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The map label for this gene is coaE

Identifier: 15606979

GI number: 15606979

Start: 1395949

End: 1396539

Strand: Direct

Name: coaE

Synonym: aq_1985

Alternate gene names: 15606979

Gene position: 1395949-1396539 (Clockwise)

Preceding gene: 15606978

Following gene: 15606989

Centisome position: 89.98

GC content: 40.95

Gene sequence:

>591_bases
GTGAAGAGAATCGGACTTACGGGAAACATAGGTTGCGGAAAGTCCACGGTAGCACAAATGTTCAGAGAACTCGGGGCTTA
TGTCCTAGACGCAGATAAGTTAATCCACTCCTTTTACAGAAAAGGACACCCCGTTTACGAGGAAGTCGTTAAAACCTTCG
GTAAAGGTATACTGGACGAAGAGGGAAATATAGACAGGAAAAAACTCGCAGACATAGTTTTTAAAGATGAAGAGAAGTTA
AGAAAACTGGAAGAAATCACCCACAGAGCCCTTTACAAAGAGATTGAAAAAATTACTAAAAACCTATCCGAAGACACCCT
CTTTATCTTGGAAGCCAGTCTCCTAGTTGAGAAGGGAACTTACAAAAATTACGATAAGTTAATCGTGGTTTACGCACCTT
ATGAGGTTTGCAAAGAGAGGGCAATAAAGAGAGGTATGAGTGAAGAGGACTTTGAAAGGAGATGGAAAAAGCAGATGCCA
ATAGAGGAAAAGGTAAAGTACGCGGACTACGTTATAGACAACTCAGGAAGTATTGAAGAGACCTATAAGCAGGTAAAGAA
GGTTTACGAAGAACTCACAAGAGACCCTTGA

Upstream 100 bases:

>100_bases
TTGTGGGAGAACCCTTCGGAGTTTCGGACATAATTGCGGGCAACAAAGCCCTCCACGACTTTATACTTCAGGTAGCCAAA
AAGTATATGGAAGTGGCGGT

Downstream 100 bases:

>100_bases
GTTTGTAAAAGAGCAATCCTATGTACTCCCTAATGGCTATGGACGAGTCGTAAAAGACGCTGTACTTTGGAAAAAGGCTA
TAAACGTTGTACTTCCCTTC

Product: hypothetical protein

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MKRIGLTGNIGCGKSTVAQMFRELGAYVLDADKLIHSFYRKGHPVYEEVVKTFGKGILDEEGNIDRKKLADIVFKDEEKL
RKLEEITHRALYKEIEKITKNLSEDTLFILEASLLVEKGTYKNYDKLIVVYAPYEVCKERAIKRGMSEEDFERRWKKQMP
IEEKVKYADYVIDNSGSIEETYKQVKKVYEELTRDP

Sequences:

>Translated_196_residues
MKRIGLTGNIGCGKSTVAQMFRELGAYVLDADKLIHSFYRKGHPVYEEVVKTFGKGILDEEGNIDRKKLADIVFKDEEKL
RKLEEITHRALYKEIEKITKNLSEDTLFILEASLLVEKGTYKNYDKLIVVYAPYEVCKERAIKRGMSEEDFERRWKKQMP
IEEKVKYADYVIDNSGSIEETYKQVKKVYEELTRDP
>Mature_196_residues
MKRIGLTGNIGCGKSTVAQMFRELGAYVLDADKLIHSFYRKGHPVYEEVVKTFGKGILDEEGNIDRKKLADIVFKDEEKL
RKLEEITHRALYKEIEKITKNLSEDTLFILEASLLVEKGTYKNYDKLIVVYAPYEVCKERAIKRGMSEEDFERRWKKQMP
IEEKVKYADYVIDNSGSIEETYKQVKKVYEELTRDP

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=199, Percent_Identity=35.1758793969849, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI191252795, Length=199, Percent_Identity=35.1758793969849, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI110227607, Length=194, Percent_Identity=31.9587628865979, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI110227605, Length=194, Percent_Identity=31.9587628865979, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI110227603, Length=194, Percent_Identity=31.9587628865979, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI110227601, Length=194, Percent_Identity=31.9587628865979, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI205277394, Length=194, Percent_Identity=31.9587628865979, Blast_Score=95, Evalue=3e-20,
Organism=Escherichia coli, GI1786292, Length=191, Percent_Identity=28.7958115183246, Blast_Score=90, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17554944, Length=197, Percent_Identity=36.5482233502538, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25143409, Length=193, Percent_Identity=30.0518134715026, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320402, Length=202, Percent_Identity=31.1881188118812, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24658602, Length=197, Percent_Identity=31.4720812182741, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24644728, Length=196, Percent_Identity=32.1428571428571, Blast_Score=104, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_AQUAE (O67792)

Other databases:

- EMBL:   AE000657
- PIR:   D70470
- RefSeq:   NP_214361.1
- PDB:   2IF2
- PDBsum:   2IF2
- ProteinModelPortal:   O67792
- SMR:   O67792
- GeneID:   1193689
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1985
- NMPDR:   fig|224324.1.peg.1376
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- PhylomeDB:   O67792
- ProtClustDB:   CLSK2748540
- BioCyc:   AAEO224324:AQ_1985-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 22931; Mature: 22931

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIGLTGNIGCGKSTVAQMFRELGAYVLDADKLIHSFYRKGHPVYEEVVKTFGKGILDE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
EGNIDRKKLADIVFKDEEKLRKLEEITHRALYKEIEKITKNLSEDTLFILEASLLVEKGT
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
YKNYDKLIVVYAPYEVCKERAIKRGMSEEDFERRWKKQMPIEEKVKYADYVIDNSGSIEE
CCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHH
TYKQVKKVYEELTRDP
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRIGLTGNIGCGKSTVAQMFRELGAYVLDADKLIHSFYRKGHPVYEEVVKTFGKGILDE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
EGNIDRKKLADIVFKDEEKLRKLEEITHRALYKEIEKITKNLSEDTLFILEASLLVEKGT
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
YKNYDKLIVVYAPYEVCKERAIKRGMSEEDFERRWKKQMPIEEKVKYADYVIDNSGSIEE
CCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHH
TYKQVKKVYEELTRDP
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320