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The map label for this gene is sucC

Identifier: 15606731

GI number: 15606731

Start: 1137329

End: 1138486

Strand: Direct

Name: sucC

Synonym: aq_1620

Alternate gene names: 15606731

Gene position: 1137329-1138486 (Clockwise)

Preceding gene: 15606730

Following gene: 15606732

Centisome position: 73.31

GC content: 47.58

Gene sequence:

>1158_bases
ATGAAGCTCCACGAACATCAGGCAAAGGAGATATTTGCAAAATACGGAATTCCCGTTCCGGAAGGCAAGGTGGCATTTTC
CCTGAAGGAAGCAAAAGAAGTCGCAGAAGAACTCGGAGAATTTCCTCTCGTTGTAAAGGCTCAGATTCACTGCGGTGGTA
GGGGTAAAGCAGGCGGAGTGAAGATAGTCAAGGACATGGACGAGCTGGAAAAGGCAGTTGAATCACTCCTCGGTAAGGTT
CTAAAAACCTTTCAGTGTCCCGACGGAAAACCCGTAAACAGGGTACTCATAGAAAAGGCTACGAACATAGACAAGGAGTA
CTATCTTGCTATAACTTTGGACCGTTCAAAGTCCAAGCCCGTTATAATGGCTTCCGCAGCGGGCGGTATGGAAATTGAAG
AAATAGTCAAAGAAAATCCAGAGGCGATAATAATCGAAACAATAGACCCAGAACTGGGACTTATGCCCTATCAGGCGAGG
GAGCTTGCCTTTAAGTTGAACCTGCCCGTAAAGGAATTCGCAAGCATAGCCCTGAAACTTTACCAGATATATTCCGACCT
TGACGCTTCACTCGTTGAGATAAATCCCCTCGTTCTCACAAAGGAAGGAAACCTTATAGCCCTTGACGCAAAACTCGACA
TAGACGACAACGCCCTCTTCAGGCACAAGGACCTTGAAGAGATGGAAGACGAAACACAACTTCCACAACTTGAGGTGGAA
GCCAAGAAGTACGGCCTTAACTACATAAAACTCAATGGAAATATAGGTTGTATGGTTAACGGTGCGGGGCTCGCTATGGC
GACTATGGACATAATCAAGCTCGCGGGAGGAGAACCCGCGAACTTCCTTGACGTGGGTGGTGGCGCGAACGTAGAGCAAA
TCGCGAACGCCTTCAGAATACTCATGGCGGACCCGGACGTGAAGGCGGTCTTCATAAATATATTCGGTGGAATACTGAGG
GTGGACAGGCTGGCTCAGGGACTCATAGAAGCCTCCAAAATGGTAGAACTCAGAGTTCCCATTGTTGCGAGACTTGAAGG
AACGAACGTTGAAGAAGGAAAGAGGATGCTCCAAGAGAGTGGACTCAACTTCATAATAGCGGAAGACATGTGGGACGGAG
CGAAAAAGGCTGTGGAAATAGCGAATAAACAAAGCTAA

Upstream 100 bases:

>100_bases
TCACAAAAGGTTATTCCAAACTTCTTCCTTTGGGTGTTGTAAACCTATATCTAATCTTTAAAATAAATTAAAACATTTTT
TTACTTTCGGAGGTGGATGT

Downstream 100 bases:

>100_bases
GGAGGTTAAAAATGGCTATTTTGGTAAACAAAGATACCAAGGTGGTAGTTCAAGGTATAACGGGTAAAGAAGGTTCTTTC
CACGCAAAGCAATGCAAAGA

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKLHEHQAKEIFAKYGIPVPEGKVAFSLKEAKEVAEELGEFPLVVKAQIHCGGRGKAGGVKIVKDMDELEKAVESLLGKV
LKTFQCPDGKPVNRVLIEKATNIDKEYYLAITLDRSKSKPVIMASAAGGMEIEEIVKENPEAIIIETIDPELGLMPYQAR
ELAFKLNLPVKEFASIALKLYQIYSDLDASLVEINPLVLTKEGNLIALDAKLDIDDNALFRHKDLEEMEDETQLPQLEVE
AKKYGLNYIKLNGNIGCMVNGAGLAMATMDIIKLAGGEPANFLDVGGGANVEQIANAFRILMADPDVKAVFINIFGGILR
VDRLAQGLIEASKMVELRVPIVARLEGTNVEEGKRMLQESGLNFIIAEDMWDGAKKAVEIANKQS

Sequences:

>Translated_385_residues
MKLHEHQAKEIFAKYGIPVPEGKVAFSLKEAKEVAEELGEFPLVVKAQIHCGGRGKAGGVKIVKDMDELEKAVESLLGKV
LKTFQCPDGKPVNRVLIEKATNIDKEYYLAITLDRSKSKPVIMASAAGGMEIEEIVKENPEAIIIETIDPELGLMPYQAR
ELAFKLNLPVKEFASIALKLYQIYSDLDASLVEINPLVLTKEGNLIALDAKLDIDDNALFRHKDLEEMEDETQLPQLEVE
AKKYGLNYIKLNGNIGCMVNGAGLAMATMDIIKLAGGEPANFLDVGGGANVEQIANAFRILMADPDVKAVFINIFGGILR
VDRLAQGLIEASKMVELRVPIVARLEGTNVEEGKRMLQESGLNFIIAEDMWDGAKKAVEIANKQS
>Mature_385_residues
MKLHEHQAKEIFAKYGIPVPEGKVAFSLKEAKEVAEELGEFPLVVKAQIHCGGRGKAGGVKIVKDMDELEKAVESLLGKV
LKTFQCPDGKPVNRVLIEKATNIDKEYYLAITLDRSKSKPVIMASAAGGMEIEEIVKENPEAIIIETIDPELGLMPYQAR
ELAFKLNLPVKEFASIALKLYQIYSDLDASLVEINPLVLTKEGNLIALDAKLDIDDNALFRHKDLEEMEDETQLPQLEVE
AKKYGLNYIKLNGNIGCMVNGAGLAMATMDIIKLAGGEPANFLDVGGGANVEQIANAFRILMADPDVKAVFINIFGGILR
VDRLAQGLIEASKMVELRVPIVARLEGTNVEEGKRMLQESGLNFIIAEDMWDGAKKAVEIANKQS

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI11321583, Length=392, Percent_Identity=43.8775510204082, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI157779135, Length=383, Percent_Identity=44.6475195822454, Blast_Score=307, Evalue=9e-84,
Organism=Homo sapiens, GI294862256, Length=375, Percent_Identity=44, Blast_Score=291, Evalue=6e-79,
Organism=Escherichia coli, GI1786948, Length=382, Percent_Identity=52.8795811518325, Blast_Score=391, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17567829, Length=394, Percent_Identity=44.4162436548223, Blast_Score=318, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17539378, Length=391, Percent_Identity=43.2225063938619, Blast_Score=303, Evalue=8e-83,
Organism=Saccharomyces cerevisiae, GI6321683, Length=395, Percent_Identity=43.7974683544304, Blast_Score=313, Evalue=3e-86,
Organism=Drosophila melanogaster, GI21356231, Length=397, Percent_Identity=46.8513853904282, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI161078106, Length=393, Percent_Identity=43.0025445292621, Blast_Score=300, Evalue=8e-82,
Organism=Drosophila melanogaster, GI24645208, Length=393, Percent_Identity=43.0025445292621, Blast_Score=300, Evalue=8e-82,
Organism=Drosophila melanogaster, GI281361397, Length=394, Percent_Identity=43.1472081218274, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI281361395, Length=394, Percent_Identity=43.1472081218274, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI281363477, Length=353, Percent_Identity=26.9121813031161, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363475, Length=353, Percent_Identity=26.9121813031161, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363473, Length=353, Percent_Identity=26.9121813031161, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SUCC_AQUAE (O67546)

Other databases:

- EMBL:   AE000657
- PIR:   H70439
- RefSeq:   NP_214111.1
- ProteinModelPortal:   O67546
- SMR:   O67546
- GeneID:   1193169
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1620
- NMPDR:   fig|224324.1.peg.1126
- HOGENOM:   HBG315432
- OMA:   MADGAEK
- PhylomeDB:   O67546
- ProtClustDB:   PRK00696
- BioCyc:   AAEO224324:AQ_1620-MONOMER
- BRENDA:   6.2.1.5
- HAMAP:   MF_00558
- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.261
- PANTHER:   PTHR11815
- TIGRFAMs:   TIGR01016

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 42187; Mature: 42187

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50975 ATP_GRASP; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLHEHQAKEIFAKYGIPVPEGKVAFSLKEAKEVAEELGEFPLVVKAQIHCGGRGKAGGV
CCCCHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCC
KIVKDMDELEKAVESLLGKVLKTFQCPDGKPVNRVLIEKATNIDKEYYLAITLDRSKSKP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCC
VIMASAAGGMEIEEIVKENPEAIIIETIDPELGLMPYQARELAFKLNLPVKEFASIALKL
EEEEECCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHH
YQIYSDLDASLVEINPLVLTKEGNLIALDAKLDIDDNALFRHKDLEEMEDETQLPQLEVE
HHHHHCCCCCEEEECEEEEEECCCEEEEEEEECCCCCCEECCCCHHHHHHHHCCCCEEEE
AKKYGLNYIKLNGNIGCMVNGAGLAMATMDIIKLAGGEPANFLDVGGGANVEQIANAFRI
HHHCCCEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHEE
LMADPDVKAVFINIFGGILRVDRLAQGLIEASKMVELRVPIVARLEGTNVEEGKRMLQES
EEECCCHHEEHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEECCCCHHHHHHHHHHC
GLNFIIAEDMWDGAKKAVEIANKQS
CCCEEEECCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKLHEHQAKEIFAKYGIPVPEGKVAFSLKEAKEVAEELGEFPLVVKAQIHCGGRGKAGGV
CCCCHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCC
KIVKDMDELEKAVESLLGKVLKTFQCPDGKPVNRVLIEKATNIDKEYYLAITLDRSKSKP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCC
VIMASAAGGMEIEEIVKENPEAIIIETIDPELGLMPYQARELAFKLNLPVKEFASIALKL
EEEEECCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHH
YQIYSDLDASLVEINPLVLTKEGNLIALDAKLDIDDNALFRHKDLEEMEDETQLPQLEVE
HHHHHCCCCCEEEECEEEEEECCCEEEEEEEECCCCCCEECCCCHHHHHHHHCCCCEEEE
AKKYGLNYIKLNGNIGCMVNGAGLAMATMDIIKLAGGEPANFLDVGGGANVEQIANAFRI
HHHCCCEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHEE
LMADPDVKAVFINIFGGILRVDRLAQGLIEASKMVELRVPIVARLEGTNVEEGKRMLQES
EEECCCHHEEHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEECCCCHHHHHHHHHHC
GLNFIIAEDMWDGAKKAVEIANKQS
CCCEEEECCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320