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The map label for this gene is aroA

Identifier: 15618947

GI number: 15618947

Start: 1192662

End: 1193999

Strand: Reverse

Name: aroA

Synonym: CPn1039

Alternate gene names: 15618947

Gene position: 1193999-1192662 (Counterclockwise)

Preceding gene: 15618948

Following gene: 15618946

Centisome position: 97.05

GC content: 43.5

Gene sequence:

>1338_bases
ATGCTTACTTATAAAGTTTCACCTTCTTCTGTGTATGGGAACGCCTTCATTCCTTCCTCAAAGTCCCATACTCTAAGAGC
CATTCTATGGGCTTCTGTTGCCGAGGGAAAATCTATAATTTATAATTATTTAGATTCTCCTGATACTGAGGCTATGATTT
GTGCTTGCAAGCAGATGGGAGCTTCTATAAAGAAATTCCCTCAAATTTTGGAAATTGTGGGCAATCCCTTGGCTATATTT
CCAAAATATACTCTCATAGACGCTGGAAATTCTGGTATCGTGTTGCGTTTTATGACTGCCCTTGCCTGTGTCTTCTCTAA
AGAAATCACCGTCACAGGATCGTCACAGTTGCAACGGCGTCCTATGGCCCCTCTACTTCAAGCCTTGAGAAACTTTGGAG
CTTCGTTTCATTTCTCTTCAGATAAAAGCGTTCTACCTTTCACAATGTCAGGACCGTTACGCTCTGCTTATAGCGATGTT
GAAGGTAGTGATTCTCAATTTGCCTCAGCACTAGCCGTAGCATGTTCGTTAGCCGAAGGTCCCTGTTCCTTTACTATCAT
AGAACCGAAAGAGCGTCCATGGTTTGATCTTAGTCTCTGGTGGTTAGAGAAACTCCATCTTCCCTATTCTTGTTCTGATA
CTACCTATTCTTTCCCGGGAAGTTCACATCCTCAAGGTTTCTCTTACCACGTAACTGGTGATTTCAGCAGCGCAGCTTTC
ATTGCTGCAGCTGCTCTACTTTCAAAATCACTCCAACCGATACGTCTTCGTAACTTGGACATCTTAGATATCCAAGGAGA
CAAAATCTTTTTTTCTCTCATGCAAAACTTAGGAGCCTCTATACAGTACGACAACGAAGAGATCTTAGTATTCCCTTCGT
CGTTCTCTGGTGGCTCTATAGATATGGATGGTTGTATCGATGCTCTTCCCATTCTCACAGTCCTTTGTTGTTTTGCAGAT
TCCCCTTCGCACCTCTACAATGCACGCAGTGCTAAAGACAAGGAAAGCGATCGCATTCTTGCAATCACCGAAGAACTACA
GAAAATGGGAGCATGCATACAGCCAACTCATGATGGCTTACTGGTGAATCCCAGTCCCCTCTACGGTGCTGTTTTGGACT
CTCACGATGATCATAGAATTGCCATGGCCTTGACCATAGCAGCTCTATATGCTTCTGGCGATAGTCGTATTCACAACACT
GCGTGCGTTAGGAAAACCTTTCCTAACTTCGTTCAGACTCTAAATATAATGGAAGCTCGAATTGAGGAATGTCATGACAA
TTATTCTATGTGGTCTACCCACAAGCGGAAAGTCTTCGCTCGGGAAAGCTTTGGCTAA

Upstream 100 bases:

>100_bases
GATCCTTCCTCGACTTTTACAAAGTTCTAGAATTTTTCTTAGACGACAAATCAGAAGTCAGGCAAATTACCTAAAAAAAA
AGAGATAAGTTTGCTTTACA

Downstream 100 bases:

>100_bases
ATTTCTAAACCTTCCTTTTTATGATCTTGATGATTTAATTGTAAGCAACTACAGCAGTGCACTATACTCCTCATCTGCAG
AGATCTATAAAGCTTATGGG

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MLTYKVSPSSVYGNAFIPSSKSHTLRAILWASVAEGKSIIYNYLDSPDTEAMICACKQMGASIKKFPQILEIVGNPLAIF
PKYTLIDAGNSGIVLRFMTALACVFSKEITVTGSSQLQRRPMAPLLQALRNFGASFHFSSDKSVLPFTMSGPLRSAYSDV
EGSDSQFASALAVACSLAEGPCSFTIIEPKERPWFDLSLWWLEKLHLPYSCSDTTYSFPGSSHPQGFSYHVTGDFSSAAF
IAAAALLSKSLQPIRLRNLDILDIQGDKIFFSLMQNLGASIQYDNEEILVFPSSFSGGSIDMDGCIDALPILTVLCCFAD
SPSHLYNARSAKDKESDRILAITEELQKMGACIQPTHDGLLVNPSPLYGAVLDSHDDHRIAMALTIAALYASGDSRIHNT
ACVRKTFPNFVQTLNIMEARIEECHDNYSMWSTHKRKVFARESFG

Sequences:

>Translated_445_residues
MLTYKVSPSSVYGNAFIPSSKSHTLRAILWASVAEGKSIIYNYLDSPDTEAMICACKQMGASIKKFPQILEIVGNPLAIF
PKYTLIDAGNSGIVLRFMTALACVFSKEITVTGSSQLQRRPMAPLLQALRNFGASFHFSSDKSVLPFTMSGPLRSAYSDV
EGSDSQFASALAVACSLAEGPCSFTIIEPKERPWFDLSLWWLEKLHLPYSCSDTTYSFPGSSHPQGFSYHVTGDFSSAAF
IAAAALLSKSLQPIRLRNLDILDIQGDKIFFSLMQNLGASIQYDNEEILVFPSSFSGGSIDMDGCIDALPILTVLCCFAD
SPSHLYNARSAKDKESDRILAITEELQKMGACIQPTHDGLLVNPSPLYGAVLDSHDDHRIAMALTIAALYASGDSRIHNT
ACVRKTFPNFVQTLNIMEARIEECHDNYSMWSTHKRKVFARESFG
>Mature_445_residues
MLTYKVSPSSVYGNAFIPSSKSHTLRAILWASVAEGKSIIYNYLDSPDTEAMICACKQMGASIKKFPQILEIVGNPLAIF
PKYTLIDAGNSGIVLRFMTALACVFSKEITVTGSSQLQRRPMAPLLQALRNFGASFHFSSDKSVLPFTMSGPLRSAYSDV
EGSDSQFASALAVACSLAEGPCSFTIIEPKERPWFDLSLWWLEKLHLPYSCSDTTYSFPGSSHPQGFSYHVTGDFSSAAF
IAAAALLSKSLQPIRLRNLDILDIQGDKIFFSLMQNLGASIQYDNEEILVFPSSFSGGSIDMDGCIDALPILTVLCCFAD
SPSHLYNARSAKDKESDRILAITEELQKMGACIQPTHDGLLVNPSPLYGAVLDSHDDHRIAMALTIAALYASGDSRIHNT
ACVRKTFPNFVQTLNIMEARIEECHDNYSMWSTHKRKVFARESFG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=430, Percent_Identity=29.5348837209302, Blast_Score=154, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6320332, Length=455, Percent_Identity=25.4945054945055, Blast_Score=113, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_CHLPN (Q9Z6M0)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   C72004
- PIR:   D86620
- RefSeq:   NP_225233.1
- RefSeq:   NP_301094.1
- RefSeq:   NP_445352.1
- RefSeq:   NP_877351.1
- ProteinModelPortal:   Q9Z6M0
- GeneID:   1467758
- GeneID:   894689
- GeneID:   919800
- GeneID:   962755
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0813
- KEGG:   cpn:CPn1039
- KEGG:   cpt:CpB1079
- TIGR:   CP_0813
- HOGENOM:   HBG646626
- OMA:   HRMATAG
- PhylomeDB:   Q9Z6M0
- ProtClustDB:   PRK02427
- BioCyc:   CPNE115711:CP_0813-MONOMER
- BioCyc:   CPNE115713:CPN1039-MONOMER
- BioCyc:   CPNE138677:CPJ1039-MONOMER
- BioCyc:   CPNE182082:CPB1079-MONOMER
- BRENDA:   2.5.1.19
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 48848; Mature: 48848

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYKVSPSSVYGNAFIPSSKSHTLRAILWASVAEGKSIIYNYLDSPDTEAMICACKQMG
CEEEEECCCCCCCCEECCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHC
ASIKKFPQILEIVGNPLAIFPKYTLIDAGNSGIVLRFMTALACVFSKEITVTGSSQLQRR
CHHHHHHHHHHHHCCCEEECCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCHHHHCC
PMAPLLQALRNFGASFHFSSDKSVLPFTMSGPLRSAYSDVEGSDSQFASALAVACSLAEG
CHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCC
PCSFTIIEPKERPWFDLSLWWLEKLHLPYSCSDTTYSFPGSSHPQGFSYHVTGDFSSAAF
CEEEEEECCCCCCCEEEHHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEEECCCCHHHH
IAAAALLSKSLQPIRLRNLDILDIQGDKIFFSLMQNLGASIQYDNEEILVFPSSFSGGSI
HHHHHHHHCCCCCEEECCCEEEEECCCHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCC
DMDGCIDALPILTVLCCFADSPSHLYNARSAKDKESDRILAITEELQKMGACIQPTHDGL
CHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCCCCCCCCCE
LVNPSPLYGAVLDSHDDHRIAMALTIAALYASGDSRIHNTACVRKTFPNFVQTLNIMEAR
EECCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IEECHDNYSMWSTHKRKVFARESFG
HHHHHCCCHHHHHHHHHEEECCCCC
>Mature Secondary Structure
MLTYKVSPSSVYGNAFIPSSKSHTLRAILWASVAEGKSIIYNYLDSPDTEAMICACKQMG
CEEEEECCCCCCCCEECCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHC
ASIKKFPQILEIVGNPLAIFPKYTLIDAGNSGIVLRFMTALACVFSKEITVTGSSQLQRR
CHHHHHHHHHHHHCCCEEECCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCHHHHCC
PMAPLLQALRNFGASFHFSSDKSVLPFTMSGPLRSAYSDVEGSDSQFASALAVACSLAEG
CHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCC
PCSFTIIEPKERPWFDLSLWWLEKLHLPYSCSDTTYSFPGSSHPQGFSYHVTGDFSSAAF
CEEEEEECCCCCCCEEEHHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEEECCCCHHHH
IAAAALLSKSLQPIRLRNLDILDIQGDKIFFSLMQNLGASIQYDNEEILVFPSSFSGGSI
HHHHHHHHCCCCCEEECCCEEEEECCCHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCC
DMDGCIDALPILTVLCCFADSPSHLYNARSAKDKESDRILAITEELQKMGACIQPTHDGL
CHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCCCCCCCCCE
LVNPSPLYGAVLDSHDDHRIAMALTIAALYASGDSRIHNTACVRKTFPNFVQTLNIMEAR
EECCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IEECHDNYSMWSTHKRKVFARESFG
HHHHHCCCHHHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362