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The map label for this gene is fmt

Identifier: 15645755

GI number: 15645755

Start: 1202071

End: 1202982

Strand: Reverse

Name: fmt

Synonym: HP1141

Alternate gene names: 15645755

Gene position: 1202982-1202071 (Counterclockwise)

Preceding gene: 15645756

Following gene: 15645754

Centisome position: 72.13

GC content: 39.91

Gene sequence:

>912_bases
ATGCGAATCGTATTTATGGGAACGCCGGGGTTTGCTGAAGTGATCTTAAGGGCGTTAGTTGGAGATAAAGACATAGAAGT
GGTGGGGCTATTCACGCAGATGGATAAACCTTTTGGGCGTAAAAAGGAATTGAAAGCCCCAGAGACTAAAACATACATTC
TAGAAAATCATTTAAACATCCCCATTTTCCAGCCACAAAGTTTGAAAGAGCCTGAAGTTCAAATCTTAAAAGATCTAAAG
CCTAATTTTATCGTGGTGGTGGCTTATGGTAAGATTTTGCCTAAAGAGGTTTTAACCATCGCTCCTTGCATCAATTTGCA
TGCGTCGTTATTACCTAAATACAGGGGGGCTTCGCCCATTCATGAGATGATACTCAATGACAATAAGATCTATGGCATAA
GCACCATGCTTATGGATGTGGAGTTGGATAGCGGGGATATTTTAGAGAGCGCTTCTTTTTTAAGAGAAGATTATTTGGAT
TTAGACGCTTTAAGTTTAAAATTGGCGCATATGGGGGCAGCCTTACTCCTTTCAACGCTCAAAAATTTCTCTTCCATCAC
AAGAAAATCTCAAGATCACATGCAGGCTAGTTTTTGTAAAAAAATCACCAAATCCGATGGTTTAGTGGGTTTTAAAGACG
CTAAAAGCTTGTTTTTAAAATCGCTTGCGTTTAAGAGTTGGCCAGAAATCTTTTTAGAAAATGGCCTTAAACTTTTAGAA
GTGGAGTTGGTGGAGAATGAAAAGAGCCACAAGGAAGGCGAGATTTTAGAAATTGATGAAAAAGGCGTTCTTGTGGGTTG
CTTGAAGGGTAGCGTGCGTATAGCAAGGTTGCAAGCGGTGGGTAAAAAGCCTTTGAAAGCGAAGGATTATTTGAATGGCA
AGCGTTTGAAAATAGGCGGTATTTTGGCATGA

Upstream 100 bases:

>100_bases
ATTTAAAAGTTTTTGAAAAAATATTTAAAGAAACCGGTCATGAAGCTCATTATAAAATGATGATGAGAATGAAGTAATTG
AATTAAAAACAAGGAATAAC

Downstream 100 bases:

>100_bases
GACAATGTGAAAAAAGGGTTTTTGATAGCCTGCCTTCCACGCAAACCTATCTTTTAGAAAAACTCAAAAGTAATGAACTC
AAAGCCCCCATTTTGATCGT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MRIVFMGTPGFAEVILRALVGDKDIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNIPIFQPQSLKEPEVQILKDLK
PNFIVVVAYGKILPKEVLTIAPCINLHASLLPKYRGASPIHEMILNDNKIYGISTMLMDVELDSGDILESASFLREDYLD
LDALSLKLAHMGAALLLSTLKNFSSITRKSQDHMQASFCKKITKSDGLVGFKDAKSLFLKSLAFKSWPEIFLENGLKLLE
VELVENEKSHKEGEILEIDEKGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGKRLKIGGILA

Sequences:

>Translated_303_residues
MRIVFMGTPGFAEVILRALVGDKDIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNIPIFQPQSLKEPEVQILKDLK
PNFIVVVAYGKILPKEVLTIAPCINLHASLLPKYRGASPIHEMILNDNKIYGISTMLMDVELDSGDILESASFLREDYLD
LDALSLKLAHMGAALLLSTLKNFSSITRKSQDHMQASFCKKITKSDGLVGFKDAKSLFLKSLAFKSWPEIFLENGLKLLE
VELVENEKSHKEGEILEIDEKGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGKRLKIGGILA
>Mature_303_residues
MRIVFMGTPGFAEVILRALVGDKDIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNIPIFQPQSLKEPEVQILKDLK
PNFIVVVAYGKILPKEVLTIAPCINLHASLLPKYRGASPIHEMILNDNKIYGISTMLMDVELDSGDILESASFLREDYLD
LDALSLKLAHMGAALLLSTLKNFSSITRKSQDHMQASFCKKITKSDGLVGFKDAKSLFLKSLAFKSWPEIFLENGLKLLE
VELVENEKSHKEGEILEIDEKGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGKRLKIGGILA

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI164663775, Length=325, Percent_Identity=24.6153846153846, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789683, Length=306, Percent_Identity=36.2745098039216, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI1788589, Length=271, Percent_Identity=24.3542435424354, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550868, Length=311, Percent_Identity=29.2604501607717, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28571984, Length=222, Percent_Identity=30.6306306306306, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 33730; Mature: 33730

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVFMGTPGFAEVILRALVGDKDIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNI
CEEEEECCCCHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCEEEEECCCCC
PIFQPQSLKEPEVQILKDLKPNFIVVVAYGKILPKEVLTIAPCINLHASLLPKYRGASPI
CEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHH
HEMILNDNKIYGISTMLMDVELDSGDILESASFLREDYLDLDALSLKLAHMGAALLLSTL
HHHHHCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KNFSSITRKSQDHMQASFCKKITKSDGLVGFKDAKSLFLKSLAFKSWPEIFLENGLKLLE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VELVENEKSHKEGEILEIDEKGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGKRLKIGG
EEEECCCCCCCCCCEEEECCCCEEEEEECCCEEEEEEHHHCCCCCCHHHCCCCCEEEECC
ILA
CCC
>Mature Secondary Structure
MRIVFMGTPGFAEVILRALVGDKDIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNI
CEEEEECCCCHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCEEEEECCCCC
PIFQPQSLKEPEVQILKDLKPNFIVVVAYGKILPKEVLTIAPCINLHASLLPKYRGASPI
CEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHH
HEMILNDNKIYGISTMLMDVELDSGDILESASFLREDYLDLDALSLKLAHMGAALLLSTL
HHHHHCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KNFSSITRKSQDHMQASFCKKITKSDGLVGFKDAKSLFLKSLAFKSWPEIFLENGLKLLE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VELVENEKSHKEGEILEIDEKGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGKRLKIGG
EEEECCCCCCCCCCEEEECCCCEEEEEECCCEEEEEEHHHCCCCCCHHHCCCCCEEEECC
ILA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA