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The map label for this gene is mutH

Identifier: 15602932

GI number: 15602932

Start: 1257783

End: 1258451

Strand: Reverse

Name: mutH

Synonym: PM1067

Alternate gene names: 15602932

Gene position: 1258451-1257783 (Counterclockwise)

Preceding gene: 15602933

Following gene: 15602931

Centisome position: 55.75

GC content: 46.34

Gene sequence:

>669_bases
ATGACACCTCAAACTGAGCAAGAATTATTACAACGGGCACAGGCGATTGCAGGCTTACGCTTTGCTGAGCTGGCACAAAG
CCTGCATATGCCGGTTCCACCTGACTTAAAACGAGATAAAGGCTGGGTGGGTATGTTAATTGAAACCGCTCTCGGTGCAA
CCGCAGGCAGTAAAGCTGAGCAAGATTTTGCGCACTTGGGGATTGAGTTAAAAACGCTCCCGATTAATGCACAGGGGATG
CCGTTAGAAACCACCTTTGTCAGCTTAGCGCCCTTAACGCAGAATGTGGGGGTCAGTTGGGAAAACTCACATGTTAGGCA
TAAACTCAGTAAGGTACTGTGGATTTTAGTTGAAGGGGAAAGACAGATTCCGTTGTCTGAACGGCGTGTTGGGCAGCCGA
TTTTATGGCAGCCTTCAGCACAGCAAGAATTGCGTTTAAAGCGAGATTGGGAAGAGCTAATGGAATATATTAGCTTAGGC
AAGCTTGAGCAGATTAATGCGACCTTAGGCGAGGTGTTACAGCTTCGTCCGAAAGGGGCAAACAGTAAAGCGTTGACCCG
TGGAATTGGCAAACACGGTGAAATGATTGATACGTTACCTTTAGGCTTTTATTTACGTAAAACCTTTACTGCGGAAATTT
TACAACAATTTTTGCTTGGCACGGGGTAA

Upstream 100 bases:

>100_bases
CCATTTGTTGCAATTAGAACAAATTGACTATGTGGATCACGGGGTAGAGTTTGTAAAACCTAAACACCTCAAAAAATATC
AGCAAAAATGACCGCACTTT

Downstream 100 bases:

>100_bases
TTGACTTGGTGTCTTTGCACAAAATGATATGATTTATCTCATTTTTATGAAAAAAGGAACAGACTATGTTTGAATGGCTT
GCGAGTCCGGAGGCTTGGGT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTPQTEQELLQRAQAIAGLRFAELAQSLHMPVPPDLKRDKGWVGMLIETALGATAGSKAEQDFAHLGIELKTLPINAQGM
PLETTFVSLAPLTQNVGVSWENSHVRHKLSKVLWILVEGERQIPLSERRVGQPILWQPSAQQELRLKRDWEELMEYISLG
KLEQINATLGEVLQLRPKGANSKALTRGIGKHGEMIDTLPLGFYLRKTFTAEILQQFLLGTG

Sequences:

>Translated_222_residues
MTPQTEQELLQRAQAIAGLRFAELAQSLHMPVPPDLKRDKGWVGMLIETALGATAGSKAEQDFAHLGIELKTLPINAQGM
PLETTFVSLAPLTQNVGVSWENSHVRHKLSKVLWILVEGERQIPLSERRVGQPILWQPSAQQELRLKRDWEELMEYISLG
KLEQINATLGEVLQLRPKGANSKALTRGIGKHGEMIDTLPLGFYLRKTFTAEILQQFLLGTG
>Mature_221_residues
TPQTEQELLQRAQAIAGLRFAELAQSLHMPVPPDLKRDKGWVGMLIETALGATAGSKAEQDFAHLGIELKTLPINAQGMP
LETTFVSLAPLTQNVGVSWENSHVRHKLSKVLWILVEGERQIPLSERRVGQPILWQPSAQQELRLKRDWEELMEYISLGK
LEQINATLGEVLQLRPKGANSKALTRGIGKHGEMIDTLPLGFYLRKTFTAEILQQFLLGTG

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family

Homologues:

Organism=Escherichia coli, GI1789196, Length=217, Percent_Identity=58.9861751152074, Blast_Score=268, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTH_PASMU (Q9CLY2)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246004.1
- ProteinModelPortal:   Q9CLY2
- SMR:   Q9CLY2
- GeneID:   1244414
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1067
- NMPDR:   fig|272843.1.peg.1067
- HOGENOM:   HBG296591
- OMA:   QDWEELM
- ProtClustDB:   PRK05070
- BioCyc:   PMUL272843:PM1067-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00759
- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335
- Gene3D:   G3DSA:3.40.600.10
- SMART:   SM00927
- TIGRFAMs:   TIGR02248

Pfam domain/function: PF02976 MutH; SSF52980 Restrict_endonuc_II-like_core

EC number: NA

Molecular weight: Translated: 24762; Mature: 24631

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPQTEQELLQRAQAIAGLRFAELAQSLHMPVPPDLKRDKGWVGMLIETALGATAGSKAE
CCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHH
QDFAHLGIELKTLPINAQGMPLETTFVSLAPLTQNVGVSWENSHVRHKLSKVLWILVEGE
HHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCC
RQIPLSERRVGQPILWQPSAQQELRLKRDWEELMEYISLGKLEQINATLGEVLQLRPKGA
CCCCCHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
NSKALTRGIGKHGEMIDTLPLGFYLRKTFTAEILQQFLLGTG
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPQTEQELLQRAQAIAGLRFAELAQSLHMPVPPDLKRDKGWVGMLIETALGATAGSKAE
CCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHH
QDFAHLGIELKTLPINAQGMPLETTFVSLAPLTQNVGVSWENSHVRHKLSKVLWILVEGE
HHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCC
RQIPLSERRVGQPILWQPSAQQELRLKRDWEELMEYISLGKLEQINATLGEVLQLRPKGA
CCCCCHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
NSKALTRGIGKHGEMIDTLPLGFYLRKTFTAEILQQFLLGTG
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100