIACVGGGSNAIGIFS
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHH
AFLNDKEVKLIGVEPAGLGLETNKHGATLNKGRVGILHGNKTYLLQDDEGQIAESHSISA
HHHCCCCEEEEEECCCCCCCCCCCCCCEECCCEEEEEECCEEEEEECCCCCCHHCCCCCC
GLDYPGVGPEHSYLKESGRAVYESASDAEALEAFKLLCQKEGIIPALESSHALAYALKLA
CCCCCCCCCCHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
QKCEEESIIVVNLSGRGDKDLSTVYNALKGGLK
HHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]