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Identifier: 15645650

GI number: 15645650

Start: 1096987

End: 1097478

Strand: Reverse

Name: Not Available

Synonym: HP1036

Alternate gene names: 15645650

Gene position: 1097478-1096987 (Counterclockwise)

Preceding gene: 15645651

Following gene: 15645649

Centisome position: 65.8

GC content: 35.37

Gene sequence:

>492_bases
GTGATGCGAGAGATCCTTACTAGCCGCTTTTTCCCTAGCCTTTTTAAAAAAAGGCTTGATTTTTCTAACAGGGTGGTTTT
AGGGTTGGGATCTAATCTTAAAAATCCTTTAAAAATATTAAAAAATTGTTTTTTGTATTTTAAAAATCATAGTAAAATCG
GGAAAATTTTTTCTTCGCCCATTTATATCAATCCGCCTTTTGGTTACACTAAGCAACCTAACTTTTATAACGCTACGATC
ATCCTTAAAACATCTTTAAGTTTGCGCCATTTTTTTGCTCTGGTTTTTTATATAGAAAGGCGTTTTGGCCGCCAAAGGAA
GCGCGATTTTAAAGACGCTCCAAGAACTTTAGACATTGATATTATCGCTTTCAACCAAGTCATTTTAAGACAGAATGATT
TGGCTTTACCTCACCCTAAATGGAGTGAAAGGGATTCGGTGTTAGTGCCGTTGGCTTTGCAACAAATTCTTTTTAAAAAA
GGGGAGTGGTGA

Upstream 100 bases:

>100_bases
GCATGGTGTTTTCTGTAGAGCCTGGGATTTATATCCCTGGGTTTTTTGGGGTGCGCATTGAAGATTTAGTGGTGATCAAA
AATTCTAGGTCTGAGCTTTT

Downstream 100 bases:

>100_bases
AATTCTATACCTATAGTGGGGAGACGGCCGCTGAAGCTTTAAAGATCGCTCAAAGCCACCATGGGGTGGATACGCTGGTG
TTTAAAACCCAAGAAATCCG

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (folK)

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MMREILTSRFFPSLFKKRLDFSNRVVLGLGSNLKNPLKILKNCFLYFKNHSKIGKIFSSPIYINPPFGYTKQPNFYNATI
ILKTSLSLRHFFALVFYIERRFGRQRKRDFKDAPRTLDIDIIAFNQVILRQNDLALPHPKWSERDSVLVPLALQQILFKK
GEW

Sequences:

>Translated_163_residues
MMREILTSRFFPSLFKKRLDFSNRVVLGLGSNLKNPLKILKNCFLYFKNHSKIGKIFSSPIYINPPFGYTKQPNFYNATI
ILKTSLSLRHFFALVFYIERRFGRQRKRDFKDAPRTLDIDIIAFNQVILRQNDLALPHPKWSERDSVLVPLALQQILFKK
GEW
>Mature_163_residues
MMREILTSRFFPSLFKKRLDFSNRVVLGLGSNLKNPLKILKNCFLYFKNHSKIGKIFSSPIYINPPFGYTKQPNFYNATI
ILKTSLSLRHFFALVFYIERRFGRQRKRDFKDAPRTLDIDIIAFNQVILRQNDLALPHPKWSERDSVLVPLALQQILFKK
GEW

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=31.1594202898551, Blast_Score=70, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19282; Mature: 19282

Theoretical pI: Translated: 11.10; Mature: 11.10

Prosite motif: PS00092 N6_MTASE ; PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMREILTSRFFPSLFKKRLDFSNRVVLGLGSNLKNPLKILKNCFLYFKNHSKIGKIFSSP
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHCCC
IYINPPFGYTKQPNFYNATIILKTSLSLRHFFALVFYIERRFGRQRKRDFKDAPRTLDID
EEECCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IIAFNQVILRQNDLALPHPKWSERDSVLVPLALQQILFKKGEW
EEEHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMREILTSRFFPSLFKKRLDFSNRVVLGLGSNLKNPLKILKNCFLYFKNHSKIGKIFSSP
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHCCC
IYINPPFGYTKQPNFYNATIILKTSLSLRHFFALVFYIERRFGRQRKRDFKDAPRTLDID
EEECCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IIAFNQVILRQNDLALPHPKWSERDSVLVPLALQQILFKKGEW
EEEHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]