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Identifier: 15618941

GI number: 15618941

Start: 1186184

End: 1187500

Strand: Reverse

Name: Not Available

Synonym: CPn1033

Alternate gene names: 15618941

Gene position: 1187500-1186184 (Counterclockwise)

Preceding gene: 15618942

Following gene: 15618940

Centisome position: 96.53

GC content: 42.75

Gene sequence:

>1317_bases
ATGATATCCTTTCGTTTTCTTTTACTTTCAGGACTCTGCGCTCTTGGAATTTCCTCTTATGCCGAAACTCCTAAAGAAAC
GACGGGCCACTACCATCGTTATAAAGCAAGAATTCAAAAAAAACATCCCGAGTCCATAAAAGAAAGCGCCCCTTCGGAAA
CTCCACATCATAACAGCCTTCTCTCTCCAGTTACTAATATCTTCTGTTCACATCCTTGGAAGGATGGCATTTCCGTATCC
AACCTATTAACATCTGTAGAAAAAGCGACAAATACTCAGATATCCTTGGACTTCAGTATTCTTCCCCAGTGGTTTTACCC
TCACAAAGCTCTTGGCCAAACGCAAGCCCTAGAGATTCCTTCGTGGCAGTTCTACTTCAGTCCTAGCACTACCTGGACTC
TTTATGATTCTCCAACAGCAGGTCAAGGAATCGTAGACTTTAGCTATACGTTGATACATTACTGGCAAACTAACGGTGTT
GACGCCAATCAAGCCGCGGGAACCGCTTCCAGTATGAATGATTACTCTAATAGAGAAAATAACCTAGCACAGCTTACCTT
CTCTCAGACTTTCCCTGGAGACTTTTTGACCCTAGCTATAGGACAATACAGCCTCTATGCTATAGACGGCACGCTTTACG
ATAATGATCAGTACTCTGGGTTTATTAGCTACGCCTTATCACAAAACGCAAGTGCTACCTACTCATTGGGAAGTACAGGT
GCTTATCTGCAGTTCACTCCAAATTCTGAAATCAAGGTTCAACTAGGTTTTCAAGATTCCTATAATATTGATGGAACCAA
CTTTTCGATTTATAATCTGACAAAAAGCAAATACAACTTTTACGGCTACGCCTCCTGGACTCCAAAACCTTCGTGTGGAG
ATGGACAGTACTCTGTATTGCTCTATAGCACACGCAAAGTTCCTGAGCAAAACTCCCAGGTCACAGGATGGTCCCTGAAT
GCTGCTCAACATATTCATGAAAAGCTCTATCTATTCGGAAGAATCAACGGAGCTACGGGAACAGCACTCCCCATAAACCG
TTCGTATGTTTTAGGTCTTGTCTCTGAGAATCCCTTAAACCGCCACTCTCAAGATCTTCTTGGCATAGGATTTGCTACAA
ATAAGGTAAATGCTAAAGCGATTTCCAATGTGAACAAGCTACGACGTTATGAGTCTGTTATGGAAGCTTTCGCTACTATT
GGCTTTGGACCTTATATATCTCTAACTCCAGATTTCCAACTCTATATCCACCCAGCGTTACGCCCAGAGAGGAGAACCTC
TCAAGTGTATGGCCTGCGTGCAAATCTTTCCTTATAA

Upstream 100 bases:

>100_bases
CATAGCATTCCTCCCCTCAGAAGAAAATTTTTGCTACATAAAAACAATTCTTTTTTTTAGAGTCAAAAAAAAACACTATG
CCTTCTTCTACGGGGAATTC

Downstream 100 bases:

>100_bases
CAAAACCACACCAATATTATTTAGGAGTAACTTATGGCTTACGGAACTCGTTATCCCACGCTAGCATTCCATACAGGGGG
CATTGGTGAATCTGATGACG

Product: hypothetical protein

Products: NA

Alternate protein names: Outer membrane protein AaxA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MISFRFLLLSGLCALGISSYAETPKETTGHYHRYKARIQKKHPESIKESAPSETPHHNSLLSPVTNIFCSHPWKDGISVS
NLLTSVEKATNTQISLDFSILPQWFYPHKALGQTQALEIPSWQFYFSPSTTWTLYDSPTAGQGIVDFSYTLIHYWQTNGV
DANQAAGTASSMNDYSNRENNLAQLTFSQTFPGDFLTLAIGQYSLYAIDGTLYDNDQYSGFISYALSQNASATYSLGSTG
AYLQFTPNSEIKVQLGFQDSYNIDGTNFSIYNLTKSKYNFYGYASWTPKPSCGDGQYSVLLYSTRKVPEQNSQVTGWSLN
AAQHIHEKLYLFGRINGATGTALPINRSYVLGLVSENPLNRHSQDLLGIGFATNKVNAKAISNVNKLRRYESVMEAFATI
GFGPYISLTPDFQLYIHPALRPERRTSQVYGLRANLSL

Sequences:

>Translated_438_residues
MISFRFLLLSGLCALGISSYAETPKETTGHYHRYKARIQKKHPESIKESAPSETPHHNSLLSPVTNIFCSHPWKDGISVS
NLLTSVEKATNTQISLDFSILPQWFYPHKALGQTQALEIPSWQFYFSPSTTWTLYDSPTAGQGIVDFSYTLIHYWQTNGV
DANQAAGTASSMNDYSNRENNLAQLTFSQTFPGDFLTLAIGQYSLYAIDGTLYDNDQYSGFISYALSQNASATYSLGSTG
AYLQFTPNSEIKVQLGFQDSYNIDGTNFSIYNLTKSKYNFYGYASWTPKPSCGDGQYSVLLYSTRKVPEQNSQVTGWSLN
AAQHIHEKLYLFGRINGATGTALPINRSYVLGLVSENPLNRHSQDLLGIGFATNKVNAKAISNVNKLRRYESVMEAFATI
GFGPYISLTPDFQLYIHPALRPERRTSQVYGLRANLSL
>Mature_438_residues
MISFRFLLLSGLCALGISSYAETPKETTGHYHRYKARIQKKHPESIKESAPSETPHHNSLLSPVTNIFCSHPWKDGISVS
NLLTSVEKATNTQISLDFSILPQWFYPHKALGQTQALEIPSWQFYFSPSTTWTLYDSPTAGQGIVDFSYTLIHYWQTNGV
DANQAAGTASSMNDYSNRENNLAQLTFSQTFPGDFLTLAIGQYSLYAIDGTLYDNDQYSGFISYALSQNASATYSLGSTG
AYLQFTPNSEIKVQLGFQDSYNIDGTNFSIYNLTKSKYNFYGYASWTPKPSCGDGQYSVLLYSTRKVPEQNSQVTGWSLN
AAQHIHEKLYLFGRINGATGTALPINRSYVLGLVSENPLNRHSQDLLGIGFATNKVNAKAISNVNKLRRYESVMEAFATI
GFGPYISLTPDFQLYIHPALRPERRTSQVYGLRANLSL

Specific function: Facilitates L-arginine uptake, as part of the AaxABC system. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oprB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AAXA_CHLPN (Q9Z6M6)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   C72006
- PIR:   F86619
- RefSeq:   NP_225227.1
- RefSeq:   NP_301088.1
- RefSeq:   NP_445358.1
- RefSeq:   NP_877345.1
- GeneID:   1467752
- GeneID:   895500
- GeneID:   919807
- GeneID:   962774
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0819
- KEGG:   cpj:CPj1033
- KEGG:   cpn:CPn1033
- KEGG:   cpt:CpB1073
- TIGR:   CP_0819
- HOGENOM:   HBG414055
- OMA:   TLYDNDQ
- ProtClustDB:   CLSK871338
- BioCyc:   CPNE115711:CP_0819-MONOMER
- BioCyc:   CPNE115713:CPN1033-MONOMER
- BioCyc:   CPNE138677:CPJ1033-MONOMER
- GO:   GO:0009405
- InterPro:   IPR007049

Pfam domain/function: PF04966 OprB

EC number: NA

Molecular weight: Translated: 48843; Mature: 48843

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISFRFLLLSGLCALGISSYAETPKETTGHYHRYKARIQKKHPESIKESAPSETPHHNSL
CCEEHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHH
LSPVTNIFCSHPWKDGISVSNLLTSVEKATNTQISLDFSILPQWFYPHKALGQTQALEIP
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHCCCCEEEECC
SWQFYFSPSTTWTLYDSPTAGQGIVDFSYTLIHYWQTNGVDANQAAGTASSMNDYSNREN
CEEEEECCCCEEEEECCCCCCCCEEEEEEEEEEEEECCCCCCHHCCCCHHHHHHHCCCCC
NLAQLTFSQTFPGDFLTLAIGQYSLYAIDGTLYDNDQYSGFISYALSQNASATYSLGSTG
CEEEEEEECCCCCCEEEEEECCEEEEEEECEEECCCCCCEEEEEEECCCCCEEEEECCCC
AYLQFTPNSEIKVQLGFQDSYNIDGTNFSIYNLTKSKYNFYGYASWTPKPSCGDGQYSVL
EEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCCEEEE
LYSTRKVPEQNSQVTGWSLNAAQHIHEKLYLFGRINGATGTALPINRSYVLGLVSENPLN
EEEECCCCCCCCEECEEECHHHHHHHHEEEEEEEECCCCCCEEECCCCEEEEEECCCCCC
RHSQDLLGIGFATNKVNAKAISNVNKLRRYESVMEAFATIGFGPYISLTPDFQLYIHPAL
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCC
RPERRTSQVYGLRANLSL
CCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MISFRFLLLSGLCALGISSYAETPKETTGHYHRYKARIQKKHPESIKESAPSETPHHNSL
CCEEHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHH
LSPVTNIFCSHPWKDGISVSNLLTSVEKATNTQISLDFSILPQWFYPHKALGQTQALEIP
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHCCCCEEEECC
SWQFYFSPSTTWTLYDSPTAGQGIVDFSYTLIHYWQTNGVDANQAAGTASSMNDYSNREN
CEEEEECCCCEEEEECCCCCCCCEEEEEEEEEEEEECCCCCCHHCCCCHHHHHHHCCCCC
NLAQLTFSQTFPGDFLTLAIGQYSLYAIDGTLYDNDQYSGFISYALSQNASATYSLGSTG
CEEEEEEECCCCCCEEEEEECCEEEEEEECEEECCCCCCEEEEEEECCCCCEEEEECCCC
AYLQFTPNSEIKVQLGFQDSYNIDGTNFSIYNLTKSKYNFYGYASWTPKPSCGDGQYSVL
EEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCCEEEE
LYSTRKVPEQNSQVTGWSLNAAQHIHEKLYLFGRINGATGTALPINRSYVLGLVSENPLN
EEEECCCCCCCCEECEEECHHHHHHHHEEEEEEEECCCCCCEEECCCCEEEEEECCCCCC
RHSQDLLGIGFATNKVNAKAISNVNKLRRYESVMEAFATIGFGPYISLTPDFQLYIHPAL
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCC
RPERRTSQVYGLRANLSL
CCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362