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The map label for this gene is devB [H]

Identifier: 161723308

GI number: 161723308

Start: 1753276

End: 1753974

Strand: Direct

Name: devB [H]

Synonym: PM1550

Alternate gene names: 161723308

Gene position: 1753276-1753974 (Clockwise)

Preceding gene: 15603414

Following gene: 15603416

Centisome position: 77.66

GC content: 44.49

Gene sequence:

>699_bases
ATGAATACAATCATTTTTGACAGTGCACAGCATGCCGTAGAGAAAATTGCACAAGAATTGTTAGCGTATAGCTTAGAAGG
CCGCCCTGTGCATATTTCCTTATCTGGAGGCTCAACGCCGAAATTGTTATTTAAAACTTTAGCTCAAGCACCGTATAACA
CCGAGATTCAATGGCAAAATTTGCATTTTTGGTGGGGCGATGATCGTATGGTGCCACCAACCGATCCAGAAAGTAATTAC
GGCGAGGTGCAAAAATTGTTATTCGATCATATTCAGATCCCCGCAGAAAATATTCACCGTATTCGTGGTGAAGCCCCCGT
TGAGAGTGAACTTCAACGTTTTGAACAAGCGCTAAGTGCGGTCATTCCTGGGCAAGTTTTTGATTGGATTATTTTGGGCA
TGGGAACGGACGGGCACACCGCCTCATTATTCCCGCATCAAACCGATTTTGACGACCCTCATTTCGCCGTGATCGCTAAA
CACCCTGAGACAGGGCAAATTCGTATTTCAAAAACAGCGAAACTGATTGAACAAGCAAAGCGGGTGACCTATTTGGTGAC
AGGTAGTGGTAAAGCCGAGATCTTAAAAGAAATTCAAACTACGCCGGCAGAACAACTGCCTTATCCTGCTGCGAAAATCA
AAGCGAAGCATGGGGTGACGGAATGGTATTTGGATAAGGATGCGGCAAAATTACTGTAA

Upstream 100 bases:

>100_bases
GGCGTAAACCAAGTGGATTAATGAAAAAGAAAGTGTAATGTCCGCCCCTTTCGTAAGAAATGCGAGGGGCTAGTGTGAGC
AGATTGAGTAAGGAAAGATC

Downstream 100 bases:

>100_bases
TGCGTCGTGAGATTTTTCAACATTTTTGCAAAGAGACTTGAAACAAAATAGACCATAGCGTTCGTTTTCAAGGAGTGCTG
AAAATGAAGGCTCTCGTTGA

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNTIIFDSAQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYNTEIQWQNLHFWWGDDRMVPPTDPESNY
GEVQKLLFDHIQIPAENIHRIRGEAPVESELQRFEQALSAVIPGQVFDWIILGMGTDGHTASLFPHQTDFDDPHFAVIAK
HPETGQIRISKTAKLIEQAKRVTYLVTGSGKAEILKEIQTTPAEQLPYPAAKIKAKHGVTEWYLDKDAAKLL

Sequences:

>Translated_232_residues
MNTIIFDSAQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYNTEIQWQNLHFWWGDDRMVPPTDPESNY
GEVQKLLFDHIQIPAENIHRIRGEAPVESELQRFEQALSAVIPGQVFDWIILGMGTDGHTASLFPHQTDFDDPHFAVIAK
HPETGQIRISKTAKLIEQAKRVTYLVTGSGKAEILKEIQTTPAEQLPYPAAKIKAKHGVTEWYLDKDAAKLL
>Mature_232_residues
MNTIIFDSAQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYNTEIQWQNLHFWWGDDRMVPPTDPESNY
GEVQKLLFDHIQIPAENIHRIRGEAPVESELQRFEQALSAVIPGQVFDWIILGMGTDGHTASLFPHQTDFDDPHFAVIAK
HPETGQIRISKTAKLIEQAKRVTYLVTGSGKAEILKEIQTTPAEQLPYPAAKIKAKHGVTEWYLDKDAAKLL

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=205, Percent_Identity=38.0487804878049, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI6912586, Length=241, Percent_Identity=32.3651452282158, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1786893, Length=116, Percent_Identity=30.1724137931034, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533058, Length=231, Percent_Identity=29.004329004329, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533060, Length=231, Percent_Identity=29.004329004329, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321957, Length=208, Percent_Identity=29.3269230769231, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321687, Length=220, Percent_Identity=28.6363636363636, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319918, Length=212, Percent_Identity=29.7169811320755, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324362, Length=214, Percent_Identity=31.3084112149533, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641119, Length=224, Percent_Identity=30.3571428571429, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26013; Mature: 26013

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIIFDSAQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYNTEIQWQN
CCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEE
LHFWWGDDRMVPPTDPESNYGEVQKLLFDHIQIPAENIHRIRGEAPVESELQRFEQALSA
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
VIPGQVFDWIILGMGTDGHTASLFPHQTDFDDPHFAVIAKHPETGQIRISKTAKLIEQAK
HCCCHHHEEEEEECCCCCCEEECCCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHH
RVTYLVTGSGKAEILKEIQTTPAEQLPYPAAKIKAKHGVTEWYLDKDAAKLL
HEEEEEECCCHHHHHHHHHCCCHHHCCCCHHHHHHHCCCHHEEECCHHHHCC
>Mature Secondary Structure
MNTIIFDSAQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYNTEIQWQN
CCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEE
LHFWWGDDRMVPPTDPESNYGEVQKLLFDHIQIPAENIHRIRGEAPVESELQRFEQALSA
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
VIPGQVFDWIILGMGTDGHTASLFPHQTDFDDPHFAVIAKHPETGQIRISKTAKLIEQAK
HCCCHHHEEEEEECCCCCCEEECCCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHH
RVTYLVTGSGKAEILKEIQTTPAEQLPYPAAKIKAKHGVTEWYLDKDAAKLL
HEEEEEECCCHHHHHHHHHCCCHHHCCCCHHHHHHHCCCHHEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]