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The map label for this gene is uppS

Identifier: 15606475

GI number: 15606475

Start: 880332

End: 881027

Strand: Direct

Name: uppS

Synonym: aq_1248

Alternate gene names: 15606475

Gene position: 880332-881027 (Clockwise)

Preceding gene: 15606474

Following gene: 15606476

Centisome position: 56.75

GC content: 43.82

Gene sequence:

>696_bases
ATGAGCTTAAAACTTCCAGAGCACGTTGCGATAATAATGGACGGAAACGGGCGGTGGGCAAGACAGAGGGGTCTACCCAG
AGTTGCGGGACATTACAGAGGTGCAGAGGTAGCCGAAGACATAATAGAGTACTGTATAGAGCTGGGAATAAAACACCTGA
CTTTGTTTGCCTTCTCTACGGAAAACTGGAACAGACCTAAAGAAGAAGTTAAAGCCCTGTTTGAGCTTATGGAAAACTAC
ATAAGGAGTAAGAGGGAAAAACTTTACTCCTTAGGTGTAAGGGTAAGGTTAATAGGAAGGAGGGACAGACTCAGTAGAGG
CTTAGTAAACTTAATGGAAGAACTGGAAAGTGATTCAAAGGATTTCAAAAATCTCTTTTTAAACGTTGCCATAGACTACG
GCGGAAGGGATGACATACTGAGGGCTGTGAAAAAAATAATGGAAGTTCAACCGAGCAAACTTGATGAGGAGACTTTTTCT
CAGTTTCTGGATCTCTCCTGCTCTCCTGACCCTGACCTTCTAATAAGAACCGCGGGAGAGAAGAGGATTTCCAACTTCCT
CCTATGGAACCTGGCGTACACGGAGCTTTACTTTACTGATACACTCTGGCCCGATTTCACGAGAGAAGAATTTATGAAAG
CCCTTGAGGATTACTCAAGGAGAAAGAGAAAGTTCGGGAGAGTTCTTGATGAGTAG

Upstream 100 bases:

>100_bases
GGAACATAGAAGAGGCAAACAGGTACTTATCCATACTTGAGGAAAAGTTTCCCGATGCAGAGGCAACCCAAAGGGCAAAG
GAGTTAATATATAAAACTCC

Downstream 100 bases:

>100_bases
AGAATTTTACGGCGTGCTTATAGGCGTAACGACACTTCTTGTTATCTTCTTACCGAAATCTTTATTCCTTTTAGTGATTT
TGTTCTTGTGTTTTGCCATA

Product: hypothetical protein

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSLKLPEHVAIIMDGNGRWARQRGLPRVAGHYRGAEVAEDIIEYCIELGIKHLTLFAFSTENWNRPKEEVKALFELMENY
IRSKREKLYSLGVRVRLIGRRDRLSRGLVNLMEELESDSKDFKNLFLNVAIDYGGRDDILRAVKKIMEVQPSKLDEETFS
QFLDLSCSPDPDLLIRTAGEKRISNFLLWNLAYTELYFTDTLWPDFTREEFMKALEDYSRRKRKFGRVLDE

Sequences:

>Translated_231_residues
MSLKLPEHVAIIMDGNGRWARQRGLPRVAGHYRGAEVAEDIIEYCIELGIKHLTLFAFSTENWNRPKEEVKALFELMENY
IRSKREKLYSLGVRVRLIGRRDRLSRGLVNLMEELESDSKDFKNLFLNVAIDYGGRDDILRAVKKIMEVQPSKLDEETFS
QFLDLSCSPDPDLLIRTAGEKRISNFLLWNLAYTELYFTDTLWPDFTREEFMKALEDYSRRKRKFGRVLDE
>Mature_230_residues
SLKLPEHVAIIMDGNGRWARQRGLPRVAGHYRGAEVAEDIIEYCIELGIKHLTLFAFSTENWNRPKEEVKALFELMENYI
RSKREKLYSLGVRVRLIGRRDRLSRGLVNLMEELESDSKDFKNLFLNVAIDYGGRDDILRAVKKIMEVQPSKLDEETFSQ
FLDLSCSPDPDLLIRTAGEKRISNFLLWNLAYTELYFTDTLWPDFTREEFMKALEDYSRRKRKFGRVLDE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=212, Percent_Identity=35.8490566037736, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI45580738, Length=212, Percent_Identity=35.8490566037736, Blast_Score=143, Evalue=1e-34,
Organism=Escherichia coli, GI1786371, Length=236, Percent_Identity=44.9152542372881, Blast_Score=204, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=36.8888888888889, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=209, Percent_Identity=35.4066985645933, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=221, Percent_Identity=34.3891402714932, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=38.8392857142857, Blast_Score=161, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_AQUAE (O67291)

Other databases:

- EMBL:   AE000657
- PIR:   H70407
- RefSeq:   NP_213855.1
- ProteinModelPortal:   O67291
- SMR:   O67291
- GeneID:   1192729
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1248
- NMPDR:   fig|224324.1.peg.870
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   O67291
- ProtClustDB:   CLSK2748432
- BioCyc:   AAEO224324:AQ_1248-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 27149; Mature: 27017

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 14-14

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKLPEHVAIIMDGNGRWARQRGLPRVAGHYRGAEVAEDIIEYCIELGIKHLTLFAFST
CCCCCCCCEEEEECCCCCCHHHCCCCHHHHCCCCHHHHHHHHHHHHHHCHHHHHEEEEEC
ENWNRPKEEVKALFELMENYIRSKREKLYSLGVRVRLIGRRDRLSRGLVNLMEELESDSK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEECCHHHHHHHHHHHHHHHHCCHH
DFKNLFLNVAIDYGGRDDILRAVKKIMEVQPSKLDEETFSQFLDLSCSPDPDLLIRTAGE
HHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEECCCH
KRISNFLLWNLAYTELYFTDTLWPDFTREEFMKALEDYSRRKRKFGRVLDE
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLKLPEHVAIIMDGNGRWARQRGLPRVAGHYRGAEVAEDIIEYCIELGIKHLTLFAFST
CCCCCCCEEEEECCCCCCHHHCCCCHHHHCCCCHHHHHHHHHHHHHHCHHHHHEEEEEC
ENWNRPKEEVKALFELMENYIRSKREKLYSLGVRVRLIGRRDRLSRGLVNLMEELESDSK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEECCHHHHHHHHHHHHHHHHCCHH
DFKNLFLNVAIDYGGRDDILRAVKKIMEVQPSKLDEETFSQFLDLSCSPDPDLLIRTAGE
HHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEECCCH
KRISNFLLWNLAYTELYFTDTLWPDFTREEFMKALEDYSRRKRKFGRVLDE
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320