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Identifier: 15645893

GI number: 15645893

Start: 1354331

End: 1355689

Strand: Reverse

Name: Not Available

Synonym: HP1279

Alternate gene names: 15645893

Gene position: 1355689-1354331 (Counterclockwise)

Preceding gene: 15646202

Following gene: 15645892

Centisome position: 81.28

GC content: 36.79

Gene sequence:

>1359_bases
ATGCCTAGCGTGTTAGAAAACATCCTTAAAGACAAGCTCCTAGAAGTCTCTGATCTTAAAAAAAACCACGCTTTACCGAT
AAACATAAACCCAAGCGATAGGGATTTTAAAAAGGCGTTACTAGAAAAAAAGACCAGCTTTATTTTAGAATGCAAAAAAG
CATCGCCCTCTAAAGGTTTAATCAGAAAAGATTTTGATCTGTTAAAAATAACCAAGACTTATGAAAAATTCGCCTCTTGT
ATTTCGGTTTTAGCCGATTCTAAATATTTTTTAGGCTCTTATGAAAACATTAAGATCGTTTCGCAGCATTCCACCAAGCC
CATTTTGTGTAAAGATTTTATCATTGACGCTTTTCAGATCAAACTCGCTAGAATGATGGGGGCGAATGCGGTGCTTTTAA
TGTTAAGCGTGTTAGATGATAAAAATTATTTAGAGCTTTTCAACCTCGCCAAATCCTTAAACATGAGCGTGCTGACTGAA
GTTTCCAACCAGCAAGAAATTGAGCACTTGCTCAAACTCCAATACGACATTATAGGCATCAATAACAGGGATTTACACAC
CTTAAAAACCGATATTAACCACACGCTCAAATTACGCCCCCTGTTGCCTAAAGATGCGCTCATTATCAGTGAGTCCGGTA
TTTATTCGCATGCACAAATCAAAGCCCTAGCCCCTTATGTGAATGGCTTTTTAGTGGGTAGCTCTTTGATGAAAGAAAAG
GATTTGAAAAAAGCGTGTATTAAATTGATTTTAGGCGAAAATAAAGTGTGCGGGCTTACAAGGATTAAAGACGCTAAAGC
CGTTTATAAAAACCATTTTATTTATGGGGGTTTGATTTTTGAAAAATCTTCGCCCCGATACATCAAGCCTAAAGAAGCCC
TAAAAATCACAAAAGCGGTTAAAAAACTGGATTTTGTGGGCGTGTTTGTGAAAGATAGCATTAAAAAAATTCAAAAAATC
GTTAAAAAACTTGATTTAAAAGCGGTGCAGCTTTATGGCTATTCGCAAAAAGAAATCGCTCAATTGAAAAAAGCACTCCC
TAAAACTTGCGCGATCTGGCAAGTAATAAGCGTGATGAGTGCTAAAGATTTAGTGCCTAAAACTAAAGAGGCCTCTCTAA
TCTTATACGACACTAAAGGGGATAAAATGGGAGGCAATGGCGTGAGTTTTGATTGGGAAATTTTAGAAAATGTCAAAACG
CCTTTCATGCTAGCTGGGGGGCTTAATTTGGATAATATTCAAAAAGCCTTGAAAGTTGAAGCGTTGGGTTTGGATTTCAA
TTCCGGTTTAGAAATAAGCCCTGGGATTAAAAATAAGGATAAAATCAAGCGATTAGCCCGAATTTTAAGAGAGTATTAA

Upstream 100 bases:

>100_bases
CATAAAGCTAAAGATTTAAAAGAGGGTGTGAGCATGACTTTAGAGCATTTAAAAACCAAAGCGCCTTATGCGCATTTGCA
AAAAATCATAAGGCTAAGCC

Downstream 100 bases:

>100_bases
GATGAATAAAAAAGCGTATTTTGGGGAGTTTGGAGGGAGTTTTGTTTCGGAGTTGTTAGTGCCTGCATTAAGAGAATTAG
AACAGGCGTTTGATGCGTGT

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MPSVLENILKDKLLEVSDLKKNHALPININPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLKITKTYEKFASC
ISVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQIKLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTE
VSNQQEIEHLLKLQYDIIGINNRDLHTLKTDINHTLKLRPLLPKDALIISESGIYSHAQIKALAPYVNGFLVGSSLMKEK
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAVKKLDFVGVFVKDSIKKIQKI
VKKLDLKAVQLYGYSQKEIAQLKKALPKTCAIWQVISVMSAKDLVPKTKEASLILYDTKGDKMGGNGVSFDWEILENVKT
PFMLAGGLNLDNIQKALKVEALGLDFNSGLEISPGIKNKDKIKRLARILREY

Sequences:

>Translated_452_residues
MPSVLENILKDKLLEVSDLKKNHALPININPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLKITKTYEKFASC
ISVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQIKLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTE
VSNQQEIEHLLKLQYDIIGINNRDLHTLKTDINHTLKLRPLLPKDALIISESGIYSHAQIKALAPYVNGFLVGSSLMKEK
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAVKKLDFVGVFVKDSIKKIQKI
VKKLDLKAVQLYGYSQKEIAQLKKALPKTCAIWQVISVMSAKDLVPKTKEASLILYDTKGDKMGGNGVSFDWEILENVKT
PFMLAGGLNLDNIQKALKVEALGLDFNSGLEISPGIKNKDKIKRLARILREY
>Mature_451_residues
PSVLENILKDKLLEVSDLKKNHALPININPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLKITKTYEKFASCI
SVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQIKLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTEV
SNQQEIEHLLKLQYDIIGINNRDLHTLKTDINHTLKLRPLLPKDALIISESGIYSHAQIKALAPYVNGFLVGSSLMKEKD
LKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAVKKLDFVGVFVKDSIKKIQKIV
KKLDLKAVQLYGYSQKEIAQLKKALPKTCAIWQVISVMSAKDLVPKTKEASLILYDTKGDKMGGNGVSFDWEILENVKTP
FMLAGGLNLDNIQKALKVEALGLDFNSGLEISPGIKNKDKIKRLARILREY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=457, Percent_Identity=46.1706783369803, Blast_Score=380, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322638, Length=239, Percent_Identity=37.2384937238494, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 50859; Mature: 50728

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSVLENILKDKLLEVSDLKKNHALPININPSDRDFKKALLEKKTSFILECKKASPSKGL
CCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEECCCCCCCCC
IRKDFDLLKITKTYEKFASCISVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQI
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEECCCCCCEEHHHHHHHHHHH
KLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTEVSNQQEIEHLLKLQYDIIGI
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHEEEEC
NNRDLHTLKTDINHTLKLRPLLPKDALIISESGIYSHAQIKALAPYVNGFLVGSSLMKEK
CCCCCHHHHHCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAV
HHHHHHHHHHHCCCCEECCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHH
KKLDFVGVFVKDSIKKIQKIVKKLDLKAVQLYGYSQKEIAQLKKALPKTCAIWQVISVMS
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHH
AKDLVPKTKEASLILYDTKGDKMGGNGVSFDWEILENVKTPFMLAGGLNLDNIQKALKVE
HHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCEEEECCCCHHHHHHHHHHH
ALGLDFNSGLEISPGIKNKDKIKRLARILREY
EECCCCCCCCEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSVLENILKDKLLEVSDLKKNHALPININPSDRDFKKALLEKKTSFILECKKASPSKGL
CHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEECCCCCCCCC
IRKDFDLLKITKTYEKFASCISVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQI
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEECCCCCCEEHHHHHHHHHHH
KLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTEVSNQQEIEHLLKLQYDIIGI
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHEEEEC
NNRDLHTLKTDINHTLKLRPLLPKDALIISESGIYSHAQIKALAPYVNGFLVGSSLMKEK
CCCCCHHHHHCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAV
HHHHHHHHHHHCCCCEECCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHH
KKLDFVGVFVKDSIKKIQKIVKKLDLKAVQLYGYSQKEIAQLKKALPKTCAIWQVISVMS
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHH
AKDLVPKTKEASLILYDTKGDKMGGNGVSFDWEILENVKTPFMLAGGLNLDNIQKALKVE
HHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCEEEECCCCHHHHHHHHHHH
ALGLDFNSGLEISPGIKNKDKIKRLARILREY
EECCCCCCCCEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]