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The map label for this gene is hyuA

Identifier: 15606108

GI number: 15606108

Start: 484648

End: 486630

Strand: Direct

Name: hyuA

Synonym: aq_708

Alternate gene names: NA

Gene position: 484648-486630 (Clockwise)

Preceding gene: 15606107

Following gene: 15606115

Centisome position: 31.24

GC content: 46.39

Gene sequence:

>1983_bases
ATGAGAGTTTACGTGGGCGTTGATACAGGCGGGACCTTTACAGACTTCGTTTACTGGGACGGAAAGGAGTGGCGTGTCCT
CAAAATCCCATCTACTCCCTCCAATCCCGCGGAAGCTGTCCTGAAAGGTCTCGAAAAGTTGAGAAGGGGGAAAGCCCTTG
ACGTGGTTCACGGCTCCACCGTAGCTACAAACGCACTCCTTGAGAGAAAGGGGGCAAAAACTGCTTTAATTACGAATAAG
GGTTTTGAAGACGTAATAGAGATAGGGAGACAAAATAGGGAAAGACTTTATGACCTTTACTACAGAAAGCCCAAGCCACT
TGTGCCGAGAGAACTCAGGTTCGGGCTAAATTGCAGGATAAACGCAAAAGGAGAGGTTTTAAAACCAATAAACAGAGAAG
AACTGAAGGAAATACTAAAAGCCTTGAAAGAAAAAGGAGTTGAGTCGGTAGCTGTATGTATGCTCCACTCTTACGCAAAT
CCCGAACATGAGAAAGAAGTGGAAGAAGAACTTAAGAAGAATTTGAGTGTTTTTGTTTCCCTCTCCTCCGAAATCCTTCC
AGAGTTTAGAGAATACGAGAGGTGTTCCACTACCGTTATAAACGCCTACGTCTCACCAAAGATGTCAAAATACCTTTATT
ACTTAAAAGATAGATTAAGGGAGGGAGACCTTTTCAGGGTGATGCAGTCAAACGGGGGACTGATTTCTCCGGAAACCGCT
TCAAAGGAGGCAGTTAGAACTATACTCTCTGGACCCGCGGGAGGAGTGATAGGTGCTCTTCACCTTGGAAAGCTCGCGGG
CTTTGAAAAGTTAATTACCTTTGACATGGGCGGGACCTCCACGGATGTGTCCCTGATATACGGAACTCCGAATATAACTA
CGGAGTCAAAGATAGATGGTCTGCCCGTAAAGGTTCCCATGATAGACATAAATACGGTGGGAGCGGGAGGAGGTTCCATA
GCCTACGTGGATGAAGGAGGAGCTCTCAGAGTAGGCCCTCAGAGTGCGGGAGCGCAGCCCGGACCCATATGCTACGGAAG
GGGAGGAAAAGAGATAACTGTAACGGATGCAAACCTCTTTCTAGGAAGACTCGTTCCGGAGCACTTCTTGGGCGGTGAGA
TGAAACTATATCCCGAACTGCTTGAAGAACCCTTCAAGGAAATGGCAAAGAAAATAGGACTCGCACCCACGGAGCTCGCG
GAAGGGATAATAAAGGTAGCTAACTCCAGCATGGAAAGGGCTATAAGGAAGGTTTCGGTAGAGAGAGGCTACAACCCTGA
AGAGTTTGCCCTCTTTTCTTTTGGAGGAGCTGGTGGCCTGCACGCTGTGCTTCTTGCAAAGAGTTTAAATATTCCGAAAG
TCATAATTCCCAGAAATCCCGGGCTTCTTTCCGCGGTAGGTATGCTCTTTGCGGATATAGTAAAGGACAAAGTAACCACC
GTTATGCTGAAAGAAGAGGAGGCAAAGCCCGAAACCCTAGAAAAGTTGTTCTTACTTATGGAGGAGAAAGTACTCTCCGA
AATGGAGGGAGAAGGCTTTCCGCCCGAGAAGGTATTCGTAGAGAGGTTTTTAGACGTAAGATACAAGGGGCAATCTTACG
AGATAACTATACCTTTTGGTGAAAACTTCAAAGAGACTTTTGAAAAAGAGCACGAAAGGCTTTACGGATATGCCCACAGG
GGAAGGAAGATAGAAATTGTAAATCTCAGGATAAAGGCAACGGGGATAAAGGAAAAACCTCCCTTGAAAGAGTTTAAGGA
AAGGGGAGATAAGTATCCCAAGGATGCAATCCTCGGAGAGCGGGAAGTGGTATTTGAAGGAAGGCTTGAGACTTTTAAAG
TTCTCGACAGAGAAAAACTCGTTTACGGGAACGTTATAGACTTTCCCGCCATAGTGGTTGAGTACTCTTCAACCACGCTC
ATACCGCCCTACGCAACCGCGGAAGTGGACAGGTATGGGAACTTGATTATTACTCTCCTTTGA

Upstream 100 bases:

>100_bases
CGCTCCCGCAACCGCTGAGGTAGCCCTGAAGTTAATAGACCAGGGGGAGGTTTCGGAATACTTCAAGACTTTCTCCCCTT
ACAGGTTCAAGGAGTAAATA

Downstream 100 bases:

>100_bases
AGTACTTCCAGAAACCCCTTCTATCCTTGTAGGCCTCCTCCTGAGCTTCTCCCAATTCTTTTAAGTACTTCACCTGAGGA
GGGATTATGAAAACGAATGC

Product: N-methylhydantoinase A

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MRVYVGVDTGGTFTDFVYWDGKEWRVLKIPSTPSNPAEAVLKGLEKLRRGKALDVVHGSTVATNALLERKGAKTALITNK
GFEDVIEIGRQNRERLYDLYYRKPKPLVPRELRFGLNCRINAKGEVLKPINREELKEILKALKEKGVESVAVCMLHSYAN
PEHEKEVEEELKKNLSVFVSLSSEILPEFREYERCSTTVINAYVSPKMSKYLYYLKDRLREGDLFRVMQSNGGLISPETA
SKEAVRTILSGPAGGVIGALHLGKLAGFEKLITFDMGGTSTDVSLIYGTPNITTESKIDGLPVKVPMIDINTVGAGGGSI
AYVDEGGALRVGPQSAGAQPGPICYGRGGKEITVTDANLFLGRLVPEHFLGGEMKLYPELLEEPFKEMAKKIGLAPTELA
EGIIKVANSSMERAIRKVSVERGYNPEEFALFSFGGAGGLHAVLLAKSLNIPKVIIPRNPGLLSAVGMLFADIVKDKVTT
VMLKEEEAKPETLEKLFLLMEEKVLSEMEGEGFPPEKVFVERFLDVRYKGQSYEITIPFGENFKETFEKEHERLYGYAHR
GRKIEIVNLRIKATGIKEKPPLKEFKERGDKYPKDAILGEREVVFEGRLETFKVLDREKLVYGNVIDFPAIVVEYSSTTL
IPPYATAEVDRYGNLIITLL

Sequences:

>Translated_660_residues
MRVYVGVDTGGTFTDFVYWDGKEWRVLKIPSTPSNPAEAVLKGLEKLRRGKALDVVHGSTVATNALLERKGAKTALITNK
GFEDVIEIGRQNRERLYDLYYRKPKPLVPRELRFGLNCRINAKGEVLKPINREELKEILKALKEKGVESVAVCMLHSYAN
PEHEKEVEEELKKNLSVFVSLSSEILPEFREYERCSTTVINAYVSPKMSKYLYYLKDRLREGDLFRVMQSNGGLISPETA
SKEAVRTILSGPAGGVIGALHLGKLAGFEKLITFDMGGTSTDVSLIYGTPNITTESKIDGLPVKVPMIDINTVGAGGGSI
AYVDEGGALRVGPQSAGAQPGPICYGRGGKEITVTDANLFLGRLVPEHFLGGEMKLYPELLEEPFKEMAKKIGLAPTELA
EGIIKVANSSMERAIRKVSVERGYNPEEFALFSFGGAGGLHAVLLAKSLNIPKVIIPRNPGLLSAVGMLFADIVKDKVTT
VMLKEEEAKPETLEKLFLLMEEKVLSEMEGEGFPPEKVFVERFLDVRYKGQSYEITIPFGENFKETFEKEHERLYGYAHR
GRKIEIVNLRIKATGIKEKPPLKEFKERGDKYPKDAILGEREVVFEGRLETFKVLDREKLVYGNVIDFPAIVVEYSSTTL
IPPYATAEVDRYGNLIITLL
>Mature_660_residues
MRVYVGVDTGGTFTDFVYWDGKEWRVLKIPSTPSNPAEAVLKGLEKLRRGKALDVVHGSTVATNALLERKGAKTALITNK
GFEDVIEIGRQNRERLYDLYYRKPKPLVPRELRFGLNCRINAKGEVLKPINREELKEILKALKEKGVESVAVCMLHSYAN
PEHEKEVEEELKKNLSVFVSLSSEILPEFREYERCSTTVINAYVSPKMSKYLYYLKDRLREGDLFRVMQSNGGLISPETA
SKEAVRTILSGPAGGVIGALHLGKLAGFEKLITFDMGGTSTDVSLIYGTPNITTESKIDGLPVKVPMIDINTVGAGGGSI
AYVDEGGALRVGPQSAGAQPGPICYGRGGKEITVTDANLFLGRLVPEHFLGGEMKLYPELLEEPFKEMAKKIGLAPTELA
EGIIKVANSSMERAIRKVSVERGYNPEEFALFSFGGAGGLHAVLLAKSLNIPKVIIPRNPGLLSAVGMLFADIVKDKVTT
VMLKEEEAKPETLEKLFLLMEEKVLSEMEGEGFPPEKVFVERFLDVRYKGQSYEITIPFGENFKETFEKEHERLYGYAHR
GRKIEIVNLRIKATGIKEKPPLKEFKERGDKYPKDAILGEREVVFEGRLETFKVLDREKLVYGNVIDFPAIVVEYSSTTL
IPPYATAEVDRYGNLIITLL

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=731, Percent_Identity=33.9261285909713, Blast_Score=323, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI133901900, Length=696, Percent_Identity=32.6149425287356, Blast_Score=287, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6322634, Length=730, Percent_Identity=33.8356164383562, Blast_Score=306, Evalue=8e-84,
Organism=Drosophila melanogaster, GI45550492, Length=724, Percent_Identity=32.7348066298343, Blast_Score=329, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 73394; Mature: 73394

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYVGVDTGGTFTDFVYWDGKEWRVLKIPSTPSNPAEAVLKGLEKLRRGKALDVVHGST
CEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCH
VATNALLERKGAKTALITNKGFEDVIEIGRQNRERLYDLYYRKPKPLVPRELRFGLNCRI
HHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHCCCCCEEE
NAKGEVLKPINREELKEILKALKEKGVESVAVCMLHSYANPEHEKEVEEELKKNLSVFVS
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEE
LSSEILPEFREYERCSTTVINAYVSPKMSKYLYYLKDRLREGDLFRVMQSNGGLISPETA
ECHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCC
SKEAVRTILSGPAGGVIGALHLGKLAGFEKLITFDMGGTSTDVSLIYGTPNITTESKIDG
HHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEEEEECCCCCCCEEEEECCCCCCCCCCCCC
LPVKVPMIDINTVGAGGGSIAYVDEGGALRVGPQSAGAQPGPICYGRGGKEITVTDANLF
CEEEEEEEEEEEECCCCCEEEEEECCCEEEECCCCCCCCCCCEEECCCCCEEEEEEHHHH
LGRLVPEHFLGGEMKLYPELLEEPFKEMAKKIGLAPTELAEGIIKVANSSMERAIRKVSV
HHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ERGYNPEEFALFSFGGAGGLHAVLLAKSLNIPKVIIPRNPGLLSAVGMLFADIVKDKVTT
HCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHE
VMLKEEEAKPETLEKLFLLMEEKVLSEMEGEGFPPEKVFVERFLDVRYKGQSYEITIPFG
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCEEEEEECCC
ENFKETFEKEHERLYGYAHRGRKIEIVNLRIKATGIKEKPPLKEFKERGDKYPKDAILGE
CCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCHHHHHHHCCCCCCHHHCCC
REVVFEGRLETFKVLDREKLVYGNVIDFPAIVVEYSSTTLIPPYATAEVDRYGNLIITLL
CEEEECCCHHHHHHHCCCCEEECCCCCCCEEEEEECCCEECCCCCCCCHHCCCCEEEEEC
>Mature Secondary Structure
MRVYVGVDTGGTFTDFVYWDGKEWRVLKIPSTPSNPAEAVLKGLEKLRRGKALDVVHGST
CEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCH
VATNALLERKGAKTALITNKGFEDVIEIGRQNRERLYDLYYRKPKPLVPRELRFGLNCRI
HHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHCCCCCEEE
NAKGEVLKPINREELKEILKALKEKGVESVAVCMLHSYANPEHEKEVEEELKKNLSVFVS
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEE
LSSEILPEFREYERCSTTVINAYVSPKMSKYLYYLKDRLREGDLFRVMQSNGGLISPETA
ECHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCC
SKEAVRTILSGPAGGVIGALHLGKLAGFEKLITFDMGGTSTDVSLIYGTPNITTESKIDG
HHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEEEEECCCCCCCEEEEECCCCCCCCCCCCC
LPVKVPMIDINTVGAGGGSIAYVDEGGALRVGPQSAGAQPGPICYGRGGKEITVTDANLF
CEEEEEEEEEEEECCCCCEEEEEECCCEEEECCCCCCCCCCCEEECCCCCEEEEEEHHHH
LGRLVPEHFLGGEMKLYPELLEEPFKEMAKKIGLAPTELAEGIIKVANSSMERAIRKVSV
HHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ERGYNPEEFALFSFGGAGGLHAVLLAKSLNIPKVIIPRNPGLLSAVGMLFADIVKDKVTT
HCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHE
VMLKEEEAKPETLEKLFLLMEEKVLSEMEGEGFPPEKVFVERFLDVRYKGQSYEITIPFG
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCEEEEEECCC
ENFKETFEKEHERLYGYAHRGRKIEIVNLRIKATGIKEKPPLKEFKERGDKYPKDAILGE
CCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCHHHHHHHCCCCCCHHHCCC
REVVFEGRLETFKVLDREKLVYGNVIDFPAIVVEYSSTTLIPPYATAEVDRYGNLIITLL
CEEEECCCHHHHHHHCCCCEEECCCCCCCEEEEEECCCEECCCCCCCCHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]