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Identifier: 15645248

GI number: 15645248

Start: 670363

End: 671490

Strand: Reverse

Name: Not Available

Synonym: HP0624

Alternate gene names: 15645248

Gene position: 671490-670363 (Counterclockwise)

Preceding gene: 15645254

Following gene: 15645247

Centisome position: 40.26

GC content: 39.63

Gene sequence:

>1128_bases
ATGACCTTTGAGCCTTATCCTTTTGAACGATTAAGAGCCTTGCTTAAAGAGATCACCCCTAAAAAAAGGGGGCTAGATTT
AGGCATCGGCGAGCCGCAATTTGAAACGCCCAAATTCATTCAAGACGCTCTCAAAAACCACACCCATTCGCTCAATATCT
ACCCTAAAAGTGCGTTTGAAGAGAGTTTGAGAGCGGCTCAAAGGGGTTTTTTTAAACGCCGTTTTAAAATAGAATTGAAA
GAAAATGAACTCATCTCCACGCTAGGATCTAGGGAAGTGTTATTCAATTTCCCTAGTTTTGTTTTATTTGATTATCAAAA
CCCCACCATCGCCTACCCTAACCCCTTTTATCAAATCTATGAAGGAGCGGCTAAATTTATCAAAGCTAAAAGCCTTTTAA
TGCCCTTAACTAAAGAAAACGATTTCACGCCAAGCTTGAATGAAAAAGAGTTGCAAGAAGTGGATTTAGTGATCTTAAAT
TCCCCTAACAACCCCACTGGAAGAACCCTTTCTTTAGAAGAGCTGATTAGTTGGGTCAAACTCGCTTTAAAACATGATTT
TATTTTAATTAATGATGAATGCTATAGTGAAATTTATGAAAATACGCCTCCCCCTTCGCTTTTAGAAGCTTGCATGCTAG
CTGGTAATGAAGCGTTTAAAAATGTTTTGGTTATCCATTCGCTCTCCAAACGCTCTAGCGCTCCAGGGCTAAGGAGTGGT
TTTATCGCTGGGGATAGCCGTCTTTTAGAAAAATACAAAGCGTTTCGCGCTTATTTAGGCTATACGAGCGCTAATGCGAT
CCAAAAGGCTAGTGAAGCGGCTTGGCTAGATGATAGGCATGCAGAATTTTTCCGCAATATTTATGCGAATAATTTGAAAC
TGGCGCGAAAAATCTTTAAAAACACGCTCATTTATCCTTATAGTTTTTATGTGTATCTGCCCGTTCAAAACGGCGAAAAT
TTTGCCAAAACGCTTTATCAAAACGAAGGCATTATCACTTTACCGGCTTTGTATTTAGGGCGTAATCGTATCGGCGCTGA
CTATGTGCGTTTAGCCCTTGTCTATGACACCCCCCTTTTAGAAAAGCCTTTAGAAATCATAGAAACTTATCGAGAAAATC
ATGCTTGA

Upstream 100 bases:

>100_bases
AATTCTTATGCGCTATTATACTCTTTCTTGGTGGTTTCATACCATAACGCTTAAATTTTAGGTAAGATTAACTATTCCAT
TTTAAGATTAAAGTAGCCCT

Downstream 100 bases:

>100_bases
AACCCCAAAAGTTTTACTCAAAAACCTGCAAGATTGCAAGATCCATTTTATCGGTATAGGGGGGATTGGCATTTCAGGCT
TGGCCAAATACCTTAAAGCG

Product: hypothetical protein

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTFEPYPFERLRALLKEITPKKRGLDLGIGEPQFETPKFIQDALKNHTHSLNIYPKSAFEESLRAAQRGFFKRRFKIELK
ENELISTLGSREVLFNFPSFVLFDYQNPTIAYPNPFYQIYEGAAKFIKAKSLLMPLTKENDFTPSLNEKELQEVDLVILN
SPNNPTGRTLSLEELISWVKLALKHDFILINDECYSEIYENTPPPSLLEACMLAGNEAFKNVLVIHSLSKRSSAPGLRSG
FIAGDSRLLEKYKAFRAYLGYTSANAIQKASEAAWLDDRHAEFFRNIYANNLKLARKIFKNTLIYPYSFYVYLPVQNGEN
FAKTLYQNEGIITLPALYLGRNRIGADYVRLALVYDTPLLEKPLEIIETYRENHA

Sequences:

>Translated_375_residues
MTFEPYPFERLRALLKEITPKKRGLDLGIGEPQFETPKFIQDALKNHTHSLNIYPKSAFEESLRAAQRGFFKRRFKIELK
ENELISTLGSREVLFNFPSFVLFDYQNPTIAYPNPFYQIYEGAAKFIKAKSLLMPLTKENDFTPSLNEKELQEVDLVILN
SPNNPTGRTLSLEELISWVKLALKHDFILINDECYSEIYENTPPPSLLEACMLAGNEAFKNVLVIHSLSKRSSAPGLRSG
FIAGDSRLLEKYKAFRAYLGYTSANAIQKASEAAWLDDRHAEFFRNIYANNLKLARKIFKNTLIYPYSFYVYLPVQNGEN
FAKTLYQNEGIITLPALYLGRNRIGADYVRLALVYDTPLLEKPLEIIETYRENHA
>Mature_374_residues
TFEPYPFERLRALLKEITPKKRGLDLGIGEPQFETPKFIQDALKNHTHSLNIYPKSAFEESLRAAQRGFFKRRFKIELKE
NELISTLGSREVLFNFPSFVLFDYQNPTIAYPNPFYQIYEGAAKFIKAKSLLMPLTKENDFTPSLNEKELQEVDLVILNS
PNNPTGRTLSLEELISWVKLALKHDFILINDECYSEIYENTPPPSLLEACMLAGNEAFKNVLVIHSLSKRSSAPGLRSGF
IAGDSRLLEKYKAFRAYLGYTSANAIQKASEAAWLDDRHAEFFRNIYANNLKLARKIFKNTLIYPYSFYVYLPVQNGENF
AKTLYQNEGIITLPALYLGRNRIGADYVRLALVYDTPLLEKPLEIIETYRENHA

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=285, Percent_Identity=25.6140350877193, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI56713254, Length=285, Percent_Identity=25.6140350877193, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788722, Length=379, Percent_Identity=27.4406332453826, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71994476, Length=302, Percent_Identity=23.841059602649, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=302, Percent_Identity=23.841059602649, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=271, Percent_Identity=24.3542435424354, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 43125; Mature: 42994

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS01037 SBP_BACTERIAL_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFEPYPFERLRALLKEITPKKRGLDLGIGEPQFETPKFIQDALKNHTHSLNIYPKSAFE
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHH
ESLRAAQRGFFKRRFKIELKENELISTLGSREVLFNFPSFVLFDYQNPTIAYPNPFYQIY
HHHHHHHHHHHHHHEEEEECHHHHHHHCCCCCEEEECCCEEEEECCCCEEECCCHHHHHH
EGAAKFIKAKSLLMPLTKENDFTPSLNEKELQEVDLVILNSPNNPTGRTLSLEELISWVK
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCEEEHHHHHHHHH
LALKHDFILINDECYSEIYENTPPPSLLEACMLAGNEAFKNVLVIHSLSKRSSAPGLRSG
HHHHCCEEEECHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHEEEHHHCCCCCCCCCC
FIAGDSRLLEKYKAFRAYLGYTSANAIQKASEAAWLDDRHAEFFRNIYANNLKLARKIFK
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
NTLIYPYSFYVYLPVQNGENFAKTLYQNEGIITLPALYLGRNRIGADYVRLALVYDTPLL
CCEECEEEEEEEEEECCCCHHHHHHHCCCCEEEEHHHHHCCCCCCHHHHEEEEEECCCHH
EKPLEIIETYRENHA
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
TFEPYPFERLRALLKEITPKKRGLDLGIGEPQFETPKFIQDALKNHTHSLNIYPKSAFE
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHH
ESLRAAQRGFFKRRFKIELKENELISTLGSREVLFNFPSFVLFDYQNPTIAYPNPFYQIY
HHHHHHHHHHHHHHEEEEECHHHHHHHCCCCCEEEECCCEEEEECCCCEEECCCHHHHHH
EGAAKFIKAKSLLMPLTKENDFTPSLNEKELQEVDLVILNSPNNPTGRTLSLEELISWVK
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCEEEHHHHHHHHH
LALKHDFILINDECYSEIYENTPPPSLLEACMLAGNEAFKNVLVIHSLSKRSSAPGLRSG
HHHHCCEEEECHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHEEEHHHCCCCCCCCCC
FIAGDSRLLEKYKAFRAYLGYTSANAIQKASEAAWLDDRHAEFFRNIYANNLKLARKIFK
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
NTLIYPYSFYVYLPVQNGENFAKTLYQNEGIITLPALYLGRNRIGADYVRLALVYDTPLL
CCEECEEEEEEEEEECCCCHHHHHHHCCCCEEEEHHHHHCCCCCCHHHHEEEEEECCCHH
EKPLEIIETYRENHA
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA