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Identifier: 15645591

GI number: 15645591

Start: 1037710

End: 1039020

Strand: Reverse

Name: Not Available

Synonym: HP0976

Alternate gene names: 15645591

Gene position: 1039020-1037710 (Counterclockwise)

Preceding gene: 15645600

Following gene: 15645587

Centisome position: 62.3

GC content: 39.59

Gene sequence:

>1311_bases
ATGAATTTTCAAGAAAATTTAGCCGCTTTGGATTTGGAGTATCTTTGGCACCCTTGTTCGCAAATGCAAGAGCATCAAAA
TTTCCCCATTATCCCCATTAAAAAGGCTCAAGGGATTTACCTCTATGATTTTAATGATAACGCTTACATGGATTTGATCA
GCTCATGGTGGGTGAATCTTTTTGGGCATAATAACGCCTACATCAGCCAGCAACTCAAAAATCAAATTGATGATTTAGAG
CATGTCCTTTTGGCTTCTTTTAGCCATAAGCCCATTATCACGCTCTCTCAAAGGCTTTGCCAGCTCACTCATATGGATAA
ATGCTTTTATGCGGATAACGGCTCATCTTGTGTTGAAATCGCTTTGAAAATGAGCTATCACGCCCATTTTTTAAAGAATC
AAACGCGCCGCAAAAAGCTTTTTTTATCGCTCTCTAATTCCTATCATGGCGAGACTTTGGGAGCGTTAAGCGTGGGCGAT
GTGAAACTTTATAAAGACACTTACACCCCTTTATTGCTCAAAAATCTCACCACACCTGTGCCTAAAAACGACCATGAAAT
AGAAAATAGTTTGAACGCTTTAAAGCGTTTGTTAGACAAGCATAGTGAAGAAATTTGCGCTTTCATTGCAGAGCCTCTTT
TGCAATGCGCAGGGAATATGCATATTTATAGCGCAAGATATTTAAAACAAGCCGTTTTATTGTGCAAGCAAAAAAACATC
CACATTATTTTTGATGAAATCGCTACCGGGTTTGGGCGCACAGGGAGCATGTTTGCTTATGAACAATGCGAAATTAAGCC
GGATTTTTTATGCTTGTCTAAGGGGATTAGTGGGGGGTATTTGCCTTTAAGCGCACTATTAACCCATAATGAAATCTATA
ACCAATTTTACGCCCCCTATGAAGAAAATAAAGCGTTTTTGCATTCGCACAGCTACACAGGAAACGCTTTGGCATGCGCA
TGCGCGAACGCTACGCTGGATATTTTTGAAAAAGAAAATGTTATTGAAAAGAACAAGGCTTTAAGCGGGTTTATTTTTAA
TACGCTCCAAAACGCATTAAAACCCTTGATGGAGCAACAAGTGGTGTCTGATTTAAGGCATTTGGGCATGGTCTTTGCCT
TTGAAGTCTTTATTCAAACCAAAGAGCGTTTGAGTTTGGCGGTTTTTAAAAAAACTCTAAAAAAAGGCCTGTTATTACGC
CCTTTAAACAACACCATTTACCTCATGCCCCCTTACATTATCACGCATGAAGAAGTCAAAAAGGCGGTTGCGGGGCTAGT
GGAAATTCTTGATGAGTTAAGAAAAGGCTGA

Upstream 100 bases:

>100_bases
AAATATGAAATTCAGGTTTAAACAACCTTATAGTAAAATCAAATAACCTTATTTTAACCAAAGGTTATTAAAATTATCCT
TATTATAGAGAGTTTTTAAC

Downstream 100 bases:

>100_bases
AAGCGTTTTTAAAAATAAAATAGTAAAAAGCTTGAATTGGATCAAGCGATAGCTTTTTTCTGTCTGTTTGATTTCAAAAA
TCAAGTTTTTAACTTGATAT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNDNAYMDLISSWWVNLFGHNNAYISQQLKNQIDDLE
HVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCVEIALKMSYHAHFLKNQTRRKKLFLSLSNSYHGETLGALSVGD
VKLYKDTYTPLLLKNLTTPVPKNDHEIENSLNALKRLLDKHSEEICAFIAEPLLQCAGNMHIYSARYLKQAVLLCKQKNI
HIIFDEIATGFGRTGSMFAYEQCEIKPDFLCLSKGISGGYLPLSALLTHNEIYNQFYAPYEENKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKALSGFIFNTLQNALKPLMEQQVVSDLRHLGMVFAFEVFIQTKERLSLAVFKKTLKKGLLLR
PLNNTIYLMPPYIITHEEVKKAVAGLVEILDELRKG

Sequences:

>Translated_436_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNDNAYMDLISSWWVNLFGHNNAYISQQLKNQIDDLE
HVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCVEIALKMSYHAHFLKNQTRRKKLFLSLSNSYHGETLGALSVGD
VKLYKDTYTPLLLKNLTTPVPKNDHEIENSLNALKRLLDKHSEEICAFIAEPLLQCAGNMHIYSARYLKQAVLLCKQKNI
HIIFDEIATGFGRTGSMFAYEQCEIKPDFLCLSKGISGGYLPLSALLTHNEIYNQFYAPYEENKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKALSGFIFNTLQNALKPLMEQQVVSDLRHLGMVFAFEVFIQTKERLSLAVFKKTLKKGLLLR
PLNNTIYLMPPYIITHEEVKKAVAGLVEILDELRKG
>Mature_436_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNDNAYMDLISSWWVNLFGHNNAYISQQLKNQIDDLE
HVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCVEIALKMSYHAHFLKNQTRRKKLFLSLSNSYHGETLGALSVGD
VKLYKDTYTPLLLKNLTTPVPKNDHEIENSLNALKRLLDKHSEEICAFIAEPLLQCAGNMHIYSARYLKQAVLLCKQKNI
HIIFDEIATGFGRTGSMFAYEQCEIKPDFLCLSKGISGGYLPLSALLTHNEIYNQFYAPYEENKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKALSGFIFNTLQNALKPLMEQQVVSDLRHLGMVFAFEVFIQTKERLSLAVFKKTLKKGLLLR
PLNNTIYLMPPYIITHEEVKKAVAGLVEILDELRKG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=402, Percent_Identity=27.6119402985075, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI284507298, Length=311, Percent_Identity=28.6173633440514, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI37574042, Length=425, Percent_Identity=25.1764705882353, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI13994255, Length=375, Percent_Identity=24.8, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI226442705, Length=423, Percent_Identity=24.3498817966903, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI24119277, Length=446, Percent_Identity=24.6636771300448, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI226442709, Length=376, Percent_Identity=24.7340425531915, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1786991, Length=429, Percent_Identity=35.6643356643357, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1789759, Length=395, Percent_Identity=27.5949367088608, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI145693181, Length=401, Percent_Identity=27.1820448877805, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1789016, Length=418, Percent_Identity=25.3588516746411, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1788044, Length=402, Percent_Identity=26.6169154228856, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1787560, Length=414, Percent_Identity=27.0531400966184, Blast_Score=119, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=413, Percent_Identity=23.9709443099274, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=27.816091954023, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=310, Percent_Identity=25.8064516129032, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=436, Percent_Identity=22.4770642201835, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324386, Length=469, Percent_Identity=32.409381663113, Blast_Score=256, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6323470, Length=434, Percent_Identity=25.8064516129032, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=24.6913580246914, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=25.2427184466019, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI21356575, Length=427, Percent_Identity=25.0585480093677, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28574759, Length=435, Percent_Identity=26.2068965517241, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI161085790, Length=440, Percent_Identity=25.9090909090909, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49769; Mature: 49769

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNDNAYMDLISSWWVNL
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHH
FGHNNAYISQQLKNQIDDLEHVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCVEI
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHH
ALKMSYHAHFLKNQTRRKKLFLSLSNSYHGETLGALSVGDVKLYKDTYTPLLLKNLTTPV
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEECCEEECCEEEECCCCCHHHHHHCCCCC
PKNDHEIENSLNALKRLLDKHSEEICAFIAEPLLQCAGNMHIYSARYLKQAVLLCKQKNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCC
HIIFDEIATGFGRTGSMFAYEQCEIKPDFLCLSKGISGGYLPLSALLTHNEIYNQFYAPY
EEEHHHHHCCCCCCCCEEEEHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCH
EENKAFLHSHSYTGNALACACANATLDIFEKENVIEKNKALSGFIFNTLQNALKPLMEQQ
HCCCEEEEECCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSDLRHLGMVFAFEVFIQTKERLSLAVFKKTLKKGLLLRPLNNTIYLMPPYIITHEEVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCEEECHHHHH
KAVAGLVEILDELRKG
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNDNAYMDLISSWWVNL
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHH
FGHNNAYISQQLKNQIDDLEHVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCVEI
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHH
ALKMSYHAHFLKNQTRRKKLFLSLSNSYHGETLGALSVGDVKLYKDTYTPLLLKNLTTPV
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEECCEEECCEEEECCCCCHHHHHHCCCCC
PKNDHEIENSLNALKRLLDKHSEEICAFIAEPLLQCAGNMHIYSARYLKQAVLLCKQKNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCC
HIIFDEIATGFGRTGSMFAYEQCEIKPDFLCLSKGISGGYLPLSALLTHNEIYNQFYAPY
EEEHHHHHCCCCCCCCEEEEHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCH
EENKAFLHSHSYTGNALACACANATLDIFEKENVIEKNKALSGFIFNTLQNALKPLMEQQ
HCCCEEEEECCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSDLRHLGMVFAFEVFIQTKERLSLAVFKKTLKKGLLLRPLNNTIYLMPPYIITHEEVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCEEECHHHHH
KAVAGLVEILDELRKG
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]