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Identifier: 15618940

GI number: 15618940

Start: 1185563

End: 1186150

Strand: Reverse

Name: Not Available

Synonym: CPn1032

Alternate gene names: 15618940

Gene position: 1186150-1185563 (Counterclockwise)

Preceding gene: 15618941

Following gene: 15618939

Centisome position: 96.42

GC content: 42.01

Gene sequence:

>588_bases
ATGGCTTACGGAACTCGTTATCCCACGCTAGCATTCCATACAGGGGGCATTGGTGAATCTGATGACGGTATGCCCCCACA
ACCCTTTGAAACTTTCTGCTACGATTCTGCTCTTCTACAAGCAAAAATCGAAAATTTTAATATCGTCCCTTATACATCTG
TACTTCCTAAAGAGCTCTTTGGGAATATCGTTCCTGTAGATACCTGTGTAAAATCTTTCAAACACGGCGCTGTCCTTGAA
GTAATCATGGCGGGTCGTGGTGCTGCTCTCTCTGACGGAACCCATGCGATCGCCACCGGAATCGGCATTTGCTGGGGTAA
AGATAAAAATGGAGAGCTTATTGGCGGATGGGCAGCAGAATATGTTGAATTCTTCCCTACATGGATAAATGACGAAATTG
CAGAAACCCATGCTAAAATGTGGTTGAAAAAATCCCTACAACACGAACTTGACCTACGCTCTATAGCAAAGCATAGCGAA
TTCCAATTCTTCCATAATTACATCAACATCAAACAAAAATTCGGTTTTTGCTTAACTGCATTAGGATTCCTAAATTTCGA
AAATGCTGAACCAGCTAAGGTAAATTAA

Upstream 100 bases:

>100_bases
CCCAGCGTTACGCCCAGAGAGGAGAACCTCTCAAGTGTATGGCCTGCGTGCAAATCTTTCCTTATAACAAAACCACACCA
ATATTATTTAGGAGTAACTT

Downstream 100 bases:

>100_bases
GGAGACTTTCATGACCTCAAGGACTAAATCCTCAAAAAATTTAGGGACCATAGCCCTTGCGGGTATGGTAGTCAGTTCCA
TAATTGGGGGAGGGATTTTC

Product: hypothetical protein

Products: NA

Alternate protein names: PvlArgDC; Biodegradative arginine decarboxylase

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MAYGTRYPTLAFHTGGIGESDDGMPPQPFETFCYDSALLQAKIENFNIVPYTSVLPKELFGNIVPVDTCVKSFKHGAVLE
VIMAGRGAALSDGTHAIATGIGICWGKDKNGELIGGWAAEYVEFFPTWINDEIAETHAKMWLKKSLQHELDLRSIAKHSE
FQFFHNYINIKQKFGFCLTALGFLNFENAEPAKVN

Sequences:

>Translated_195_residues
MAYGTRYPTLAFHTGGIGESDDGMPPQPFETFCYDSALLQAKIENFNIVPYTSVLPKELFGNIVPVDTCVKSFKHGAVLE
VIMAGRGAALSDGTHAIATGIGICWGKDKNGELIGGWAAEYVEFFPTWINDEIAETHAKMWLKKSLQHELDLRSIAKHSE
FQFFHNYINIKQKFGFCLTALGFLNFENAEPAKVN
>Mature_194_residues
AYGTRYPTLAFHTGGIGESDDGMPPQPFETFCYDSALLQAKIENFNIVPYTSVLPKELFGNIVPVDTCVKSFKHGAVLEV
IMAGRGAALSDGTHAIATGIGICWGKDKNGELIGGWAAEYVEFFPTWINDEIAETHAKMWLKKSLQHELDLRSIAKHSEF
QFFHNYINIKQKFGFCLTALGFLNFENAEPAKVN

Specific function: Part of the AaxABC system, catalyzes the decarboxylation of L-arginine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response

COG id: COG1945

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyruvoyl-dependent arginine decarboxylase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AAXB_CHLPN (Q9Z6M7)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B72006
- PIR:   E86619
- RefSeq:   NP_225226.1
- RefSeq:   NP_301087.1
- RefSeq:   NP_445359.1
- RefSeq:   NP_877344.1
- ProteinModelPortal:   Q9Z6M7
- PHCI-2DPAGE:   Q9Z6M7
- GeneID:   1467751
- GeneID:   895497
- GeneID:   919806
- GeneID:   962776
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0820
- KEGG:   cpj:CPj1032
- KEGG:   cpn:CPn1032
- KEGG:   cpt:CpB1072
- TIGR:   CP_0820
- HOGENOM:   HBG414056
- OMA:   WIDDEIA
- ProtClustDB:   CLSK403032
- BioCyc:   CPNE115711:CP_0820-MONOMER
- BioCyc:   CPNE115713:CPN1032-MONOMER
- BioCyc:   CPNE138677:CPJ1032-MONOMER
- BioCyc:   CPNE182082:CPB1072-MONOMER
- GO:   GO:0005737
- GO:   GO:0009405
- InterPro:   IPR016104
- InterPro:   IPR016105
- InterPro:   IPR002724
- Gene3D:   G3DSA:3.50.20.10
- ProDom:   PD010449

Pfam domain/function: PF01862 PvlArgDC; SSF56271 His_carbxylase

EC number: =4.1.1.19

Molecular weight: Translated: 21655; Mature: 21524

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYGTRYPTLAFHTGGIGESDDGMPPQPFETFCYDSALLQAKIENFNIVPYTSVLPKELF
CCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
GNIVPVDTCVKSFKHGAVLEVIMAGRGAALSDGTHAIATGIGICWGKDKNGELIGGWAAE
CCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHCEEEECCCCCCCEECHHHHH
YVEFFPTWINDEIAETHAKMWLKKSLQHELDLRSIAKHSEFQFFHNYINIKQKFGFCLTA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFLNFENAEPAKVN
HHHHCCCCCCCCCCC
>Mature Secondary Structure 
AYGTRYPTLAFHTGGIGESDDGMPPQPFETFCYDSALLQAKIENFNIVPYTSVLPKELF
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
GNIVPVDTCVKSFKHGAVLEVIMAGRGAALSDGTHAIATGIGICWGKDKNGELIGGWAAE
CCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHCEEEECCCCCCCEECHHHHH
YVEFFPTWINDEIAETHAKMWLKKSLQHELDLRSIAKHSEFQFFHNYINIKQKFGFCLTA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFLNFENAEPAKVN
HHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362