Click here to switch to the map view.

The map label for this gene is murC

Identifier: 15645247

GI number: 15645247

Start: 669021

End: 670370

Strand: Reverse

Name: murC

Synonym: HP0623

Alternate gene names: 15645247

Gene position: 670370-669021 (Counterclockwise)

Preceding gene: 15645248

Following gene: 15645246

Centisome position: 40.19

GC content: 37.85

Gene sequence:

>1350_bases
ATGCTTGAAACCCCAAAAGTTTTACTCAAAAACCTGCAAGATTGCAAGATCCATTTTATCGGTATAGGGGGGATTGGCAT
TTCAGGCTTGGCCAAATACCTTAAAGCGCAAGGGGCTACAATCAGCGGCTCTGATATTGCCATAAGCCCTAGCGTTAAGT
ATTTGAAAGCTTTAGGCGTAGAAATTAATATCCCGCATGATCCAAAAGCGATCAACAATCAAGATGTCATTATCCATTCA
GCCATTATTAAAGAAGACAATAAAGAAATACAAAGGGCTAAGGAATTAGAAATCCCTATTTTGTCTCGTAAAGACGCTTT
GTATTCTATCCTTAAAGACAAGCGCGTTTTTAGCGTGTGTGGGGCTCATGGAAAGAGCAGTATCACGGCCATGTTGAGCG
CGATTTGCCCATCGTTTGGAGCGATTATTGGGGCGCATTCTAAAGAATTTGATTCCAATGTGCGAGAGAGCGCGAATGAT
AGCTTAGTTTTTGAAGCCGATGAGAGCGATTCGAGTTTTTTATTTTCCAACCCTTATGCTGCGATTGTGCCTAACACAGA
GCCAGAACATTTGGAGCATTATGGCCACGATTTAGAGCGTTTTTTCTTTGCTTATGAGTATTTTTTAGACCATGCTCAAA
AAAGAGTGATCTATAAAGAAGATCCTTTTTTAAAAAACTATTCTAAAAACGCTATTGTTTTAGAAAAAAAAGACATTTAT
AATATCCAATACATTTTAAAAGACGGCGAGCCTTACACTTCATTTGAATTGAAAGATTTGGGGGCTTTTTTGGTGTGGGG
GTTAGGCGAACATAACGCTACGAATGCGAGTTTGGCGATTTTAAGCGCTTTAGATGAATTGCATTTAGAAGAAATTAGAA
ATAATTTATTGAATTTCAAAGGCATTAAAAAACGCTTTGATATTTTGCAAAAAAACGCGCTCATCCTCATTGATGATTAC
GCCCACCACCCCACTGAAATCAGTGCCACTTTAAAAAGCGCTAGGATTTATGCTAACTTATTGAACACGCAAGAAAAAAT
TATAGTGATCTGGCAAGCGCACAAATATTCTCGCTTAATGGATAATTTAGAAGAGTTTAAAAAATGTTTTTCAGAGCATT
GCGACAGATTGATCATTTTACCCGTTTATAGCGCGAGTGAAGTCAAAAGAGACATTGATTTGAAAGCCCATTTTAAACAT
TATAACCCCACCTTTATAGACAGGGTGCGTAAAAAGGGGGATTTTTTAGAGCTCTTAGTCAATGATAATGTGGTAGAAAC
GATTGAAAAAGGCTTTGTGATAGGTTTTGGAGCGGGGGATATTACCTATCAATTAAGAGGCGAAATGTAA

Upstream 100 bases:

>100_bases
CGTAATCGTATCGGCGCTGACTATGTGCGTTTAGCCCTTGTCTATGACACCCCCCTTTTAGAAAAGCCTTTAGAAATCAT
AGAAACTTATCGAGAAAATC

Downstream 100 bases:

>100_bases
TGGGTGCAGTGGTTGTTTTATTTTTAACGCTGGTTTTATTGTTTTTAGTTTTAAGGGATTTTGGTTTAGCAAGCCCCAAA
CAAAAGATTTTAGCTTTTTT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MLETPKVLLKNLQDCKIHFIGIGGIGISGLAKYLKAQGATISGSDIAISPSVKYLKALGVEINIPHDPKAINNQDVIIHS
AIIKEDNKEIQRAKELEIPILSRKDALYSILKDKRVFSVCGAHGKSSITAMLSAICPSFGAIIGAHSKEFDSNVRESAND
SLVFEADESDSSFLFSNPYAAIVPNTEPEHLEHYGHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSKNAIVLEKKDIY
NIQYILKDGEPYTSFELKDLGAFLVWGLGEHNATNASLAILSALDELHLEEIRNNLLNFKGIKKRFDILQKNALILIDDY
AHHPTEISATLKSARIYANLLNTQEKIIVIWQAHKYSRLMDNLEEFKKCFSEHCDRLIILPVYSASEVKRDIDLKAHFKH
YNPTFIDRVRKKGDFLELLVNDNVVETIEKGFVIGFGAGDITYQLRGEM

Sequences:

>Translated_449_residues
MLETPKVLLKNLQDCKIHFIGIGGIGISGLAKYLKAQGATISGSDIAISPSVKYLKALGVEINIPHDPKAINNQDVIIHS
AIIKEDNKEIQRAKELEIPILSRKDALYSILKDKRVFSVCGAHGKSSITAMLSAICPSFGAIIGAHSKEFDSNVRESAND
SLVFEADESDSSFLFSNPYAAIVPNTEPEHLEHYGHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSKNAIVLEKKDIY
NIQYILKDGEPYTSFELKDLGAFLVWGLGEHNATNASLAILSALDELHLEEIRNNLLNFKGIKKRFDILQKNALILIDDY
AHHPTEISATLKSARIYANLLNTQEKIIVIWQAHKYSRLMDNLEEFKKCFSEHCDRLIILPVYSASEVKRDIDLKAHFKH
YNPTFIDRVRKKGDFLELLVNDNVVETIEKGFVIGFGAGDITYQLRGEM
>Mature_449_residues
MLETPKVLLKNLQDCKIHFIGIGGIGISGLAKYLKAQGATISGSDIAISPSVKYLKALGVEINIPHDPKAINNQDVIIHS
AIIKEDNKEIQRAKELEIPILSRKDALYSILKDKRVFSVCGAHGKSSITAMLSAICPSFGAIIGAHSKEFDSNVRESAND
SLVFEADESDSSFLFSNPYAAIVPNTEPEHLEHYGHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSKNAIVLEKKDIY
NIQYILKDGEPYTSFELKDLGAFLVWGLGEHNATNASLAILSALDELHLEEIRNNLLNFKGIKKRFDILQKNALILIDDY
AHHPTEISATLKSARIYANLLNTQEKIIVIWQAHKYSRLMDNLEEFKKCFSEHCDRLIILPVYSASEVKRDIDLKAHFKH
YNPTFIDRVRKKGDFLELLVNDNVVETIEKGFVIGFGAGDITYQLRGEM

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=404, Percent_Identity=31.6831683168317, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1790680, Length=348, Percent_Identity=26.7241379310345, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 50794; Mature: 50794

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLETPKVLLKNLQDCKIHFIGIGGIGISGLAKYLKAQGATISGSDIAISPSVKYLKALGV
CCCCHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCEEECCCHHHHHHCCC
EINIPHDPKAINNQDVIIHSAIIKEDNKEIQRAKELEIPILSRKDALYSILKDKRVFSVC
EEECCCCCCCCCCCCEEEEEEHHCCCCHHHHHHHHCCCCEECCHHHHHHHHHCCHHHHHH
GAHGKSSITAMLSAICPSFGAIIGAHSKEFDSNVRESANDSLVFEADESDSSFLFSNPYA
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEECCEE
AIVPNTEPEHLEHYGHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSKNAIVLEKKDIY
EEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCEEEEECCCCE
NIQYILKDGEPYTSFELKDLGAFLVWGLGEHNATNASLAILSALDELHLEEIRNNLLNFK
EEEEEEECCCCCCCEEHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHH
GIKKRFDILQKNALILIDDYAHHPTEISATLKSARIYANLLNTQEKIIVIWQAHKYSRLM
HHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHH
DNLEEFKKCFSEHCDRLIILPVYSASEVKRDIDLKAHFKHYNPTFIDRVRKKGDFLELLV
HHHHHHHHHHHHHCCEEEEEEECCHHHHHHCCCCEEEECCCCCHHHHHHHCCCCEEEEEE
NDNVVETIEKGFVIGFGAGDITYQLRGEM
CCCHHHHHHCCCEEEECCCCEEEEEECCC
>Mature Secondary Structure
MLETPKVLLKNLQDCKIHFIGIGGIGISGLAKYLKAQGATISGSDIAISPSVKYLKALGV
CCCCHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCEEECCCHHHHHHCCC
EINIPHDPKAINNQDVIIHSAIIKEDNKEIQRAKELEIPILSRKDALYSILKDKRVFSVC
EEECCCCCCCCCCCCEEEEEEHHCCCCHHHHHHHHCCCCEECCHHHHHHHHHCCHHHHHH
GAHGKSSITAMLSAICPSFGAIIGAHSKEFDSNVRESANDSLVFEADESDSSFLFSNPYA
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEECCEE
AIVPNTEPEHLEHYGHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSKNAIVLEKKDIY
EEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCEEEEECCCCE
NIQYILKDGEPYTSFELKDLGAFLVWGLGEHNATNASLAILSALDELHLEEIRNNLLNFK
EEEEEEECCCCCCCEEHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHH
GIKKRFDILQKNALILIDDYAHHPTEISATLKSARIYANLLNTQEKIIVIWQAHKYSRLM
HHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHH
DNLEEFKKCFSEHCDRLIILPVYSASEVKRDIDLKAHFKHYNPTFIDRVRKKGDFLELLV
HHHHHHHHHHHHHCCEEEEEEECCHHHHHHCCCCEEEECCCCCHHHHHHHCCCCEEEEEE
NDNVVETIEKGFVIGFGAGDITYQLRGEM
CCCHHHHHHCCCEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA