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Identifier: 15645754

GI number: 15645754

Start: 1201436

End: 1202074

Strand: Reverse

Name: Not Available

Synonym: HP1140

Alternate gene names: 15645754

Gene position: 1202074-1201436 (Counterclockwise)

Preceding gene: 15645755

Following gene: 15645753

Centisome position: 72.07

GC content: 39.44

Gene sequence:

>639_bases
ATGAGACAATGTGAAAAAAGGGTTTTTGATAGCCTGCCTTCCACGCAAACCTATCTTTTAGAAAAACTCAAAAGTAATGA
ACTCAAAGCCCCCATTTTGATCGTGGCTAAAAACCAAAGCGCTGGGATAGGCAGTAGGGGGAATATTTGGGAGGGTGCAA
AAAGCGCTTTGACTTTTTCGCTCGCTTTAAACGCAAGCGATTTGCCTAAAGATTTACCCATGCAAGCGAACGCTTTGTAT
TTAGGGTTTTTATTCAAAGAAGTTTTAAAAGAGCTAGGCTCTCAAACCTGGCTTAAATGGCCTAACGACTTGTATTTAGA
GGATCAAAAAATAGGGGGCGTGCTGGTTAATGTTTATAAAGACATGCGGGTGTGCGGCATTGGCGTGAATAGGGTTTCAA
AGAAATGGGCATGTTTAGATATTGGTGCGAGCGATGGTTTGATTATAGAGGGCTTTTTAAAAAAAATAGAAGAAAATCTT
TTTTGGGGGGAAGTTTTAAGTAAGTATGCGTTAGAATTTCATAGAAGCAACTCTTTTAGTTTCCATAATGATTGGGGCGA
AGCGATGAGTTTGAAAGATGCGGAATTGTTAGAAGACGGCCGCATTTGTATTAAAGGTAAGATTTATGATAGGATGTGA

Upstream 100 bases:

>100_bases
GTAGCGTGCGTATAGCAAGGTTGCAAGCGGTGGGTAAAAAGCCTTTGAAAGCGAAGGATTATTTGAATGGCAAGCGTTTG
AAAATAGGCGGTATTTTGGC

Downstream 100 bases:

>100_bases
GTATGATGAGTGAAATCATTGCGGTGGCTAATCAAAAAGGGGGTGTGGGCAAAACAACAACAGCGGTTAATTTAGCGGCT
TCTTTAGCGGTGCATGAAAA

Product: biotin--protein ligase

Products: AMP; diphosphate; [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

Alternate protein names: Biotin/Acetyl-CoA-Carboxylase Ligase; Biotin-[Acetyl-CoA-Carboxylase] Synthetase; Biotin-[Acetyl-CoA-Carboxylase] Ligase; Biotin Operon Repressor; Biotin-(Acetyl-CoA-Carboxylase) Ligase; Biotin-Acetyl-CoA-Carboxylase Ligase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MRQCEKRVFDSLPSTQTYLLEKLKSNELKAPILIVAKNQSAGIGSRGNIWEGAKSALTFSLALNASDLPKDLPMQANALY
LGFLFKEVLKELGSQTWLKWPNDLYLEDQKIGGVLVNVYKDMRVCGIGVNRVSKKWACLDIGASDGLIIEGFLKKIEENL
FWGEVLSKYALEFHRSNSFSFHNDWGEAMSLKDAELLEDGRICIKGKIYDRM

Sequences:

>Translated_212_residues
MRQCEKRVFDSLPSTQTYLLEKLKSNELKAPILIVAKNQSAGIGSRGNIWEGAKSALTFSLALNASDLPKDLPMQANALY
LGFLFKEVLKELGSQTWLKWPNDLYLEDQKIGGVLVNVYKDMRVCGIGVNRVSKKWACLDIGASDGLIIEGFLKKIEENL
FWGEVLSKYALEFHRSNSFSFHNDWGEAMSLKDAELLEDGRICIKGKIYDRM
>Mature_212_residues
MRQCEKRVFDSLPSTQTYLLEKLKSNELKAPILIVAKNQSAGIGSRGNIWEGAKSALTFSLALNASDLPKDLPMQANALY
LGFLFKEVLKELGSQTWLKWPNDLYLEDQKIGGVLVNVYKDMRVCGIGVNRVSKKWACLDIGASDGLIIEGFLKKIEENL
FWGEVLSKYALEFHRSNSFSFHNDWGEAMSLKDAELLEDGRICIKGKIYDRM

Specific function: Bira Acts Both As A Biotin-Operon Repressor And As The Enzyme That Synthesizes The Corepressor, Acetyl-CoA:Carbon- Dioxide Ligase. This Protein Also Activates Biotin To Form Biotinyl-5'-Adenylate And Transfers The Biotin Moiety To Biotin-Accepting Protei

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.4.15

Molecular weight: Translated: 23929; Mature: 23929

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQCEKRVFDSLPSTQTYLLEKLKSNELKAPILIVAKNQSAGIGSRGNIWEGAKSALTFS
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHEEEE
LALNASDLPKDLPMQANALYLGFLFKEVLKELGSQTWLKWPNDLYLEDQKIGGVLVNVYK
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHEEHHH
DMRVCGIGVNRVSKKWACLDIGASDGLIIEGFLKKIEENLFWGEVLSKYALEFHRSNSFS
HHHHCCCCHHHHCCCEEEEEECCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
FHNDWGEAMSLKDAELLEDGRICIKGKIYDRM
CCCCHHHHCCCCCHHHHCCCCEEEEEEECCCC
>Mature Secondary Structure
MRQCEKRVFDSLPSTQTYLLEKLKSNELKAPILIVAKNQSAGIGSRGNIWEGAKSALTFS
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHEEEE
LALNASDLPKDLPMQANALYLGFLFKEVLKELGSQTWLKWPNDLYLEDQKIGGVLVNVYK
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHEEHHH
DMRVCGIGVNRVSKKWACLDIGASDGLIIEGFLKKIEENLFWGEVLSKYALEFHRSNSFS
HHHHCCCCHHHHCCCEEEEEECCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
FHNDWGEAMSLKDAELLEDGRICIKGKIYDRM
CCCCHHHHCCCCCHHHHCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; biotin; apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

Specific reaction: ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

General reaction: Amination; Carboxylic acid formation (carboxamide formation [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA