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The map label for this gene is zwf [H]

Identifier: 15603414

GI number: 15603414

Start: 1751723

End: 1753213

Strand: Direct

Name: zwf [H]

Synonym: PM1549

Alternate gene names: 15603414

Gene position: 1751723-1753213 (Clockwise)

Preceding gene: 15603413

Following gene: 161723308

Centisome position: 77.6

GC content: 41.58

Gene sequence:

>1491_bases
ATGAAAATTGAAGCAGACAACAATTGTATTGTAATTTTTGGTGCATCAGGTGATTTAACTTATCGTAAATTGATTCCTGC
ACTGTATAACTTATATAAAATCGGTCGTTTGACTGAGCATTTCTCCGTGTTAGGTGTGGCAAGAACGGAATTAAGTGATG
AGGGTTTCCGTGAAAAAATGCGCCAAGCGTTGATCAAAAGTGAAAAAGCGAATGGCGAAACACTCGATCAATTTTGTAGC
CACCTTTATTATCAGGCATTAAATACCGCGGATGCTGCCGATTATGGCAAGTTAATTCCTCGTCTTGATGATTTACATGA
TAAATATCAAACCTGTGGTAACACACTTTACTATTTATCCACGCCGCCAAGTCTTTATGGTGTGATTCCAGAATGTCTTG
CGGCACATGGGTTAAATACTGAAGAGTTTGGCTGGAAGCGGTTAATTGTGGAAAAACCGTTTGGTTATGATATCCGCACG
GCAAAAGAACTCGATATTCAAATTCACCGTTTCTTTGATGAACACCAAATTTATCGTATTGACCACTATCTTGGTAAAGA
AACGGTTCAAAATCTGCTCGTGCTGCGTTTTTCTAATGGATGGTTTGAACCACTCTGGAACCGTAATTTTATTGATTATA
TTGAAATCACGGGCGCAGAATCTATCGGTGTAGAAGAGCGTGGTGGTTATTACGATGATTCTGGCGCAATGCGTGATATG
TTCCAAAACCATTTGTTGCAAGTGTTAGCCATGGTTGCGATGGAGCCACCGGCAATTATTAATGCTGACTCAATGCGTGA
TGAAGTGGCAAAAGTCTTGTATTGTTTACATCCATTAAGTGAGGATGACTTAGAAAATCATTTAGTCTTAGGGCAATATA
CGGCAGGCACAGTTGAAGGTGAAGCAGTTAAGGGCTACTTACAGGAAAAAGGTGTACCGGCAGAGTCTAATACGGAAACT
TACATGGCATTACGCTGTGAAATTGACAACTGGCGTTGGGCGGGTGTGCCATTTTATGTGCGTACTGGGAAACGGTTACC
AAGTCGAGTGACCGAAATTGTGATTCATTTCAAAACCACACCACATCCGGTATTTAGCCAAAAAGCACCAGAAAACAAAT
TAATTATCCGTATTCAACCCGATGAAGCGATTTCGATGCGTTTTGGTTTGAAAAAACCGGGAGCAGGTTTTGAAGCAAAA
GAAGTGTCGATGGATTTCCGTTATGCGGATCTTGCCTCACCAAGCTTACTGACCGCTTATGAGCGTTTATTATTGGATTC
TATGAAAGGCGATGCCACTTTGTTTGCGCGTACTGATGCGGTACATGCCTGTTGGCAGTTTGTGGAGCCGATTTTACAAT
ATAAAGCACAAAATGGGCGTGTTTATGAGTATGAAGCCGGTACTTGGGGACCGACAGAAGCCGACAAACTGATCGCGAAA
ACGGGTCGTGTTTGGCGTAAACCAAGTGGATTAATGAAAAAGAAAGTGTAA

Upstream 100 bases:

>100_bases
TGGCAGAAAATTTTTCAATTTCATTCGCACTAGGCATTATTTATTATAAGATGCGATATCTTATGACCTCTATTTTTAAC
AAACGGATTTCAGGAAAAAA

Downstream 100 bases:

>100_bases
TGTCCGCCCCTTTCGTAAGAAATGCGAGGGGCTAGTGTGAGCAGATTGAGTAAGGAAAGATCATGAATACAATCATTTTT
GACAGTGCACAGCATGCCGT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MKIEADNNCIVIFGASGDLTYRKLIPALYNLYKIGRLTEHFSVLGVARTELSDEGFREKMRQALIKSEKANGETLDQFCS
HLYYQALNTADAADYGKLIPRLDDLHDKYQTCGNTLYYLSTPPSLYGVIPECLAAHGLNTEEFGWKRLIVEKPFGYDIRT
AKELDIQIHRFFDEHQIYRIDHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYIEITGAESIGVEERGGYYDDSGAMRDM
FQNHLLQVLAMVAMEPPAIINADSMRDEVAKVLYCLHPLSEDDLENHLVLGQYTAGTVEGEAVKGYLQEKGVPAESNTET
YMALRCEIDNWRWAGVPFYVRTGKRLPSRVTEIVIHFKTTPHPVFSQKAPENKLIIRIQPDEAISMRFGLKKPGAGFEAK
EVSMDFRYADLASPSLLTAYERLLLDSMKGDATLFARTDAVHACWQFVEPILQYKAQNGRVYEYEAGTWGPTEADKLIAK
TGRVWRKPSGLMKKKV

Sequences:

>Translated_496_residues
MKIEADNNCIVIFGASGDLTYRKLIPALYNLYKIGRLTEHFSVLGVARTELSDEGFREKMRQALIKSEKANGETLDQFCS
HLYYQALNTADAADYGKLIPRLDDLHDKYQTCGNTLYYLSTPPSLYGVIPECLAAHGLNTEEFGWKRLIVEKPFGYDIRT
AKELDIQIHRFFDEHQIYRIDHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYIEITGAESIGVEERGGYYDDSGAMRDM
FQNHLLQVLAMVAMEPPAIINADSMRDEVAKVLYCLHPLSEDDLENHLVLGQYTAGTVEGEAVKGYLQEKGVPAESNTET
YMALRCEIDNWRWAGVPFYVRTGKRLPSRVTEIVIHFKTTPHPVFSQKAPENKLIIRIQPDEAISMRFGLKKPGAGFEAK
EVSMDFRYADLASPSLLTAYERLLLDSMKGDATLFARTDAVHACWQFVEPILQYKAQNGRVYEYEAGTWGPTEADKLIAK
TGRVWRKPSGLMKKKV
>Mature_496_residues
MKIEADNNCIVIFGASGDLTYRKLIPALYNLYKIGRLTEHFSVLGVARTELSDEGFREKMRQALIKSEKANGETLDQFCS
HLYYQALNTADAADYGKLIPRLDDLHDKYQTCGNTLYYLSTPPSLYGVIPECLAAHGLNTEEFGWKRLIVEKPFGYDIRT
AKELDIQIHRFFDEHQIYRIDHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYIEITGAESIGVEERGGYYDDSGAMRDM
FQNHLLQVLAMVAMEPPAIINADSMRDEVAKVLYCLHPLSEDDLENHLVLGQYTAGTVEGEAVKGYLQEKGVPAESNTET
YMALRCEIDNWRWAGVPFYVRTGKRLPSRVTEIVIHFKTTPHPVFSQKAPENKLIIRIQPDEAISMRFGLKKPGAGFEAK
EVSMDFRYADLASPSLLTAYERLLLDSMKGDATLFARTDAVHACWQFVEPILQYKAQNGRVYEYEAGTWGPTEADKLIAK
TGRVWRKPSGLMKKKV

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=482, Percent_Identity=40.4564315352697, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI108773793, Length=482, Percent_Identity=40.4564315352697, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI52145310, Length=511, Percent_Identity=29.9412915851272, Blast_Score=169, Evalue=7e-42,
Organism=Escherichia coli, GI1788158, Length=485, Percent_Identity=42.8865979381443, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17538218, Length=484, Percent_Identity=38.0165289256198, Blast_Score=329, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6324088, Length=478, Percent_Identity=35.7740585774059, Blast_Score=288, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24643350, Length=474, Percent_Identity=36.9198312236287, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI24643352, Length=472, Percent_Identity=37.0762711864407, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI221513548, Length=483, Percent_Identity=30.2277432712215, Blast_Score=212, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56519; Mature: 56519

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEADNNCIVIFGASGDLTYRKLIPALYNLYKIGRLTEHFSVLGVARTELSDEGFREKM
CEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RQALIKSEKANGETLDQFCSHLYYQALNTADAADYGKLIPRLDDLHDKYQTCGNTLYYLS
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCEEEEEE
TPPSLYGVIPECLAAHGLNTEEFGWKRLIVEKPFGYDIRTAKELDIQIHRFFDEHQIYRI
CCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHEHHEEHHCCCCEEEH
DHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYIEITGAESIGVEERGGYYDDSGAMRDM
HHHHCHHHHHHEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEECCCHHHHHH
FQNHLLQVLAMVAMEPPAIINADSMRDEVAKVLYCLHPLSEDDLENHLVLGQYTAGTVEG
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCH
EAVKGYLQEKGVPAESNTETYMALRCEIDNWRWAGVPFYVRTGKRLPSRVTEIVIHFKTT
HHHHHHHHHCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCCCHHHHHHEEEEEECC
PHPVFSQKAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEVSMDFRYADLASPSLLTAY
CCCCCCCCCCCCCEEEEECCCCCEEHEECCCCCCCCCCHHHEEECEEEHHCCCCHHHHHH
ERLLLDSMKGDATLFARTDAVHACWQFVEPILQYKAQNGRVYEYEAGTWGPTEADKLIAK
HHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHH
TGRVWRKPSGLMKKKV
HCHHHCCCCCHHHCCC
>Mature Secondary Structure
MKIEADNNCIVIFGASGDLTYRKLIPALYNLYKIGRLTEHFSVLGVARTELSDEGFREKM
CEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RQALIKSEKANGETLDQFCSHLYYQALNTADAADYGKLIPRLDDLHDKYQTCGNTLYYLS
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCEEEEEE
TPPSLYGVIPECLAAHGLNTEEFGWKRLIVEKPFGYDIRTAKELDIQIHRFFDEHQIYRI
CCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHEHHEEHHCCCCEEEH
DHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYIEITGAESIGVEERGGYYDDSGAMRDM
HHHHCHHHHHHEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEECCCHHHHHH
FQNHLLQVLAMVAMEPPAIINADSMRDEVAKVLYCLHPLSEDDLENHLVLGQYTAGTVEG
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCH
EAVKGYLQEKGVPAESNTETYMALRCEIDNWRWAGVPFYVRTGKRLPSRVTEIVIHFKTT
HHHHHHHHHCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCCCHHHHHHEEEEEECC
PHPVFSQKAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEVSMDFRYADLASPSLLTAY
CCCCCCCCCCCCCEEEEECCCCCEEHEECCCCCCCCCCHHHEEECEEEHHCCCCHHHHHH
ERLLLDSMKGDATLFARTDAVHACWQFVEPILQYKAQNGRVYEYEAGTWGPTEADKLIAK
HHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHH
TGRVWRKPSGLMKKKV
HCHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]