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The map label for this gene is uvrB

Identifier: 15618710

GI number: 15618710

Start: 906724

End: 908697

Strand: Reverse

Name: uvrB

Synonym: CPn0801

Alternate gene names: 15618710

Gene position: 908697-906724 (Counterclockwise)

Preceding gene: 15618711

Following gene: 15618709

Centisome position: 73.86

GC content: 43.77

Gene sequence:

>1974_bases
ATGACATTCCAACTTCATGCTCCTTTTGCTCCTTGCGGCGACCAGCCAGAGGCGATTGCTCGGCTGTCTGCGGGTGTGCG
TAATCAGGTAAAATCACAAGTACTTCTTGGAACTACAGGTTCTGGGAAGACATTCACTATTGCGAATGTTGTTGCCAACG
TAAATCTCCCTACCCTGGTTTTAGCCCATAACAAAACGCTAGCTGCTCAGCTGTATCAAGAATTTCGTGAATTTTTCCCT
AATAATGCCGTTGAGTATTTCATCTCTTACTACGATTACTATCAACCTGAGGCCTATATTGCCCGTAGTGATACCTATAT
AGAAAAAAGCCTCCTTATCAATGATGAAATCGATAAGTTACGTTTATCAGCAACACGGTCTATTTTAGAGCGCCGAGACA
CTTTAATCGTTTCCTCAGTATCTTGCATTTATGGTATTGGTTCTCCTGAAAACTATACATCCATGGCGTTAGTCTTAGAG
GTAGGGAAAGAGTACCCTAGGAATATCCTGACAGCTCAGCTTGTTAAAATGCACTATCAAGCATCTCCCATCCCACAGAG
AAGTGCATTTCGAGAGCGTGGGAGTGTAATCGATATTTTCCCTGCATACGAAAGTGAACTTGCCCTAAGATTAGAATTTC
TAAATGACACCCTTACCTCCATAGAATACAGCGATCCCCTCACTATGATTCCCAAGGAAAGTGTCCCTTCGGCTACTTTA
TATCCTGGATCTCATTACGTCATTCCTGAGGCAATTCGCGAGCAAGCGATCCGAACCATTCAGGAAGAGTTAGAAGAGCG
CATGGCCTTTTTTGACGACCGTCCTATAGAAAAGGACCGCATTTTCCATCGTACGACTCATGACATTGAGATGATCAAGG
AAATCGGATTCTGCAAGGGCATAGAAAACTATTCACGGCATTTTACAGGGGCGCCCCCAGGAGCACCGCCTACGTGCCTC
TTAGATTATTTTCCTGAGGACTTTCTCCTTATTATCGATGAGTCTCATCAAACACTACCTCAAATACGTGCTATGTATCG
TGGAGACCAATCTCGGAAGCAATCTTTAGTAGAATATGGATTCCGTCTCCCCTCAGCCTTCGATAACCGCCCGCTAACCT
ATGAAGAAGCCCAGAAGTACTTTCGTAAAGTCATCTATGTCTCTGCAACACCAGGTGATACGGAAGTCCAAGAGAGCTCA
GGTCATATTGTACAACAAATCATCCGCCCGACGGGGATCCCCGATCCTATGCCTGAAATCCGTCCTGCTACAGGACAAGT
GGATGATCTTCTTGAAGAAATTCGTTTGCGGCTGTCTCAGAAACATGAAAAAATCCTAGTGATTTCTATAACAAAGAAAC
TTGCCGAAGATATGGCGGGTTTTCTTTCAGAATTAGAGATCCCTGCGGCATACTTGCATTCTGGAATAGAAACTGCAGAA
CGCACGCAAATCCTTACAGACCTACGCTCGGGCGTTATTGACGTATTGATTGGAGTCAATCTCCTACGTGAAGGACTCGA
TCTTCCCGAGGTCTCTTTAGTTGCGATCTTAGATGCTGACAAAGAGGGCTTTTTAAGAAGCACGTCATCTCTGATTCAGT
TTTGTGGAAGAGCTGCTAGGAATATCAATGGTAAAGTCATTTTCTATGCTGATCAAAAAACCCGTTCTATAGAGGAGACT
CTTCGAGAGACCGAACGCCGGCGTCAGATACAGTTAGATTACAATAAAGAGCACAATATTGTTCCTAAGCCCATTATAAA
AGCTATTTTTGCCAATCCTATTCTACAAACCTCTAAAGACTCGGAGTCTCCCAAGGAATCTCAACGCCCCCTATCTAAAG
AAGATCTTGAAGAGCAAATTAAGAAATACGAAGCTCTCATGCAACGTGCTGCTAAAGAATTTCGATTCAACGAAGCTGCG
AAATACCGCGATGCAATGCAAGCTTGCAAAGAACAGCTTCTCTATTTGTTCTAA

Upstream 100 bases:

>100_bases
CGCATAAAATGCGTGAAGTAGCCAAAGTCACTATGGAAGAAGTTCATGACAAATTTGGGTTTAGCCATAAATGGCGCTCA
TTGCTTAAATAATTTTTACT

Downstream 100 bases:

>100_bases
GAGAATTTCTGATCTCGATATTCAAGAATATTCCTCCCCAAATTTATCTATTTTTGTCATTATGAGTTTGATGTGAATCC
GTAGCTACGTATTTTAGAAT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MTFQLHAPFAPCGDQPEAIARLSAGVRNQVKSQVLLGTTGSGKTFTIANVVANVNLPTLVLAHNKTLAAQLYQEFREFFP
NNAVEYFISYYDYYQPEAYIARSDTYIEKSLLINDEIDKLRLSATRSILERRDTLIVSSVSCIYGIGSPENYTSMALVLE
VGKEYPRNILTAQLVKMHYQASPIPQRSAFRERGSVIDIFPAYESELALRLEFLNDTLTSIEYSDPLTMIPKESVPSATL
YPGSHYVIPEAIREQAIRTIQEELEERMAFFDDRPIEKDRIFHRTTHDIEMIKEIGFCKGIENYSRHFTGAPPGAPPTCL
LDYFPEDFLLIIDESHQTLPQIRAMYRGDQSRKQSLVEYGFRLPSAFDNRPLTYEEAQKYFRKVIYVSATPGDTEVQESS
GHIVQQIIRPTGIPDPMPEIRPATGQVDDLLEEIRLRLSQKHEKILVISITKKLAEDMAGFLSELEIPAAYLHSGIETAE
RTQILTDLRSGVIDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSTSSLIQFCGRAARNINGKVIFYADQKTRSIEET
LRETERRRQIQLDYNKEHNIVPKPIIKAIFANPILQTSKDSESPKESQRPLSKEDLEEQIKKYEALMQRAAKEFRFNEAA
KYRDAMQACKEQLLYLF

Sequences:

>Translated_657_residues
MTFQLHAPFAPCGDQPEAIARLSAGVRNQVKSQVLLGTTGSGKTFTIANVVANVNLPTLVLAHNKTLAAQLYQEFREFFP
NNAVEYFISYYDYYQPEAYIARSDTYIEKSLLINDEIDKLRLSATRSILERRDTLIVSSVSCIYGIGSPENYTSMALVLE
VGKEYPRNILTAQLVKMHYQASPIPQRSAFRERGSVIDIFPAYESELALRLEFLNDTLTSIEYSDPLTMIPKESVPSATL
YPGSHYVIPEAIREQAIRTIQEELEERMAFFDDRPIEKDRIFHRTTHDIEMIKEIGFCKGIENYSRHFTGAPPGAPPTCL
LDYFPEDFLLIIDESHQTLPQIRAMYRGDQSRKQSLVEYGFRLPSAFDNRPLTYEEAQKYFRKVIYVSATPGDTEVQESS
GHIVQQIIRPTGIPDPMPEIRPATGQVDDLLEEIRLRLSQKHEKILVISITKKLAEDMAGFLSELEIPAAYLHSGIETAE
RTQILTDLRSGVIDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSTSSLIQFCGRAARNINGKVIFYADQKTRSIEET
LRETERRRQIQLDYNKEHNIVPKPIIKAIFANPILQTSKDSESPKESQRPLSKEDLEEQIKKYEALMQRAAKEFRFNEAA
KYRDAMQACKEQLLYLF
>Mature_656_residues
TFQLHAPFAPCGDQPEAIARLSAGVRNQVKSQVLLGTTGSGKTFTIANVVANVNLPTLVLAHNKTLAAQLYQEFREFFPN
NAVEYFISYYDYYQPEAYIARSDTYIEKSLLINDEIDKLRLSATRSILERRDTLIVSSVSCIYGIGSPENYTSMALVLEV
GKEYPRNILTAQLVKMHYQASPIPQRSAFRERGSVIDIFPAYESELALRLEFLNDTLTSIEYSDPLTMIPKESVPSATLY
PGSHYVIPEAIREQAIRTIQEELEERMAFFDDRPIEKDRIFHRTTHDIEMIKEIGFCKGIENYSRHFTGAPPGAPPTCLL
DYFPEDFLLIIDESHQTLPQIRAMYRGDQSRKQSLVEYGFRLPSAFDNRPLTYEEAQKYFRKVIYVSATPGDTEVQESSG
HIVQQIIRPTGIPDPMPEIRPATGQVDDLLEEIRLRLSQKHEKILVISITKKLAEDMAGFLSELEIPAAYLHSGIETAER
TQILTDLRSGVIDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSTSSLIQFCGRAARNINGKVIFYADQKTRSIEETL
RETERRRQIQLDYNKEHNIVPKPIIKAIFANPILQTSKDSESPKESQRPLSKEDLEEQIKKYEALMQRAAKEFRFNEAAK
YRDAMQACKEQLLYLF

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=664, Percent_Identity=50.6024096385542, Blast_Score=652, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_CHLPN (Q9Z7A5)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B72034
- PIR:   G86590
- RefSeq:   NP_224996.1
- RefSeq:   NP_300858.1
- RefSeq:   NP_445607.1
- RefSeq:   NP_877102.1
- ProteinModelPortal:   Q9Z7A5
- GeneID:   1467509
- GeneID:   894666
- GeneID:   919563
- GeneID:   963554
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP1070
- KEGG:   cpn:CPn0801
- KEGG:   cpt:CpB0830
- TIGR:   CP_1070
- HOGENOM:   HBG703949
- OMA:   EKDLAIN
- ProtClustDB:   PRK05298
- BioCyc:   CPNE115711:CP_1070-MONOMER
- BioCyc:   CPNE115713:CPN0801-MONOMER
- BioCyc:   CPNE138677:CPJ0801-MONOMER
- BioCyc:   CPNE182082:CPB0830-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 74831; Mature: 74700

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFQLHAPFAPCGDQPEAIARLSAGVRNQVKSQVLLGTTGSGKTFTIANVVANVNLPTLV
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEHHHHHHCCCCCEEE
LAHNKTLAAQLYQEFREFFPNNAVEYFISYYDYYQPEAYIARSDTYIEKSLLINDEIDKL
EECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHEECCCHHHH
RLSATRSILERRDTLIVSSVSCIYGIGSPENYTSMALVLEVGKEYPRNILTAQLVKMHYQ
HHHHHHHHHHHHHHHHEEHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ASPIPQRSAFRERGSVIDIFPAYESELALRLEFLNDTLTSIEYSDPLTMIPKESVPSATL
CCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEE
YPGSHYVIPEAIREQAIRTIQEELEERMAFFDDRPIEKDRIFHRTTHDIEMIKEIGFCKG
CCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
IENYSRHFTGAPPGAPPTCLLDYFPEDFLLIIDESHQTLPQIRAMYRGDQSRKQSLVEYG
HHHHHHCCCCCCCCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHH
FRLPSAFDNRPLTYEEAQKYFRKVIYVSATPGDTEVQESSGHIVQQIIRPTGIPDPMPEI
CCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCHHCCCHHHHHHHHCCCCCCCCCCC
RPATGQVDDLLEEIRLRLSQKHEKILVISITKKLAEDMAGFLSELEIPAAYLHSGIETAE
CCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHH
RTQILTDLRSGVIDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSTSSLIQFCGRAAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHC
NINGKVIFYADQKTRSIEETLRETERRRQIQLDYNKEHNIVPKPIIKAIFANPILQTSKD
CCCCEEEEEECCHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHCCHHCCCCC
SESPKESQRPLSKEDLEEQIKKYEALMQRAAKEFRFNEAAKYRDAMQACKEQLLYLF
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TFQLHAPFAPCGDQPEAIARLSAGVRNQVKSQVLLGTTGSGKTFTIANVVANVNLPTLV
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEHHHHHHCCCCCEEE
LAHNKTLAAQLYQEFREFFPNNAVEYFISYYDYYQPEAYIARSDTYIEKSLLINDEIDKL
EECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHEECCCHHHH
RLSATRSILERRDTLIVSSVSCIYGIGSPENYTSMALVLEVGKEYPRNILTAQLVKMHYQ
HHHHHHHHHHHHHHHHEEHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ASPIPQRSAFRERGSVIDIFPAYESELALRLEFLNDTLTSIEYSDPLTMIPKESVPSATL
CCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEE
YPGSHYVIPEAIREQAIRTIQEELEERMAFFDDRPIEKDRIFHRTTHDIEMIKEIGFCKG
CCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
IENYSRHFTGAPPGAPPTCLLDYFPEDFLLIIDESHQTLPQIRAMYRGDQSRKQSLVEYG
HHHHHHCCCCCCCCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHH
FRLPSAFDNRPLTYEEAQKYFRKVIYVSATPGDTEVQESSGHIVQQIIRPTGIPDPMPEI
CCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCHHCCCHHHHHHHHCCCCCCCCCCC
RPATGQVDDLLEEIRLRLSQKHEKILVISITKKLAEDMAGFLSELEIPAAYLHSGIETAE
CCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHH
RTQILTDLRSGVIDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSTSSLIQFCGRAAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHC
NINGKVIFYADQKTRSIEETLRETERRRQIQLDYNKEHNIVPKPIIKAIFANPILQTSKD
CCCCEEEEEECCHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHCCHHCCCCC
SESPKESQRPLSKEDLEEQIKKYEALMQRAAKEFRFNEAAKYRDAMQACKEQLLYLF
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362