Click here to switch to the map view.

The map label for this gene is ptmA [H]

Identifier: 15602926

GI number: 15602926

Start: 1249331

End: 1251232

Strand: Direct

Name: ptmA [H]

Synonym: PM1061

Alternate gene names: 15602926

Gene position: 1249331-1251232 (Clockwise)

Preceding gene: 15602923

Following gene: 15602927

Centisome position: 55.34

GC content: 41.96

Gene sequence:

>1902_bases
TTGGTCATTTTATCGACGAGGTTAACTATGCTTTCAGCAAATGCAAAAGTCAAAGTACAAAATTTTGGTCGTTTCTTATC
CAACATGGTGATGCCCAATATTGGTGCATTTATTGCTTGGGGTTTTATCACCGCACTTTTCATTCCAACGGGTTGGCTAC
CCAATGAAACGTTAGCCAAATTAGTAGGACCGATGATCACCTACTTATTACCACTCTTAATTGGTTATTCTGGTGGTAAA
TTGATTGCTGGTGAGCGCGGTGCGGTGGTCGGCGCGATTGCTACTGCGGGGGTCATTGTAGGTACTGACATCCCAATGTT
TTTAGGCGCCATGATCGCGGGTCCGACAGGGGGCTGGGCAATTAAACGTTTTGATAAATGGGCTGATGGTAAAATTAAAA
GTGGCTTTGAGATGTTAGTCAATAACTTCTCTTCAGGAATCATTGGTATGATCTTGGCTATTTTATTCTTCTGGCTAATT
GGTCCTGCGGTGAAAGCGTTGTCTACTATGTTAGCTGCTGGTGTCGATATTTTAGTAAAAGCTCACTTACTGCCGCTCAC
CTCTATCTTTGTTGAGCCAGCCAAAATCCTCTTCTTAAACAACGCAATTAACCATGGAATTTTCTCCCCACTTGGTATTC
AACAATCGCAAGAATTTGGACAATCCATTTTCTTCTTGATTGAGGCCAACCCGGGTCCGGGCTTAGGGGTGTTACTTGCT
TATATTATATTTGGGAAAGGTACAGCAAAACAAACAGCAGGCGGTGCCACGATCATCCATTTCTTTGGGGGAATCCACGA
GATTTATTTCCCTTATGTTTTAATGAATCCGCGTCTCTTACTGGCCGTGATTGCAGGTGGTGTATCTGGTGTATTCACAT
TGGTATTATTTAATGCAGGTCTTGTGGCACCCGCTTCACCAGGTTCGATTATTGCGGTTTTATTAATGACACCACAAAAC
GCTATCGTTGGTGTTCTCGCTTCTGTTGCCATCGCGGCGACGGTATCTTTCGTTATCGCTTCATTCTTCTTAAAAATTCA
AAAAGAAGAAAATGGGCATTCATTAGAGAAAATGCAAGCCGCATCAAAAGCGATGAAATCCGGTGTACAGTTCAATACAC
CAGCTCGTTATCAAGGTGTACAAAAAATCTTTGTTGCTTGTGATGCCGGTATGGGATCAAGTGCAATGGGCGCAAGCATG
TTACGTAAAAAAGTCAAAGAAGCAGGGTTAGCCATTGAAGTGACAAACTGTGCAATTAATGATTTACCGGAAGACGCGCA
ATTAGTCATTACGCATCAAGACTTAACATTACGTGCCAAAAAACATACGCCAAATGCTATGCATTTTTCCTTAAACAATT
TCTTAGATGCCCATTTCTACGATAACCTCGTTCAAGATTTGAGCAATACAAAGGTGGCTGATTTAGCAAAGGTCAGCACG
CTTGAGCCACAAGAAGCGCCTCAAACTGCATTTGTACTCACTGAAAAACAAGTCTTCTTAGGCTTAAAAGCAGCAAATAA
AGAAGAAGCCATTCGATTCGCGGGTGAACGTTTAGTTGAATCAGGTTTTGTGCTACCAAGTTATGTTGATGCGATGTTTG
AGCGTGAAAAAATGGTTTCCACTTATTTAGGTGAAGGTATTGCGGTACCACATGGCACAATCGAAGCTAAAGATGCGGTA
CTCAAAACAGGTGTTGTTGTCTGTCAGTATCCAGAAGGTGTCAAATTTAATGAGGATGAAGAAGACAGTATCGCAAAATT
AGTGATTGGGATTGCCGCCAAAAACAACGAGCATCTGCAAGTGGTTTCTGCCATTACCAATGCACTAGATAACGAGGATG
CCATTCGCATTTTATCGGAAACGGATGATGTCGAAAAAGTCTTAGCGTTATTAAAAGCATAA

Upstream 100 bases:

>100_bases
TTCAAACAAATCAAAGAAAAAAACATTGTGATACTCATCACATATTTAATATGAAAAATTTTAGATTTCAGTTTCGCTAT
GCTATTTTGACAGTTGAAAA

Downstream 100 bases:

>100_bases
TCTTCTTGGGCAGATCATTATCTGCCCATGTTTATTTAAACTCTTTTCTTATTTTTGGAGTAAGCGATGAAAGCATTACA
TTTTGGTGCGGGTAATATTG

Product: PtmA

Products: NA

Alternate protein names: EIICBA-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific EIIA component [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MVILSTRLTMLSANAKVKVQNFGRFLSNMVMPNIGAFIAWGFITALFIPTGWLPNETLAKLVGPMITYLLPLLIGYSGGK
LIAGERGAVVGAIATAGVIVGTDIPMFLGAMIAGPTGGWAIKRFDKWADGKIKSGFEMLVNNFSSGIIGMILAILFFWLI
GPAVKALSTMLAAGVDILVKAHLLPLTSIFVEPAKILFLNNAINHGIFSPLGIQQSQEFGQSIFFLIEANPGPGLGVLLA
YIIFGKGTAKQTAGGATIIHFFGGIHEIYFPYVLMNPRLLLAVIAGGVSGVFTLVLFNAGLVAPASPGSIIAVLLMTPQN
AIVGVLASVAIAATVSFVIASFFLKIQKEENGHSLEKMQAASKAMKSGVQFNTPARYQGVQKIFVACDAGMGSSAMGASM
LRKKVKEAGLAIEVTNCAINDLPEDAQLVITHQDLTLRAKKHTPNAMHFSLNNFLDAHFYDNLVQDLSNTKVADLAKVST
LEPQEAPQTAFVLTEKQVFLGLKAANKEEAIRFAGERLVESGFVLPSYVDAMFEREKMVSTYLGEGIAVPHGTIEAKDAV
LKTGVVVCQYPEGVKFNEDEEDSIAKLVIGIAAKNNEHLQVVSAITNALDNEDAIRILSETDDVEKVLALLKA

Sequences:

>Translated_633_residues
MVILSTRLTMLSANAKVKVQNFGRFLSNMVMPNIGAFIAWGFITALFIPTGWLPNETLAKLVGPMITYLLPLLIGYSGGK
LIAGERGAVVGAIATAGVIVGTDIPMFLGAMIAGPTGGWAIKRFDKWADGKIKSGFEMLVNNFSSGIIGMILAILFFWLI
GPAVKALSTMLAAGVDILVKAHLLPLTSIFVEPAKILFLNNAINHGIFSPLGIQQSQEFGQSIFFLIEANPGPGLGVLLA
YIIFGKGTAKQTAGGATIIHFFGGIHEIYFPYVLMNPRLLLAVIAGGVSGVFTLVLFNAGLVAPASPGSIIAVLLMTPQN
AIVGVLASVAIAATVSFVIASFFLKIQKEENGHSLEKMQAASKAMKSGVQFNTPARYQGVQKIFVACDAGMGSSAMGASM
LRKKVKEAGLAIEVTNCAINDLPEDAQLVITHQDLTLRAKKHTPNAMHFSLNNFLDAHFYDNLVQDLSNTKVADLAKVST
LEPQEAPQTAFVLTEKQVFLGLKAANKEEAIRFAGERLVESGFVLPSYVDAMFEREKMVSTYLGEGIAVPHGTIEAKDAV
LKTGVVVCQYPEGVKFNEDEEDSIAKLVIGIAAKNNEHLQVVSAITNALDNEDAIRILSETDDVEKVLALLKA
>Mature_633_residues
MVILSTRLTMLSANAKVKVQNFGRFLSNMVMPNIGAFIAWGFITALFIPTGWLPNETLAKLVGPMITYLLPLLIGYSGGK
LIAGERGAVVGAIATAGVIVGTDIPMFLGAMIAGPTGGWAIKRFDKWADGKIKSGFEMLVNNFSSGIIGMILAILFFWLI
GPAVKALSTMLAAGVDILVKAHLLPLTSIFVEPAKILFLNNAINHGIFSPLGIQQSQEFGQSIFFLIEANPGPGLGVLLA
YIIFGKGTAKQTAGGATIIHFFGGIHEIYFPYVLMNPRLLLAVIAGGVSGVFTLVLFNAGLVAPASPGSIIAVLLMTPQN
AIVGVLASVAIAATVSFVIASFFLKIQKEENGHSLEKMQAASKAMKSGVQFNTPARYQGVQKIFVACDAGMGSSAMGASM
LRKKVKEAGLAIEVTNCAINDLPEDAQLVITHQDLTLRAKKHTPNAMHFSLNNFLDAHFYDNLVQDLSNTKVADLAKVST
LEPQEAPQTAFVLTEKQVFLGLKAANKEEAIRFAGERLVESGFVLPSYVDAMFEREKMVSTYLGEGIAVPHGTIEAKDAV
LKTGVVVCQYPEGVKFNEDEEDSIAKLVIGIAAKNNEHLQVVSAITNALDNEDAIRILSETDDVEKVLALLKA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=637, Percent_Identity=66.0910518053375, Blast_Score=811, Evalue=0.0,
Organism=Escherichia coli, GI1789301, Length=459, Percent_Identity=52.9411764705882, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI1788494, Length=141, Percent_Identity=42.5531914893617, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 67566; Mature: 67566

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVILSTRLTMLSANAKVKVQNFGRFLSNMVMPNIGAFIAWGFITALFIPTGWLPNETLAK
CEEEEEEHEEEECCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
LVGPMITYLLPLLIGYSGGKLIAGERGAVVGAIATAGVIVGTDIPMFLGAMIAGPTGGWA
HHHHHHHHHHHHHHCCCCCEEEECCCCCEEEHHHHCCEEEECCHHHHHHHHHCCCCCCHH
IKRFDKWADGKIKSGFEMLVNNFSSGIIGMILAILFFWLIGPAVKALSTMLAAGVDILVK
HHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHLLPLTSIFVEPAKILFLNNAINHGIFSPLGIQQSQEFGQSIFFLIEANPGPGLGVLLA
HHHHHHHHHHHCCHHEEEEECHHCCCCCCCCCCCHHHHCCCEEEEEEECCCCCCHHHHHH
YIIFGKGTAKQTAGGATIIHFFGGIHEIYFPYVLMNPRLLLAVIAGGVSGVFTLVLFNAG
HHHHCCCCCCCCCCCEEHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCC
LVAPASPGSIIAVLLMTPQNAIVGVLASVAIAATVSFVIASFFLKIQKEENGHSLEKMQA
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
ASKAMKSGVQFNTPARYQGVQKIFVACDAGMGSSAMGASMLRKKVKEAGLAIEVTNCAIN
HHHHHHCCCCCCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCC
DLPEDAQLVITHQDLTLRAKKHTPNAMHFSLNNFLDAHFYDNLVQDLSNTKVADLAKVST
CCCCCCEEEEEECCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
LEPQEAPQTAFVLTEKQVFLGLKAANKEEAIRFAGERLVESGFVLPSYVDAMFEREKMVS
CCCCCCCCEEEEEEEHHHEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
TYLGEGIAVPHGTIEAKDAVLKTGVVVCQYPEGVKFNEDEEDSIAKLVIGIAAKNNEHLQ
HHHCCCEECCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHEEECCCCCHHH
VVSAITNALDNEDAIRILSETDDVEKVLALLKA
HHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MVILSTRLTMLSANAKVKVQNFGRFLSNMVMPNIGAFIAWGFITALFIPTGWLPNETLAK
CEEEEEEHEEEECCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
LVGPMITYLLPLLIGYSGGKLIAGERGAVVGAIATAGVIVGTDIPMFLGAMIAGPTGGWA
HHHHHHHHHHHHHHCCCCCEEEECCCCCEEEHHHHCCEEEECCHHHHHHHHHCCCCCCHH
IKRFDKWADGKIKSGFEMLVNNFSSGIIGMILAILFFWLIGPAVKALSTMLAAGVDILVK
HHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHLLPLTSIFVEPAKILFLNNAINHGIFSPLGIQQSQEFGQSIFFLIEANPGPGLGVLLA
HHHHHHHHHHHCCHHEEEEECHHCCCCCCCCCCCHHHHCCCEEEEEEECCCCCCHHHHHH
YIIFGKGTAKQTAGGATIIHFFGGIHEIYFPYVLMNPRLLLAVIAGGVSGVFTLVLFNAG
HHHHCCCCCCCCCCCEEHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCC
LVAPASPGSIIAVLLMTPQNAIVGVLASVAIAATVSFVIASFFLKIQKEENGHSLEKMQA
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
ASKAMKSGVQFNTPARYQGVQKIFVACDAGMGSSAMGASMLRKKVKEAGLAIEVTNCAIN
HHHHHHCCCCCCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCC
DLPEDAQLVITHQDLTLRAKKHTPNAMHFSLNNFLDAHFYDNLVQDLSNTKVADLAKVST
CCCCCCEEEEEECCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
LEPQEAPQTAFVLTEKQVFLGLKAANKEEAIRFAGERLVESGFVLPSYVDAMFEREKMVS
CCCCCCCCEEEEEEEHHHEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
TYLGEGIAVPHGTIEAKDAVLKTGVVVCQYPEGVKFNEDEEDSIAKLVIGIAAKNNEHLQ
HHHCCCEECCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHEEECCCCCHHH
VVSAITNALDNEDAIRILSETDDVEKVLALLKA
HHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]