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Identifier: 15645254

GI number: 15645254

Start: 677214

End: 677798

Strand: Reverse

Name: Not Available

Synonym: HP0630

Alternate gene names: 15645254

Gene position: 677798-677214 (Counterclockwise)

Preceding gene: 15645260

Following gene: 15645248

Centisome position: 40.64

GC content: 44.96

Gene sequence:

>585_bases
ATGAAAAAAGTACTCATCATTAACGGGGCCAAAGCGTTCGGGAGCTCTGGAGGGAAACTCAATGAAACCTTGACTGACCA
TGCAAAAAAGACTCTAGAGTCTTTGGGGCTAGAAGTGGATACTACGATCGTGGATAAAGGCTATGAACATGCTCAAGAAG
TGGAGAAAGTCTTTAGCGCTGATGCGACGATTTGGCAAATGCCTGGCTGGTGGATGGGAGAGCCTTGGATTGTGAAAAAA
TACATTGATGAAGTCTTTAGCGTAGGGCATGGAAAGCTTTATGCTAGCGATGGCAGAAGCTCGCAAAACCCCACTAAAAA
CTACGGGAAAGGGGGCTTGATGCAAGGCAAAAAATACATGTTGAGCTTGACTTGGAACGCTCCCATTGAAGCCTTTAATG
ATCCTAGTGAATTTTTTGAAGGGGTGGGTGTGGATGTTGTGTATTTGCATTTGCATAAAGCGTTCCAATTTTTAGGGCTT
TCAGCGTTGCCCACTTTTATTTGCAACGATGTGGTGAAAAACCCCCAAGTGGAGCAGTATCTTAACTCTCTCACCACGCA
TTTGCGCCAAGCTTTTGGCAAGTGA

Upstream 100 bases:

>100_bases
ATTGATTGTTTTTTAGTTTTTATTGAGATTGAGGGAATTTCTTTAATATTAAGTTTCATTTGGATAGAATGCCACCCTAT
TTTATTAGAAAAGGAACAAA

Downstream 100 bases:

>100_bases
TTTTAAAATTTTTTTAACCCCCCCATTTCTTTGGGGGGGCTTGTTTATTCCACAATAAAGTCTCTGGGATTGAGATCGCA
GCCTAAGATAAGATCCCTAA

Product: modulator of drug activity (mda66)

Products: NADP; a reduced quinone; reduced acceptor [C]

Alternate protein names: NA

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MKKVLIINGAKAFGSSGGKLNETLTDHAKKTLESLGLEVDTTIVDKGYEHAQEVEKVFSADATIWQMPGWWMGEPWIVKK
YIDEVFSVGHGKLYASDGRSSQNPTKNYGKGGLMQGKKYMLSLTWNAPIEAFNDPSEFFEGVGVDVVYLHLHKAFQFLGL
SALPTFICNDVVKNPQVEQYLNSLTTHLRQAFGK

Sequences:

>Translated_194_residues
MKKVLIINGAKAFGSSGGKLNETLTDHAKKTLESLGLEVDTTIVDKGYEHAQEVEKVFSADATIWQMPGWWMGEPWIVKK
YIDEVFSVGHGKLYASDGRSSQNPTKNYGKGGLMQGKKYMLSLTWNAPIEAFNDPSEFFEGVGVDVVYLHLHKAFQFLGL
SALPTFICNDVVKNPQVEQYLNSLTTHLRQAFGK
>Mature_194_residues
MKKVLIINGAKAFGSSGGKLNETLTDHAKKTLESLGLEVDTTIVDKGYEHAQEVEKVFSADATIWQMPGWWMGEPWIVKK
YIDEVFSVGHGKLYASDGRSSQNPTKNYGKGGLMQGKKYMLSLTWNAPIEAFNDPSEFFEGVGVDVVYLHLHKAFQFLGL
SALPTFICNDVVKNPQVEQYLNSLTTHLRQAFGK

Specific function: Unknown

COG id: COG2249

COG function: function code R; Putative NADPH-quinone reductase (modulator of drug activity B)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli madB and S.pombe SPAC5H10.05c [H]

Homologues:

Organism=Escherichia coli, GI1789406, Length=193, Percent_Identity=59.5854922279793, Blast_Score=243, Evalue=8e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003680 [H]

Pfam domain/function: PF02525 Flavodoxin_2 [H]

EC number: NA

Molecular weight: Translated: 21605; Mature: 21605

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIINGAKAFGSSGGKLNETLTDHAKKTLESLGLEVDTTIVDKGYEHAQEVEKVFSA
CCEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHC
DATIWQMPGWWMGEPWIVKKYIDEVFSVGHGKLYASDGRSSQNPTKNYGKGGLMQGKKYM
CCEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEE
LSLTWNAPIEAFNDPSEFFEGVGVDVVYLHLHKAFQFLGLSALPTFICNDVVKNPQVEQY
EEEEECCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LNSLTTHLRQAFGK
HHHHHHHHHHHHCC
>Mature Secondary Structure
MKKVLIINGAKAFGSSGGKLNETLTDHAKKTLESLGLEVDTTIVDKGYEHAQEVEKVFSA
CCEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHC
DATIWQMPGWWMGEPWIVKKYIDEVFSVGHGKLYASDGRSSQNPTKNYGKGGLMQGKKYM
CCEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEE
LSLTWNAPIEAFNDPSEFFEGVGVDVVYLHLHKAFQFLGLSALPTFICNDVVKNPQVEQY
EEEEECCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LNSLTTHLRQAFGK
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH; a quinone; Acceptor; NADPH [C]

Specific reaction: NADPH + a quinone = NADP + a reduced quinone Acceptor + NADPH = reduced acceptor + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]