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The map label for this gene is dusC

Identifier: 15603745

GI number: 15603745

Start: 2121795

End: 2122733

Strand: Direct

Name: dusC

Synonym: PM1880

Alternate gene names: 15603745

Gene position: 2121795-2122733 (Clockwise)

Preceding gene: 15603744

Following gene: 15603746

Centisome position: 93.99

GC content: 45.69

Gene sequence:

>939_bases
ATGCGCGTAATTCTTGCTCCGATGCAAGGGGTATTAGACCCTTTTGTTCGTCAACTTCTCACACAGGTCAATCAGTATGA
TTTGTGTGTTTCTGAATTTGTGCGGGTGGTCGATCAACTTCTTCCCACGAAAGTATTCTATCGTCTGTGCCCTGAATTAT
ATCAACAAGGATTGACCGCTTCGGGAACGCCAGTGCGTGTGCAACTATTGGGGCAACATCCTCAATGGTTAGCGGAAAAT
GCGCAGCGCGCGATTGAATTAGGTTCGCATGGTATTGATCTCAATTGTGGTTGTCCGTCAAAAACGGTGAATGGCAGCAA
TGGCGGCGCGTCTCTCTTAAAACAACCCGAACTGATTTATCACGCCACCAAAGCCTTACGCGCGGCAGTGCCAAAGGCAT
TGCCAGTTAGTGTAAAAGTGCGTTTAGGTTGGGATAATTCAGAACAAGCGTTTGAGATCGCTGATGCGGTACAACAAGGT
GGTGCGACAGAGATTACTATCCATGGACGAACCAAAATGGATGGTTATCGTGCTGATCGGATTAATTGGGCAAAAATTAA
TGACGTACGTCAACGCTTATCTATTCCAGTGATTGCCAATGGTGAGATCTGGGACTGGCAATCAGGGCAAGCCTGTTTAG
CTGAAACGGGGTGCCAAGATTTGATGATTGGGCGCGGCGCTTTGAATATTCCGAATTTAAGCCAAGTGGTGAAATTCAAT
CAAGCAAAAATGCCGTGGGCTGAGGTGCTTATCCTGTTACATCAATATGCGCATACGGAAAACCAATTTGATACGGGGTT
TTATCATGTCGCGCGTATAAAACAATGGCTAGGTTATCTTAAAAAAGCATACCCACAAGCCGATGCGCTCTTTCAGCTCA
TTAAAACCTGTCATGATGGACAGGCGTTACGCATGAAAATAGACGGAGTTATGAACTAA

Upstream 100 bases:

>100_bases
CGCAGGGCGATCAGTGGGATGCGCAAAAAGATATTTTGGCAGATACATTCGGGGCGTTAAGCGCGTTGGCATTGTTTTAT
CTCGTGAGAACGGATAAAAC

Downstream 100 bases:

>100_bases
TGAAATATCAATGGATTTTTTTTGATGCAGATGAAACCTTGTTTTCATTTGATGCTTTTGCAGGATTGCAGAAATTGTTT
TCAGATTATGGTGTTGATTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MRVILAPMQGVLDPFVRQLLTQVNQYDLCVSEFVRVVDQLLPTKVFYRLCPELYQQGLTASGTPVRVQLLGQHPQWLAEN
AQRAIELGSHGIDLNCGCPSKTVNGSNGGASLLKQPELIYHATKALRAAVPKALPVSVKVRLGWDNSEQAFEIADAVQQG
GATEITIHGRTKMDGYRADRINWAKINDVRQRLSIPVIANGEIWDWQSGQACLAETGCQDLMIGRGALNIPNLSQVVKFN
QAKMPWAEVLILLHQYAHTENQFDTGFYHVARIKQWLGYLKKAYPQADALFQLIKTCHDGQALRMKIDGVMN

Sequences:

>Translated_312_residues
MRVILAPMQGVLDPFVRQLLTQVNQYDLCVSEFVRVVDQLLPTKVFYRLCPELYQQGLTASGTPVRVQLLGQHPQWLAEN
AQRAIELGSHGIDLNCGCPSKTVNGSNGGASLLKQPELIYHATKALRAAVPKALPVSVKVRLGWDNSEQAFEIADAVQQG
GATEITIHGRTKMDGYRADRINWAKINDVRQRLSIPVIANGEIWDWQSGQACLAETGCQDLMIGRGALNIPNLSQVVKFN
QAKMPWAEVLILLHQYAHTENQFDTGFYHVARIKQWLGYLKKAYPQADALFQLIKTCHDGQALRMKIDGVMN
>Mature_312_residues
MRVILAPMQGVLDPFVRQLLTQVNQYDLCVSEFVRVVDQLLPTKVFYRLCPELYQQGLTASGTPVRVQLLGQHPQWLAEN
AQRAIELGSHGIDLNCGCPSKTVNGSNGGASLLKQPELIYHATKALRAAVPKALPVSVKVRLGWDNSEQAFEIADAVQQG
GATEITIHGRTKMDGYRADRINWAKINDVRQRLSIPVIANGEIWDWQSGQACLAETGCQDLMIGRGALNIPNLSQVVKFN
QAKMPWAEVLILLHQYAHTENQFDTGFYHVARIKQWLGYLKKAYPQADALFQLIKTCHDGQALRMKIDGVMN

Specific function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs

COG id: COG0042

COG function: function code J; tRNA-dihydrouridine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dus family. DusC subfamily

Homologues:

Organism=Homo sapiens, GI31742496, Length=251, Percent_Identity=29.0836653386454, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI40807366, Length=239, Percent_Identity=28.4518828451883, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1788462, Length=310, Percent_Identity=67.741935483871, Blast_Score=449, Evalue=1e-128,
Organism=Escherichia coli, GI1789660, Length=293, Percent_Identity=31.3993174061433, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI145693211, Length=322, Percent_Identity=23.9130434782609, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144369, Length=172, Percent_Identity=33.1395348837209, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17507177, Length=179, Percent_Identity=32.4022346368715, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323560, Length=196, Percent_Identity=26.0204081632653, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19921524, Length=176, Percent_Identity=32.3863636363636, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24585320, Length=232, Percent_Identity=31.4655172413793, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24580595, Length=285, Percent_Identity=27.719298245614, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19920448, Length=285, Percent_Identity=27.719298245614, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUSC_PASMU (Q9CJW1)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246819.1
- ProteinModelPortal:   Q9CJW1
- SMR:   Q9CJW1
- GeneID:   1245227
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1880
- NMPDR:   fig|272843.1.peg.1881
- HOGENOM:   HBG557545
- OMA:   VGGIDWC
- ProtClustDB:   CLSK789896
- BioCyc:   PMUL272843:PM1880-MONOMER
- InterPro:   IPR013785
- InterPro:   IPR001269
- InterPro:   IPR018517
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR11082
- PIRSF:   PIRSF006621

Pfam domain/function: PF01207 Dus

EC number: NA

Molecular weight: Translated: 34786; Mature: 34786

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS01136 UPF0034

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVILAPMQGVLDPFVRQLLTQVNQYDLCVSEFVRVVDQLLPTKVFYRLCPELYQQGLTA
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SGTPVRVQLLGQHPQWLAENAQRAIELGSHGIDLNCGCPSKTVNGSNGGASLLKQPELIY
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHCCCHHHH
HATKALRAAVPKALPVSVKVRLGWDNSEQAFEIADAVQQGGATEITIHGRTKMDGYRADR
HHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
INWAKINDVRQRLSIPVIANGEIWDWQSGQACLAETGCQDLMIGRGALNIPNLSQVVKFN
CCHHHHHHHHHHHCCCEEECCCEECCCCCCHHHHHCCCHHHHCCCCCCCCCCHHHHHHHC
QAKMPWAEVLILLHQYAHTENQFDTGFYHVARIKQWLGYLKKAYPQADALFQLIKTCHDG
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
QALRMKIDGVMN
CEEEEEECCCCC
>Mature Secondary Structure
MRVILAPMQGVLDPFVRQLLTQVNQYDLCVSEFVRVVDQLLPTKVFYRLCPELYQQGLTA
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SGTPVRVQLLGQHPQWLAENAQRAIELGSHGIDLNCGCPSKTVNGSNGGASLLKQPELIY
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHCCCHHHH
HATKALRAAVPKALPVSVKVRLGWDNSEQAFEIADAVQQGGATEITIHGRTKMDGYRADR
HHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
INWAKINDVRQRLSIPVIANGEIWDWQSGQACLAETGCQDLMIGRGALNIPNLSQVVKFN
CCHHHHHHHHHHHCCCEEECCCEECCCCCCHHHHHCCCHHHHCCCCCCCCCCHHHHHHHC
QAKMPWAEVLILLHQYAHTENQFDTGFYHVARIKQWLGYLKKAYPQADALFQLIKTCHDG
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
QALRMKIDGVMN
CEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100