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The map label for this gene is sucD2

Identifier: 15606732

GI number: 15606732

Start: 1138498

End: 1139415

Strand: Direct

Name: sucD2

Synonym: aq_1622

Alternate gene names: 15606732

Gene position: 1138498-1139415 (Clockwise)

Preceding gene: 15606731

Following gene: 15606733

Centisome position: 73.39

GC content: 50.44

Gene sequence:

>918_bases
ATGGCTATTTTGGTAAACAAAGATACCAAGGTGGTAGTTCAAGGTATAACGGGTAAAGAAGGTTCTTTCCACGCAAAGCA
ATGCAAAGAATACGGAACTCAGGTTGTCGCAGGAGTAACCCCCGGCAAGGGAGGAATGGAGGTAGAGGGAATTCCCGTAT
TCAACACTGTGAAGGAAGCGGTAAAAGAGACAGGTGCAAACTGTTCACTCATATTCGTTCCAGCCCCCTTTGCGGCGGAC
GCTATAGTGGAAGCTCTGGACGCGGGGATAGAACTCGTGGTGTGTATAACGGAAGGAATTCCCGTAAAAGACATGATGAT
GGTAAAGGACTACATGCTCAAGAACTATCCGAACGCTAAACTCGTAGGTCCCAACTGCCCCGGAGTGATTACCCCCGGAG
AGGCGAAGGTGGGCATAATGCCCGGACACATATTCAAAAGAGGTAAAATAGGCATAGTTTCGAGGAGCGGAACCCTCACG
TACGAGGCGGCTTATCAGCTCACGAAGTACGGACTCGGGCAGTCCACTGCTGTTGGTATAGGCGGTGACCCCGTCCACGG
ACTCACACACAGGGATGTTATAGAGATGTTCAACAAGGACCCCGAAACGGAAGCCATTTTAATGATCGGAGAAATCGGTG
GAACGGAAGAAGAGGAAGCTGCGGAGTACATAGAGAAGGAAGTTGACAAGCCCGTATTTGCCTACATAGCCGGAATCACC
GCGCCTCCCGGAAAGAGGATGGGACACGCGGGAGCTATCATCATGGGCGGAAAGGGAACGGCTAAGGCCAAGATGGAAGC
CCTTGAAAAGGCGGGAGCTTACGTCATAGAGAATCCCGCAAAGATAGGTGAGACAGTGGCGAAAATACTGAAGGTTATAG
AACTGGAAGAAGAAGAAAGGACTTCCGATGCTGAGTAA

Upstream 100 bases:

>100_bases
TCCAAGAGAGTGGACTCAACTTCATAATAGCGGAAGACATGTGGGACGGAGCGAAAAAGGCTGTGGAAATAGCGAATAAA
CAAAGCTAAGGAGGTTAAAA

Downstream 100 bases:

>100_bases
GATTATATTAATATTTTTCTATTCGCATTATTTTTATGAAAAACCCTAAAGGAGGTAAGTGCTATGGGACTTAAAGTTAG
AGTAGATCAGGACACCTGCA

Product: succinyl-CoA ligase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MAILVNKDTKVVVQGITGKEGSFHAKQCKEYGTQVVAGVTPGKGGMEVEGIPVFNTVKEAVKETGANCSLIFVPAPFAAD
AIVEALDAGIELVVCITEGIPVKDMMMVKDYMLKNYPNAKLVGPNCPGVITPGEAKVGIMPGHIFKRGKIGIVSRSGTLT
YEAAYQLTKYGLGQSTAVGIGGDPVHGLTHRDVIEMFNKDPETEAILMIGEIGGTEEEEAAEYIEKEVDKPVFAYIAGIT
APPGKRMGHAGAIIMGGKGTAKAKMEALEKAGAYVIENPAKIGETVAKILKVIELEEEERTSDAE

Sequences:

>Translated_305_residues
MAILVNKDTKVVVQGITGKEGSFHAKQCKEYGTQVVAGVTPGKGGMEVEGIPVFNTVKEAVKETGANCSLIFVPAPFAAD
AIVEALDAGIELVVCITEGIPVKDMMMVKDYMLKNYPNAKLVGPNCPGVITPGEAKVGIMPGHIFKRGKIGIVSRSGTLT
YEAAYQLTKYGLGQSTAVGIGGDPVHGLTHRDVIEMFNKDPETEAILMIGEIGGTEEEEAAEYIEKEVDKPVFAYIAGIT
APPGKRMGHAGAIIMGGKGTAKAKMEALEKAGAYVIENPAKIGETVAKILKVIELEEEERTSDAE
>Mature_304_residues
AILVNKDTKVVVQGITGKEGSFHAKQCKEYGTQVVAGVTPGKGGMEVEGIPVFNTVKEAVKETGANCSLIFVPAPFAADA
IVEALDAGIELVVCITEGIPVKDMMMVKDYMLKNYPNAKLVGPNCPGVITPGEAKVGIMPGHIFKRGKIGIVSRSGTLTY
EAAYQLTKYGLGQSTAVGIGGDPVHGLTHRDVIEMFNKDPETEAILMIGEIGGTEEEEAAEYIEKEVDKPVFAYIAGITA
PPGKRMGHAGAIIMGGKGTAKAKMEALEKAGAYVIENPAKIGETVAKILKVIELEEEERTSDAE

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family

Homologues:

Organism=Homo sapiens, GI109452591, Length=290, Percent_Identity=59.6551724137931, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI38569421, Length=311, Percent_Identity=28.6173633440514, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI38569423, Length=311, Percent_Identity=28.6173633440514, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786949, Length=291, Percent_Identity=62.5429553264605, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1786513, Length=150, Percent_Identity=31.3333333333333, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17550194, Length=287, Percent_Identity=58.8850174216028, Blast_Score=316, Evalue=8e-87,
Organism=Caenorhabditis elegans, GI17553126, Length=292, Percent_Identity=55.4794520547945, Blast_Score=306, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17557344, Length=319, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17551266, Length=310, Percent_Identity=27.0967741935484, Blast_Score=88, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6324716, Length=292, Percent_Identity=49.6575342465753, Blast_Score=269, Evalue=3e-73,
Organism=Drosophila melanogaster, GI21356559, Length=286, Percent_Identity=52.7972027972028, Blast_Score=300, Evalue=6e-82,
Organism=Drosophila melanogaster, GI28574296, Length=295, Percent_Identity=56.271186440678, Blast_Score=293, Evalue=7e-80,
Organism=Drosophila melanogaster, GI281363475, Length=284, Percent_Identity=29.5774647887324, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI281363473, Length=284, Percent_Identity=29.5774647887324, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI281363477, Length=284, Percent_Identity=29.5774647887324, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SUCD_AQUAE (O67547)

Other databases:

- EMBL:   AE000657
- PIR:   A70440
- RefSeq:   NP_214112.1
- ProteinModelPortal:   O67547
- SMR:   O67547
- GeneID:   1193170
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1622
- NMPDR:   fig|224324.1.peg.1127
- HOGENOM:   HBG615372
- OMA:   ADAICEA
- PhylomeDB:   O67547
- ProtClustDB:   CLSK2299773
- BioCyc:   AAEO224324:AQ_1622-MONOMER
- BRENDA:   6.2.1.5
- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:3.40.50.261
- PIRSF:   PIRSF001553
- PRINTS:   PR01798
- SMART:   SM00881
- TIGRFAMs:   TIGR01019

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 32222; Mature: 32091

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS01216 SUCCINYL_COA_LIG_1; PS00399 SUCCINYL_COA_LIG_2

Important sites: ACT_SITE 249-249

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVNKDTKVVVQGITGKEGSFHAKQCKEYGTQVVAGVTPGKGGMEVEGIPVFNTVKEA
CEEEEECCCEEEEEECCCCCCCCHHHHHHHHCCEEEEECCCCCCCEEECCCCHHHHHHHH
VKETGANCSLIFVPAPFAADAIVEALDAGIELVVCITEGIPVKDMMMVKDYMLKNYPNAK
HHHCCCCEEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCE
LVGPNCPGVITPGEAKVGIMPGHIFKRGKIGIVSRSGTLTYEAAYQLTKYGLGQSTAVGI
EECCCCCCEECCCCCEEEECCCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEECC
GGDPVHGLTHRDVIEMFNKDPETEAILMIGEIGGTEEEEAAEYIEKEVDKPVFAYIAGIT
CCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEHHCCCC
APPGKRMGHAGAIIMGGKGTAKAKMEALEKAGAYVIENPAKIGETVAKILKVIELEEEER
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCCHHHC
TSDAE
CCCCC
>Mature Secondary Structure 
AILVNKDTKVVVQGITGKEGSFHAKQCKEYGTQVVAGVTPGKGGMEVEGIPVFNTVKEA
EEEEECCCEEEEEECCCCCCCCHHHHHHHHCCEEEEECCCCCCCEEECCCCHHHHHHHH
VKETGANCSLIFVPAPFAADAIVEALDAGIELVVCITEGIPVKDMMMVKDYMLKNYPNAK
HHHCCCCEEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCE
LVGPNCPGVITPGEAKVGIMPGHIFKRGKIGIVSRSGTLTYEAAYQLTKYGLGQSTAVGI
EECCCCCCEECCCCCEEEECCCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEECC
GGDPVHGLTHRDVIEMFNKDPETEAILMIGEIGGTEEEEAAEYIEKEVDKPVFAYIAGIT
CCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEHHCCCC
APPGKRMGHAGAIIMGGKGTAKAKMEALEKAGAYVIENPAKIGETVAKILKVIELEEEER
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCCHHHC
TSDAE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320