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The map label for this gene is imp2

Identifier: 15606978

GI number: 15606978

Start: 1395158

End: 1395952

Strand: Direct

Name: imp2

Synonym: aq_1983

Alternate gene names: 15606978

Gene position: 1395158-1395952 (Clockwise)

Preceding gene: 15606977

Following gene: 15606979

Centisome position: 89.93

GC content: 47.42

Gene sequence:

>795_bases
ATGGAAAACTTAAAAAAGTACCTAGAAGTTGCAAAAATAGCCGCGCTCGCGGGTGGGCAGGTTCTGAAAGAAAACTTCGG
AAAGGTAAAAAAGGAAAACATAGAGGAAAAAGGGGAAAAGGACTTTGTAAGTTACGTGGATAAAACTTCAGAGGAAAGGA
TAAAGGAGGTGATACTCAAGTTCTTTCCCGATCACGAGGTCGTAGGGGAAGAGATGGGTGCGGAGGGAAGCGGAAGCGAA
TACAGGTGGTTCATAGACCCCCTTGACGGCACAAAGAACTACATAAACGGTTTTCCCATCTTTGCCGTATCAGTGGGACT
TGTTAAGGGAGAAGAGCCAATTGTGGGTGCGGTTTACCTTCCTTACTTTGACAAGCTTTACTGGGGTGCTAAAGGTCTCG
GGGCTTACGTAAACGGAAAGAGGATAAAGGTAAAGGACAATGAGAGTTTAAAGCACGCCGGAGTGGTTTACGGATTTCCC
TCTAGGAGCAGGAGGGACATATCTATCTACTTGAACATATTCAAGGATGTCTTTTACGAAGTTGGCTCTATGAGGAGACC
CGGGGCTGCTGCGGTTGACCTCTGCATGGTGGCGGAAGGGATATTTGACGGGATGATGGAGTTTGAAATGAAGCCGTGGG
ACATAACCGCAGGGCTTGTAATACTGAAGGAAGCCGGGGGCGTTTACACACTTGTGGGAGAACCCTTCGGAGTTTCGGAC
ATAATTGCGGGCAACAAAGCCCTCCACGACTTTATACTTCAGGTAGCCAAAAAGTATATGGAAGTGGCGGTGTGA

Upstream 100 bases:

>100_bases
CTTTTGAGATTTACGAAAAAACTGAAGTTTGAACCTATTGAAGTTCCCGAAGTTCAGGAAGGTGTGATAACCTTTACTTT
TTCCACTTAAAATTTATGGT

Downstream 100 bases:

>100_bases
AGAGAATCGGACTTACGGGAAACATAGGTTGCGGAAAGTCCACGGTAGCACAAATGTTCAGAGAACTCGGGGCTTATGTC
CTAGACGCAGATAAGTTAAT

Product: myo-inositol-1(or 4)-monophosphatase

Products: NA

Alternate protein names: I-1-Pase; IMPase; Inositol-1-phosphatase

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MENLKKYLEVAKIAALAGGQVLKENFGKVKKENIEEKGEKDFVSYVDKTSEERIKEVILKFFPDHEVVGEEMGAEGSGSE
YRWFIDPLDGTKNYINGFPIFAVSVGLVKGEEPIVGAVYLPYFDKLYWGAKGLGAYVNGKRIKVKDNESLKHAGVVYGFP
SRSRRDISIYLNIFKDVFYEVGSMRRPGAAAVDLCMVAEGIFDGMMEFEMKPWDITAGLVILKEAGGVYTLVGEPFGVSD
IIAGNKALHDFILQVAKKYMEVAV

Sequences:

>Translated_264_residues
MENLKKYLEVAKIAALAGGQVLKENFGKVKKENIEEKGEKDFVSYVDKTSEERIKEVILKFFPDHEVVGEEMGAEGSGSE
YRWFIDPLDGTKNYINGFPIFAVSVGLVKGEEPIVGAVYLPYFDKLYWGAKGLGAYVNGKRIKVKDNESLKHAGVVYGFP
SRSRRDISIYLNIFKDVFYEVGSMRRPGAAAVDLCMVAEGIFDGMMEFEMKPWDITAGLVILKEAGGVYTLVGEPFGVSD
IIAGNKALHDFILQVAKKYMEVAV
>Mature_264_residues
MENLKKYLEVAKIAALAGGQVLKENFGKVKKENIEEKGEKDFVSYVDKTSEERIKEVILKFFPDHEVVGEEMGAEGSGSE
YRWFIDPLDGTKNYINGFPIFAVSVGLVKGEEPIVGAVYLPYFDKLYWGAKGLGAYVNGKRIKVKDNESLKHAGVVYGFP
SRSRRDISIYLNIFKDVFYEVGSMRRPGAAAVDLCMVAEGIFDGMMEFEMKPWDITAGLVILKEAGGVYTLVGEPFGVSD
IIAGNKALHDFILQVAKKYMEVAV

Specific function: Unknown

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family

Homologues:

Organism=Homo sapiens, GI7657236, Length=220, Percent_Identity=30.9090909090909, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI5031789, Length=260, Percent_Identity=31.5384615384615, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI221625487, Length=222, Percent_Identity=32.8828828828829, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI221625507, Length=112, Percent_Identity=35.7142857142857, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1788882, Length=253, Percent_Identity=35.9683794466403, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1790659, Length=202, Percent_Identity=27.2277227722772, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193202572, Length=229, Percent_Identity=30.5676855895196, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193202570, Length=233, Percent_Identity=30.9012875536481, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320493, Length=202, Percent_Identity=33.1683168316832, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6321836, Length=242, Percent_Identity=28.5123966942149, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357329, Length=232, Percent_Identity=33.1896551724138, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24664922, Length=233, Percent_Identity=34.7639484978541, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24664926, Length=246, Percent_Identity=34.1463414634146, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21357957, Length=234, Percent_Identity=36.3247863247863, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24664918, Length=259, Percent_Identity=35.1351351351351, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI21357303, Length=228, Percent_Identity=31.140350877193, Blast_Score=107, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SUHB_AQUAE (O67791)

Other databases:

- EMBL:   AE000657
- PIR:   C70470
- RefSeq:   NP_214360.1
- PDB:   2PCR
- PDBsum:   2PCR
- ProteinModelPortal:   O67791
- SMR:   O67791
- GeneID:   1193688
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1983
- NMPDR:   fig|224324.1.peg.1375
- HOGENOM:   HBG730251
- OMA:   YAHGYPF
- PhylomeDB:   O67791
- ProtClustDB:   CLSK2299891
- BioCyc:   AAEO224324:AQ_1983-MONOMER
- BRENDA:   3.1.3.25
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR022337
- PANTHER:   PTHR20854
- PRINTS:   PR00377
- PRINTS:   PR01959

Pfam domain/function: PF00459 Inositol_P

EC number: =3.1.3.25

Molecular weight: Translated: 29336; Mature: 29336

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00629 IMP_1; PS00630 IMP_2

Important sites: BINDING 70-70 BINDING 157-157 BINDING 185-185 BINDING 214-214

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENLKKYLEVAKIAALAGGQVLKENFGKVKKENIEEKGEKDFVSYVDKTSEERIKEVILK
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHH
FFPDHEVVGEEMGAEGSGSEYRWFIDPLDGTKNYINGFPIFAVSVGLVKGEEPIVGAVYL
HCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHCCCCEEHEEEEEECCCCCCEEEEEH
PYFDKLYWGAKGLGAYVNGKRIKVKDNESLKHAGVVYGFPSRSRRDISIYLNIFKDVFYE
HHHHHHHHCCCCCCEEECCCEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
VGSMRRPGAAAVDLCMVAEGIFDGMMEFEMKPWDITAGLVILKEAGGVYTLVGEPFGVSD
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEHEEEEEEECCCCEEEEECCCCCCHH
IIAGNKALHDFILQVAKKYMEVAV
HHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MENLKKYLEVAKIAALAGGQVLKENFGKVKKENIEEKGEKDFVSYVDKTSEERIKEVILK
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHH
FFPDHEVVGEEMGAEGSGSEYRWFIDPLDGTKNYINGFPIFAVSVGLVKGEEPIVGAVYL
HCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHCCCCEEHEEEEEECCCCCCEEEEEH
PYFDKLYWGAKGLGAYVNGKRIKVKDNESLKHAGVVYGFPSRSRRDISIYLNIFKDVFYE
HHHHHHHHCCCCCCEEECCCEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
VGSMRRPGAAAVDLCMVAEGIFDGMMEFEMKPWDITAGLVILKEAGGVYTLVGEPFGVSD
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEHEEEEEEECCCCEEEEECCCCCCHH
IIAGNKALHDFILQVAKKYMEVAV
HHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320