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The map label for this gene is mazG [H]

Identifier: 15603150

GI number: 15603150

Start: 1479501

End: 1480301

Strand: Reverse

Name: mazG [H]

Synonym: PM1285

Alternate gene names: 15603150

Gene position: 1480301-1479501 (Counterclockwise)

Preceding gene: 15603156

Following gene: 15603148

Centisome position: 65.57

GC content: 40.07

Gene sequence:

>801_bases
ATGGCTTATTCAATCGACGATTTTATTCATCTCATCGCCCAGTTACGCAATCCAAATGGAGGATGCCCGTGGGATCTTAA
ACAAACGTATCACAGCATGATTCCCTGTCTAACGGAAGAAACCTACGAAGTGATTGAAGCCATCCAACAACAAAATATGC
ACGATCTGAAAGAAGAATTGGGTGATCTGTTATTACAAGTTATTTTCTTCAGCCAATTAGCAACCGAAGATCAACATTTC
ACCTTTAACGATGTCGTCGCGACTGTTGCTGAAAAGATTATCCGTCGACACCCTCATGTTTTTGGTGAGAAGATCGCAAA
TAACGAACAAGAAGCGTTACAAAACTGGAACGCCATCAAAGCACAAGAACATAAAGAAAAAGGGCAACATTCTATTTTAG
ATAATGTACCACATGCTTTCCCTGCCCTGATGCGCGCGGAAAAACTACAAAAACGCTGTGCTAAAGTCGGGTTCGACTGG
GATGATAGCCAGCAAGTTATTGACAAAATCAAAGAAGAATTAACAGAAGTTCAACAAGAAATGGCAAAAGCGGACAAACA
ACAAGCCAAAATTGAAGAAGAAGTGGGTGATTTATTGTTTGCGGTGGTCAATCTGTGTCGCCATTTAAACTGCCAACCAG
AAGAAAGTTTACGTAAAGCTAACCATAAATTTGAGCAACGCTTCCGCGCCGTTGAAAACAAACTCAAAGCTCATCATAAA
ACTCTTGAACAAAGCTCGTTAATGGAAATGGACTTATTATGGGATGAAGTCAAACGAGAAGAAAAAAATAAGGTGCTCTA
A

Upstream 100 bases:

>100_bases
ACGTTTTAAAAAACTTTTCAATACACAAACACATTTCCATGGCGCAAAAGAAAATTATGCTATGATAAACCTCATTATTT
TTTCTGTAGGAATCATCAAC

Downstream 100 bases:

>100_bases
GCACCTTATTTTTAGACTATTTTTTCGCTTAATGAGAGGAAATACGTTTCATATCTGTCATATAACCACGTAATTCTTGC
CCGATCAATTCAATTGGATG

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MAYSIDDFIHLIAQLRNPNGGCPWDLKQTYHSMIPCLTEETYEVIEAIQQQNMHDLKEELGDLLLQVIFFSQLATEDQHF
TFNDVVATVAEKIIRRHPHVFGEKIANNEQEALQNWNAIKAQEHKEKGQHSILDNVPHAFPALMRAEKLQKRCAKVGFDW
DDSQQVIDKIKEELTEVQQEMAKADKQQAKIEEEVGDLLFAVVNLCRHLNCQPEESLRKANHKFEQRFRAVENKLKAHHK
TLEQSSLMEMDLLWDEVKREEKNKVL

Sequences:

>Translated_266_residues
MAYSIDDFIHLIAQLRNPNGGCPWDLKQTYHSMIPCLTEETYEVIEAIQQQNMHDLKEELGDLLLQVIFFSQLATEDQHF
TFNDVVATVAEKIIRRHPHVFGEKIANNEQEALQNWNAIKAQEHKEKGQHSILDNVPHAFPALMRAEKLQKRCAKVGFDW
DDSQQVIDKIKEELTEVQQEMAKADKQQAKIEEEVGDLLFAVVNLCRHLNCQPEESLRKANHKFEQRFRAVENKLKAHHK
TLEQSSLMEMDLLWDEVKREEKNKVL
>Mature_265_residues
AYSIDDFIHLIAQLRNPNGGCPWDLKQTYHSMIPCLTEETYEVIEAIQQQNMHDLKEELGDLLLQVIFFSQLATEDQHFT
FNDVVATVAEKIIRRHPHVFGEKIANNEQEALQNWNAIKAQEHKEKGQHSILDNVPHAFPALMRAEKLQKRCAKVGFDWD
DSQQVIDKIKEELTEVQQEMAKADKQQAKIEEEVGDLLFAVVNLCRHLNCQPEESLRKANHKFEQRFRAVENKLKAHHKT
LEQSSLMEMDLLWDEVKREEKNKVL

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=257, Percent_Identity=49.8054474708171, Blast_Score=275, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31033; Mature: 30901

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSIDDFIHLIAQLRNPNGGCPWDLKQTYHSMIPCLTEETYEVIEAIQQQNMHDLKEEL
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
GDLLLQVIFFSQLATEDQHFTFNDVVATVAEKIIRRHPHVFGEKIANNEQEALQNWNAIK
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHCCHHHH
AQEHKEKGQHSILDNVPHAFPALMRAEKLQKRCAKVGFDWDDSQQVIDKIKEELTEVQQE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
MAKADKQQAKIEEEVGDLLFAVVNLCRHLNCQPEESLRKANHKFEQRFRAVENKLKAHHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLEQSSLMEMDLLWDEVKREEKNKVL
HHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AYSIDDFIHLIAQLRNPNGGCPWDLKQTYHSMIPCLTEETYEVIEAIQQQNMHDLKEEL
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
GDLLLQVIFFSQLATEDQHFTFNDVVATVAEKIIRRHPHVFGEKIANNEQEALQNWNAIK
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHCCHHHH
AQEHKEKGQHSILDNVPHAFPALMRAEKLQKRCAKVGFDWDDSQQVIDKIKEELTEVQQE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
MAKADKQQAKIEEEVGDLLFAVVNLCRHLNCQPEESLRKANHKFEQRFRAVENKLKAHHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLEQSSLMEMDLLWDEVKREEKNKVL
HHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]