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The map label for this gene is nanM

Identifier: 15603572

GI number: 15603572

Start: 1914725

End: 1915867

Strand: Reverse

Name: nanM

Synonym: PM1707

Alternate gene names: 15603572

Gene position: 1915867-1914725 (Counterclockwise)

Preceding gene: 15603573

Following gene: 15603568

Centisome position: 84.87

GC content: 41.56

Gene sequence:

>1143_bases
ATGAAATTTACAAAAACAGCGTTATTTACGGTATTAGCAGCAACGGCATTTGCCGCACAAGCAGGTCAGTATCCAGATTT
ACCAGAAGGCATTAAAGCCGGTGCAGGTGCATTAATTGGTGATACCGTTTATGTGGGGTTAGGTGGTACTGGCACAACAA
AATTCTATTCATTAAATTTGAAAGATCCAAAAGAATGGAAAGAAATTGCAGAATTCCCTGGTGGTAAACGTAATCAGCCT
GTTGCTGCGGGTGTGAATGGTAAGCTTTATGTGTTTGGTGGTTTCCAAGATACAGATGTCGCGAAAAATCAAATTATCAA
TGATGCTTATGAGTATAATCCGGCAGATAATACGTGGACAAAATTAAGCACACGTTCTCCTCGTTCTACATCTGTGGGAG
CGAGTGTTGCAGCAGATGGCGGTAAAATTTACTTCGTAGGTGGGGTAAACCACGAAATTTGGAATGGTTTATTCCAAGAT
GTTAAAGCTGCAGGTGGTGATAAAGAGAAAGAAAAAGCGATCTTTGACCCGTATTTCAATTTACGCGCACAAGATTTCTT
CTTCTCACCAGAAATCATCAGTTATGAGCCAGCTAACAATGTATGGCGTAACGAAGGCTACTTCCCATATTCAGGTCGTG
CAGGCGCTGCGGTTGCGATTAAAGATGGTAAATTATTAGTCGTGAATGGTGAAGTGAAAGCAGGTTTACGCTCGCCAGGT
ACTGCGTTAGGTACGATTGGTAAAGATGGCGTTACTTGGAAAAAACTCGGTGATTTACCAGCACCAACAGGCTATGACAA
ACAAGATGGTATTGCAGGCGGTATGGGTGGTTATACCAACGGTCATTATATCGTGACAGGTGGTGCGAACTTCCCTGGCG
CATTAGCAAACTATGAAAAAGGGATTATGGACGCGCACCGTACTGGTGGCTTGAAGAAAACCTATCATAAAGCAGTTTAT
GCGTTGGATGGCAAAACAGGTAACTGGAAAATTGTGGGTGAATTACCAGCAACAATTGGTTATGGTTTAGCGGTTTCTTA
TAACAATAAAGTATTGTTAATTGGCGGTGAAACTGATGGTGGTAAACCATTAAGCGCTGTACAAACAATGAGTTATGATG
GTAAGAAATTAACAGTAGAATAA

Upstream 100 bases:

>100_bases
ATCGGACTCGGTTGGCTTTAATTTAAAAAACTTGCCATTCAGTATTATGCTATCTGAATCGGTATTCATTCTTACTAACC
TAATTAATTGAGGTAATAAA

Downstream 100 bases:

>100_bases
TCGTTTTATTCGTGATTTAAGGGCTGTATAAACAGCCCTTTTTTCGTTGCGTTAATCATAATGTGAAAAAACGTAGCGCA
CTTTTTAAGAGTTAAAAGCG

Product: N-acetylneuraminic acid mutarotase

Products: NA

Alternate protein names: N-acetylneuraminate mutarotase; Neu5Ac mutarotase; Sialic acid epimerase

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKFTKTALFTVLAATAFAAQAGQYPDLPEGIKAGAGALIGDTVYVGLGGTGTTKFYSLNLKDPKEWKEIAEFPGGKRNQP
VAAGVNGKLYVFGGFQDTDVAKNQIINDAYEYNPADNTWTKLSTRSPRSTSVGASVAADGGKIYFVGGVNHEIWNGLFQD
VKAAGGDKEKEKAIFDPYFNLRAQDFFFSPEIISYEPANNVWRNEGYFPYSGRAGAAVAIKDGKLLVVNGEVKAGLRSPG
TALGTIGKDGVTWKKLGDLPAPTGYDKQDGIAGGMGGYTNGHYIVTGGANFPGALANYEKGIMDAHRTGGLKKTYHKAVY
ALDGKTGNWKIVGELPATIGYGLAVSYNNKVLLIGGETDGGKPLSAVQTMSYDGKKLTVE

Sequences:

>Translated_380_residues
MKFTKTALFTVLAATAFAAQAGQYPDLPEGIKAGAGALIGDTVYVGLGGTGTTKFYSLNLKDPKEWKEIAEFPGGKRNQP
VAAGVNGKLYVFGGFQDTDVAKNQIINDAYEYNPADNTWTKLSTRSPRSTSVGASVAADGGKIYFVGGVNHEIWNGLFQD
VKAAGGDKEKEKAIFDPYFNLRAQDFFFSPEIISYEPANNVWRNEGYFPYSGRAGAAVAIKDGKLLVVNGEVKAGLRSPG
TALGTIGKDGVTWKKLGDLPAPTGYDKQDGIAGGMGGYTNGHYIVTGGANFPGALANYEKGIMDAHRTGGLKKTYHKAVY
ALDGKTGNWKIVGELPATIGYGLAVSYNNKVLLIGGETDGGKPLSAVQTMSYDGKKLTVE
>Mature_380_residues
MKFTKTALFTVLAATAFAAQAGQYPDLPEGIKAGAGALIGDTVYVGLGGTGTTKFYSLNLKDPKEWKEIAEFPGGKRNQP
VAAGVNGKLYVFGGFQDTDVAKNQIINDAYEYNPADNTWTKLSTRSPRSTSVGASVAADGGKIYFVGGVNHEIWNGLFQD
VKAAGGDKEKEKAIFDPYFNLRAQDFFFSPEIISYEPANNVWRNEGYFPYSGRAGAAVAIKDGKLLVVNGEVKAGLRSPG
TALGTIGKDGVTWKKLGDLPAPTGYDKQDGIAGGMGGYTNGHYIVTGGANFPGALANYEKGIMDAHRTGGLKKTYHKAVY
ALDGKTGNWKIVGELPATIGYGLAVSYNNKVLLIGGETDGGKPLSAVQTMSYDGKKLTVE

Specific function: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, whic

COG id: COG3055

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Periplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 7 Kelch repeats

Homologues:

Organism=Escherichia coli, GI87082419, Length=381, Percent_Identity=38.3202099737533, Blast_Score=244, Evalue=8e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NANM_PASMU (Q9CKB7)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246646.1
- ProteinModelPortal:   Q9CKB7
- GeneID:   1245054
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1707
- NMPDR:   fig|272843.1.peg.1708
- HOGENOM:   HBG365569
- OMA:   FTTAEII
- ProtClustDB:   PRK14131
- BioCyc:   PMUL272843:PM1707-MONOMER
- HAMAP:   MF_01195
- InterPro:   IPR015915
- InterPro:   IPR006652
- InterPro:   IPR019936
- Gene3D:   G3DSA:2.120.10.80
- TIGRFAMs:   TIGR03547

Pfam domain/function: PF01344 Kelch_1

EC number: NA

Molecular weight: Translated: 40260; Mature: 40260

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: ACT_SITE 231-231

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTKTALFTVLAATAFAAQAGQYPDLPEGIKAGAGALIGDTVYVGLGGTGTTKFYSLNL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECEEEEEECCCCCCEEEEEEC
KDPKEWKEIAEFPGGKRNQPVAAGVNGKLYVFGGFQDTDVAKNQIINDAYEYNPADNTWT
CCHHHHHHHHHCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEE
KLSTRSPRSTSVGASVAADGGKIYFVGGVNHEIWNGLFQDVKAAGGDKEKEKAIFDPYFN
EEECCCCCCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHCEEECCCCC
LRAQDFFFSPEIISYEPANNVWRNEGYFPYSGRAGAAVAIKDGKLLVVNGEVKAGLRSPG
CEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCEEEEECCCEECCCCCCC
TALGTIGKDGVTWKKLGDLPAPTGYDKQDGIAGGMGGYTNGHYIVTGGANFPGALANYEK
CEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHH
GIMDAHRTGGLKKTYHKAVYALDGKTGNWKIVGELPATIGYGLAVSYNNKVLLIGGETDG
HHHHHHHCCCCHHHHEEEEEEECCCCCCEEEEEECCCCCCCCEEEEECCEEEEEECCCCC
GKPLSAVQTMSYDGKKLTVE
CCCHHHHHHCCCCCCEEEEC
>Mature Secondary Structure
MKFTKTALFTVLAATAFAAQAGQYPDLPEGIKAGAGALIGDTVYVGLGGTGTTKFYSLNL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECEEEEEECCCCCCEEEEEEC
KDPKEWKEIAEFPGGKRNQPVAAGVNGKLYVFGGFQDTDVAKNQIINDAYEYNPADNTWT
CCHHHHHHHHHCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEE
KLSTRSPRSTSVGASVAADGGKIYFVGGVNHEIWNGLFQDVKAAGGDKEKEKAIFDPYFN
EEECCCCCCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHCEEECCCCC
LRAQDFFFSPEIISYEPANNVWRNEGYFPYSGRAGAAVAIKDGKLLVVNGEVKAGLRSPG
CEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCEEEEECCCEECCCCCCC
TALGTIGKDGVTWKKLGDLPAPTGYDKQDGIAGGMGGYTNGHYIVTGGANFPGALANYEK
CEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHH
GIMDAHRTGGLKKTYHKAVYALDGKTGNWKIVGELPATIGYGLAVSYNNKVLLIGGETDG
HHHHHHHCCCCHHHHEEEEEEECCCCCCEEEEEECCCCCCCCEEEEECCEEEEEECCCCC
GKPLSAVQTMSYDGKKLTVE
CCCHHHHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100