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The map label for this gene is mtlD

Identifier: 15602927

GI number: 15602927

Start: 1251299

End: 1252456

Strand: Direct

Name: mtlD

Synonym: PM1062

Alternate gene names: 15602927

Gene position: 1251299-1252456 (Clockwise)

Preceding gene: 15602926

Following gene: 15602928

Centisome position: 55.43

GC content: 40.16

Gene sequence:

>1158_bases
ATGAAAGCATTACATTTTGGTGCGGGTAATATTGGACGTGGATTTATCGGAAAATTATTAGCTGATAGTGGTATTCAAGT
CATCTTTGCCGATGTCAATGATCATGTTATTGAGCAACTCAAAACACAACGGGCTTATCCAGTCAAAATTGTTGGCGATC
GCCTGAATGTGATTGAAACCGTGTCAAACGTCACAGGAGTCAATTCTAAAAATGAGGCGGATATTATTGCATGCTTTACT
GAAGTTGATTTAGTGACCACCGCGGTGGGACCTAATGTATTAAAAATCATTTCAAGCACTATTGCAAAAGGCTTAAGCGC
ACGTTTTCGTGCAGGAAATACCCGCCCATTAAATATTATTGCATGTGAAAATATGGTGCGAGGTACCAGCTTTTTAAAAG
ACAATGTATTCTCTTATCTCACCCCTGAAGAACAGCAACAAGCGGAAGCACAGATTGGCTTTGTTGATTCTGCCGTTGAT
CGCATCGTGCCACCAGTACAGTTTGATCCCGCCAACCCGTTATTAGTGACGGTTGAAGAGTTCAGTGAATGGATTGTAGA
TAAAACCCAATTTAAAGGTACAATTCCAGCTATTACTGGTATGGAGCAAACGGATAATTTAATGGCATTTGTTGAGCGCA
AACTGTTTACATTAAATACTGGACACGCCACGACCGCCTATTTAGGCAAATTAAAAGGTCACCAATTTGTCAAAGACAGC
ATTGATGATCCAGATATCAGGGAAGCCGTTAAAGCCACGATGCAAGAAAGTGGTGCCGTATTAATTAAACGTTATGGTTT
TGATCCTCATGCCCACGCGGCTTACATTGAAAAAATCCTGAAGCGTTTTGCCAATCCGTATTTACAAGATGATGTTGATC
GTGTGGGCAGAGAACCTTTACGAAAACTCAGCTATAACGATCGTTTAATCAAACCATTACGTGGCACCTTAGAATATGGA
TTACCGAATCAACATTTAATTCAAACCATTGCTAGTGCCTTAGCCTATCGCAATGAGAGTGATCCACAAGCAGTTGAATT
AGCTCAACTTTTACAGCAAGATACGCTCGAAAGTGCGGTGAAAAAAATCACTGAACTGACAGAATCAAACATTGTGCAAC
AAATCGTAACTGCTTATAATGCCTTGCAAAAAAACTAA

Upstream 100 bases:

>100_bases
TGTCGAAAAAGTCTTAGCGTTATTAAAAGCATAATCTTCTTGGGCAGATCATTATCTGCCCATGTTTATTTAAACTCTTT
TCTTATTTTTGGAGTAAGCG

Downstream 100 bases:

>100_bases
AGTGCCAATGCGGTCTTAATTCGGTCTAGAAAAGGATAACGAGTGCAGTCAGTCGATCCCATTTATGAAAAACTCAATGA
AGCCACCTCAATTCGTGGTT

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKALHFGAGNIGRGFIGKLLADSGIQVIFADVNDHVIEQLKTQRAYPVKIVGDRLNVIETVSNVTGVNSKNEADIIACFT
EVDLVTTAVGPNVLKIISSTIAKGLSARFRAGNTRPLNIIACENMVRGTSFLKDNVFSYLTPEEQQQAEAQIGFVDSAVD
RIVPPVQFDPANPLLVTVEEFSEWIVDKTQFKGTIPAITGMEQTDNLMAFVERKLFTLNTGHATTAYLGKLKGHQFVKDS
IDDPDIREAVKATMQESGAVLIKRYGFDPHAHAAYIEKILKRFANPYLQDDVDRVGREPLRKLSYNDRLIKPLRGTLEYG
LPNQHLIQTIASALAYRNESDPQAVELAQLLQQDTLESAVKKITELTESNIVQQIVTAYNALQKN

Sequences:

>Translated_385_residues
MKALHFGAGNIGRGFIGKLLADSGIQVIFADVNDHVIEQLKTQRAYPVKIVGDRLNVIETVSNVTGVNSKNEADIIACFT
EVDLVTTAVGPNVLKIISSTIAKGLSARFRAGNTRPLNIIACENMVRGTSFLKDNVFSYLTPEEQQQAEAQIGFVDSAVD
RIVPPVQFDPANPLLVTVEEFSEWIVDKTQFKGTIPAITGMEQTDNLMAFVERKLFTLNTGHATTAYLGKLKGHQFVKDS
IDDPDIREAVKATMQESGAVLIKRYGFDPHAHAAYIEKILKRFANPYLQDDVDRVGREPLRKLSYNDRLIKPLRGTLEYG
LPNQHLIQTIASALAYRNESDPQAVELAQLLQQDTLESAVKKITELTESNIVQQIVTAYNALQKN
>Mature_385_residues
MKALHFGAGNIGRGFIGKLLADSGIQVIFADVNDHVIEQLKTQRAYPVKIVGDRLNVIETVSNVTGVNSKNEADIIACFT
EVDLVTTAVGPNVLKIISSTIAKGLSARFRAGNTRPLNIIACENMVRGTSFLKDNVFSYLTPEEQQQAEAQIGFVDSAVD
RIVPPVQFDPANPLLVTVEEFSEWIVDKTQFKGTIPAITGMEQTDNLMAFVERKLFTLNTGHATTAYLGKLKGHQFVKDS
IDDPDIREAVKATMQESGAVLIKRYGFDPHAHAAYIEKILKRFANPYLQDDVDRVGREPLRKLSYNDRLIKPLRGTLEYG
LPNQHLIQTIASALAYRNESDPQAVELAQLLQQDTLESAVKKITELTESNIVQQIVTAYNALQKN

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=384, Percent_Identity=62.2395833333333, Blast_Score=467, Evalue=1e-133,
Organism=Escherichia coli, GI1787823, Length=269, Percent_Identity=26.3940520446097, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790779, Length=270, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788497, Length=211, Percent_Identity=25.5924170616114, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324401, Length=211, Percent_Identity=26.5402843601896, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320765, Length=211, Percent_Identity=26.5402843601896, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_PASMU (Q9CLY7)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245999.1
- ProteinModelPortal:   Q9CLY7
- GeneID:   1244409
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1062
- NMPDR:   fig|272843.1.peg.1062
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- ProtClustDB:   PRK02318
- BioCyc:   PMUL272843:PM1062-MONOMER
- BRENDA:   1.1.1.17
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 42595; Mature: 42595

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALHFGAGNIGRGFIGKLLADSGIQVIFADVNDHVIEQLKTQRAYPVKIVGDRLNVIET
CCCEECCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCEEEECCHHHHHHH
VSNVTGVNSKNEADIIACFTEVDLVTTAVGPNVLKIISSTIAKGLSARFRAGNTRPLNII
HHHHCCCCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
ACENMVRGTSFLKDNVFSYLTPEEQQQAEAQIGFVDSAVDRIVPPVQFDPANPLLVTVEE
ECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHH
FSEWIVDKTQFKGTIPAITGMEQTDNLMAFVERKLFTLNTGHATTAYLGKLKGHQFVKDS
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHCCCHHHHHC
IDDPDIREAVKATMQESGAVLIKRYGFDPHAHAAYIEKILKRFANPYLQDDVDRVGREPL
CCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RKLSYNDRLIKPLRGTLEYGLPNQHLIQTIASALAYRNESDPQAVELAQLLQQDTLESAV
HHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KKITELTESNIVQQIVTAYNALQKN
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKALHFGAGNIGRGFIGKLLADSGIQVIFADVNDHVIEQLKTQRAYPVKIVGDRLNVIET
CCCEECCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCEEEECCHHHHHHH
VSNVTGVNSKNEADIIACFTEVDLVTTAVGPNVLKIISSTIAKGLSARFRAGNTRPLNII
HHHHCCCCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
ACENMVRGTSFLKDNVFSYLTPEEQQQAEAQIGFVDSAVDRIVPPVQFDPANPLLVTVEE
ECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHH
FSEWIVDKTQFKGTIPAITGMEQTDNLMAFVERKLFTLNTGHATTAYLGKLKGHQFVKDS
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHCCCHHHHHC
IDDPDIREAVKATMQESGAVLIKRYGFDPHAHAAYIEKILKRFANPYLQDDVDRVGREPL
CCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RKLSYNDRLIKPLRGTLEYGLPNQHLIQTIASALAYRNESDPQAVELAQLLQQDTLESAV
HHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KKITELTESNIVQQIVTAYNALQKN
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100