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The map label for this gene is arcD

Identifier: 15618939

GI number: 15618939

Start: 1184095

End: 1185552

Strand: Reverse

Name: arcD

Synonym: CPn1031

Alternate gene names: 15618939

Gene position: 1185552-1184095 (Counterclockwise)

Preceding gene: 15618940

Following gene: 15618938

Centisome position: 96.37

GC content: 43.42

Gene sequence:

>1458_bases
ATGACCTCAAGGACTAAATCCTCAAAAAATTTAGGGACCATAGCCCTTGCGGGTATGGTAGTCAGTTCCATAATTGGGGG
AGGGATTTTCAGCCTCCCCCAAAACATGGCAGCGACAGCAGGAGCTGGTGCCGTAATCCTATCTTGGATACTCACTGGCT
TCGGCATGTTCTTTATCGCAAATACGTTTAGGATCCTCTCTACAATACGTCCCGACCTTAAGGAAGGGATCTACATGTAC
AGTAGAGAAGGTTTCGGCCCCTACATAGGATTCACCATCGGCTGGGGATATTGGCTTTGTCAAATCTTCGGTAATGTGGG
ATATGCCGTAATTACTATGGATGCTCTAAACTACTTCTTCCCTCCCTACTTCCAAGGAGGAAATACCCTACCTGCTATTT
TAGGAGGCTCCATTCTTATCTGGGTGTTCAACTTCATAGTTCTGAAAGGAATCCGTCAAGCATCGATAATCAACGTCATC
GGAACTATATTTAAAATCATCCCTCTAATCATCTTCATTATCCTGACTGCGTTCTTCTTCAAGCTCGCTGTTTTCAAAAC
AGATTTTTGGGGACATGCCGTAACAAAAGCCCAACCGAGTTTAGGATCCGTAAGTTCACAACTTAAAGGGACTATGTTGG
TCACCCTATGGGCATTTATAGGAATCGAAGGTGCCGTGGTGATGTCTGGACGAGCAAAAAATCCTCTCTCTGTAGGGCAA
GCTACAGTCTTAGGATTTTTAGGTTGCCTAACAATCTACATCTTATTTTCTTTATTACCTTTTGGCTCGCTCTTCCAACA
TCAACTAGCGAACATCCCCAATCCCTCTACAGCTGGTGTCCTCGACATCCTCGTAGGGAAATGGGGAGAAGTGCTCATGA
ATGTCGGCCTGATTATTGCTGTTTTATCTAGCTGGTTATCCTGGACGATCATCGTTGCAGAAATCCCCTTCTCAGCAGCT
AAAAATGGCACCTTCCCTGAGATCTTCACTATAGAAAATAAAGAGAAATCTCCCAGCGTCTCCCTATACATTACGAGCTC
TGTGATGCAGCTCGCCATGCTCCTTGTTTACTTTTCTTCGAATGCTTGGAATACTATGCTCAGCATCACGGGGGTCATGG
TTCTCCCTGCGTATCTAGCGAGTGCTGCCTTTCTCTTTAAACTTAGCAAAAGCAAAACATATCCTAAAAAAGGGTCTATT
AAAGCCCCTTTGGCAATGATAACTGGTATCCTGGGAGTGGTTTACTCTCTATGGCTTATCTATGCAGGAGGTCTAAAATA
CCTCTTTATGGCCTTAGTTCTTTTAGCTCTTGGCATCCCCTTCTATATAGACGCAGGGAAAAAGAAGAAAAATGCTAAGA
CATTCTTTGCTAAAAAAGAAATTGTAGGAATGACTTTCATAGGCCTTCTTGCACTGACAGCGATCTTCCTATTCTTAACA
GGAAGAATCAAAATTTAA

Upstream 100 bases:

>100_bases
TACATCAACATCAAACAAAAATTCGGTTTTTGCTTAACTGCATTAGGATTCCTAAATTTCGAAAATGCTGAACCAGCTAA
GGTAAATTAAGGAGACTTTC

Downstream 100 bases:

>100_bases
TTAAACTTTCATCCTTCCCCACGGCTTATGCCGTGGGGGTCTCCCTAATTCTCTTCTCTATAGTAAAAAATTCACCCTTA
AGAATCAGGTTTTCATCTTC

Product: arginine/ornithine antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MTSRTKSSKNLGTIALAGMVVSSIIGGGIFSLPQNMAATAGAGAVILSWILTGFGMFFIANTFRILSTIRPDLKEGIYMY
SREGFGPYIGFTIGWGYWLCQIFGNVGYAVITMDALNYFFPPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASIINVI
GTIFKIIPLIIFIILTAFFFKLAVFKTDFWGHAVTKAQPSLGSVSSQLKGTMLVTLWAFIGIEGAVVMSGRAKNPLSVGQ
ATVLGFLGCLTIYILFSLLPFGSLFQHQLANIPNPSTAGVLDILVGKWGEVLMNVGLIIAVLSSWLSWTIIVAEIPFSAA
KNGTFPEIFTIENKEKSPSVSLYITSSVMQLAMLLVYFSSNAWNTMLSITGVMVLPAYLASAAFLFKLSKSKTYPKKGSI
KAPLAMITGILGVVYSLWLIYAGGLKYLFMALVLLALGIPFYIDAGKKKKNAKTFFAKKEIVGMTFIGLLALTAIFLFLT
GRIKI

Sequences:

>Translated_485_residues
MTSRTKSSKNLGTIALAGMVVSSIIGGGIFSLPQNMAATAGAGAVILSWILTGFGMFFIANTFRILSTIRPDLKEGIYMY
SREGFGPYIGFTIGWGYWLCQIFGNVGYAVITMDALNYFFPPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASIINVI
GTIFKIIPLIIFIILTAFFFKLAVFKTDFWGHAVTKAQPSLGSVSSQLKGTMLVTLWAFIGIEGAVVMSGRAKNPLSVGQ
ATVLGFLGCLTIYILFSLLPFGSLFQHQLANIPNPSTAGVLDILVGKWGEVLMNVGLIIAVLSSWLSWTIIVAEIPFSAA
KNGTFPEIFTIENKEKSPSVSLYITSSVMQLAMLLVYFSSNAWNTMLSITGVMVLPAYLASAAFLFKLSKSKTYPKKGSI
KAPLAMITGILGVVYSLWLIYAGGLKYLFMALVLLALGIPFYIDAGKKKKNAKTFFAKKEIVGMTFIGLLALTAIFLFLT
GRIKI
>Mature_484_residues
TSRTKSSKNLGTIALAGMVVSSIIGGGIFSLPQNMAATAGAGAVILSWILTGFGMFFIANTFRILSTIRPDLKEGIYMYS
REGFGPYIGFTIGWGYWLCQIFGNVGYAVITMDALNYFFPPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASIINVIG
TIFKIIPLIIFIILTAFFFKLAVFKTDFWGHAVTKAQPSLGSVSSQLKGTMLVTLWAFIGIEGAVVMSGRAKNPLSVGQA
TVLGFLGCLTIYILFSLLPFGSLFQHQLANIPNPSTAGVLDILVGKWGEVLMNVGLIIAVLSSWLSWTIIVAEIPFSAAK
NGTFPEIFTIENKEKSPSVSLYITSSVMQLAMLLVYFSSNAWNTMLSITGVMVLPAYLASAAFLFKLSKSKTYPKKGSIK
APLAMITGILGVVYSLWLIYAGGLKYLFMALVLLALGIPFYIDAGKKKKNAKTFFAKKEIVGMTFIGLLALTAIFLFLTG
RIKI

Specific function: Catalyzes the exchange of L-arginine for agmatine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1787890, Length=472, Percent_Identity=40.6779661016949, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI2367353, Length=454, Percent_Identity=26.431718061674, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790575, Length=365, Percent_Identity=26.8493150684932, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786908, Length=446, Percent_Identity=24.6636771300448, Blast_Score=92, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52575; Mature: 52443

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRTKSSKNLGTIALAGMVVSSIIGGGIFSLPQNMAATAGAGAVILSWILTGFGMFFIA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
NTFRILSTIRPDLKEGIYMYSREGFGPYIGFTIGWGYWLCQIFGNVGYAVITMDALNYFF
HHHHHHHHHCHHHHHCCEEEECCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHC
PPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASIINVIGTIFKIIPLIIFIILTAFFF
CCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLAVFKTDFWGHAVTKAQPSLGSVSSQLKGTMLVTLWAFIGIEGAVVMSGRAKNPLSVGQ
HHHHHHCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHH
ATVLGFLGCLTIYILFSLLPFGSLFQHQLANIPNPSTAGVLDILVGKWGEVLMNVGLIIA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
VLSSWLSWTIIVAEIPFSAAKNGTFPEIFTIENKEKSPSVSLYITSSVMQLAMLLVYFSS
HHHHHHHHEEEEEECCCHHCCCCCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHCC
NAWNTMLSITGVMVLPAYLASAAFLFKLSKSKTYPKKGSIKAPLAMITGILGVVYSLWLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YAGGLKYLFMALVLLALGIPFYIDAGKKKKNAKTFFAKKEIVGMTFIGLLALTAIFLFLT
HHCCHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRIKI
CCCCC
>Mature Secondary Structure 
TSRTKSSKNLGTIALAGMVVSSIIGGGIFSLPQNMAATAGAGAVILSWILTGFGMFFIA
CCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHH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CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]