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The map label for this gene is uhpC [H]

Identifier: 15603203

GI number: 15603203

Start: 1529874

End: 1531166

Strand: Reverse

Name: uhpC [H]

Synonym: PM1338

Alternate gene names: 15603203

Gene position: 1531166-1529874 (Counterclockwise)

Preceding gene: 15603204

Following gene: 15603190

Centisome position: 67.83

GC content: 44.55

Gene sequence:

>1293_bases
ATGATGCCAATACAAAACTTTTCGCAAATTGACCGCACTTATCGCTACTGGCGCATTCACTTAATGATTGCCATGTACGT
AGGCTATGCCGGTTTTTACCTCAGCCGTAAAAGCTTGAATTATGCCATGCCCGCCTTAATCAGCGATTTGGCTATGGATA
AAAATGCCATTGGACTCATGGCAACTTTGTTTTATCTCACCTATGGTTTATCCAAATTTTTCTCTGGACTTTTTTCTGAT
CAAGCCAACCCCCGTTACATTATGGCTATCGGCTTGATGATGACAGGGATCACGAATATTTTATTCGGTTTATCCAGTTC
CGTGTTTCTGTTCACTTGCCTATGGGTCATCAATGCGTGGTTTCAGGGGTGGGGCTGGCCTGCGTGTTCTAAATATCTCA
CTACGTGGTATTCCCGTAGCGAGCGAGGTTTATGGTGGTCTATTTGGAATACTGCGCACAATGTGGGAGGCGCCTTAATT
CCGCTAATTGTTGGCTATCTCACTTTACATTACAGCTGGCGACACGGCTTTATTGTAGCAGGCATAATCGTCATACTCAT
CAGTGTATTTTTACTGTGGCGTTTACCTAGCACGCCAGATGCAATGGGGTTGCCTAGTATTGGACAATGGCGTCATGATC
CTTTGGAATTAGCACAAGAAAAGGAAGGACAAGATTTACCATGGCGGCAAATCTTGCGTGATTATGTGTTCTACAATAAA
TATCTTTGGCTACTCGCAATGAGCTATGCATTGGTCTATCTCGTGCGGACCGCCATTAATGACTGGGGTAATCTCTATCT
AAGTGAACGTTATCACTATGACTTAGTCAGTGCGAACAGCGCACTCTCTTTATTTGAAATCGGTGGTTTTATGGGATCAC
TAGTCGCCGGTTGGGGATCAGATAAACTGTTTTCTAGCAATCGAGGACCTATGGCATTGGTGTTTGCCATTGGCATTTTC
TTTTCGATTACCGCGCTTTGGCTGATGCCAAAAGAAAACATGCTATTACAGTCTGGCTTATTTTTCTGTGTCGGCTTTTT
TGTGTTTGGTCCGCAAATGTTAATCGGCATGGCTGCTGCGGAATGTGCCCACAAAAAAACCGCAGGCACCGCCACGGGTT
TTGTTGGCTTGTTTGCTTATCTGGGGGCAGCCCTCGCTGGCTACCCACTGGCACTCATCACACAAACGTTTCATTGGACC
GGTTTTTTTGTCGTAATTTCTTGCTGTGCATTTGCTATTGCGTTACTGCTACTGCCTTTTTTAAAAGTACAGCCAAATCA
ATCGTCTTGTTGA

Upstream 100 bases:

>100_bases
GCGAATTTCAGCTCTCCTCAAGCACGGCGAACATGCGTTCCTCTTCAATTCAACCTTTGACACAAGGCACTTCCCTTGTG
ATCACTCTCCCTCGATTTTA

Downstream 100 bases:

>100_bases
ATGAAAATGTGCGGTTAAAAAGTGTATGATGTTGAGCCCTGTTTTATTATTCCAAATTCAAAATCGCCTCTTTTGTCACG
GCATAACCACTTTTCAAAAT

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MMPIQNFSQIDRTYRYWRIHLMIAMYVGYAGFYLSRKSLNYAMPALISDLAMDKNAIGLMATLFYLTYGLSKFFSGLFSD
QANPRYIMAIGLMMTGITNILFGLSSSVFLFTCLWVINAWFQGWGWPACSKYLTTWYSRSERGLWWSIWNTAHNVGGALI
PLIVGYLTLHYSWRHGFIVAGIIVILISVFLLWRLPSTPDAMGLPSIGQWRHDPLELAQEKEGQDLPWRQILRDYVFYNK
YLWLLAMSYALVYLVRTAINDWGNLYLSERYHYDLVSANSALSLFEIGGFMGSLVAGWGSDKLFSSNRGPMALVFAIGIF
FSITALWLMPKENMLLQSGLFFCVGFFVFGPQMLIGMAAAECAHKKTAGTATGFVGLFAYLGAALAGYPLALITQTFHWT
GFFVVISCCAFAIALLLLPFLKVQPNQSSC

Sequences:

>Translated_430_residues
MMPIQNFSQIDRTYRYWRIHLMIAMYVGYAGFYLSRKSLNYAMPALISDLAMDKNAIGLMATLFYLTYGLSKFFSGLFSD
QANPRYIMAIGLMMTGITNILFGLSSSVFLFTCLWVINAWFQGWGWPACSKYLTTWYSRSERGLWWSIWNTAHNVGGALI
PLIVGYLTLHYSWRHGFIVAGIIVILISVFLLWRLPSTPDAMGLPSIGQWRHDPLELAQEKEGQDLPWRQILRDYVFYNK
YLWLLAMSYALVYLVRTAINDWGNLYLSERYHYDLVSANSALSLFEIGGFMGSLVAGWGSDKLFSSNRGPMALVFAIGIF
FSITALWLMPKENMLLQSGLFFCVGFFVFGPQMLIGMAAAECAHKKTAGTATGFVGLFAYLGAALAGYPLALITQTFHWT
GFFVVISCCAFAIALLLLPFLKVQPNQSSC
>Mature_430_residues
MMPIQNFSQIDRTYRYWRIHLMIAMYVGYAGFYLSRKSLNYAMPALISDLAMDKNAIGLMATLFYLTYGLSKFFSGLFSD
QANPRYIMAIGLMMTGITNILFGLSSSVFLFTCLWVINAWFQGWGWPACSKYLTTWYSRSERGLWWSIWNTAHNVGGALI
PLIVGYLTLHYSWRHGFIVAGIIVILISVFLLWRLPSTPDAMGLPSIGQWRHDPLELAQEKEGQDLPWRQILRDYVFYNK
YLWLLAMSYALVYLVRTAINDWGNLYLSERYHYDLVSANSALSLFEIGGFMGSLVAGWGSDKLFSSNRGPMALVFAIGIF
FSITALWLMPKENMLLQSGLFFCVGFFVFGPQMLIGMAAAECAHKKTAGTATGFVGLFAYLGAALAGYPLALITQTFHWT
GFFVVISCCAFAIALLLLPFLKVQPNQSSC

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=421, Percent_Identity=32.541567695962, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI4503847, Length=421, Percent_Identity=32.541567695962, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI256219483, Length=421, Percent_Identity=32.541567695962, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI256219543, Length=440, Percent_Identity=31.1363636363636, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI256219564, Length=350, Percent_Identity=32, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI46361976, Length=389, Percent_Identity=23.3933161953728, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI14150047, Length=271, Percent_Identity=22.5092250922509, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI49619231, Length=448, Percent_Identity=24.5535714285714, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI223717983, Length=411, Percent_Identity=26.2773722627737, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI38093649, Length=411, Percent_Identity=26.2773722627737, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI87082310, Length=421, Percent_Identity=59.6199524940618, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1788573, Length=419, Percent_Identity=36.0381861575179, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI2367259, Length=392, Percent_Identity=30.1020408163265, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI2367379, Length=448, Percent_Identity=23.2142857142857, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17542316, Length=451, Percent_Identity=22.8381374722838, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI133901854, Length=447, Percent_Identity=22.8187919463087, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI133901856, Length=447, Percent_Identity=22.8187919463087, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI133930953, Length=434, Percent_Identity=22.8110599078341, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17561094, Length=410, Percent_Identity=22.4390243902439, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17539138, Length=311, Percent_Identity=24.7588424437299, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17564202, Length=438, Percent_Identity=21.2328767123288, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17564204, Length=264, Percent_Identity=22.3484848484848, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656866, Length=472, Percent_Identity=23.0932203389831, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45550478, Length=472, Percent_Identity=23.0932203389831, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24656861, Length=472, Percent_Identity=23.0932203389831, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48494; Mature: 48494

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPIQNFSQIDRTYRYWRIHLMIAMYVGYAGFYLSRKSLNYAMPALISDLAMDKNAIGLM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
ATLFYLTYGLSKFFSGLFSDQANPRYIMAIGLMMTGITNILFGLSSSVFLFTCLWVINAW
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
FQGWGWPACSKYLTTWYSRSERGLWWSIWNTAHNVGGALIPLIVGYLTLHYSWRHGFIVA
HHCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHH
GIIVILISVFLLWRLPSTPDAMGLPSIGQWRHDPLELAQEKEGQDLPWRQILRDYVFYNK
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
YLWLLAMSYALVYLVRTAINDWGNLYLSERYHYDLVSANSALSLFEIGGFMGSLVAGWGS
HHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCC
DKLFSSNRGPMALVFAIGIFFSITALWLMPKENMLLQSGLFFCVGFFVFGPQMLIGMAAA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ECAHKKTAGTATGFVGLFAYLGAALAGYPLALITQTFHWTGFFVVISCCAFAIALLLLPF
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKVQPNQSSC
HHCCCCCCCC
>Mature Secondary Structure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HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]