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The map label for this gene is ilvY [H]

Identifier: 15603148

GI number: 15603148

Start: 1476863

End: 1477744

Strand: Reverse

Name: ilvY [H]

Synonym: PM1283

Alternate gene names: 15603148

Gene position: 1477744-1476863 (Counterclockwise)

Preceding gene: 15603150

Following gene: 15603146

Centisome position: 65.46

GC content: 44.1

Gene sequence:

>882_bases
TTGAACTTCACTTATCTCAAACTCTTTCTCCACTTATGTGAAACGAAAAACTTCGCCAAAACGGCGGCACAAAATCACAT
GTCGCCCTCTACTCTCTCACGCCAAATTCAGCGTATGGAACAAGACGTAGGACAAATACTGTTTTTACGTAACAATCGCC
AAGTTGAATTAACCGATGCAGGTGAAAAATTGCTACCTTTTGCACAACAAAGCTGGATGCAATGGCAACAGATCAAACAG
CAACTGCGTGATAGTGCTCAGCAAGAACTCAACGGGGAATTAAAATTATTTTGCTCGGTCACCGCTGCTTATAGCCACTT
ACCAGCGATTTTGGAACGTTTTCGTACACGTTATCCGAAAGTAGAAATCCAGCTCACCACAGGTGACCCTTCGCTTGCCT
TACAACTGGTAGAAACACAACAAGTGGACCTTGCACTAGCAGGGCAACCCAAAAATTTACCCAACCACATTGCATTTCAC
TATATTGACGATATCAGCCTGTCTCTAATTGCACCACGTATTGCCTGTTCTGCTACACAATTATTGCAGCAAACCCCAAT
CAATTGGCAACAAATCCCCTTTATTTTGCCGGTAGAAGGACCTGCGCGCCAACGCATTGACCAATGGTTTAAACAACAAA
AAATCAAACACCCTAAAATCTATGCCACAGTCGCTGGACATGAGGCGATCATGCCAATGGTCGCACTCGGTTGTGGGGTC
GCGATGTTACCCGATGTCGTCATTAAAAACAGCCCGATGAATAGCCAAGTTTCTATTTTGCATCTCAAAACCCCAATCAC
GCCCTTTGCTCTCGGAATTTGTGTGCAGAAAAAAAGCTTAACGCAACCATTAGTGCGTGCATTTTGGCAAATACTCCAAT
GA

Upstream 100 bases:

>100_bases
TTGTCATAAAGCGCTACAAATTTTTGAAAAATCGACCGCACTTTTTATTGAGTAAAACGCAAAGCTGAATGTGTCCACCA
CCCAAATAGGAAATCCCATT

Downstream 100 bases:

>100_bases
TTAATTAAAAAAGGTGGTCAACAGAATGCGACCACCTTTACTGTACAAGATAACCTCACTTAGAACATCAATTTCACACC
TAAACGTACATTTCTACCAG

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MNFTYLKLFLHLCETKNFAKTAAQNHMSPSTLSRQIQRMEQDVGQILFLRNNRQVELTDAGEKLLPFAQQSWMQWQQIKQ
QLRDSAQQELNGELKLFCSVTAAYSHLPAILERFRTRYPKVEIQLTTGDPSLALQLVETQQVDLALAGQPKNLPNHIAFH
YIDDISLSLIAPRIACSATQLLQQTPINWQQIPFILPVEGPARQRIDQWFKQQKIKHPKIYATVAGHEAIMPMVALGCGV
AMLPDVVIKNSPMNSQVSILHLKTPITPFALGICVQKKSLTQPLVRAFWQILQ

Sequences:

>Translated_293_residues
MNFTYLKLFLHLCETKNFAKTAAQNHMSPSTLSRQIQRMEQDVGQILFLRNNRQVELTDAGEKLLPFAQQSWMQWQQIKQ
QLRDSAQQELNGELKLFCSVTAAYSHLPAILERFRTRYPKVEIQLTTGDPSLALQLVETQQVDLALAGQPKNLPNHIAFH
YIDDISLSLIAPRIACSATQLLQQTPINWQQIPFILPVEGPARQRIDQWFKQQKIKHPKIYATVAGHEAIMPMVALGCGV
AMLPDVVIKNSPMNSQVSILHLKTPITPFALGICVQKKSLTQPLVRAFWQILQ
>Mature_293_residues
MNFTYLKLFLHLCETKNFAKTAAQNHMSPSTLSRQIQRMEQDVGQILFLRNNRQVELTDAGEKLLPFAQQSWMQWQQIKQ
QLRDSAQQELNGELKLFCSVTAAYSHLPAILERFRTRYPKVEIQLTTGDPSLALQLVETQQVDLALAGQPKNLPNHIAFH
YIDDISLSLIAPRIACSATQLLQQTPINWQQIPFILPVEGPARQRIDQWFKQQKIKHPKIYATVAGHEAIMPMVALGCGV
AMLPDVVIKNSPMNSQVSILHLKTPITPFALGICVQKKSLTQPLVRAFWQILQ

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=294, Percent_Identity=52.0408163265306, Blast_Score=310, Evalue=5e-86,
Organism=Escherichia coli, GI1787806, Length=298, Percent_Identity=25.1677852348993, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI145693105, Length=295, Percent_Identity=24.7457627118644, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788887, Length=296, Percent_Identity=26.0135135135135, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788481, Length=248, Percent_Identity=23.7903225806452, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788296, Length=255, Percent_Identity=26.2745098039216, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788706, Length=131, Percent_Identity=32.824427480916, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI157672245, Length=243, Percent_Identity=21.3991769547325, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788297, Length=250, Percent_Identity=25.6, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789204, Length=250, Percent_Identity=25.6, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI2367136, Length=145, Percent_Identity=25.5172413793103, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33282; Mature: 33282

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFTYLKLFLHLCETKNFAKTAAQNHMSPSTLSRQIQRMEQDVGQILFLRNNRQVELTDA
CCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEECCCEEEEECC
GEKLLPFAQQSWMQWQQIKQQLRDSAQQELNGELKLFCSVTAAYSHLPAILERFRTRYPK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCE
VEIQLTTGDPSLALQLVETQQVDLALAGQPKNLPNHIAFHYIDDISLSLIAPRIACSATQ
EEEEEECCCHHHEEEEEHHCCCCEEECCCCCCCCCHHEEEEECCCHHHHHHHHHHHHHHH
LLQQTPINWQQIPFILPVEGPARQRIDQWFKQQKIKHPKIYATVAGHEAIMPMVALGCGV
HHHHCCCCHHHCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCH
AMLPDVVIKNSPMNSQVSILHLKTPITPFALGICVQKKSLTQPLVRAFWQILQ
HHHCHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNFTYLKLFLHLCETKNFAKTAAQNHMSPSTLSRQIQRMEQDVGQILFLRNNRQVELTDA
CCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEECCCEEEEECC
GEKLLPFAQQSWMQWQQIKQQLRDSAQQELNGELKLFCSVTAAYSHLPAILERFRTRYPK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCE
VEIQLTTGDPSLALQLVETQQVDLALAGQPKNLPNHIAFHYIDDISLSLIAPRIACSATQ
EEEEEECCCHHHEEEEEHHCCCCEEECCCCCCCCCHHEEEEECCCHHHHHHHHHHHHHHH
LLQQTPINWQQIPFILPVEGPARQRIDQWFKQQKIKHPKIYATVAGHEAIMPMVALGCGV
HHHHCCCCHHHCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCH
AMLPDVVIKNSPMNSQVSILHLKTPITPFALGICVQKKSLTQPLVRAFWQILQ
HHHCHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]